Rezultaty Websites, patent fillings, videos etc. (17) Periodic newsletters (M36) Periodic newsletters Periodic newsletters (M12) Periodic newsletters Candidate gene lists Validated growth-coupled methyl-transferase system for 1 MIA compound >1,000 refactored and prototyped MIA pathway designs 1000 refactored and prototyped MIA pathway designs Complete and publish deep learning algorithm on MIA pathway optimization in yeast cell factories Periodic newsletters (M24) Periodic newsletters Expression atlas Annotated reference genome of Rauvolfia tetraphylla Periodic newsletters (M48) Periodic newsletters Project website: the report will provide a functional description of the project website and its main sections. Technology Transfer (T&T) Activities, including training to SMEs and research centers Technology Transfer TT Activities including training to SMEs and research centers Press release about the launching of MIAMi project will be sent to the media to disseminate the project Data processing pipeline for omics data Publicly available DNA Parts repository Publicly available Bio-CAD Publicly available BioCAD "Final version of the ""Plan for the Use and Dissemination of the Foreground"" (PUDF)" Final version of the Plan for the Use and Dissemination of the Foreground PUDF Documents, reports (5) Life-Cycle and Techno-Economic Assessment - Final report LifeCycle and TechnoEconomic Assessment Final report Establish localization patterns of alkaloids in Rauvolfia sp. Establish localization patterns of alkaloids in Rauvolfia sp List of identified metabolites (and corresponding accurate masses) in Rauvolfia serpentina and Rauvolfia tetraphylla plants Publicly available SOPs Sample preparation methods for MSI studies of various parts of the Rauvolfia serpentina and Rauvolfia tetraphylla plants Demonstrators, pilots, prototypes (1) Delivery of large quantities of tabersonine, alstonine and rauwolscine Delivery of large quantities of tabersonine alstonine and rauwolscine Open Research Data Pilot (1) First version of data management plan as required by Open Research Data Pilot Publikacje Other (9) Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids Autorzy: Marcus Daniel Brandbjerg Bohn Lorensen, Sidra Yasmine Hayat, Niels Wellner, Nanna Bjarnholt, Christian Janfelt Opublikowane w: 2023 Wydawca: NIH DOI: 10.1002/pca.3202 Literate programming for iterative design-build-test-learn cycles in bioengineering Autorzy: Søren Petersen, Lucas Levassor, Christine M. Pedersen, Rasmus Frandsen, Tilmann Weber, Jan Madsen, Lea G. Hansen, Jie Zhang, Ahmad K. Haidar, Jay D. Keasling, Nikolaus Sonnenchein, and Michael K. Jensen Opublikowane w: 2023 Wydawca: BioRxiv DOI: 10.1101/2023.06.18.545451 Directed Biosynthesis of New to Nature Alkaloids in a Heterologous Nicotiana benthamiana Expression Host Autorzy: Marianna Boccia, Dagny Grzech, Adriana A. Lopes, Sarah E. O’Connor and Lorenzo Caputi Opublikowane w: Frontiers, 2022 Wydawca: Frontiers in Plant Science DOI: 10.3389/fpls.2022.919443 Boosting lignan-precursor synthesis in yeast cell factories through co-factor supply optimization Autorzy: Jennifer Perrin, Sébastien Besseau, Nicolas Papon and Vincent Courdavault1 Opublikowane w: Frontiers, 2022 Wydawca: Frontiers DOI: 10.3389/fbioe.2022.1079801 Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging Autorzy: Marcus Daniel Brandbjerg Bohn Lorensen, Nanna Bjarnholt, Benoit St-Pierre, Sarah Heinicke , Vincent Courdavault, Sarah O'Connor, Christian Janfelt Opublikowane