Descrizione del progetto
Un’azione collettiva contro il dolore osseo
Il dolore osseo può essere provocato da varie cause, tra cui artrite, fratture osteoporotiche o metastasi ossee. Fattori quali età avanzata e obesità aggravano ulteriormente gli episodi di questo tipo, comportando la necessità di nuove modalità terapeutiche per migliorare la qualità della vita di coloro che ne soffrono. Per affrontare questa esigenza medica non soddisfatta, il progetto BonePainII, finanziato dall’UE, ha riunito vari esperti in tal ambito allo scopo di approfondire i meccanismi alla base del dolore osseo in diverse condizioni, tra cui alcune patologie rare delle ossa. I ricercatori stanno studiando l’interazione tra i neuroni sensoriali e un microambiente osseo soggetto a patologia allo scopo di individuare i bersagli per interventi terapeutici specifici.
Obiettivo
In Europe 20 - 30% of adults are affected at any one time by musculoskeletal pain such as arthritic pain, lower back pain, pain from osteoporotic fractures and bone metastasis, and also most rare bone diseases are very painful. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is yet available. Therefore, there is a strong need to train highly skilled researchers within bone pain and thereby make the foundation for improved therapies. In this proposal we bring together 3 industrial beneficiaries, 8 academic beneficiaries, and one industrial partner all committed to train a new generation of 15 creative, entrepreneurial and innovative early stages researchers in bone pain research and transferable skills. The early stages researchers will train with some of the foremost neuroscientists and bone researchers in academia and industry across Europe. The BonePainII training network will provide the early stage researchers with expertise that will enable them to gain high level employment both in academia and industry. In a multidisciplinary, intersectoral and integrated project we will develop advanced 3D microfluidic in vitro platforms and high throughput techniques to investigate bone-neuron interactions; validate and investigate novel in vivo models of bone pain including a rare bone disease; and using cutting-edge technologies to identify key mechanisms underlying bone pain in osteoarthritis, rheumatoid arthritis, and cancer-induced bone pain.
Campo scientifico
Parole chiave
Programma(i)
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Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
1165 Kobenhavn
Danimarca