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CORDIS - Risultati della ricerca dell’UE
CORDIS

European Screening Centre; Unique Library for Attractive Biology

Descrizione del progetto

Collegare la ricerca allo sviluppo dei farmaci

Colmare il divario tra la ricerca di base e lo sviluppo dei farmaci potrebbe portare a nuovi farmaci con grandi benefici per la società. Il progetto ESCulab, finanziato dall’UE, permetterà la traduzione della comprensione scientifica fondamentale in punti di partenza innovativi per lo sviluppo di farmaci. Il progetto consentirà agli innovatori, dagli studiosi dell’UE alle PMI, di accedere a strutture industriali pionieristiche, alle competenze in materia di scoperta di farmaci e a un archivio con più di 550 000 composti adatti allo screening di potenziali bersagli farmacologici. ESCulab avvierà la European Lead Factory e la espanderà sostenendo 185 nuovi screening. Fornirà inoltre elenchi di risultati qualificati e creerà proposte per attrarre investitori e sviluppatori di farmaci, inducendoli a sfruttare ulteriormente i risultati.

Obiettivo

By bridging an important gap between basic research and drug development, ESCulab will facilitate the translation of fundamental scientific insights into innovative drug starting points. New biological ideas will be collected by crowdsourcing, novel targets, phenotypes and pathways translated and de-risked by delivering high-quality chemical starting points for drug development. Innovators from EU academics and SMEs are offered access to state-of-the-art industry-grade facilities, drug discovery expertise, and a top-quality, curated library with over 550,000 unique compounds suitable for screening potential drug targets. The ESCulab drug discovery data generated will allow the innovators to build a proposition that is likely to attract investors and/or drug developers and stimulate them to further exploit these findings. Ultimately, this will result in novel medicines – based on basic scientific findings – that will help patients (sooner).

ESCulab will achieve this by starting off the shoulders of the European Lead Factory (ELF), where this principle has been successfully implemented. 15 out of the 18 ESCulab consortium members were involved in ELF, thus ensuring maximum benefit from the ELF legacy. ESCulab will expand and enhance ELF by supporting 185 new screens. Important additions include the application of a much larger compound collection for screening, the ability to accommodate the more complex phenotypic screening assays, and the building of a sustainable business model to ensure access to Collaborative Drug Discovery activities beyond the funding period. The delivery of qualified hit lists (QHLs) is the end point for this project, but during the funding period, ESCulab will attract additonal funding for externally paid screens and hit-to-lead projects for organizations such as charities and foundations for long term sustainability of the initiative.

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

STICHTING LYGATURE
Contribution nette de l'UE
€ 1 434 943,75
Indirizzo
JAARBEURSPLEIN 6
3521 AL Utrecht
Paesi Bassi

Mostra sulla mappa

PMI

L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.

Regione
West-Nederland Utrecht Utrecht
Tipo di attività
Other
Collegamenti
Costo totale
€ 1 574 943,75

Partecipanti (17)