w: Phytochemistry, 2023 Wydawca: Phytochemistry DOI: 10.1016/j.phytochem.2023.113620 Gaining access to acetyl-CoA by peroxisomal surface display Autorzy: Thomas Perrot, Sébastien Besseau, Nicolas Papon, Vincent Courdavault Opublikowane w: 2023 Wydawca: Synthetic and Systems Biotechnology DOI: 10.1016/j.synbio.2023.02.003 Chromosome-scale genomes throw light on plant drug biosynthesis Autorzy: Emily Amor Stander, Thomas Dugé de Bernonville, Nicolas Papon, Vincent Courdavault Opublikowane w: Trends in Pharmacological Sciences, 2022 Wydawca: Trends in Pharmacological Sciences DOI: 10.1016/j.tips.2022.01.007 HSP70-binding motifs function as protein quality control degrons Autorzy: Amanda B. Abildgaard, Vasileios Voutsinos, Søren D. Petersen, Fia B. Larsen, Caroline Kampmeyer, Kristoffer E. Johansson, Amelie Stein, Tommer Ravid, Claes Andréasson, Michael K. Jensen, Kresten Lindorff-Larsen & Rasmus Hartmann-Petersen Opublikowane w: 2023 Wydawca: Cellular and Molecular Life Sciences DOI: 10.1007/s00018-022-04679-3 Early and Late Steps of Quinine Biosynthesis Autorzy: Francesco Trenti, Kotaro Yamamoto, Benke Hong, Christian Paetz, Yoko Nakamura, and Sarah E. O’Connor Opublikowane w: ACS Publications, 2021 Wydawca: ACS Publications DOI: 10.1021/acs.orglett.1c00206 Peer reviewed articles (24) Referee report. For: An updated version of the Madagascar periwinkle genome [version 1; peer review: 1 approved] Autorzy: Tatsis, Evangelos Opublikowane w: F1000Researcg, Issue 7, 2023, ISSN 2046-1402 Wydawca: F1000 Research Ltd. DOI: 10.5256/f1000research.141880.r158640 Peroxisomes: A New Hub for Metabolic Engineering in Yeast Autorzy: Natalja Kulagina, Sébastien Besseau, Nicolas Papon and Vincent Courdavault Opublikowane w: Frontiers in Bioengineering and Biotechnology, 2021, ISSN 2296-4185 Wydawca: Frontiers in Bioengineering and Biotechnology DOI: 10.3389/fbioe.2021.659431 Genome Assembly of the Medicinal Plant <i>Voacanga thouarsii</i> Autorzy: Clément Cuello; Emily Amor Stander; Hans J Jansen; Thomas Dugé de Bernonville; Arnaud Lanoue; Nathalie Giglioli-Guivarc'h; Nicolas Papon; Ron P Dirks; Michael Krogh Jensen; Sarah Ellen O'Connor; Sébastien Besseau; Vincent Courdavault Opublikowane w: Genome Biology and Evolution, Issue 3, 2022, ISSN 1759-6653 Wydawca: Oxford University Press DOI: 10.1093/gbe/evac158 Tracking the Origin and Evolution of Plant Metabolites Autorzy: Christophe Duplais, Nicolas Papon, Vincent Courdavault Opublikowane w: Trends in plant science, 2020, Page(s) 1182-1184, ISSN 1878-4372 Wydawca: Trends in plant science DOI: 10.1016/j.tplants.2020.08.010 Deploying Microbial Synthesis for Halogenating and Diversifying Medicinal Alkaloid Scaffolds Autorzy: Samuel Alan Bradley; Jie Zhang; Michael Krogh Jensen Opublikowane w: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020), Issue 2, 2020, ISSN 2296-4185 Wydawca: Frontiers in Bioengineering and Biotechnology DOI: 10.3389/fbioe.2020.594126 A FAIR-compliant parts catalogue for genome engineering and expression control in Saccharomyces cerevisiae Autorzy: Vasil D'Ambrosio, Lea G Hansen, Jie Zhang, Emil D Jensen, Dushica Arsovska, Marcos Laloux, Tadas Jakočiūnas, Pernille Hjort, Davide De Lucrezia , Serena Marletta, Jay D Keasling and Michael K Jensen Opublikowane w: Synth Syst Biotechnol ., Issue 16;7(2), 2022, Page(s) 657-663, ISSN 2405-805X Wydawca: KeAi Publishing Communications Ltd. DOI: 10.1016/j.synbio.2022.02.001 Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus Autorzy: Kotaro