Nanoparticle-Based Therapeutic Applications and Detection of Carbon Monoxide Releasing Molecules

Informations projet

ACORN

N° de convention de subvention: 807281

DOI

10.3030/807281

Projet clôturé

Date de signature de la CE 6 Juillet 2018

Date de début 1 Septembre 2018

Date de fin 28 Février 2022

Financé au titre de

• Twinning of research institutions

Coût total

€ 1 000 000,00

Contribution de l’UE

€ 1 000 000,00

Coordonné par

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (3)

Launch of website
Brochure and flyer development
Development of the project logo/brand

Documents, reports (9)

Report about the meetings with interest groups from industry
ACORN Thematic Workshop
ACORN Joint Summer School
KPIs definition for ACORN
Impact assessment in the 3-year period prior to ACORN for all KPIs
Public awareness campaign
"""Knowledge Transfer Zone"" through meetings between research institutions and enterprises"

Knowledge Transfer Zone through meetings between research institutions and enterprises

"„The industrial day"" related to nanochemistry applications"

The industrial day related to nanochemistry applications

Impact assessment by the end of the project and forecast of the following 3-year period

Impact assessment by the end of the project and forecast of the following 3year period

Publications

Peer reviewed articles (16)

STAT3/NF‐κB signalling disruption in M2 tumour‐associated macrophages is a major target of PLGA nanocarriers/PD‐L1 antibody immunomodulatory therapy in breast cancer

Auteurs: Rômulo S. Cavalcante, Uta Ishikawa, Emanuell S. Silva, Arnóbio A. Silva‐Júnior, Aurigena A. Araújo, Luis J. Cruz, Alan B. Chan, Raimundo F. Araújo Júnior
Publié dans: British Journal of Pharmacology, 2021, ISSN 0007-1188
Éditeur: Wiley-Blackwell
DOI: 10.1111/bph.15373

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer.

Auteurs: Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Thaís Gomes de Carvalho; Thaís Gomes de Carvalho; Alan Chan; Timo Schomann; Filippo Tamburini; Lioe-Fee de Geus-Oei; Luis J. Cruz
Publié dans: Pharmaceutics, Numéro 9, 2020, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12020193

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer.

Auteurs: Ana Luiza C. de S. L. Oliveira; Luana Zerillo; Luis J. Cruz; Timo Schomann; Alan Chan; Thaís Gomes de Carvalho; Shirley Vitória de P. Souza; Aurigena Antunes de Araújo; Lioe-Fee de Geus-Oei; Raimundo Fernandes de Araújo Júnior
Publié dans: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Numéro 7, 2021, ISSN 0928-4931
Éditeur: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Auteurs: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Publié dans: Polymers, Numéro 13/6, 2021, Page(s) 907, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym13060907

Dissecting celastrol with machine learning to unveil dark pharmacology

Auteurs: Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, Gonçalo J. L. Bernardes
Publié dans: Chemical Communications, Numéro 55/45, 2019, Page(s) 6369-6372, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9cc03116b

Machine learning for target discovery in drug development

Auteurs: Tiago Rodrigues, Gonçalo J.L. Bernardes
Publié dans: Current Opinion in Chemical Biology, Numéro 56, 2020, Page(s) 16-22, ISSN 1367-5931
Éditeur: Elsevier BV
DOI: 10.1016/j.cbpa.2019.10.003

Computational advances in combating colloidal aggregation in drug discovery

Auteurs: Daniel Reker, Gonçalo J. L. Bernardes, Tiago Rodrigues
Publié dans: Nature Chemistry, Numéro 11/5, 2019, Page(s) 402-418, ISSN 1755-4330
Éditeur: Nature Publishing Group
DOI: 10.1038/s41557-019-0234-9

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

Auteurs: Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Publié dans: Journal of Controlled Release, Numéro 323, 2020, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2020.03.050

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Auteurs: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Publié dans: Molecules, Numéro 25/9, 2020, Page(s) 2219, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Auteurs: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Publié dans: Frontiers in Chemistry, Numéro 8, 2020, ISSN 2296-2646
Éditeur: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Nanocarriers as a Tool for the Treatment of Colorectal Cancer.

Auteurs: Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Timo Schomann; Lioe-Fee de Geus-Oei; Ellen Kapiteijn; Luis J. Cruz; Raimundo Fernandes de Araújo Júnior
Publié dans: Pharmaceutics, Numéro 9, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Auteurs: Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Publié dans: Molecules, Numéro 25/5, 2020, Page(s) 1181, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Auteurs: Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Publié dans: Biomaterials, Numéro 268, 2021, Page(s) 120580, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Auteurs: Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Publié dans: Pharmaceutics, Numéro 12/11, 2020, Page(s) 1022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Auteurs: Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Publié dans: International Journal of Molecular Sciences, Numéro 22/11, 2021, Page(s) 5730, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Auteurs: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Publié dans: Molecules, Numéro 26/11, 2021, Page(s) 3272, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Other (1)

Triplet-Triplet Annihilation PLGA-Nanoparticles for Cancer Bioimaging

Auteurs: Olena Vepris, Christina Eich, Yansong Feng, Hong Zhang, Eric. L. Kaijzel, Luis J. Cruz
Publié dans: 2020
Éditeur: Biorxiv
DOI: 10.1101/2020.09.02.274969

Droits de propriété intellectuelle

Patent (1)

USE OF CONJUGATES COMPRISING TUMOUR-SELECTIVE LIGANDS AND GROUPS CAPABLE OF RELEASING CARBON MONOXIDE (CO), FOR EXERTING IMMUNOMODULATORY EFFECTS IN CANCER TREATMENT

Numéro de demande/publication: 20 21058146
Date: 2021-03-29
Demandeur(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES