Nanoparticle-Based Therapeutic Applications and Detection of Carbon Monoxide Releasing Molecules

Project Information

ACORN

Grant agreement ID: 807281

DOI

10.3030/807281

Project closed

EC signature date 6 July 2018

Start date 1 September 2018

End date 28 February 2022

Funded under

• Twinning of research institutions

Total cost

€ 1 000 000,00

EU contribution

€ 1 000 000,00

Coordinated by

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (3)

Launch of website
Brochure and flyer development
Development of the project logo/brand

Documents, reports (9)

Report about the meetings with interest groups from industry
ACORN Thematic Workshop
ACORN Joint Summer School
KPIs definition for ACORN
Impact assessment in the 3-year period prior to ACORN for all KPIs
Public awareness campaign
"""Knowledge Transfer Zone"" through meetings between research institutions and enterprises"

Knowledge Transfer Zone through meetings between research institutions and enterprises

"„The industrial day"" related to nanochemistry applications"

The industrial day related to nanochemistry applications

Impact assessment by the end of the project and forecast of the following 3-year period

Impact assessment by the end of the project and forecast of the following 3year period

Publications

Peer reviewed articles (16)

STAT3/NF‐κB signalling disruption in M2 tumour‐associated macrophages is a major target of PLGA nanocarriers/PD‐L1 antibody immunomodulatory therapy in breast cancer

Author(s): Rômulo S. Cavalcante, Uta Ishikawa, Emanuell S. Silva, Arnóbio A. Silva‐Júnior, Aurigena A. Araújo, Luis J. Cruz, Alan B. Chan, Raimundo F. Araújo Júnior
Published in: British Journal of Pharmacology, 2021, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.15373

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer.

Author(s): Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Thaís Gomes de Carvalho; Thaís Gomes de Carvalho; Alan Chan; Timo Schomann; Filippo Tamburini; Lioe-Fee de Geus-Oei; Luis J. Cruz
Published in: Pharmaceutics, Issue 9, 2020, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12020193

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer.

Author(s): Ana Luiza C. de S. L. Oliveira; Luana Zerillo; Luis J. Cruz; Timo Schomann; Alan Chan; Thaís Gomes de Carvalho; Shirley Vitória de P. Souza; Aurigena Antunes de Araújo; Lioe-Fee de Geus-Oei; Raimundo Fernandes de Araújo Júnior
Published in: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Issue 7, 2021, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Author(s): Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Published in: Polymers, Issue 13/6, 2021, Page(s) 907, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym13060907

Dissecting celastrol with machine learning to unveil dark pharmacology

Author(s): Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, Gonçalo J. L. Bernardes
Published in: Chemical Communications, Issue 55/45, 2019, Page(s) 6369-6372, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc03116b

Machine learning for target discovery in drug development

Author(s): Tiago Rodrigues, Gonçalo J.L. Bernardes
Published in: Current Opinion in Chemical Biology, Issue 56, 2020, Page(s) 16-22, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2019.10.003

Computational advances in combating colloidal aggregation in drug discovery

Author(s): Daniel Reker, Gonçalo J. L. Bernardes, Tiago Rodrigues
Published in: Nature Chemistry, Issue 11/5, 2019, Page(s) 402-418, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-019-0234-9

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

Author(s): Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Published in: Journal of Controlled Release, Issue 323, 2020, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2020.03.050

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Author(s): Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Published in: Molecules, Issue 25/9, 2020, Page(s) 2219, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Author(s): Zhenfeng Yu, Christina Eich, Luis J. Cruz
Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646
Publisher: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Nanocarriers as a Tool for the Treatment of Colorectal Cancer.

Author(s): Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Timo Schomann; Lioe-Fee de Geus-Oei; Ellen Kapiteijn; Luis J. Cruz; Raimundo Fernandes de Araújo Júnior
Published in: Pharmaceutics, Issue 9, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Author(s): Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Published in: Molecules, Issue 25/5, 2020, Page(s) 1181, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Author(s): Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Published in: Biomaterials, Issue 268, 2021, Page(s) 120580, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Author(s): Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Published in: Pharmaceutics, Issue 12/11, 2020, Page(s) 1022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Author(s): Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Published in: International Journal of Molecular Sciences, Issue 22/11, 2021, Page(s) 5730, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Author(s): Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Published in: Molecules, Issue 26/11, 2021, Page(s) 3272, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Other (1)

Triplet-Triplet Annihilation PLGA-Nanoparticles for Cancer Bioimaging

Author(s): Olena Vepris, Christina Eich, Yansong Feng, Hong Zhang, Eric. L. Kaijzel, Luis J. Cruz
Published in: 2020
Publisher: Biorxiv
DOI: 10.1101/2020.09.02.274969

Intellectual Property Rights

Patent (1)

USE OF CONJUGATES COMPRISING TUMOUR-SELECTIVE LIGANDS AND GROUPS CAPABLE OF RELEASING CARBON MONOXIDE (CO), FOR EXERTING IMMUNOMODULATORY EFFECTS IN CANCER TREATMENT

Application/Publication number: 20 21058146
Date: 2021-03-29
Applicant(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES