Risultati finali
Introduction to Unix Command line tools for biologists working with largescale data isfinished The ESRs will obtain the knowledge on how to operate within the Unix environment All ESRs will participate in workshop and complete the practical assignments
Tissue specific CIN-depletion for genomic ‘live-imaging' of gestationTissue-specific depletion of CIN has been reported as a proof-of-the principle for genomic ‘live-imaging’ of human early gestation.
Endometrial phenotype in PCOS"Provides report on ""Endometrial phenotype in PCOS"", related to research output of ESR7."
Evaluation of tissue histology course‘Evaluation of tissue histology from female reproductive tract – hands-on microscopy training’ is completed (for Task 2.4, M29).
Basics of statistical analysis for biologists’Basics of statistical analysis for biologists is completed for all ESRs The ESRs will know 1 How to analyse and visualise data in the statistical software package R 2 How to correctly interpret results and 3 How to create publicationquality tables and figures ESRs will participate in workshop and complete the practical assignments
Dissemination and Communication PlanCommunication and Dissemination Plan CCHT is responsible for compiling the plan to increase the visibility of MATER among key stakeholders and the society at large All partners will contribute in defining their respective actions resulting in a dedicated document which will be periodically reviewed
Effect of environmental factors on embryo genome activityInformation about the effects of culture media, oxygen level and embryo vitrification on embryo genome activity and CIN has been obtained.
Female reproductive endocrinology and disordersBasics of female reproductive endocrinology and most common infertilityassociated gynaecological disorders is accomplished to all ESRs
ESR recruitmentESRs recruitment finished T63 M8
Stem cells in female reproduction'‘Stem cells in female reproduction’ is successfully finished for all ESRs. Different techniques in enSC research are introduced and discussed with experienced researchers. The course is completed by written assignment and presentation (for Task 2.2, M23).
The roles of mi-RNAs in folliculogenesisThe roles of mi-RNAs in folliculogenesis have been characterized (for Task 1.9, M42).
Impact of prenatal genomic technologies‘Impact of prenatal genomic technologies – Societal aspects’ is conducted. Debates will be encouraged but no grading system is implemented for this course.
Trainig: Scientists entering life science businessThe course provides the background of doing business in biotech/healthcare and trains ESRs to manage, finance and market their projects. Topics are life-sciences/healthcareas business environment, R&D and value chains in biotech/healthcare; marketing and sales; company’s strategies and planning. ESRs will gain practical training on how innovations can be developed into products. Young start-ups will be invited to present their projects and the supportive actions/funding that enabled their success.
Causes of CIN-free pregnancy lossNovel knowledge about the causes for CIN-free pregnancy loss has been obtained.
Improved molecular model for ovarian development and folliculogenesisImproved molecular model for ovarian development and folliculogenesis. The studies have clarified the roles of EMX2, GATA4 and FSHR in folliculogenesis and etiology of POI (for Task 1.8, M42).
Start-up company trainingHands-on business development program provides knowledge and skills for start-up projects and helps teams to shape their ideas into tested business models.
Training: Trendspotting and Future ThinkingESRs will gain practical experience in trendspotting and futurethinking as a tool in business creation and development.
Endometrial receptivity course‘Focus on endometrial receptivity - from endometrial cell separation to RNA-seq’ is delivered to all ESRs. The course gives ESRs hands-on experience for endometrial research with the main focus on transcriptome profiling. Course requires full-time participation (for Task 2.1, M11).
Single-cell OMICS‘Single-cell OMICS: Fundamental and translational horizons’ is delivered to all ESRs. Afterthe course, the ESRs are able to design their single-cell experiments. A short practical assignment will be handed to all ESRs.
Functionally characterized genes involved in HPO-axis and ovarian biologyFunctionally characterized genes involved in HPO-axis and ovarian biology. The selected genes are functionally characterized by using hPSC-models (for Task 1.6, M54).
FACS cell sorting, endometrial cell culture‘FACS cell sorting and primary cell culture from endometrial tissue’ is completed for all ESRs (for Task 2.3, M29).
Non-invasive prenatal diagnosis and beyond‘Non-invasive prenatal diagnosis and beyond’ is accomplished. All ESRs participate in group exercise.
Single-cell analysis of human embryo development‘Application of single-cell analysis in research of human early embryo development’ is successfully finished for all ESRs. The course introduces single-cell analysis applications and helps to create a link with the leading scientists at KI to promote the career of ESRs.
Report on dissemination and communication activitiesReport on dissemination and communication activities.
Common understanding about the legislation governing the use of reproductive medicine in EuropeCommon understanding about the legislation governing the use of reproductive medicine in Europe, their differences and the possibilities and needs of harmonizing the legislation across Europe will be defined.
Training: Health policy, innovation and managementThe course reviews healthcare systems in the context of innovation management. ESRs learn how science & innovation can be integrated into healthcare policy. ESRs will learn how different technological regimes and healthcare systems impact their project. Practitioners and policy makers from Ministry of Social Affairs will discuss examplesof personal medicine and e-Health services. All MATER industry partners will participate in Innovation clinic, i.e. companies will propose workshop topics that are based on challenges facing their business.
Report on training course: Complementary transferable skills trainingThe skills development programme will have three parts IIntellectual Property Rights IPR training II Research Ethics and Equality training III Communication training
The incidence and origin of CIN in bovine embryosThe incidence and origin of CIN in bovine early embryos have been elucidated.
GWA-studies for ovarian aging and related phenotypesGWAstudies for ovarian aging and related phenotypes The GWAstudies for ovarian agingrelated phenotypes are finished by using two extensive biobanks in Estonia EGCUT and Finland NFBC66 for Task 17 M24
Clinical data and sample collection‘Clinical data/sample collection for scientific purposes: advantages and pitfalls’ is delivered to all ESRs. ESRsare competent to conduct clinical sample collections for research.
Human embryos in clinical setting‘Human embryos in clinical setting’ is finished for all ESRs. The course gives an overview about the profession of clinical embryologist, and deals with the most important technological, clinical and ethical aspects of IVF.
GWAS crash courseGWAS crash course is provided to all ESRs The course requires that ESRs participate in workshop and complete the practical assignments
PMC meetings, Task 6.1, M1, M17, M23, M29, M35, M41.
Summer school at KUL and UTSummer school, T5.4, M17, M49.
Doctoral Degrees awardedDissemination workshops
Dissemination workshops, T5.3, M23, M48.
ESRs Kick-off meeting at KULESRs Kickoff meeting at KUL T63 M8
Final Meeting, at UTFinal Meeting at UT, T6.1, M48
At least three start-up companies establishedAt least three start-up companies established.
Project stationary and websiteDevelopment of project stationary logotemplates banners posters flyers brochures rollup and website
At least 42 research and 14 popular-science articles.
Pubblicazioni
Autori:
Margot van Riel, Yan Zhao, Tatjana Jatsenko, Lore Lannoo, Dirk Timmerman, Joris R Vermeesch
Pubblicato in:
Clinical Chemistry, 2023, ISSN 0009-9147
Editore:
American Association for Clinical Chemistry, Inc.
DOI:
10.1093/clinchem/hvad107
Autori:
Tiny Pagnaer, Maria Siermann, Pascal Borry, Olga Tšuiko
Pubblicato in:
BMC Medical Ethics, Numero 22/1, 2021, ISSN 1472-6939
Editore:
BioMed Central
DOI:
10.1186/s12910-021-00694-4
Autori:
Deligiannis, S. P., Kask, K., Modhukur, V., Boskovic, N., Ivask, M., Jaakma, Ü., Damdimopoulou, P., Tuuri, T., Velthut-Meikas, A., Salumets, A.
Pubblicato in:
Journal of Assisted Reproduction and Genetics, 2024, ISSN 1058-0468
Editore:
Kluwer Academic/Plenum Publishers
DOI:
10.1007/s10815-024-03038-4
Autori:
Eskici, N., Madhusudan, S., Vaaralahti, K., Yellapragada, V., Gómez-Sánchez, C. E., Kärkinen, J., Almusa, H., Brandstack, N., Miettinen, P. J., Wang, Y., Raivio, T.
Pubblicato in:
European Journal of Endocrinology, 2023, ISSN 0804-4643
Editore:
BioScientifica Ltd.
DOI:
10.1093/ejendo/lvad111
Autori:
Stanley, K. E., Jatsenko, T., Tuveri, S., Sudhakaran, D., Lannoo, L., Van Calsteren, K., De Borre, M., Parijs, I., Van Coillie, L., Van Den Bogaert, K., Toledo, R. A., Lenaerts, L., Tejpar, S., Punie, K., Rengifo, L. Y., Vandenberghe, P., Thienpont, B., Vermeesch, J. R.
Pubblicato in:
Nature Communications, 2024, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-024-46435-0
Autori:
Lee, S., Arffman, R. K., Komsi, E. K., Lindgren, O., Kemppainen, J., Kask, K., Saare, M., Salumets, A., Piltonen, T.
Pubblicato in:
Journal of Pathology Informatics, 2024, ISSN 2153-3539
Editore:
Elsevier Inc.
DOI:
10.1016/j.jpi.2024.100364
Autori:
Jaakko S Tyrmi, Riikka K Arffman, Natàlia Pujol-Gualdo, Venla Kurra, Laure Morin-Papunen, Eeva Sliz, Terhi T Piltonen, Triin Laisk, Johannes Kettunen, Hannele Laivuori
Pubblicato in:
Human Reproduction, 2021, ISSN 0268-1161
Editore:
Oxford University Press
DOI:
10.1093/humrep/deab250
Autori:
Tang, Y., Frisendahl, C., Lalitkumar, P. G., Danielsson, K. G.
Pubblicato in:
Endocrines, 2023, ISSN 2673-396X
Editore:
MDPI
DOI:
10.3390/endocrines4040048
Autori:
Nina Boskovic, Gamze Yazgeldi, Sini Ezer, Mari H. Tervaniemi, Jose Inzunza, Spyridon Panagiotis Deligiannis, Barış Yaşar, Tiina Skoog, Kaarel Krjutškov, Shintaro Katayama, Juha Kere
Pubblicato in:
STAR Protocols, 2023, ISSN 2666-1667
Editore:
Elsevier Inc.
DOI:
10.1016/j.xpro.2023.102357
Autori:
Yiqun Tang; Sakthivignesh Ponandai-srinivasan; Caroline Frisendahl; Johanna K. Andersson; Dora Pavone; Elizabeth A. Stewart; Parameswaran Grace Luther Lalitkumar; Eberhard Korsching; Nageswara Rao Bogavarappu; Kristina Gemzell-Danielsson
Pubblicato in:
Frontiers in Endocrinology, 2023, ISSN 1664-2392
Editore:
Frontiers Media SA
DOI:
10.3389/fendo.2023.1026168
Autori:
Estonian Biobank Research Team; FinnGen; Koel, Mariann; Vosa, Urmo; Joeloo, Maarja; Läll, Kristi; Gualdo, Natalia P.; Laivuori, Hannele; Lemmelä, Susanna; Daly, Mark; Palta, Priit; Mägi, Reedik; Laisk, Triin
Pubblicato in:
Human Molecular Genetics, 2023, ISSN 0964-6906
Editore:
Oxford University Press
DOI:
10.1093/hmg/ddad043
Autori:
Danti, L., Lundin, K., Sepponen, K., Yohannes, D. A., Kere, J., Tuuri, T., Tapanainen, J. S.
Pubblicato in:
Journal of Ovarian Research, 2023, ISSN 1757-2215
Editore:
BioMed Central
DOI:
10.1186/s13048-023-01264-5
Autori:
Pujol-Gualdo, N., Läll, K., Lepamets, M. et al.
Pubblicato in:
Nature Communication, Numero 13, article no 3584, 2022, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-022-31188-5
Autori:
Pujol-Gualdo, N., Mägi, R., Laisk, T.
Pubblicato in:
Human Reproduction, 2023, ISSN 0268-1161
Editore:
Oxford University Press
DOI:
10.1093/humrep/dead217
Autori:
Venkatram Yellapragada, Nazli Eskici, Yafei Wang, Shrinidhi Madhusudan, Kirsi Vaaralahti, Timo Tuuri, Taneli Raivio
Pubblicato in:
Disease Models & Mechanisms, 2022, ISSN 1754-8411
Editore:
The Company of Biologists
DOI:
10.1242/dmm.049436
Autori:
Jia Zhu, Natàlia Pujol-Gualdo, Laura B L Wittemans, Cecilia M Lindgren, Triin Laisk, Joel N Hirschhorn, Yee-Ming Chan
Pubblicato in:
The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Editore:
The Endocrine Society
DOI:
10.1210/clinem/dgab838
Autori:
Maria Siermann; Zoë Claesen; Laurent Pasquier; Taneli Raivio; Olga Tšuiko; Joris Robert Vermeesch; Pascal Borry
Pubblicato in:
J Community Genet, 2022, ISSN 1868-310X
Editore:
Springer Verlag
DOI:
10.1007/s12687-021-00573-w
Autori:
Maria Siermann; Ophelia Valcke; Joris Robert Vermeesch; Taneli Raivio; Olga Tšuiko; Pascal Borry
Pubblicato in:
European Journal of Human Genetics, 2023, ISSN 1476-5438
Editore:
Springer Nature
DOI:
10.1038/s41431-023-01333-9
Autori:
Maria Siermann, Olga Tšuiko, Joris Robert Vermeesch, Taneli Raivio, Pascal Borry
Pubblicato in:
Genetics in Medicine, 2022, ISSN 1098-3600
Editore:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1016/j.gim.2022.03.001
Autori:
Yafei Wang, Shrinidhi Madhusudan, Ludovica Cotellessa, Jouni Kvist, Nazli Eskici, Venkatram Yellapragada, Kristiina Pulli, Carina Lund, Kirsi Vaaralahti, Timo Tuuri, Paolo Giacobini, Taneli Raivio
Pubblicato in:
Stem Cells, 2022, ISSN 1549-4918
Editore:
Oxford University Press
DOI:
10.1093/stmcls/sxac069
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