Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain

Información del proyecto

IM2PACT

Identificador del acuerdo de subvención: 807015

DOI

10.3030/807015

Proyecto cerrado

Fecha de la firma de la CE 14 Diciembre 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 17 410 136,00

Aportación de la UE

€ 9 000 000,00

Coordinado por

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (36)

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Autores: Rebecca Faresjö Dag Sehlin Stina Syvänen
Publicado en: Fluids and Barriers in the CNS, 2023, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-023-00435-2

Tunneling Nanotubes: A New Target for Nanomedicine?

Autores: Ottonelli, I.; Caraffi, R.; Tosi, G.; Vandelli, M.A.; Duskey, J.T.; Ruozi, B.
Publicado en: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23042237

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Autores: Dominika Luptáková, Theodosia Vallianatou, Anna Nilsson, Reza Shariatgorji, Margareta Hammarlund-Udenaes, Irena Loryan, Per E. Andrén
Publicado en: Molecular Psychiatry, 2021, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-021-01267-y

Region-independent active CNS net uptake of marketed H+/OC antiporter system substrates

Autores: Frida Bällgren, Yang Hu, Shannuo Li, Lara van de Beek, Margareta Hammarlund-Udenaes, Irena Loryan
Publicado en: Frontiers in Cellular Neuroscience, Edición 18, 2024, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1493644

Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

Autores: Ozgür, Burak; Helms, Hans Christian Cederberg; Tornabene, Erica; Brodin, Birger
Publicado en: Fluids and Barriers of the CNS, 2022, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-021-00297-6

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Autores: Frida Bällgren, Tilda Bergfast, Aghavni Ginosyan, Jessica Mahajan, Miklós Lipcsey, Margareta Hammarlund-Udenaes, Stina Syvänen, Irena Loryan
Publicado en: Fluids and Barriers of the CNS, Edición 21, 2024, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-024-00583-z

Brain endothelial LRP1 maintains blood–brain barrier integrity

Autores: Steffen E. Storck, Magdalena Kurtyka, Claus U. Pietrzik
Publicado en: Fluids and Barriers of the CNS, Edición 18/1, 2021, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-021-00260-5

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

Autores: Rinaldi, Arianna; Caraffi, Riccardo; Grazioli, Maria Vittoria; Oddone, Natalia; Giardino, Luciana; Tosi, Giovanni; Vandelli, Maria Angela; Calzà, Laura; Ruozi, Barbara; Duskey, Jason Thomas
Publicado en: Polymers, Edición 1, 2022, ISSN 2073-4360
Editor: Basel MDPI
DOI: 10.3390/polym14040687

Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Autores: Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan
Publicado en: Fluids and Barriers of the CNS, Edición 21, 2024, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-024-00598-6

Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device

Autores: Hudecz, Diana; McCloskey, Molly C.; Vergo, Sandra; Christensen, Søren; McGrath, James L.; Nielsen, Morten S.
Publicado en: International Journal of Molecular Sciences, Edición 5, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065624

Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries

Autores: Mikkel Roland Holst, Mette Richner, Pernille Olsgaard Arenshøj, Parvez Alam, Kathrine Hyldig, Morten Schallburg Nielsen
Publicado en: Fluids and Barriers of the CNS, Edición 21, 2024, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-024-00585-x

Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

Autores: Ilaria Ottonelli; Andrea Bighinati; Elisa Adani; François Loll; Riccardo Caraffi; Maria Angela Vandelli; Frank Boury; Giovanni Tosi; Jason Thomas Duskey; Valeria Marigo; Barbara Ruozi
Publicado en: Pharmaceutics, 2022, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15010025

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

Autores: Julku U, Xiong M, Wik E, Roshanbin S, Sehlin D, Syvänen S
Publicado en: Fluids Barriers CNS, 2022, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-022-00398-w

Contribution of Syndecans to the Cellular Entry of SARS-CoV-2

Autores: Anett Hudák; Annamária Letoha; László Szilák; Tamás Letoha
Publicado en: International Journal of Molecular Sciences, Edición 4, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105336

The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology.

