Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain

Publications

Tunneling Nanotubes: A New Target for Nanomedicine?

Auteurs: Ottonelli, I.; Caraffi, R.; Tosi, G.; Vandelli, M.A.; Duskey, J.T.; Ruozi, B.
Publié dans: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23042237

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Auteurs: Dominika Luptáková, Theodosia Vallianatou, Anna Nilsson, Reza Shariatgorji, Margareta Hammarlund-Udenaes, Irena Loryan, Per E. Andrén
Publié dans: Molecular Psychiatry, 2021, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-021-01267-y

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Auteurs: Faresjö, Rebecca; Sehlin, Dag; Syvänen, Stina
Publié dans: Fluids and Barriers in the CNS, Numéro 1, 2023, ISSN 2045-8118
Éditeur: BioMed Central
DOI: 10.1186/s12987-023-00435-2

Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization

Auteurs: Francesca Rodà; Riccardo Caraffi; Silvia Picciolini; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Marzia Bedoni; Ilaria Ottonelli; Jason Thomas Duskey
Publié dans: International Journal of Molecular Sciences, Numéro 1, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032496

Brain endothelial LRP1 maintains blood–brain barrier integrity

Auteurs: Steffen E. Storck, Magdalena Kurtyka, Claus U. Pietrzik
Publié dans: Fluids and Barriers of the CNS, Numéro 18/1, 2021, ISSN 2045-8118
Éditeur: BioMed Central
DOI: 10.1186/s12987-021-00260-5

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

Auteurs: Rinaldi, Arianna; Caraffi, Riccardo; Grazioli, Maria Vittoria; Oddone, Natalia; Giardino, Luciana; Tosi, Giovanni; Vandelli, Maria Angela; Calzà, Laura; Ruozi, Barbara; Duskey, Jason Thomas
Publié dans: Polymers, Numéro 1, 2022, ISSN 2073-4360
Éditeur: Basel MDPI
DOI: 10.3390/polym14040687

Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device

Auteurs: Hudecz, Diana; McCloskey, Molly C.; Vergo, Sandra; Christensen, Søren; McGrath, James L.; Nielsen, Morten S.
Publié dans: International Journal of Molecular Sciences, Numéro 5, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065624

Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation

Auteurs: Alexander D. Mazura; Claus U. Pietrzik
Publié dans: Pharmaceutics, Numéro 1, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041268

Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

Auteurs: Ilaria Ottonelli; Andrea Bighinati; Elisa Adani; François Loll; Riccardo Caraffi; Maria Angela Vandelli; Frank Boury; Giovanni Tosi; Jason Thomas Duskey; Valeria Marigo; Barbara Ruozi
Publié dans: Pharmaceutics, Numéro 3, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15010025

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

Auteurs: Julku U, Xiong M, Wik E, Roshanbin S, Sehlin D, Syvänen S
Publié dans: Fluids Barriers CNS, 2022, ISSN 2045-8118
Éditeur: BioMed Central
DOI: 10.1186/s12987-022-00398-w

Contribution of Syndecans to the Cellular Entry of SARS-CoV-2

Auteurs: Anett Hudák; Annamária Letoha; László Szilák; Tamás Letoha
Publié dans: International Journal of Molecular Sciences, Numéro 4, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105336

The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology.

Auteurs: Anett Hudák; Katalin Jósvay; Ildikó Domonkos; Annamária Letoha; László Szilák; Tamás Letoha
Publié dans: International Journal of Molecular Sciences, Numéro 5, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22137070

Applications of the ROS responsive Thioketal linker for the production of smart nanomedicines

Auteurs: Rinaldi A.,Caraffi R., Grazioli M.V., Oddone N., Giardino L., Tosi G., Vandelli M.A., Calzà L., Ruozi B. and Duskey J.T.,
Publié dans: Polymers, 2022, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym14040687

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study

Auteurs: Gina P. Hoyos-Ceballos, Barbara Ruozi, Ilaria Ottonelli, Federica Da Ros, Maria Angela Vandelli, Flavio Forni, Eleonora Daini, Antonietta Vilella, Michele Zoli, Giovanni Tosi, Jason T. Duskey, Betty L. López-Osorio
Publié dans: Pharmaceutics, Numéro 12/1, 2020, Page(s) 72, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12010072

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

Auteurs: Alexandra Pokhilko, Gaia Brezzo, Lahiru Handunnetthi, Raphael Heilig, Rachel Lennon, Colin Smith, Stuart M Allan, Alessandra Granata, Sanjay Sinha, Tao Wang, Hugh S Markus, Alexandra Naba, Roman Fischer, Tom Van Agtmael, Karen Horsburgh, M Zameel Cader
Publié dans: Journal of Cerebral Blood Flow & Metabolism, Numéro 41/9, 2021, Page(s) 2423-2438, ISSN 0271-678X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211004307

Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Auteurs: Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia; Fredriksson, Robert; Gosselet, Fabien; Culot, Maxime; Göransson, Ulf; Hammarlund-Udenaes, Margareta; Loryan, Irena
Publié dans: Pharmaceutics, Numéro 1, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15051507

