Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain

Informazioni relative al progetto

IM2PACT

ID dell’accordo di sovvenzione: 807015

DOI

10.3030/807015

Progetto chiuso

Data della firma CE 14 Dicembre 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2024

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 17 410 136,00

Contributo UE

€ 9 000 000,00

Coordinato da

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (36)

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Autori: Rebecca Faresjö Dag Sehlin Stina Syvänen
Pubblicato in: Fluids and Barriers in the CNS, 2023, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-023-00435-2

Tunneling Nanotubes: A New Target for Nanomedicine?

Autori: Ottonelli, I.; Caraffi, R.; Tosi, G.; Vandelli, M.A.; Duskey, J.T.; Ruozi, B.
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23042237

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Autori: Dominika Luptáková, Theodosia Vallianatou, Anna Nilsson, Reza Shariatgorji, Margareta Hammarlund-Udenaes, Irena Loryan, Per E. Andrén
Pubblicato in: Molecular Psychiatry, 2021, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-021-01267-y

Region-independent active CNS net uptake of marketed H+/OC antiporter system substrates

Autori: Frida Bällgren, Yang Hu, Shannuo Li, Lara van de Beek, Margareta Hammarlund-Udenaes, Irena Loryan
Pubblicato in: Frontiers in Cellular Neuroscience, Numero 18, 2024, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1493644

Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

Autori: Ozgür, Burak; Helms, Hans Christian Cederberg; Tornabene, Erica; Brodin, Birger
Pubblicato in: Fluids and Barriers of the CNS, 2022, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-021-00297-6

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Autori: Frida Bällgren, Tilda Bergfast, Aghavni Ginosyan, Jessica Mahajan, Miklós Lipcsey, Margareta Hammarlund-Udenaes, Stina Syvänen, Irena Loryan
Pubblicato in: Fluids and Barriers of the CNS, Numero 21, 2024, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-024-00583-z

Brain endothelial LRP1 maintains blood–brain barrier integrity

Autori: Steffen E. Storck, Magdalena Kurtyka, Claus U. Pietrzik
Pubblicato in: Fluids and Barriers of the CNS, Numero 18/1, 2021, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-021-00260-5

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

Autori: Rinaldi, Arianna; Caraffi, Riccardo; Grazioli, Maria Vittoria; Oddone, Natalia; Giardino, Luciana; Tosi, Giovanni; Vandelli, Maria Angela; Calzà, Laura; Ruozi, Barbara; Duskey, Jason Thomas
Pubblicato in: Polymers, Numero 1, 2022, ISSN 2073-4360
Editore: Basel MDPI
DOI: 10.3390/polym14040687

Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Autori: Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan
Pubblicato in: Fluids and Barriers of the CNS, Numero 21, 2024, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-024-00598-6

Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device

Autori: Hudecz, Diana; McCloskey, Molly C.; Vergo, Sandra; Christensen, Søren; McGrath, James L.; Nielsen, Morten S.
Pubblicato in: International Journal of Molecular Sciences, Numero 5, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065624

Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries

Autori: Mikkel Roland Holst, Mette Richner, Pernille Olsgaard Arenshøj, Parvez Alam, Kathrine Hyldig, Morten Schallburg Nielsen
Pubblicato in: Fluids and Barriers of the CNS, Numero 21, 2024, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-024-00585-x

Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

Autori: Ilaria Ottonelli; Andrea Bighinati; Elisa Adani; François Loll; Riccardo Caraffi; Maria Angela Vandelli; Frank Boury; Giovanni Tosi; Jason Thomas Duskey; Valeria Marigo; Barbara Ruozi
Pubblicato in: Pharmaceutics, 2022, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15010025

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis

Autori: Julku U, Xiong M, Wik E, Roshanbin S, Sehlin D, Syvänen S
Pubblicato in: Fluids Barriers CNS, 2022, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-022-00398-w

Contribution of Syndecans to the Cellular Entry of SARS-CoV-2

Autori: Anett Hudák; Annamária Letoha; László Szilák; Tamás Letoha
Pubblicato in: International Journal of Molecular Sciences, Numero 4, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105336

The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology.

Autori: Anett Hudák; Katalin Jósvay; Ildikó Domonkos; Annamária Letoha; László Szilák; Tamás Letoha
Pubblicato in: International Journal of Molecular Sciences, Numero 5, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22137070

A hydrogel model of the human blood-brain barrier using differentiated stem cells

Autori: Nandita Rahatekar Singh, Radka Gromnicova, Andreas Brachner, Igor Kraev, Ignacio A. Romero, Winfried Neuhaus, David Male
Pubblicato in: Plos One, 2023, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0283954

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier

Autori: Alexander D. Mazura; Anke Ohler; Steffen E. Storck; Magdalena Kurtyka; Franka Scharfenberg; Sascha Weggen; Christoph Becker-Pauly; Claus U. Pietrzik
Pubblicato in: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-022-04237-x

Applications of the ROS responsive Thioketal linker for the production of smart nanomedicines

Autori: Rinaldi A.,Caraffi R., Grazioli M.V., Oddone N., Giardino L., Tosi G., Vandelli M.A., Calzà L., Ruozi B. and Duskey J.T.,
Pubblicato in: Polymers, 2022, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym14040687

Generation of Advanced Blood–Brain Barrier Spheroids Using Human‐Induced Pluripotent Stem Cell‐Derived Brain Capillary Endothelial‐Like Cells

Autori: Sanjana Mathew‐Schmitt, Sabrina Oerter, Evelin Reitenbach, Sabine Gätzner, Alevtina Höchner, Heinz‐Georg Jahnke, Jörg Piontek, Winfried Neuhaus, Andreas Brachner, Marco Metzger, Antje Appelt‐Menzel
Pubblicato in: Advanced Biology, Numero 9, 2025, ISSN 2701-0198
Editore: Wiley
DOI: 10.1002/adbi.202400442

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study

Autori: Gina P. Hoyos-Ceballos, Barbara Ruozi, Ilaria Ottonelli, Federica Da Ros, Maria Angela Vandelli, Flavio Forni, Eleonora Daini, Antonietta Vilella, Michele Zoli, Giovanni Tosi, Jason T. Duskey, Betty L. López-Osorio
Pubblicato in: Pharmaceutics, Numero 12/1, 2020, Pagina/e 72, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12010072

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

Autori: Alexandra Pokhilko, Gaia Brezzo, Lahiru Handunnetthi, Raphael Heilig, Rachel Lennon, Colin Smith, Stuart M Allan, Alessandra Granata, Sanjay Sinha, Tao Wang, Hugh S Markus, Alexandra Naba, Roman Fischer, Tom Van Agtmael, Karen Horsburgh, M Zameel Cader
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, Numero 41/9, 2021, Pagina/e 2423-2438, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211004307

The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Autori: Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Nienke M. de Wit, Alberte Bay Villekjær Pedersen, Maximilian Keller, Caleb Webber, Helga E. de Vries, Olaf Ansorge, Christer Betsholtz, Marijke De Bock, Catarina Chaves, Birger Brodin, Morten S. Nielsen, Winfried Neuhaus, Robert D. Bell, Tamás Letoha, Axel H. Meyer, Germán Leparc, Martin Lenter, Dominique Lesuisse, Zameel M.
Pubblicato in: European Journal of Cell Biology, Numero 103, 2025, Pagina/e 151406, ISSN 0171-9335
Editore: Elsevier BV
DOI: 10.1016/j.ejcb.2024.151406

Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization

Autori: Francesca Rodà; Riccardo Caraffi; Silvia Picciolini; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Marzia Bedoni; Ilaria Ottonelli; Jason Thomas Duskey
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032496

Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Autori: Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia; Fredriksson, Robert; Gosselet, Fabien; Culot, Maxime; Göransson, Ulf; Hammarlund-Udenaes, Margareta; Loryan, Irena
Pubblicato in: Pharmaceutics, Numero 1, 2023, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15051507

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories

Autori: Alexandra Pokhilko, Adam E. Handel, Fabiola Curion, Viola Volpato, Emma S. Whiteley, Sunniva Bøstrand, Sarah E. Newey, Colin J. Akerman, Caleb Webber, Michael B. Clark, Rory Bowden, M. Zameel Cader
Pubblicato in: Genome Research, Numero 31/6, 2021, Pagina/e 1069-1081, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.273961.120

