Risultati finali Websites, patent fillings, videos etc. (17) Periodic newsletters (M36) Periodic newsletters Periodic newsletters (M12) Periodic newsletters Candidate gene lists Validated growth-coupled methyl-transferase system for 1 MIA compound >1,000 refactored and prototyped MIA pathway designs 1000 refactored and prototyped MIA pathway designs Complete and publish deep learning algorithm on MIA pathway optimization in yeast cell factories Periodic newsletters (M24) Periodic newsletters Expression atlas Annotated reference genome of Rauvolfia tetraphylla Periodic newsletters (M48) Periodic newsletters Project website: the report will provide a functional description of the project website and its main sections. Technology Transfer (T&T) Activities, including training to SMEs and research centers Technology Transfer TT Activities including training to SMEs and research centers Press release about the launching of MIAMi project will be sent to the media to disseminate the project Data processing pipeline for omics data Publicly available DNA Parts repository Publicly available Bio-CAD Publicly available BioCAD "Final version of the ""Plan for the Use and Dissemination of the Foreground"" (PUDF)" Final version of the Plan for the Use and Dissemination of the Foreground PUDF Documents, reports (5) Life-Cycle and Techno-Economic Assessment - Final report LifeCycle and TechnoEconomic Assessment Final report Establish localization patterns of alkaloids in Rauvolfia sp. Establish localization patterns of alkaloids in Rauvolfia sp List of identified metabolites (and corresponding accurate masses) in Rauvolfia serpentina and Rauvolfia tetraphylla plants Publicly available SOPs Sample preparation methods for MSI studies of various parts of the Rauvolfia serpentina and Rauvolfia tetraphylla plants Demonstrators, pilots, prototypes (1) Delivery of large quantities of tabersonine, alstonine and rauwolscine Delivery of large quantities of tabersonine alstonine and rauwolscine Open Research Data Pilot (1) First version of data management plan as required by Open Research Data Pilot Pubblicazioni Other (9) Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids Autori: Marcus Daniel Brandbjerg Bohn Lorensen, Sidra Yasmine Hayat, Niels Wellner, Nanna Bjarnholt, Christian Janfelt Pubblicato in: 2023 Editore: NIH DOI: 10.1002/pca.3202 Literate programming for iterative design-build-test-learn cycles in bioengineering Autori: Søren Petersen, Lucas Levassor, Christine M. Pedersen, Rasmus Frandsen, Tilmann Weber, Jan Madsen, Lea G. Hansen, Jie Zhang, Ahmad K. Haidar, Jay D. Keasling, Nikolaus Sonnenchein, and Michael K. Jensen Pubblicato in: 2023 Editore: BioRxiv DOI: 10.1101/2023.06.18.545451 Directed Biosynthesis of New to Nature Alkaloids in a Heterologous Nicotiana benthamiana Expression Host Autori: Marianna Boccia, Dagny Grzech, Adriana A. Lopes, Sarah E. O’Connor and Lorenzo Caputi Pubblicato in: Frontiers, 2022 Editore: Frontiers in Plant Science DOI: 10.3389/fpls.2022.919443 Boosting lignan-precursor synthesis in yeast cell factories through co-factor supply optimization Autori: Jennifer Perrin, Sébastien Besseau, Nicolas Papon and Vincent Courdavault1 Pubblicato in: Frontiers, 2022 Editore: Frontiers DOI: 10.3389/fbioe.2022.1079801 Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging Autori: Marcus Daniel Brandbjerg Bohn Lorensen, Nanna Bjarnholt, Benoit St-Pierre, Sarah Heinicke , Vincent Courdavault, Sarah O'Connor, Christian Janfelt Pubblicato in: Phytochemistry, 2023 Editore: Phytochemistry DOI: 10.1016/j.phytochem.2023.113620 Gaining access to acetyl-CoA by peroxisomal surface display Autori: Thomas Perrot, Sébastien Besseau, Nicolas Papon, Vincent Courdavault Pubblicato in: 2023 Editore: Synthetic and Systems Biotechnology DOI: 10.1016/j.synbio.2023.02.003 Chromosome-scale genomes throw light on plant drug biosynthesis Autori: Emily Amor Stander, Thomas Dugé de Bernonville, Nicolas Papon, Vincent Courdavault Pubblicato in: Trends in Pharmacological Sciences, 2022 Editore: Trends in Pharmacological Sciences DOI: 10.1016/j.tips.2022.01.007 HSP70-binding motifs function as protein quality control degrons Autori: Amanda B. Abildgaard, Vasileios Voutsinos, Søren D. Petersen, Fia B. Larsen, Caroline Kampmeyer, Kristoffer E. Johansson, Amelie Stein, Tommer Ravid, Claes Andréasson, Michael K. Jensen, Kresten Lindorff-Larsen & Rasmus Hartmann-Petersen Pubblicato in: 2023 Editore: Cellular and Molecular Life Sciences DOI: 10.1007/s00018-022-04679-3 Early and Late Steps of Quinine Biosynthesis Autori: Francesco Trenti, Kotaro Yamamoto, Benke Hong, Christian Paetz, Yoko Nakamura, and Sarah E. O’Connor Pubblicato in: ACS Publications, 2021 Editore: ACS Publications DOI: 10.1021/acs.orglett.1c00206 Peer reviewed articles (24) Referee report. For: An updated version of the Madagascar periwinkle genome [version 1; peer review: 1 approved] Autori: Tatsis, Evangelos Pubblicato in: F1000Researcg, Issue 7, 2023, ISSN 2046-1402 Editore: F1000 Research Ltd. DOI: 10.5256/f1000research.141880.r158640 Peroxisomes: A New Hub for Metabolic Engineering in Yeast Autori: Natalja Kulagina, Sébastien Besseau, Nicolas Papon and Vincent Courdavault Pubblicato in: Frontiers in Bioengineering and Biotechnology, 2021, ISSN 2296-4185 Editore: Frontiers in Bioengineering and Biotechnology DOI: 10.3389/fbioe.2021.659431 Genome Assembly of the Medicinal Plant <i>Voacanga thouarsii</i> Autori: Clément Cuello; Emily Amor Stander; Hans J Jansen; Thomas Dugé de Bernonville; Arnaud Lanoue; Nathalie Giglioli-Guivarc'h; Nicolas Papon; Ron P Dirks; Michael Krogh Jensen; Sarah Ellen O'Connor; Sébastien Besseau; Vincent Courdavault Pubblicato in: Genome Biology and Evolution, Issue 3, 2022, ISSN 1759-6653 Editore: Oxford University Press DOI: 10.1093/gbe/evac158 Tracking the Origin and Evolution of Plant Metabolites Autori: Christophe Duplais, Nicolas Papon, Vincent Courdavault Pubblicato in: Trends in plant science, 2020, Page(s) 1182-1184, ISSN 1878-4372 Editore: Trends in plant science DOI: 10.1016/j.tplants.2020.08.010 Deploying Microbial Synthesis for Halogenating and Diversifying Medicinal Alkaloid Scaffolds Autori: Samuel Alan Bradley; Jie Zhang; Michael Krogh Jensen Pubblicato in: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020), Issue 2, 2020, ISSN 2296-4185 Editore: Frontiers in Bioengineering and Biotechnology DOI: 10.3389/fbioe.2020.594126 A FAIR-compliant parts catalogue for genome engineering and expression control in Saccharomyces cerevisiae Autori: Vasil D'Ambrosio, Lea G Hansen, Jie Zhang, Emil D Jensen, Dushica Arsovska, Marcos Laloux, Tadas Jakočiūnas, Pernille Hjort, Davide De Lucrezia , Serena Marletta, Jay D Keasling and Michael K Jensen Pubblicato in: Synth Syst Biotechnol ., Issue 16;7(2), 2022, Page(s) 657-663, ISSN 2405-805X Editore: KeAi Publishing Communications Ltd. DOI: 10.1016/j.synbio.2022.02.001 Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus Autori: Kotaro