Descripción del proyecto
Tratamiento de hepatopatías con microbios
La esteatosis hepática no alcohólica (EHNA) se caracteriza por la acumulación de grasa en el hígado y afecta principalmente a personas con sobrepeso u obesidad. La EHNA puede convertirse en cirrosis y es una de las principales causas de cáncer de hígado. El equipo del proyecto BestTreat, financiado con fondos europeos, quiere dilucidar el papel del microbioma en la EHNA. El desequilibrio del microbioma intestinal se ha asociado a varias enfermedades, incluida la EHNA, pero se sabe poco sobre el mecanismo subyacente. La investigación del proyecto ayudará a desarrollar nuevos métodos diagnósticos y bioterapéuticos en los que intervenga el microbioma intestinal para la prevención o el tratamiento de la EHNA.
Objetivo
BestTreat fosters education of ESRs in a project to uncover microbiome signatures for risk prediction and monitoring of NAFLD and to contribute to the development of therapeutic treatments based on metabolically beneficial microbial consortia. It trains 15 ESRs at world-leading academic institutions and companies, thus forming strong interdisciplinary links between industry, life and medical sciences, and end-users. BestTreat aims to train a new generation of highly qualified ESRs with entrepreneurial competencies in modern Life Sciences through state-of-the-art research projects. The projects focus on the identification and functional characterization of microbial consortia that contribute to metabolic control, and the application of this knowledge to develop novel leads for drug discovery and therapies for NAFLD. The new field on microbiome based therapeutics requires highly skilled scientists with interdisciplinary knowledge on medicine, systems biology and computer science, as well as hands-on experience with several types of tissue samples and model organisms that can optimally translate their research findings into sustainable improvements in clinical practice. BestTreat overcomes current barriers by establishing a strong, multidisciplinary and inter-sectoral training network, developing technologies tailored to solve key questions in human metabolism, microbiology and bioinformatics. The BestTreat programme will exploit recent developments in high-throughput and genome-wide screening technologies, combine these with modern molecular cell biology and systems biology approaches and ultimately translate the data into new leads for the discovery of live biotherapeutics. This specific cross-disciplinary training program will educate young scientists to the next level needed to advance this research field for the upcoming decennium. The training programme will be complemented with a complete set of transferable skills.
Ámbito científico
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Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
07745 Jena
Alemania