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Autori: Judit P. Vigh, András Kincses, Burak Ozgür, Fruzsina R. Walter, Ana Raquel Santa-Maria, Sándor Valkai, Mónika Vastag, Winfried Neuhaus, Birger Brodin, András Dér, Mária A. Deli
Pubblicato in: Micromachines, Numero 12/6, 2021, Pagina/e 685, ISSN 2072-666X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12060685

Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation

Autori: Mazura, Alexander, Pietrzik, Claus
Pubblicato in: Pharmaceutics, 2023, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041268

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease

Autori: Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cade
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46630-z

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments

Autori: Jason Thomas Duskey; Arianna Rinaldi; Ilaria Ottonelli; Riccardo Caraffi; Chiara Alessia De Benedictis; Ann Katrin Sauer; Giovanni Tosi; Maria Angela Vandelli; Barbara Ruozi; Andreas Martin Grabrucker
Pubblicato in: Pharmaceutics;, Numero Volume 14; Numero 7, 2022, Pagina/e 1450, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071450

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Autori: Maarja A. Mäe, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Pubblicato in: Circulation Research, Numero 128/4, 2021, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317473

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Autori: Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Pubblicato in: Fluids and Barriers of the CNS, Numero 18/1, 2021, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-021-00257-0

Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action

Autori: Nana Svane, Frida Bällgren, Aghavni Ginosyan, Mie Kristensen, Birger Brodin, Irena Loryan
Pubblicato in: The Journal of Headache and Pain, Numero 25, 2024, ISSN 1129-2377
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s10194-024-01894-0

Sortilin regulates blood-brain barrier integrity.

Autori: Andrea E. Tóth; Andrea E. Tóth; Hans C. Helms; Hans C. Helms; Andras Harazin; Kasper B. Johnsen; Kasper B. Johnsen; Charlotte Goldeman; Charlotte Goldeman; Annette Burkhart; Annette Burkhart; Maj S. Thomsen; Maj S. Thomsen; Paul J. Kempen; Paul J. Kempen; Adrian Klepe; Dora V. Lipka; Peter L. Møller; Thomas Lars Andresen; Thomas Lars Andresen; Mette Nyegaard; Torben Moos; Torben Moos; Birger Br
Pubblicato in: The FEBS journal, Numero 1, 2022, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.16225

Microfluidic Technology for the Production of Hybrid Nanomedicines.

Autori: Ottonelli, Ilaria; Duskey, Jason Thomas; Rinaldi, Arianna; Grazioli, Maria Vittoria; Parmeggiani, Irene; Vandelli, Maria Angela; Wang, Leon Z.; Prud’homme, Robert K.; Tosi, Giovanni; Ruozi, Barbara
Pubblicato in: Pharmaceutics, 2021, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091495

Transferrin Receptor Binding BBB-shuttle facilitates brain delivery of anti-Aβ affibodies

Autori: Faresjö R, Lindberg H, Ståhl S, Löfblom J, Syvänen S, Sehlin D.
Pubblicato in: Pharmaceutical Research, 2022, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-022-03282-2

A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

Autori: Christoph Eilenberger, Mario Rothbauer, Florian Selinger, Anna Gerhartl, Christian Jordan, Michael Harasek, Barbara Schädl, Johannes Grillari, Julian Weghuber, Winfried Neuhaus, Seta Küpcü, Peter Ertl
Pubblicato in: Advanced Science, Numero 8/11, 2021, Pagina/e 2004856, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/advs.202004856

Book chapters (1)

Drug Delivery Strategies to Overcome the Blood–Brain Barrier (BBB)

Autori: Cederberg Helms, Hans Christian Kristensen, Mie Saaby, Lasse Fricker, Gert Brodin, Birger
Pubblicato in: Physiology, Pharmacology and Pathology of the Blood-Brain Barrier, 2020, ISSN 0171-2004
Editore: Springer Cham
DOI: 10.1007/164_2020_403

Other (1)

Amino acid and viral binding by the high-affinity Cationic Amino acidTransporter 1 (CAT1) from Mus musculus

Autori: David Sauer, Mingda Ye, Zhu Liang, Daming Zhou, Ashley Pike, SiYi Wang, Dong Wang, Souvika Bakshi, Laurent Brooke, Eleanor Williams, Jon Elkins, Benedikt Kessler, David Stuart
Pubblicato in: 2024
Editore: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-4673967/v1