Yamamoto; Dagny Grzech; Konstantinos Koudounas; Emily Amor Stander; Lorenzo Caputi; Tetsuro Mimura; Vincent Courdavault; Sarah E. O’Connor Pubblicato in: Plant Physiology, Issue 5, 2021, ISSN 0032-0889 Editore: American Society of Plant Biologists DOI: 10.1093/plphys/kiab285 Computational biotechnology guides elucidation of the biosynthesis of the plant anticancer drug camptothecin Autori: Emily Amor Stander, ThomasDugé de Bernonville, Nicolas Papon, Vincent Courdavault Pubblicato in: Computational and Structural Biotechnology Journal, 2021, ISSN 2001-0370 Editore: Computational and Structural Biotechnology Journal DOI: 10.1016/j.csbj.2021.06.028 Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits Autori: Nicolas Papon; Vincent Courdavault; Sarah O'Connor; Michael Krogh Jensen Pubblicato in: Natural Product Reports, 38(12), Issue 5, 2021, Page(s) 2145-2153, ISSN 0265-0568 Editore: Royal Society of Chemistry DOI: 10.1039/d0np00092b Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories Autori: Natalja Kulagina, Grégory Guirimand, Céline Melin, Pamela Lemos-Cruz, Ines Carqueijeiro, Johan-Owen De Craene, Audrey Oudin, Vladimir Heredia, Konstantinos Koudounas, Marianne Unlubayir, Arnaud Lanoue, Nadine Imbault, Benoit St-Pierre, Nicolas Papon, Marc Clastre, Nathalie Giglioli-Guivarc’h, Jillian Marc, Sébastien Besseau, Vincent Courdavault Pubblicato in: Microbial Biotechnology, 2021, Page(s) 2693-2699, ISSN 1751-7915 Editore: Microbial Biotechnology DOI: 10.1111/1751-7915.13898 The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis. Autori: Emily Amor Stander; Clément Cuello; Caroline Birer-Williams; Natalja Kulagina; Hans J Jansen; Ines Carqueijeiro; Louis-Valentin Méteignier; Valentin Vergès; Audrey Oudin; Nicolas Papon; Ron P Dirks; Michael Krogh Jensen; Sarah Ellen O’Connor; Thomas Dugé de Bernonville; Sébastien Besseau; Vincent Courdavault Pubblicato in: G3: Genes, Genomes, Genetics, Issue 5, 2023, ISSN 2160-1836 Editore: Genetics Society of America DOI: 10.1093/g3journal/jkac268 Supplying plant natural products by yeast cell factories Autori: David Romero-Suarez, Jay D.Keasling and Michael K.Jensen1 Pubblicato in: Current Opinion in Green and Sustainable Chemistry, 2022, ISSN 2452-2236 Editore: Elsevier BV DOI: 10.1016/j.cogsc.2021.100567 Efficient Terpene Production by Marine Thraustochytrids: Shedding Light on the Thermodynamic Driving Force Autori: Natalja Kulagina, Jennifer Perrin, Sébastien Besseau, Vincent Courdavault Pubblicato in: mBio, 2021, ISSN 2150-7511 Editore: mBio DOI: 10.1128/mbio.01976-21 Identifying Missing Biosynthesis Enzymes of Plant Natural Products Autori: Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault Pubblicato in: Trends in Pharmacological Sciences, 2020, ISSN 0165-6147 Editore: Elsevier BV DOI: 10.1016/j.tips.2019.12.006 Evolution-guided engineering of small-molecule biosensors Autori: Tim Snoek, Evan K Chaberski, Francesca Ambri, Stefan Kol, Sara P Bjørn, Bo Pang, Jesus F Barajas, Ditte H Welner, Michael K Jensen, Jay D Keasling Pubblicato in: Nucleic Acids Research, Issue 48/1, 2019, Page(s) e3-e3, ISSN 0305-1048 Editore: Oxford University Press DOI: 10.1093/nar/gkz954 Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs Autori: Ines Carqueijeiro, Chloe Langley, Dagny Grzech, Konstantinos Koudounas, Nicolas Papon, Sarah E O’Connor, Vincent Courdavault Pubblicato in: Current Opinion in Biotechnology, Issue 65, 2020, Page(s) 17-24, ISSN 0958-1669 Editore: Elsevier BV DOI: 10.1016/j.copbio.2019.11.017 Towards the Microbial Production of Plant-Derived Anticancer Drugs Autori: Vincent Courdavault, Sarah E. O’Connor, Audrey Oudin, Sébastien Besseau, Nicolas Papon Pubblicato in: Trends in Cancer, Issue 6/6, 2020, Page(s) 444-448, ISSN 2405-8033 Editore: Elsevier DOI: 10.1016/j.trecan.2020.02.004 Virus-Induced Gene Silencing: Hush Genes to Make Them Talk Autori: Vincent Courdavault, Sébastien Besseau, Audrey Oudin, Nicolas Papon, Sarah Ellen O’Connor Pubblicato in: Trends in Plant Science, Issue 25/7, 2020, Page(s) 714-715, ISSN 1360-1385 Editore: Elsevier BV DOI: 10.1016/j.tplants.2020.02.013 Engineering G protein-coupled receptor signalling in yeast for biotechnological and medical purposes Autori: Bettina Lengger, Michael K Jensen Pubblicato in: FEMS Yeast Research, Issue 20/1, 2020, ISSN 1567-1356 Editore: Blackwell DOI: 10.1093/femsyr/foz087 Identifying Genes Involved in alkaloid Biosynthesis in Vinca minor Through Transcriptomics and Gene Co-Expression Analysis Autori: Emily A. Stander; Liuda Johana Sepúlveda; Thomas Dugé de Bernonville; Inês Carqueijeiro; Konstantinos Koudounas; Pamela Lemos Cruz; Sébastien Besseau; Arnaud Lanoue; Nicolas Papon; Nathalie Giglioli-Guivarc’h; Ron Dirks; Sarah E. O'Connor; Lucía Atehortúa; Audrey Oudin; Vincent Courdavault Pubblicato in: Biomolecules, Issue 1, 2020, ISSN 2218-273X Editore: MDPI DOI: 10.3390/biom10121595 Early and Late Steps of Quinine Biosynthesis Autori: Francesco Trenti; Kotaro Yamamoto; Benke Hong; Christian Paetz; Yoko Nakamura; Sarah E. O’Connor Pubblicato in: Organic Letters 23 (5), Issue 5, 2021, Page(s) 1793 - 1797, ISSN 1523-7060 Editore: American Chemical Society DOI: 10.1021/acs.orglett.1c00206 Yeasts as Biopharmaceutical Production Platforms Autori: Natalja Kulagina, Sébastien Besseau, Charlotte Godon, Gustavo H. Goldman, Nicolas Papon and Vincent Courdavault Pubblicato in: Frontiers in fungal biotechnology, 2021, ISSN 2054-3085 Editore: Frontiers in fungal biotechnology DOI: 10.3389/ffunb.2021.733492 A microbial supply chain for production of the anti-cancer drug vinblastine Autori: Jie Zhang; Lea G. Hansen; Olga Gudich; Konrad Viehrig; Lærke M. M. Lassen; Lars Schrübbers; Khem B. Adhikari; Paulina Rubaszka; Elena Carrasquer-Alvarez; Ling Chen; Vasil D’Ambrosio; Beata Lehka; Ahmad K. Haidar; Saranya Nallapareddy; Konstantina Giannakou; Marcos Laloux; Dushica Arsovska; Marcus A. K. Jørgensen; Leanne Jade G. Chan; Mette Kristensen; Hanne B. Christensen; Suresh Sudarsan; Em Pubblicato in: Zhang , J , Hansen , L G , Gudich , O , Viehrig , K , Lassen , L M M , Schrübbers , L , Adhikari , K B , Rubaszka , P , Carrasquer-Alvarez , E , Chen , L , D’Ambrosio , V , Lehka , B , Haidar , A K , Nallapareddy , S , Giannakou , K , Laloux , M , Arsovska , D , Jørgensen , M A K , Chan , L J G , Kristensen , M , Christensen , H B , Sudarsan , S , Stander , E A , Baidoo , E , Petzold , C J , W, Issue 19, 2022, ISSN 0028-0836 Editore: Nature Publishing Group DOI: 10.1038/s41586-022-05157-3 Dietary Change Enables Robust Growth-Coupling of Heterologous Methyltransferase Activity in Yeast Autori: Anne Sofie Lærke Hansen, Maitreya J. Dunham, Dushica Arsovska, Jie Zhang, Jay D. Keasling, Markus J. Herrgard, and Michael K. Jensen* Pubblicato in: ACS Synthetic Biology, 2020, Page(s) 3408–3415, ISSN 2161-5063 Editore: American Chemical Society DOI: 10.1021/acssynbio.0c00348 È in corso la ricerca di dati su OpenAIRE... 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