Descripción del proyecto
Acción colectiva contra el dolor óseo
El dolor óseo puede deberse a varias causas, como la artritis, las fracturas osteoporóticas o las metástasis óseas. Factores como la edad avanzada y la obesidad agravan aún más la aparición del dolor óseo, por lo que son necesarias nuevas modalidades terapéuticas para mejorar la calidad de vida de los enfermos. Para abordar esta necesidad médica no cubierta, el proyecto financiado con fondos europeos BonePainII ha reunido a expertos en la materia para investigar los mecanismos que subyacen al dolor óseo en diferentes afecciones, incluidas las enfermedades óseas raras. Los investigadores están estudiando la interacción entre las neuronas sensitivas y un microentorno óseo patológico para identificar dianas para intervenciones terapéuticas específicas.
Objetivo
In Europe 20 - 30% of adults are affected at any one time by musculoskeletal pain such as arthritic pain, lower back pain, pain from osteoporotic fractures and bone metastasis, and also most rare bone diseases are very painful. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is yet available. Therefore, there is a strong need to train highly skilled researchers within bone pain and thereby make the foundation for improved therapies. In this proposal we bring together 3 industrial beneficiaries, 8 academic beneficiaries, and one industrial partner all committed to train a new generation of 15 creative, entrepreneurial and innovative early stages researchers in bone pain research and transferable skills. The early stages researchers will train with some of the foremost neuroscientists and bone researchers in academia and industry across Europe. The BonePainII training network will provide the early stage researchers with expertise that will enable them to gain high level employment both in academia and industry. In a multidisciplinary, intersectoral and integrated project we will develop advanced 3D microfluidic in vitro platforms and high throughput techniques to investigate bone-neuron interactions; validate and investigate novel in vivo models of bone pain including a rare bone disease; and using cutting-edge technologies to identify key mechanisms underlying bone pain in osteoarthritis, rheumatoid arthritis, and cancer-induced bone pain.
Ámbito científico
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
1165 Kobenhavn
Dinamarca