Nanoparticle-Based Therapeutic Applications and Detection of Carbon Monoxide Releasing Molecules

Informazioni relative al progetto

ACORN

ID dell’accordo di sovvenzione: 807281

DOI

10.3030/807281

Progetto chiuso

Data della firma CE 6 Luglio 2018

Data di avvio 1 Settembre 2018

Data di completamento 28 Febbraio 2022

Finanziato da

• Twinning of research institutions

Costo totale

€ 1 000 000,00

Contributo UE

€ 1 000 000,00

Coordinato da

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (3)

Launch of website
Brochure and flyer development
Development of the project logo/brand

Documents, reports (9)

Report about the meetings with interest groups from industry
ACORN Thematic Workshop
ACORN Joint Summer School
KPIs definition for ACORN
Impact assessment in the 3-year period prior to ACORN for all KPIs
Public awareness campaign
"""Knowledge Transfer Zone"" through meetings between research institutions and enterprises"

Knowledge Transfer Zone through meetings between research institutions and enterprises

"„The industrial day"" related to nanochemistry applications"

The industrial day related to nanochemistry applications

Impact assessment by the end of the project and forecast of the following 3-year period

Impact assessment by the end of the project and forecast of the following 3year period

Pubblicazioni

Peer reviewed articles (16)

STAT3/NF‐κB signalling disruption in M2 tumour‐associated macrophages is a major target of PLGA nanocarriers/PD‐L1 antibody immunomodulatory therapy in breast cancer

Autori: Rômulo S. Cavalcante, Uta Ishikawa, Emanuell S. Silva, Arnóbio A. Silva‐Júnior, Aurigena A. Araújo, Luis J. Cruz, Alan B. Chan, Raimundo F. Araújo Júnior
Pubblicato in: British Journal of Pharmacology, 2021, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.15373

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer.

Autori: Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Thaís Gomes de Carvalho; Thaís Gomes de Carvalho; Alan Chan; Timo Schomann; Filippo Tamburini; Lioe-Fee de Geus-Oei; Luis J. Cruz
Pubblicato in: Pharmaceutics, Numero 9, 2020, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12020193

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer.

Autori: Ana Luiza C. de S. L. Oliveira; Luana Zerillo; Luis J. Cruz; Timo Schomann; Alan Chan; Thaís Gomes de Carvalho; Shirley Vitória de P. Souza; Aurigena Antunes de Araújo; Lioe-Fee de Geus-Oei; Raimundo Fernandes de Araújo Júnior
Pubblicato in: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Numero 7, 2021, ISSN 0928-4931
Editore: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Autori: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Pubblicato in: Polymers, Numero 13/6, 2021, Pagina/e 907, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym13060907

Dissecting celastrol with machine learning to unveil dark pharmacology

Autori: Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, Gonçalo J. L. Bernardes
Pubblicato in: Chemical Communications, Numero 55/45, 2019, Pagina/e 6369-6372, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cc03116b

Machine learning for target discovery in drug development

Autori: Tiago Rodrigues, Gonçalo J.L. Bernardes
Pubblicato in: Current Opinion in Chemical Biology, Numero 56, 2020, Pagina/e 16-22, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2019.10.003

Computational advances in combating colloidal aggregation in drug discovery

Autori: Daniel Reker, Gonçalo J. L. Bernardes, Tiago Rodrigues
Pubblicato in: Nature Chemistry, Numero 11/5, 2019, Pagina/e 402-418, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-019-0234-9

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

Autori: Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Pubblicato in: Journal of Controlled Release, Numero 323, 2020, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2020.03.050

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Autori: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Pubblicato in: Molecules, Numero 25/9, 2020, Pagina/e 2219, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Autori: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Pubblicato in: Frontiers in Chemistry, Numero 8, 2020, ISSN 2296-2646
Editore: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Nanocarriers as a Tool for the Treatment of Colorectal Cancer.

Autori: Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Timo Schomann; Lioe-Fee de Geus-Oei; Ellen Kapiteijn; Luis J. Cruz; Raimundo Fernandes de Araújo Júnior
Pubblicato in: Pharmaceutics, Numero 9, 2021, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Autori: Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Pubblicato in: Molecules, Numero 25/5, 2020, Pagina/e 1181, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Autori: Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Pubblicato in: Biomaterials, Numero 268, 2021, Pagina/e 120580, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Autori: Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Pubblicato in: Pharmaceutics, Numero 12/11, 2020, Pagina/e 1022, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Autori: Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Pubblicato in: International Journal of Molecular Sciences, Numero 22/11, 2021, Pagina/e 5730, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Autori: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Pubblicato in: Molecules, Numero 26/11, 2021, Pagina/e 3272, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Other (1)

Triplet-Triplet Annihilation PLGA-Nanoparticles for Cancer Bioimaging

Autori: Olena Vepris, Christina Eich, Yansong Feng, Hong Zhang, Eric. L. Kaijzel, Luis J. Cruz
Pubblicato in: 2020
Editore: Biorxiv
DOI: 10.1101/2020.09.02.274969

Diritti di proprietà intellettuale

Patent (1)

USE OF CONJUGATES COMPRISING TUMOUR-SELECTIVE LIGANDS AND GROUPS CAPABLE OF RELEASING CARBON MONOXIDE (CO), FOR EXERTING IMMUNOMODULATORY EFFECTS IN CANCER TREATMENT

Numero candidatura/pubblicazione: 20 21058146
Data: 2021-03-29
Candidato/i: INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES