Oncolytic viruses for the treatment of pediatric brain tumors: An integrated clinical and lab approach

Pubblicazioni

CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models

Autori: Montserrat Puigdelloses, Marc Garcia-Moure, Sara Labiano, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Sandra Hervás-Stubbs, Guillermo Herrador, ZhiHong Chen, Dolores Hambardzumyan, Ana Patino Garcia, Hong Jiang, Candelaria Gomez-Manzano, Juan Fueyo, Jaime Gállego Pérez-Larraya, Marta Alonso
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 9/7, 2021, Pagina/e e002644, ISSN 2051-1426
Editore: BMJ Journals
DOI: 10.1136/jitc-2021-002644

RNU6-1 in circulating exosomes differentiates GBM from non-neoplastic brain lesions and PCNSL but not from brain metastases

Autori: Montserrat Puigdelloses, Marisol González-Huárriz, Marc García-Moure, Naiara Martínez-Vélez, Inés Esparragosa Vázquez, Jordi Bruna, Beatriz Zandio, Amaia Agirre, Miguel Marigil, Gregorio Petrirena, Jorge M Nuñez-Córdoba, Sonia Tejada-Solís, Ricardo Díez-Valle, Jaime Gállego-Culleré, Eduardo Martínez-Vila, Ana Patiño-García, Marta M Alonso, Jaime Gállego Pérez-Larraya
Pubblicato in: Neuro-Oncology Advances, Numero 2/1, 2020, ISSN 2632-2498
Editore: Oxford Academic
DOI: 10.1093/noajnl/vdaa010

Oncolytic DNX-2401 Virus for PediatricDiffuse Intrinsic Pontine Glioma

Autori: J. Gállego Pérez‑Larraya, M. Garcia‑Moure, S. Labiano, A. Patiño‑García, J. Dobbs, M. Gonzalez‑Huarriz, M. Zalacain, L. Marrodan, N. Martinez‑Velez, M. Puigdelloses, V. Laspidea, I. Astigarraga, B. Lopez‑Ibor, O. Cruz, M. Oscoz Lizarbe, S. Hervas‑Stubbs, G. Alkorta‑Aranburu, I. Tamayo, B. Tavira, R. Hernandez‑Alcoceba, C. Jones, G. Dharmadhikari, C. Ruiz‑Moreno, H. Stunnenb
Pubblicato in: New England Journal of Medicine, 2022, ISSN 1533-4406
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmoa2202028

Local treatment of a pediatric osteosarcoma model with a 4-1BBL armed oncolytic adenovirus results in an antitumor effect and leads to immune memory

Autori: Martínez-Vélez N, Laspidea V, Zalacain M, Labiano S, Garcia-Moure M, Puigdelloses M, Marrodan L, Gonzalez-Huarriz M, Herrador G, de la Nava D, Ausejo-Mauleon I, Fueyo J, Gomez-Manzano C, Patiño-García A, Alonso MM
Pubblicato in: Molecular Cancer Therapeutics, 2022, ISSN 1535-7163
Editore: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-21-0565

Exploiting 4-1BB immunecheckpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas

Autori: Laspidea V, Puigdelloses M, Labiano S, Marrodan L, Garcia-Moure M, Zalacain M, Gonzalez-Huarriz M, Martinez-Vélez N, Ausejo-Mauleon I, de la Nava D, Herrado-Cañete G, Marco-Sanz J, Guruceaga E, de Andrea CE, Villalba M, Becher O, Squatrito M, Matía V, Gallego Perez-Larraya J, Patiño-Garcia A, Gupta S, Patiño-García A, Gomez-Manzano C, Fueyo J, Gallego Pérez-Larraya J and Alonso M
Pubblicato in: Journal of Clinical Investigation Insights, 2022, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.154812

Immunovirotherapy for Pediatric Solid Tumors: A Promising Treatment That is Becoming a Reality

