Nanoparticle-Based Therapeutic Applications and Detection of Carbon Monoxide Releasing Molecules

Informacje na temat projektu

ACORN

Identyfikator umowy o grant: 807281

DOI

10.3030/807281

Projekt został zamknięty

Data podpisania przez KE 6 Lipca 2018

Data rozpoczęcia 1 Września 2018

Data zakończenia 28 Lutego 2022

Finansowanie w ramach

• Twinning of research institutions

Koszt całkowity

€ 1 000 000,00

Wkład UE

€ 1 000 000,00

Koordynowany przez

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (3)

Launch of website
Brochure and flyer development
Development of the project logo/brand

Documents, reports (9)

Report about the meetings with interest groups from industry
ACORN Thematic Workshop
ACORN Joint Summer School
KPIs definition for ACORN
Impact assessment in the 3-year period prior to ACORN for all KPIs
Public awareness campaign
"""Knowledge Transfer Zone"" through meetings between research institutions and enterprises"

Knowledge Transfer Zone through meetings between research institutions and enterprises

"„The industrial day"" related to nanochemistry applications"

The industrial day related to nanochemistry applications

Impact assessment by the end of the project and forecast of the following 3-year period

Impact assessment by the end of the project and forecast of the following 3year period

Publikacje

Peer reviewed articles (16)

STAT3/NF‐κB signalling disruption in M2 tumour‐associated macrophages is a major target of PLGA nanocarriers/PD‐L1 antibody immunomodulatory therapy in breast cancer

Autorzy: Rômulo S. Cavalcante, Uta Ishikawa, Emanuell S. Silva, Arnóbio A. Silva‐Júnior, Aurigena A. Araújo, Luis J. Cruz, Alan B. Chan, Raimundo F. Araújo Júnior
Opublikowane w: British Journal of Pharmacology, 2021, ISSN 0007-1188
Wydawca: Wiley-Blackwell
DOI: 10.1111/bph.15373

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer.

Autorzy: Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Raimundo Fernandes de Araújo Júnior; Raimundo Fernandes de Araújo Júnior; Thaís Gomes de Carvalho; Thaís Gomes de Carvalho; Alan Chan; Timo Schomann; Filippo Tamburini; Lioe-Fee de Geus-Oei; Luis J. Cruz
Opublikowane w: Pharmaceutics, Numer 9, 2020, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12020193

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer.

Autorzy: Ana Luiza C. de S. L. Oliveira; Luana Zerillo; Luis J. Cruz; Timo Schomann; Alan Chan; Thaís Gomes de Carvalho; Shirley Vitória de P. Souza; Aurigena Antunes de Araújo; Lioe-Fee de Geus-Oei; Raimundo Fernandes de Araújo Júnior
Opublikowane w: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Numer 7, 2021, ISSN 0928-4931
Wydawca: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Autorzy: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Opublikowane w: Polymers, Numer 13/6, 2021, Strona(/y) 907, ISSN 2073-4360
Wydawca: MDPI
DOI: 10.3390/polym13060907

Dissecting celastrol with machine learning to unveil dark pharmacology

Autorzy: Tiago Rodrigues, Bernardo P. de Almeida, Nuno L. Barbosa-Morais, Gonçalo J. L. Bernardes
Opublikowane w: Chemical Communications, Numer 55/45, 2019, Strona(/y) 6369-6372, ISSN 1359-7345
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9cc03116b

Machine learning for target discovery in drug development

Autorzy: Tiago Rodrigues, Gonçalo J.L. Bernardes
Opublikowane w: Current Opinion in Chemical Biology, Numer 56, 2020, Strona(/y) 16-22, ISSN 1367-5931
Wydawca: Elsevier BV
DOI: 10.1016/j.cbpa.2019.10.003

Computational advances in combating colloidal aggregation in drug discovery

Autorzy: Daniel Reker, Gonçalo J. L. Bernardes, Tiago Rodrigues
Opublikowane w: Nature Chemistry, Numer 11/5, 2019, Strona(/y) 402-418, ISSN 1755-4330
Wydawca: Nature Publishing Group
DOI: 10.1038/s41557-019-0234-9

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

Autorzy: Chih Kit Chung, Marieke F. Fransen, Koen van der Maaden, Yaima Campos, Jomarien García-Couce, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Opublikowane w: Journal of Controlled Release, Numer 323, 2020, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2020.03.050

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Autorzy: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Opublikowane w: Molecules, Numer 25/9, 2020, Strona(/y) 2219, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Autorzy: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Opublikowane w: Frontiers in Chemistry, Numer 8, 2020, ISSN 2296-2646
Wydawca: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Nanocarriers as a Tool for the Treatment of Colorectal Cancer.

Autorzy: Ana Luiza C. de S. L. Oliveira; Ana Luiza C. de S. L. Oliveira; Timo Schomann; Lioe-Fee de Geus-Oei; Ellen Kapiteijn; Luis J. Cruz; Raimundo Fernandes de Araújo Júnior
Opublikowane w: Pharmaceutics, Numer 9, 2021, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Autorzy: Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Opublikowane w: Molecules, Numer 25/5, 2020, Strona(/y) 1181, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Autorzy: Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Opublikowane w: Biomaterials, Numer 268, 2021, Strona(/y) 120580, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Autorzy: Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Opublikowane w: Pharmaceutics, Numer 12/11, 2020, Strona(/y) 1022, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Autorzy: Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Opublikowane w: International Journal of Molecular Sciences, Numer 22/11, 2021, Strona(/y) 5730, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Autorzy: Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Opublikowane w: Molecules, Numer 26/11, 2021, Strona(/y) 3272, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Other (1)

Triplet-Triplet Annihilation PLGA-Nanoparticles for Cancer Bioimaging

Autorzy: Olena Vepris, Christina Eich, Yansong Feng, Hong Zhang, Eric. L. Kaijzel, Luis J. Cruz
Opublikowane w: 2020
Wydawca: Biorxiv
DOI: 10.1101/2020.09.02.274969

Prawa własności intelektualnej

Patent (1)

USE OF CONJUGATES COMPRISING TUMOUR-SELECTIVE LIGANDS AND GROUPS CAPABLE OF RELEASING CARBON MONOXIDE (CO), FOR EXERTING IMMUNOMODULATORY EFFECTS IN CANCER TREATMENT

Numer wniosku/publikacji: 20 21058146
Data: 2021-03-29
Wnioskodawca/wnioskodawcy: INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES