Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain

Informacje na temat projektu

IM2PACT

Identyfikator umowy o grant: 807015

DOI

10.3030/807015

Projekt został zamknięty

Data podpisania przez KE 14 Grudnia 2018

Data rozpoczęcia 1 Stycznia 2019

Data zakończenia 31 Grudnia 2024

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 17 410 136,00

Wkład UE

€ 9 000 000,00

Koordynowany przez

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (36)

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Autorzy: Rebecca Faresjö Dag Sehlin Stina Syvänen
Opublikowane w: Fluids and Barriers in the CNS, 2023, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-023-00435-2

Tunneling Nanotubes: A New Target for Nanomedicine?

Autorzy: Ottonelli, I.; Caraffi, R.; Tosi, G.; Vandelli, M.A.; Duskey, J.T.; Ruozi, B.
Opublikowane w: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23042237

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Autorzy: Dominika Luptáková, Theodosia Vallianatou, Anna Nilsson, Reza Shariatgorji, Margareta Hammarlund-Udenaes, Irena Loryan, Per E. Andrén
Opublikowane w: Molecular Psychiatry, 2021, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-021-01267-y

Region-independent active CNS net uptake of marketed H+/OC antiporter system substrates

Autorzy: Frida Bällgren, Yang Hu, Shannuo Li, Lara van de Beek, Margareta Hammarlund-Udenaes, Irena Loryan
Opublikowane w: Frontiers in Cellular Neuroscience, Numer 18, 2024, ISSN 1662-5102
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1493644

Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

Autorzy: Ozgür, Burak; Helms, Hans Christian Cederberg; Tornabene, Erica; Brodin, Birger
Opublikowane w: Fluids and Barriers of the CNS, 2022, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-021-00297-6

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Autorzy: Frida Bällgren, Tilda Bergfast, Aghavni Ginosyan, Jessica Mahajan, Miklós Lipcsey, Margareta Hammarlund-Udenaes, Stina Syvänen, Irena Loryan
Opublikowane w: Fluids and Barriers of the CNS, Numer 21, 2024, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-024-00583-z

Brain endothelial LRP1 maintains blood–brain barrier integrity

Autorzy: Steffen E. Storck, Magdalena Kurtyka, Claus U. Pietrzik
Opublikowane w: Fluids and Barriers of the CNS, Numer 18/1, 2021, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-021-00260-5

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

Autorzy: Rinaldi, Arianna; Caraffi, Riccardo; Grazioli, Maria Vittoria; Oddone, Natalia; Giardino, Luciana; Tosi, Giovanni; Vandelli, Maria Angela; Calzà, Laura; Ruozi, Barbara; Duskey, Jason Thomas
Opublikowane w: Polymers, Numer 1, 2022, ISSN 2073-4360
Wydawca: Basel MDPI
DOI: 10.3390/polym14040687

Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Autorzy: Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan
Opublikowane w: Fluids and Barriers of the CNS, Numer 21, 2024, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-024-00598-6

Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device

Autorzy: Hudecz, Diana; McCloskey, Molly C.; Vergo, Sandra; Christensen, Søren; McGrath, James L.; Nielsen, Morten S.
Opublikowane w: International Journal of Molecular Sciences, Numer 5, 2023, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065624

Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries

Autorzy: Mikkel Roland Holst, Mette Richner, Pernille Olsgaard Arenshøj, Parvez Alam, Kathrine Hyldig, Morten Schallburg Nielsen
Opublikowane w: Fluids and Barriers of the CNS, Numer 21, 2024, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-024-00585-x

Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

Autorzy: Ilaria Ottonelli; Andrea Bighinati; Elisa Adani; François Loll; Riccardo Caraffi; Maria Angela Vandelli; Frank Boury; Giovanni Tosi; Jason Thomas Duskey; Valeria Marigo; Barbara Ruozi
Opublikowane w: Pharmaceutics, 2022, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15010025

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

Autorzy: Julku U, Xiong M, Wik E, Roshanbin S, Sehlin D, Syvänen S
Opublikowane w: Fluids Barriers CNS, 2022, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-022-00398-w

Contribution of Syndecans to the Cellular Entry of SARS-CoV-2

Autorzy: Anett Hudák; Annamária Letoha; László Szilák; Tamás Letoha
Opublikowane w: International Journal of Molecular Sciences, Numer 4, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105336

The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology.

Autorzy: Anett Hudák; Katalin Jósvay; Ildikó Domonkos; Annamária Letoha; László Szilák; Tamás Letoha
Opublikowane w: International Journal of Molecular Sciences, Numer 5, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22137070

A hydrogel model of the human blood-brain barrier using differentiated stem cells

Autorzy: Nandita Rahatekar Singh, Radka Gromnicova, Andreas Brachner, Igor Kraev, Ignacio A. Romero, Winfried Neuhaus, David Male
Opublikowane w: Plos One, 2023, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0283954

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier

Autorzy: Alexander D. Mazura; Anke Ohler; Steffen E. Storck; Magdalena Kurtyka; Franka Scharfenberg; Sascha Weggen; Christoph Becker-Pauly; Claus U. Pietrzik
Opublikowane w: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00018-022-04237-x

Applications of the ROS responsive Thioketal linker for the production of smart nanomedicines

Autorzy: Rinaldi A.,Caraffi R., Grazioli M.V., Oddone N., Giardino L., Tosi G., Vandelli M.A., Calzà L., Ruozi B. and Duskey J.T.,
Opublikowane w: Polymers, 2022, ISSN 2073-4360
Wydawca: MDPI
DOI: 10.3390/polym14040687

Generation of Advanced Blood–Brain Barrier Spheroids Using Human‐Induced Pluripotent Stem Cell‐Derived Brain Capillary Endothelial‐Like Cells

Autorzy: Sanjana Mathew‐Schmitt, Sabrina Oerter, Evelin Reitenbach, Sabine Gätzner, Alevtina Höchner, Heinz‐Georg Jahnke, Jörg Piontek, Winfried Neuhaus, Andreas Brachner, Marco Metzger, Antje Appelt‐Menzel
Opublikowane w: Advanced Biology, Numer 9, 2025, ISSN 2701-0198
Wydawca: Wiley
DOI: 10.1002/adbi.202400442

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study

Autorzy: Gina P. Hoyos-Ceballos, Barbara Ruozi, Ilaria Ottonelli, Federica Da Ros, Maria Angela Vandelli, Flavio Forni, Eleonora Daini, Antonietta Vilella, Michele Zoli, Giovanni Tosi, Jason T. Duskey, Betty L. López-Osorio
Opublikowane w: Pharmaceutics, Numer 12/1, 2020, Strona(/y) 72, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12010072

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

Autorzy: Alexandra Pokhilko, Gaia Brezzo, Lahiru Handunnetthi, Raphael Heilig, Rachel Lennon, Colin Smith, Stuart M Allan, Alessandra Granata, Sanjay Sinha, Tao Wang, Hugh S Markus, Alexandra Naba, Roman Fischer, Tom Van Agtmael, Karen Horsburgh, M Zameel Cader
Opublikowane w: Journal of Cerebral Blood Flow & Metabolism, Numer 41/9, 2021, Strona(/y) 2423-2438, ISSN 0271-678X
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211004307

The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Autorzy: Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Nienke M. de Wit, Alberte Bay Villekjær Pedersen, Maximilian Keller, Caleb Webber, Helga E. de Vries, Olaf Ansorge, Christer Betsholtz, Marijke De Bock, Catarina Chaves, Birger Brodin, Morten S. Nielsen, Winfried Neuhaus, Robert D. Bell, Tamás Letoha, Axel H. Meyer, Germán Leparc, Martin Lenter, Dominique Lesuisse, Zameel M.
Opublikowane w: European Journal of Cell Biology, Numer 103, 2025, Strona(/y) 151406, ISSN 0171-9335
Wydawca: Elsevier BV
DOI: 10.1016/j.ejcb.2024.151406

Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization

Autorzy: Francesca Rodà; Riccardo Caraffi; Silvia Picciolini; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Marzia Bedoni; Ilaria Ottonelli; Jason Thomas Duskey
Opublikowane w: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032496

Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Autorzy: Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia; Fredriksson, Robert; Gosselet, Fabien; Culot, Maxime; Göransson, Ulf; Hammarlund-Udenaes, Margareta; Loryan, Irena
Opublikowane w: Pharmaceutics, Numer 1, 2023, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15051507

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories

Autorzy: Alexandra Pokhilko, Adam E. Handel, Fabiola Curion, Viola Volpato, Emma S. Whiteley, Sunniva Bøstrand, Sarah E. Newey, Colin J. Akerman, Caleb Webber, Michael B. Clark, Rory Bowden, M. Zameel Cader
Opublikowane w: Genome Research, Numer 31/6, 2021, Strona(/y) 1069-1081, ISSN 1088-9051
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.273961.120

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Autorzy: Judit P. Vigh, András Kincses, Burak Ozgür, Fruzsina R. Walter, Ana Raquel Santa-Maria, Sándor Valkai, Mónika Vastag, Winfried Neuhaus, Birger Brodin, András Dér, Mária A. Deli
Opublikowane w: Micromachines, Numer 12/6, 2021, Strona(/y) 685, ISSN 2072-666X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12060685

Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation

Autorzy: Mazura, Alexander, Pietrzik, Claus
Opublikowane w: Pharmaceutics, 2023, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041268

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease

Autorzy: Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cade
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-46630-z

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments

Autorzy: Jason Thomas Duskey; Arianna Rinaldi; Ilaria Ottonelli; Riccardo Caraffi; Chiara Alessia De Benedictis; Ann Katrin Sauer; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Andreas Martin Grabrucker
Opublikowane w: Pharmaceutics;, Numer Volume 14; Numer 7, 2022, Strona(/y) 1450, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071450

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Autorzy: Maarja A. Mäe, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Opublikowane w: Circulation Research, Numer 128/4, 2021, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317473

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Autorzy: Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Opublikowane w: Fluids and Barriers of the CNS, Numer 18/1, 2021, ISSN 2045-8118
Wydawca: BioMed Central
DOI: 10.1186/s12987-021-00257-0

Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action

Autorzy: Nana Svane, Frida Bällgren, Aghavni Ginosyan, Mie Kristensen, Birger Brodin, Irena Loryan
Opublikowane w: The Journal of Headache and Pain, Numer 25, 2024, ISSN 1129-2377
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s10194-024-01894-0

Sortilin regulates blood-brain barrier integrity.

Autorzy: Andrea E. Tóth; Andrea E. Tóth; Hans C. Helms; Hans C. Helms; Andras Harazin; Kasper B. Johnsen; Kasper B. Johnsen; Charlotte Goldeman; Charlotte Goldeman; Annette Burkhart; Annette Burkhart; Maj S. Thomsen; Maj S. Thomsen; Paul J. Kempen; Paul J. Kempen; Adrian Klepe; Dora V. Lipka; Peter L. Møller; Thomas Lars Andresen; Thomas Lars Andresen; Mette Nyegaard; Torben Moos; Torben Moos; Birger Br
Opublikowane w: The FEBS journal, Numer 1, 2022, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.16225

Microfluidic Technology for the Production of Hybrid Nanomedicines.

Autorzy: Ottonelli, Ilaria; Duskey, Jason Thomas; Rinaldi, Arianna; Grazioli, Maria Vittoria; Parmeggiani, Irene; Vandelli, Maria Angela; Wang, Leon Z.; Prud’homme, Robert K.; Tosi, Giovanni; Ruozi, Barbara
Opublikowane w: Pharmaceutics, 2021, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091495

Transferrin Receptor Binding BBB-shuttle facilitates brain delivery of anti-Aβ affibodies

Autorzy: Faresjö R, Lindberg H, Ståhl S, Löfblom J, Syvänen S, Sehlin D.
Opublikowane w: Pharmaceutical Research, 2022, ISSN 0724-8741
Wydawca: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-022-03282-2

A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

Autorzy: Christoph Eilenberger, Mario Rothbauer, Florian Selinger, Anna Gerhartl, Christian Jordan, Michael Harasek, Barbara Schädl, Johannes Grillari, Julian Weghuber, Winfried Neuhaus, Seta Küpcü, Peter Ertl
Opublikowane w: Advanced Science, Numer 8/11, 2021, Strona(/y) 2004856, ISSN 2198-3844
Wydawca: Wiley-VCH
DOI: 10.1002/advs.202004856

Book chapters (1)

Drug Delivery Strategies to Overcome the Blood–Brain Barrier (BBB)

Autorzy: Cederberg Helms, Hans Christian Kristensen, Mie Saaby, Lasse Fricker, Gert Brodin, Birger
Opublikowane w: Physiology, Pharmacology and Pathology of the Blood-Brain Barrier, 2020, ISSN 0171-2004
Wydawca: Springer Cham
DOI: 10.1007/164_2020_403

Other (1)

Amino acid and viral binding by the high-affinity Cationic Amino acidTransporter 1 (CAT1) from Mus musculus

Autorzy: David Sauer, Mingda Ye, Zhu Liang, Daming Zhou, Ashley Pike, SiYi Wang, Dong Wang, Souvika Bakshi, Laurent Brooke, Eleanor Williams, Jon Elkins, Benedikt Kessler, David Stuart
Opublikowane w: 2024
Wydawca: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-4673967/v1