Autori: Daniel de la Nava, Kadir Mert Selvi and Marta M Alonso
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.866892

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Autori: Naiara Martinez-Velez, Miguel Marigil, Marc García-Moure, Marisol Gonzalez-Huarriz, Jose Javier Aristu, Luis-Isaac Ramos-García, Sonia Tejada, Ricardo Díez-Valle, Ana Patiño-García, Oren J. Becher, Candelaria Gomez-Manzano, Juan Fueyo, Marta M. Alonso
Pubblicato in: Acta Neuropathologica Communications, Numero 7/1, 2019, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-019-0714-6

The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models

Autori: Naiara Martínez-Vélez, Marc Garcia-Moure, Miguel Marigil, Marisol González-Huarriz, Montse Puigdelloses, Jaime Gallego Pérez-Larraya, Marta Zalacaín, Lucía Marrodán, Maider Varela-Guruceaga, Virginia Laspidea, Jose Javier Aristu, Luis Isaac Ramos, Sonia Tejada-Solís, Ricardo Díez-Valle, Chris Jones, Alan Mackay, Jose A. Martínez-Climent, Maria Jose García-Barchino, Eric Raabe, Michelle
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-10043-0

The Importance of Gender-Related Anticancer Research on Mitochondrial Regulator Sodium Dichloroacetate in Preclinical Studies In Vivo

Autori: Donatas Stakišaitis, Milda Juknevičienė, Eligija Damanskienė, Angelija Valančiūtė, Ingrida Balnytė, Marta Maria Alonso
Pubblicato in: Cancers, Numero 11/8, 2019, Pagina/e 1210, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081210

The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models

Autori: Marc Garcia-Moure, Naiara Martinez-Velez, Marisol Gonzalez-Huarriz, Lucía Marrodán, Manel Cascallo, Ramón Alemany, Ana Patiño-García, Marta M. Alonso
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-51014-1

Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma

Autori: Marta Zalacain, María Bunuales, Lucía Marrodan, Sara Labiano, Marisol Gonzalez-Huarriz, Naiara Martinez-Vélez, Virginia Laspidea, Montse Puigdelloses, Marc García-Moure, Manuela Gonzalez-Aparicio, Rubén Hernandez-Alcoceba, Marta M. Alonso, Ana Patiño-García
Pubblicato in: Molecular Therapy - Oncolytics, Numero 20, 2021, Pagina/e 23-33, ISSN 2372-7705
Editore: elsevier
DOI: 10.1016/j.omto.2020.11.003

Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET

Autori: Marc Garcia-Moure, Marisol Gonzalez-Huarriz, Sara Labiano, Elizabeth Guruceaga, Eva Bandres, Marta Zalacain, Lucia Marrodan, Carlos de Andrea, Maria Villalba, Naiara Martinez-Velez, Virginia Laspidea, Montse Puigdelloses, Jaime Gallego Perez-Larraya, Ignacio Iñigo-Marco, Renata Stripecke, Jennifer A. Chan, Eric H. Raabe, Marcel Kool, Candelaria Gomez-Manzano, Juan Fueyo, Ana Patiño-García, Mart
Pubblicato in: Clinical Cancer Research, Numero 27/6, 2021, Pagina/e 1807-1820, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-3313

Destress and do not suppress: targeting adrenergic signaling in tumor immunosuppression

Autori: Ignacio Iñigo-Marco, Marta M. Alonso
Pubblicato in: Journal of Clinical Investigation, Numero 129/12, 2019, Pagina/e 5086-5088, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci133115

Hitchhiking to brain tumours: stem cell delivery of oncolytic viruses

Autori: Juan Fueyo, Candelaria Gomez-Manzano, Frederick F Lang, Marta M Alonso
Pubblicato in: The Lancet Oncology, Numero 22/8, 2021, Pagina/e 1049-1051, ISSN 1470-2045
Editore: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(21)00296-5

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