EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

Informations projet

EVPRO

N° de convention de subvention: 814495

DOI

10.3030/814495

Projet clôturé

Date de signature de la CE 14 Decembre 2018

Date de début 1 Janvier 2019

Date de fin 30 Novembre 2023

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials

Coût total

€ 5 799 088,75

Contribution de l’UE

€ 5 799 088,75

Coordonné par

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (2)

Summary Report on Dissemination and Communication Activities

With their active participation in the dissemination and the exploitation activities, all partners contribute to an effective and time sustainable deployment of project results. Dissemination of the project results is performed in parallel with exploitation, maximising the potential benefits of public awareness.

Dissemination and Communication Plan

This is targets a broad audience and the highest possible impact. For this reason, the dissemination of the developed concept includes newsletters, papers on scientific and technical journals and conferences and the creation and management of a website and the respective forum in social media.

Websites, patent fillings, videos etc. (1)

Project website, Twitter, Facebook

Coordinate the dissemination of project results to targeted audiences with the use of adequate sets of mediaThe purpose of the website is to make project developments visible in a timely manner; the forum will be used for discussions to get direct feedback of external stakeholders

Publications

Peer reviewed articles (8)

Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers

Auteurs: Qi Xiao, Martina Delbianco, Samuel E. Sherman, Aracelee M. Reveron Perez, Priya Bharate, Alonso Pardo-Vargas, Cesar Rodriguez-Emmenegger, Nina Yu Kostina, Khosrow Rahimi, Dominik Söder, Martin Möller, Michael L. Klein, Peter H. Seeberger, Virgil Percec
Publié dans: Proceedings of the National Academy of Sciences, Numéro 117/22, 2020, Page(s) 11931-11939, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2003938117

Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications

Auteurs: Dimitrios Tsiapalis, Lorraine O’Driscoll
Publié dans: Cells, Numéro 9/4, 2020, Page(s) 991, ISSN 2073-4409
Éditeur: MDPI AG
DOI: 10.3390/cells9040991

Unraveling topology-induced shape transformations in dendrimersomes

Auteurs: Nina Yu. Kostina, Anna M. Wagner, Tamás Haraszti, Khosrow Rahimi, Qi Xiao, Michael L. Klein, Virgil Percec, Cesar Rodriguez-Emmenegger
Publié dans: Soft Matter, 2020, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0sm01097a

Photoinduced Upgrading of Lactic Acid-Based Solvents to Block Copolymer Surfactants

Auteurs: Nabil Bensabeh, Adrian Moreno, Adrià Roig, Mehrnoush Rahimzadeh, Khosrow Rahimi, Juan Carlos Ronda, Virginia Cádiz, Marina Galià, Virgil Percec, Cesar Rodriguez-Emmenegger, Gerard Lligadas
Publié dans: ACS Sustainable Chemistry & Engineering, Numéro 8/2, 2019, Page(s) 1276-1284, ISSN 2168-0485
Éditeur: American Chemical Society
DOI: 10.1021/acssuschemeng.9b06599

Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms

Auteurs: Shangda Li, Boao Xia, Bilal Javed, William D. Hasley, Adriel Melendez-Davila, Matthew Liu, Meir Kerzner, Shriya Agarwal, Qi Xiao, Paola Torre, Jessica G. Bermudez, Khosrow Rahimi, Nina Yu. Kostina, Martin Möller, Cesar Rodriguez-Emmenegger, Michael L. Klein, Virgil Percec, Matthew C. Good
Publié dans: ACS Nano, Numéro 14/6, 2020, Page(s) 7398-7411, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.0c02912

In vitro biocompatibility analysis of protein-resistant amphiphilic polysulfobetaines as coatings for surgical implants in contact with complex body fluids

Auteurs: Jana F. Karthäuser, Dierk Gruhn, Alejandro Martínez Guajardo, Regina Kopecz, Nina Babel, Ulrik Stervbo, André Laschewsky, Richard Viebahn, Jochen Salber, Axel Rosenhahn
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 12, 2024, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1403654

Doxorubicin Loading into Milk and Mesenchymal Stem Cells’ Extracellular Vesicles as Drug Delivery Vehicles

Auteurs: Anindya Mukhopadhya, Dimitrios Tsiapalis, Niamh McNamee, Brian Talbot, Lorraine O’Driscoll
Publié dans: Pharmaceutics, Numéro 15, 2023, Page(s) 718, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15030718

Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids

Auteurs: Paola Torre, Qi Xiao, Irene Buzzacchera, Samuel E. Sherman, Khosrow Rahimi, Nina Yu. Kostina, Cesar Rodriguez-Emmenegger, Martin Möller, Christopher J. Wilson, Michael L. Klein, Matthew C. Good, Virgil Percec
Publié dans: Proceedings of the National Academy of Sciences, Numéro 116/31, 2019, Page(s) 15378-15385, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1904868116