Yamamoto; Dagny Grzech; Konstantinos Koudounas; Emily Amor Stander; Lorenzo Caputi; Tetsuro Mimura; Vincent Courdavault; Sarah E. O’Connor Opublikowane w: Plant Physiology, Issue 5, 2021, ISSN 0032-0889 Wydawca: American Society of Plant Biologists DOI: 10.1093/plphys/kiab285 Computational biotechnology guides elucidation of the biosynthesis of the plant anticancer drug camptothecin Autorzy: Emily Amor Stander, ThomasDugé de Bernonville, Nicolas Papon, Vincent Courdavault Opublikowane w: Computational and Structural Biotechnology Journal, 2021, ISSN 2001-0370 Wydawca: Computational and Structural Biotechnology Journal DOI: 10.1016/j.csbj.2021.06.028 Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits Autorzy: Nicolas Papon; Vincent Courdavault; Sarah O'Connor; Michael Krogh Jensen Opublikowane w: Natural Product Reports, 38(12), Issue 5, 2021, Page(s) 2145-2153, ISSN 0265-0568 Wydawca: Royal Society of Chemistry DOI: 10.1039/d0np00092b Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories Autorzy: Natalja Kulagina, Grégory Guirimand, Céline Melin, Pamela Lemos-Cruz, Ines Carqueijeiro, Johan-Owen De Craene, Audrey Oudin, Vladimir Heredia, Konstantinos Koudounas, Marianne Unlubayir, Arnaud Lanoue, Nadine Imbault, Benoit St-Pierre, Nicolas Papon, Marc Clastre, Nathalie Giglioli-Guivarc’h, Jillian Marc, Sébastien Besseau, Vincent Courdavault Opublikowane w: Microbial Biotechnology, 2021, Page(s) 2693-2699, ISSN 1751-7915 Wydawca: Microbial Biotechnology DOI: 10.1111/1751-7915.13898 The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis. Autorzy: Emily Amor Stander; Clément Cuello; Caroline Birer-Williams; Natalja Kulagina; Hans J Jansen; Ines Carqueijeiro; Louis-Valentin Méteignier; Valentin Vergès; Audrey Oudin; Nicolas Papon; Ron P Dirks; Michael Krogh Jensen; Sarah Ellen O’Connor; Thomas Dugé de Bernonville; Sébastien Besseau; Vincent Courdavault Opublikowane w: G3: Genes, Genomes, Genetics, Issue 5, 2023, ISSN 2160-1836 Wydawca: Genetics Society of America DOI: 10.1093/g3journal/jkac268 Supplying plant natural products by yeast cell factories Autorzy: David Romero-Suarez, Jay D.Keasling and Michael K.Jensen1 Opublikowane w: Current Opinion in Green and Sustainable Chemistry, 2022, ISSN 2452-2236 Wydawca: Elsevier BV DOI: 10.1016/j.cogsc.2021.100567 Efficient Terpene Production by Marine Thraustochytrids: Shedding Light on the Thermodynamic Driving Force Autorzy: Natalja Kulagina, Jennifer Perrin, Sébastien Besseau, Vincent Courdavault Opublikowane w: mBio, 2021, ISSN 2150-7511 Wydawca: mBio DOI: 10.1128/mbio.01976-21 Identifying Missing Biosynthesis Enzymes of Plant Natural Products Autorzy: Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault Opublikowane w: Trends in Pharmacological Sciences, 2020, ISSN 0165-6147 Wydawca: Elsevier BV DOI: 10.1016/j.tips.2019.12.006 Evolution-guided engineering of small-molecule biosensors Autorzy: Tim Snoek, Evan K Chaberski, Francesca Ambri, Stefan Kol, Sara P Bjørn, Bo Pang, Jesus F Barajas, Ditte H Welner, Michael K Jensen, Jay D Keasling Opublikowane w: Nucleic Acids Research, Issue 48/1, 2019, Page(s) e3-e3, ISSN 0305-1048 Wydawca: Oxford University Press DOI: 10.1093/nar/gkz954 Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs Autorzy: Ines Carqueijeiro, Chloe Langley, Dagny Grzech, Konstantinos Koudounas, Nicolas Papon, Sarah E O’Connor, Vincent Courdavault Opublikowane w: Current Opinion in Biotechnology, Issue 65, 2020, Page(s) 17-24, ISSN 0958-1669 Wydawca: Elsevier BV DOI: 10.1016/j.copbio.2019.11.017 Towards the Microbial Production of Plant-Derived Anticancer Drugs Autorzy: Vincent Courdavault, Sarah E. O’Connor, Audrey Oudin, Sébastien Besseau, Nicolas Papon Opublikowane w: Trends in Cancer, Issue 6/6, 2020, Page(s) 444-448, ISSN 2405-8033 Wydawca: Elsevier DOI: 10.1016/j.trecan.2020.02.004 Virus-Induced Gene Silencing: Hush Genes to Make Them Talk Autorzy: Vincent Courdavault, Sébastien Besseau, Audrey Oudin, Nicolas Papon, Sarah Ellen O’Connor Opublikowane w: Trends in Plant Science, Issue 25/7, 2020, Page(s) 714-715, ISSN 1360-1385 Wydawca: Elsevier BV DOI: 10.1016/j.tplants.2020.02.013 Engineering G protein-coupled receptor signalling in yeast for biotechnological and medical purposes Autorzy: Bettina Lengger, Michael K Jensen Opublikowane w: FEMS Yeast Research, Issue 20/1, 2020, ISSN 1567-1356 Wydawca: Blackwell DOI: 10.1093/femsyr/foz087 Identifying Genes Involved in alkaloid Biosynthesis in Vinca minor Through Transcriptomics and Gene Co-Expression Analysis Autorzy: Emily A. Stander; Liuda Johana Sepúlveda; Thomas Dugé de Bernonville; Inês Carqueijeiro; Konstantinos Koudounas; Pamela Lemos Cruz; Sébastien Besseau; Arnaud Lanoue; Nicolas Papon; Nathalie Giglioli-Guivarc’h; Ron Dirks; Sarah E. O'Connor; Lucía Atehortúa; Audrey Oudin; Vincent Courdavault Opublikowane w: Biomolecules, Issue 1, 2020, ISSN 2218-273X Wydawca: MDPI DOI: 10.3390/biom10121595 Early and Late Steps of Quinine Biosynthesis Autorzy: Francesco Trenti; Kotaro Yamamoto; Benke Hong; Christian Paetz; Yoko Nakamura; Sarah E. O’Connor Opublikowane w: Organic Letters 23 (5), Issue 5, 2021, Page(s) 1793 - 1797, ISSN 1523-7060 Wydawca: American Chemical Society DOI: 10.1021/acs.orglett.1c00206 Yeasts as Biopharmaceutical Production Platforms Autorzy: Natalja Kulagina, Sébastien Besseau, Charlotte Godon, Gustavo H. Goldman, Nicolas Papon and Vincent Courdavault Opublikowane w: Frontiers in fungal biotechnology, 2021, ISSN 2054-3085 Wydawca: Frontiers in fungal biotechnology DOI: 10.3389/ffunb.2021.733492 A microbial supply chain for production of the anti-cancer drug vinblastine Autorzy: Jie Zhang; Lea G. Hansen; Olga Gudich; Konrad Viehrig; Lærke M. M. Lassen; Lars Schrübbers; Khem B. Adhikari; Paulina Rubaszka; Elena Carrasquer-Alvarez; Ling Chen; Vasil D’Ambrosio; Beata Lehka; Ahmad K. Haidar; Saranya Nallapareddy; Konstantina Giannakou; Marcos Laloux; Dushica Arsovska; Marcus A. K. Jørgensen; Leanne Jade G. Chan; Mette Kristensen; Hanne B. Christensen; Suresh Sudarsan; Em Opublikowane w: Zhang , J , Hansen , L G , Gudich , O , Viehrig , K , Lassen , L M M , Schrübbers , L , Adhikari , K B , Rubaszka , P , Carrasquer-Alvarez , E , Chen , L , D’Ambrosio , V , Lehka , B , Haidar , A K , Nallapareddy , S , Giannakou , K , Laloux , M , Arsovska , D , Jørgensen , M A K , Chan , L J G , Kristensen , M , Christensen , H B , Sudarsan , S , Stander , E A , Baidoo , E , Petzold , C J , W, Issue 19, 2022, ISSN 0028-0836 Wydawca: Nature Publishing Group DOI: 10.1038/s41586-022-05157-3 Dietary Change Enables Robust Growth-Coupling of Heterologous Methyltransferase Activity in Yeast Autorzy: Anne Sofie Lærke Hansen, Maitreya J. Dunham, Dushica Arsovska, Jie Zhang, Jay D. Keasling, Markus J. Herrgard, and Michael K. Jensen* Opublikowane w: ACS Synthetic Biology, 2020, Page(s) 3408–3415, ISSN 2161-5063 Wydawca: American Chemical Society DOI: 10.1021/acssynbio.0c00348 Wyszukiwanie danych OpenAIRE... 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