Descrizione del progetto
Nuovi marcatori biomeccanici per la diagnosi precoce
È stato a lungo dimostrato che la meccanica cellulare è correlata a varie malattie e condizioni. Il progetto Phys2BioMed, finanziato dal programma di azioni Marie Skłodowska-Curie, si propone di individuare e definire marcatori biomeccanici per il rilevamento precoce di disfunzioni cellulari e tissutali all’insorgere della malattia. L’obiettivo è creare una rete di formazione per la ricerca interdisciplinare rivolta a ricercatori e ricercatrici in fase iniziale di carriera incentrata sull’applicazione di strumenti fisici per la fenotipizzazione meccanica di cellule e tessuti, sviluppando una nuova diagnostica precoce. La rete unirà la formazione in diversi ambiti, tra cui nanoscienze e nanotecnologie, fisica, biologia e medicina, definendo le caratteristiche principali della strumentazione di nuova generazione ottimizzata per la fenotipizzazione meccanica dei materiali clinici.
Obiettivo
Phys2BioMed will offer excellent interdisciplinary and cross-sectoral training to a team of motivated early stage researchers (ESRs) on the application of cutting-edge physical tools for the mechanical phenotyping of cells and tissues of clinical relevance, aiming at developing novel early-diagnostic tools. The Phys2BioMed network will merge diverse competences at European level, from different fields like nanoscience and nanotechnology, physics, biology, and medicine, and will expose ESRs to the non academic and private sector. A key element of the project is the peer-to-peer collaboration of research academic institutions with industries and world-leading medical and clinical centers; these are the main actors of the global challenge against diseases, and within Phys2BioMed they will highlight unmet clinical needs, and actively cooperate with academic colleagues for developing novel diagnostic strategies. ESRs will be trained-through-research by world-leading junior and senior PIs, and will benefit of lecture courses, dedicated international schools and workshops, and topical conferences. Secondments to other nodes of the network will represent the main and more effective channel of dissemination and cross-fertilization of competences, ideas, and knowledge within the network. Besides training talented young scientists, ready to work at the boundary of diverse disciplines in the field of nanomedicine, Phys2BioMed will provide scientific and technological outcomes on biomechanics, and the mechanical determinants of diseases. Technology-wise, it will define standardized procedures for nanomechanical measurements, and the definition of the main features of new-generation instrumentation optimized for the mechanical phenotyping of clinical specimens. In the longer-term, Phys2BioMed will provide the platform and know-how to build a data bank of mechanical fingerprints of diseases, setting the ground for the development of effective early-diagnostic tools.
Campo scientifico
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
20122 Milano
Italia