Autores: Anett Hudák; Katalin Jósvay; Ildikó Domonkos; Annamária Letoha; László Szilák; Tamás Letoha
Publicado en: International Journal of Molecular Sciences, Edición 5, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22137070

A hydrogel model of the human blood-brain barrier using differentiated stem cells

Autores: Nandita Rahatekar Singh, Radka Gromnicova, Andreas Brachner, Igor Kraev, Ignacio A. Romero, Winfried Neuhaus, David Male
Publicado en: Plos One, 2023, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0283954

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier

Autores: Alexander D. Mazura; Anke Ohler; Steffen E. Storck; Magdalena Kurtyka; Franka Scharfenberg; Sascha Weggen; Christoph Becker-Pauly; Claus U. Pietrzik
Publicado en: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-022-04237-x

Applications of the ROS responsive Thioketal linker for the production of smart nanomedicines

Autores: Rinaldi A.,Caraffi R., Grazioli M.V., Oddone N., Giardino L., Tosi G., Vandelli M.A., Calzà L., Ruozi B. and Duskey J.T.,
Publicado en: Polymers, 2022, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym14040687

Generation of Advanced Blood–Brain Barrier Spheroids Using Human‐Induced Pluripotent Stem Cell‐Derived Brain Capillary Endothelial‐Like Cells

Autores: Sanjana Mathew‐Schmitt, Sabrina Oerter, Evelin Reitenbach, Sabine Gätzner, Alevtina Höchner, Heinz‐Georg Jahnke, Jörg Piontek, Winfried Neuhaus, Andreas Brachner, Marco Metzger, Antje Appelt‐Menzel
Publicado en: Advanced Biology, Edición 9, 2025, ISSN 2701-0198
Editor: Wiley
DOI: 10.1002/adbi.202400442

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study

Autores: Gina P. Hoyos-Ceballos, Barbara Ruozi, Ilaria Ottonelli, Federica Da Ros, Maria Angela Vandelli, Flavio Forni, Eleonora Daini, Antonietta Vilella, Michele Zoli, Giovanni Tosi, Jason T. Duskey, Betty L. López-Osorio
Publicado en: Pharmaceutics, Edición 12/1, 2020, Página(s) 72, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12010072

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

Autores: Alexandra Pokhilko, Gaia Brezzo, Lahiru Handunnetthi, Raphael Heilig, Rachel Lennon, Colin Smith, Stuart M Allan, Alessandra Granata, Sanjay Sinha, Tao Wang, Hugh S Markus, Alexandra Naba, Roman Fischer, Tom Van Agtmael, Karen Horsburgh, M Zameel Cader
Publicado en: Journal of Cerebral Blood Flow & Metabolism, Edición 41/9, 2021, Página(s) 2423-2438, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211004307

The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Autores: Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Nienke M. de Wit, Alberte Bay Villekjær Pedersen, Maximilian Keller, Caleb Webber, Helga E. de Vries, Olaf Ansorge, Christer Betsholtz, Marijke De Bock, Catarina Chaves, Birger Brodin, Morten S. Nielsen, Winfried Neuhaus, Robert D. Bell, Tamás Letoha, Axel H. Meyer, Germán Leparc, Martin Lenter, Dominique Lesuisse, Zameel M.
Publicado en: European Journal of Cell Biology, Edición 103, 2025, Página(s) 151406, ISSN 0171-9335
Editor: Elsevier BV
DOI: 10.1016/j.ejcb.2024.151406

Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization

Autores: Francesca Rodà; Riccardo Caraffi; Silvia Picciolini; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Marzia Bedoni; Ilaria Ottonelli; Jason Thomas Duskey
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032496

Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Autores: Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia; Fredriksson, Robert; Gosselet, Fabien; Culot, Maxime; Göransson, Ulf; Hammarlund-Udenaes, Margareta; Loryan, Irena
Publicado en: Pharmaceutics, Edición 1, 2023, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15051507

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories

Autores: Alexandra Pokhilko, Adam E. Handel, Fabiola Curion, Viola Volpato, Emma S. Whiteley, Sunniva Bøstrand, Sarah E. Newey, Colin J. Akerman, Caleb Webber, Michael B. Clark, Rory Bowden, M. Zameel Cader
Publicado en: Genome Research, Edición 31/6, 2021, Página(s) 1069-1081, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.273961.120

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Autores: Judit P. Vigh, András Kincses, Burak Ozgür, Fruzsina R. Walter, Ana Raquel Santa-Maria, Sándor Valkai, Mónika Vastag, Winfried Neuhaus, Birger Brodin, András Dér, Mária A. Deli
Publicado en: Micromachines, Edición 12/6, 2021, Página(s) 685, ISSN 2072-666X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12060685

Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation

Autores: Mazura, Alexander, Pietrzik, Claus
Publicado en: Pharmaceutics, 2023, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041268

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease

Autores: Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cade
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-46630-z

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments

Autores: Jason Thomas Duskey; Arianna Rinaldi; Ilaria Ottonelli; Riccardo Caraffi; Chiara Alessia De Benedictis; Ann Katrin Sauer; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Andreas Martin Grabrucker
Publicado en: Pharmaceutics;, Edición Volume 14; Edición 7, 2022, Página(s) 1450, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071450

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Autores: Maarja A. Mäe, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Publicado en: Circulation Research, Edición 128/4, 2021, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317473

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Autores: Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Publicado en: Fluids and Barriers of the CNS, Edición 18/1, 2021, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-021-00257-0

Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action

Autores: Nana Svane, Frida Bällgren, Aghavni Ginosyan, Mie Kristensen, Birger Brodin, Irena Loryan
Publicado en: The Journal of Headache and Pain, Edición 25, 2024, ISSN 1129-2377
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s10194-024-01894-0

Sortilin regulates blood-brain barrier integrity.

Autores: Andrea E. Tóth; Andrea E. Tóth; Hans C. Helms; Hans C. Helms; Andras Harazin; Kasper B. Johnsen; Kasper B. Johnsen; Charlotte Goldeman; Charlotte Goldeman; Annette Burkhart; Annette Burkhart; Maj S. Thomsen; Maj S. Thomsen; Paul J. Kempen; Paul J. Kempen; Adrian Klepe; Dora V. Lipka; Peter L. Møller; Thomas Lars Andresen; Thomas Lars Andresen; Mette Nyegaard; Torben Moos; Torben Moos; Birger Br
Publicado en: The FEBS journal, Edición 1, 2022, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.16225

Microfluidic Technology for the Production of Hybrid Nanomedicines.

Autores: Ottonelli, Ilaria; Duskey, Jason Thomas; Rinaldi, Arianna; Grazioli, Maria Vittoria; Parmeggiani, Irene; Vandelli, Maria Angela; Wang, Leon Z.; Prud’homme, Robert K.; Tosi, Giovanni; Ruozi, Barbara
Publicado en: Pharmaceutics, 2021, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091495

Transferrin Receptor Binding BBB-shuttle facilitates brain delivery of anti-Aβ affibodies

Autores: Faresjö R, Lindberg H, Ståhl S, Löfblom J, Syvänen S, Sehlin D.
Publicado en: Pharmaceutical Research, 2022, ISSN 0724-8741
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-022-03282-2

A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

Autores: Christoph Eilenberger, Mario Rothbauer, Florian Selinger, Anna Gerhartl, Christian Jordan, Michael Harasek, Barbara Schädl, Johannes Grillari, Julian Weghuber, Winfried Neuhaus, Seta Küpcü, Peter Ertl
Publicado en: Advanced Science, Edición 8/11, 2021, Página(s) 2004856, ISSN 2198-3844
Editor: Wiley-VCH
DOI: 10.1002/advs.202004856

Book chapters (1)

Drug Delivery Strategies to Overcome the Blood–Brain Barrier (BBB)

Autores: Cederberg Helms, Hans Christian Kristensen, Mie Saaby, Lasse Fricker, Gert Brodin, Birger
Publicado en: Physiology, Pharmacology and Pathology of the Blood-Brain Barrier, 2020, ISSN 0171-2004
Editor: Springer Cham
DOI: 10.1007/164_2020_403

Other (1)

Amino acid and viral binding by the high-affinity Cationic Amino acidTransporter 1 (CAT1) from Mus musculus

Autores: David Sauer, Mingda Ye, Zhu Liang, Daming Zhou, Ashley Pike, SiYi Wang, Dong Wang, Souvika Bakshi, Laurent Brooke, Eleanor Williams, Jon Elkins, Benedikt Kessler, David Stuart
Publicado en: 2024
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-4673967/v1