Nanoparticle-Based Therapeutic Applications and Detection of Carbon Monoxide Releasing Molecules

Resultado final

Launch of website
Brochure and flyer development
Development of the project logo/brand

Report about the meetings with interest groups from industry
ACORN Thematic Workshop
ACORN Joint Summer School
KPIs definition for ACORN
Impact assessment in the 3-year period prior to ACORN for all KPIs
Public awareness campaign
"""Knowledge Transfer Zone"" through meetings between research institutions and enterprises"

Knowledge Transfer Zone through meetings between research institutions and enterprises

"„The industrial day"" related to nanochemistry applications"

The industrial day related to nanochemistry applications

Impact assessment by the end of the project and forecast of the following 3-year period

Impact assessment by the end of the project and forecast of the following 3year period

Publicaciones

STAT3/NF‐κB signalling disruption in M2 tumour‐associated macrophages is a major target of PLGA nanocarriers/PD‐L1 antibody immunomodulatory therapy in breast cancer

Autores: Rômulo S. Cavalcante, Uta Ishikawa, Emanuell S. Silva, Arnóbio A. Silva‐Júnior, Aurigena A. Araújo, Luis J. Cruz, Alan B. Chan, Raimundo F. Araújo Júnior
Publicado en: British Journal of Pharmacology, 2021, ISSN 0007-1188
Editor: Wiley-Blackwell
DOI: 10.1111/bph.15373

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer.

Autores: Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Thaís Gomes de Carvalho; Thaís Gomes de Carvalho; Alan Chan; Timo Schomann; Filippo Tamburini; Lioe-Fee de Geus-Oei; Luis J. Cruz
Publicado en: Pharmaceutics, Edición 9, 2020, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12020193

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer.

Autores: Ana Luiza C. de S. L. Oliveira; Luana Zerillo; Luis J. Cruz; Timo Schomann; Alan Chan; Thaís Gomes de Carvalho; Shirley Vitória de P. Souza; Aurigena Antunes de Araújo; Lioe-Fee de Geus-Oei; Raimundo Fernandes de Araújo Júnior
Publicado en: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Edición 7, 2021, ISSN 0928-4931
Editor: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Autores: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Publicado en: Polymers, Edición 13/6, 2021, Página(s) 907, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym13060907

Dissecting celastrol with machine learning to unveil dark pharmacology

Autores: Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, Gonçalo J. L. Bernardes
Publicado en: Chemical Communications, Edición 55/45, 2019, Página(s) 6369-6372, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c9cc03116b

Machine learning for target discovery in drug development

Autores: Tiago Rodrigues, Gonçalo J.L. Bernardes
Publicado en: Current Opinion in Chemical Biology, Edición 56, 2020, Página(s) 16-22, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/j.cbpa.2019.10.003

Computational advances in combating colloidal aggregation in drug discovery

Autores: Daniel Reker, Gonçalo J. L. Bernardes, Tiago Rodrigues
Publicado en: Nature Chemistry, Edición 11/5, 2019, Página(s) 402-418, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-019-0234-9

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

Autores: Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Publicado en: Journal of Controlled Release, 2020, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2020.03.050

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Autores: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Publicado en: Molecules, Edición 25/9, 2020, Página(s) 2219, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Autores: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Publicado en: Frontiers in Chemistry, Edición 8, 2020, ISSN 2296-2646
Editor: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Nanocarriers as a Tool for the Treatment of Colorectal Cancer.

Autores: Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Timo Schomann; Lioe-Fee de Geus-Oei; Ellen Kapiteijn; Luis J. Cruz; Raimundo Fernandes de Araújo Júnior
Publicado en: Pharmaceutics, Edición 9, 2021, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Autores: Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Publicado en: Molecules, Edición 25/5, 2020, Página(s) 1181, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Autores: Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Publicado en: Biomaterials, Edición 268, 2021, Página(s) 120580, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Autores: Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Publicado en: Pharmaceutics, Edición 12/11, 2020, Página(s) 1022, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Autores: Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Publicado en: International Journal of Molecular Sciences, Edición 22/11, 2021, Página(s) 5730, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Autores: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Publicado en: Molecules, Edición 26/11, 2021, Página(s) 3272, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Triplet-Triplet Annihilation PLGA-Nanoparticles for Cancer Bioimaging

Autores: Olena Vepris, Christina Eich, Yansong Feng, Hong Zhang, Eric. L. Kaijzel, Luis J. Cruz
Publicado en: 2020
Editor: Biorxiv
DOI: 10.1101/2020.09.02.274969

Derechos de propiedad intelectual

USE OF CONJUGATES COMPRISING TUMOUR-SELECTIVE LIGANDS AND GROUPS CAPABLE OF RELEASING CARBON MONOXIDE (CO), FOR EXERTING IMMUNOMODULATORY EFFECTS IN CANCER TREATMENT

Número de solicitud/publicación: 20 21058146
Fecha: 2021-03-29

Resultado final

Publicaciones

Derechos de propiedad intelectual

Compartir esta página

Descargar