Descrizione del progetto
Trattamenti rigenerativi per la malattia renale
La malattia renale cronica è caratterizzata da una graduale perdita della funzione dei reni, il che comporta la necessità di dialisi o, in casi estremi, il trapianto di questi organi. I progressi compiuti nel campo della biologia delle cellule staminali consentono lo sviluppo di terapie rigenerative intese a riparare o sostituire il tessuto renale danneggiato. L’obiettivo del progetto RenalToolBox, finanziato dall’UE, è quello di sviluppare tecnologie volte ad agevolare la traduzione di questi interventi rigenerativi basati sulle cellule alla fase clinica. Il progetto prevede la formazione multidisciplinare e multisettoriale di giovani ricercatori nei settori delle terapie cellulari e della medicina rigenerativa. I tirocinanti svilupperanno nuovi strumenti diagnostici e concentreranno l’attenzione su terapie basate su cellule stromali mesenchimali.
Obiettivo
The RenalToolBox ITN comprises a team of world-leading clinicians, scientists and industrialists from academia and private enterprise whose common goal is to develop innovative medical devices and imaging technologies to expedite the translation of cell-based regenerative medicine therapies (RMTs) to the clinic. The target disease for RenalToolBox is kidney disease, the incidence of which is increasing annually. The ITN provides an excellent framework for training 15 early stage researchers (ESRs) in a range of technological, entrepreneurial and transferable skills that will not only enhance their career prospects, but will also boost European scientific excellence and business innovation. By the end of the programme, the ESRs will have benefitted from a comprehensive multidisciplinary and multi-sectoral training experience that will equip them to expedite progress in the emerging supradisciplinary fields of biomedical devices, bio-imaging, cellular therapeutics and regenerative medicine. The research training objectives are as follows: 1. Train the young researchers in the development of diagnostic devices and novel tracers for monitoring renal function. 2. Apply cutting-edge imaging technologies to evaluate the safety and efficacy of novel cell-based RMTs in a rodent model of kidney disease. 3. Assess the safety and efficacy of different sources of mesenchymal stromal cells and explore the mechanisms whereby these cells can ameliorate kidney disease. This comprehensive training programme will endow the young researchers with the necessary scientific and industrial skills to ensure their employability and readiness to engage and lead the next European generation of scientists-entrepreneurs.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
L69 7ZX Liverpool
Regno Unito