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories

Auteurs: Alexandra Pokhilko, Adam E. Handel, Fabiola Curion, Viola Volpato, Emma S. Whiteley, Sunniva Bøstrand, Sarah E. Newey, Colin J. Akerman, Caleb Webber, Michael B. Clark, Rory Bowden, M. Zameel Cader
Publié dans: Genome Research, Numéro 31/6, 2021, Page(s) 1069-1081, ISSN 1088-9051
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.273961.120

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier

Auteurs: Alexander D. Mazura; Anke Ohler; Steffen E. Storck; Magdalena Kurtyka; Franka Scharfenberg; Sascha Weggen; Christoph Becker-Pauly; Claus U. Pietrzik
Publié dans: Cellular and Molecular Life Sciences, Numéro 1, 2022, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-022-04237-x

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Auteurs: Judit P. Vigh, András Kincses, Burak Ozgür, Fruzsina R. Walter, Ana Raquel Santa-Maria, Sándor Valkai, Mónika Vastag, Winfried Neuhaus, Birger Brodin, András Dér, Mária A. Deli
Publié dans: Micromachines, Numéro 12/6, 2021, Page(s) 685, ISSN 2072-666X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12060685

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments

Auteurs: Jason Thomas Duskey; Arianna Rinaldi; Ilaria Ottonelli; Riccardo Caraffi; Chiara Alessia De Benedictis; Ann Katrin Sauer; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Andreas Martin Grabrucker
Publié dans: Pharmaceutics;, Numéro Volume 14; Numéro 7, 2022, Page(s) 1450, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071450

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Auteurs: Maarja A. Mäe, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Publié dans: Circulation Research, Numéro 128/4, 2021, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317473

A hydrogel model of the human blood-brain barrier using differentiated stem cells

Auteurs: Singh, Nandita Rahatekar; Gromnicova, Radka; Brachner, Andreas; Kraev, Igor; Romero, Ignacio A.; Neuhaus, Winfried; Male, David
Publié dans: Plos One, Numéro 1, 2023, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0283954

Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

Auteurs: Ozgür, Burak; Helms, Hans Christian Cederberg; Tornabene, Erica; Brodin, Birger
Publié dans: Fluids and Barriers of the CNS, Numéro 1, 2022, ISSN 2045-8118
Éditeur: BioMed Central
DOI: 10.1186/s12987-021-00297-6

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Auteurs: Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Publié dans: Fluids and Barriers of the CNS, Numéro 18/1, 2021, ISSN 2045-8118
Éditeur: BioMed Central
DOI: 10.1186/s12987-021-00257-0

Microfluidic Technology for the Production of Hybrid Nanomedicines.

Auteurs: Ottonelli, Ilaria; Duskey, Jason Thomas; Rinaldi, Arianna; Grazioli, Maria Vittoria; Parmeggiani, Irene; Vandelli, Maria Angela; Wang, Leon Z.; Prud’homme, Robert K.; Tosi, Giovanni; Ruozi, Barbara
Publié dans: Pharmaceutics, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091495

Sortilin regulates blood-brain barrier integrity.

Auteurs: Andrea E. Tóth; Andrea E. Tóth; Hans C. Helms; Hans C. Helms; Andras Harazin; Kasper B. Johnsen; Kasper B. Johnsen; Charlotte Goldeman; Charlotte Goldeman; Annette Burkhart; Annette Burkhart; Maj S. Thomsen; Maj S. Thomsen; Paul J. Kempen; Paul J. Kempen; Adrian Klepe; Dora V. Lipka; Peter L. Møller; Thomas Lars Andresen; Thomas Lars Andresen; Mette Nyegaard; Torben Moos; Torben Moos; Birger Br
Publié dans: The FEBS journal, Numéro 1, 2022, ISSN 1742-464X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/febs.16225

Transferrin Receptor Binding BBB-shuttle facilitates brain delivery of anti-Aβ affibodies

Auteurs: Faresjö R, Lindberg H, Ståhl S, Löfblom J, Syvänen S, Sehlin D.
Publié dans: Pharmaceutical Research, 2022, ISSN 0724-8741
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-022-03282-2

A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

Auteurs: Christoph Eilenberger, Mario Rothbauer, Florian Selinger, Anna Gerhartl, Christian Jordan, Michael Harasek, Barbara Schädl, Johannes Grillari, Julian Weghuber, Winfried Neuhaus, Seta Küpcü, Peter Ertl
Publié dans: Advanced Science, Numéro 8/11, 2021, Page(s) 2004856, ISSN 2198-3844
Éditeur: Wiley-VCH
DOI: 10.1002/advs.202004856

Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB).

Auteurs: Helms, Hans Christian Cederberg; Kristensen, Mie; Saaby, Lasse; Fricker, Gert; Brodin, Birger
Publié dans: Physiology, Pharmacology and Pathology of the Blood-Brain Barrier, Numéro 1, 2020, ISSN 0171-2004
Éditeur: Springer Cham
DOI: 10.1007/164_2020_403

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