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Theoretical and computational investigation of tuberculosis antimicrobial resistance development based on extensive experimental library of mycobacterium strains

Obiettivo

Multidrug resistance of Mycobacterium tuberculosis is declared a serious global threat by the World Health Organization.
Our project aims at developing a comprehensive model of molecular mechanisms responsible for antimicrobial drug resistance of tuberculosis. Isoniazid is the main drug used for TB treatment, because it interacts with the bacterial catalase
that leads to the bacterial death. The library of isoniazid resistant strains (over 100 different strains) will be used as
experimental basis for building theoretical and computational models of the molecular processes leading to drug resistance
of mutated bacteria. The model will be used for suggesting effective treatment targeting these mechanisms and overcoming
the resistance.
AMR-TB RISE will be used to utilise the expertise of highly specialised research groups of biologists, clinicians, biochemists,
physicists, computer engineers, and mathematicians allowing the researches from these groups to work in multiple
laboratories of the Consortium all over the world. Particular attention will be given to training the next generation of young
researcher and forming tightly interconnected, long term collaboration devoted to solving the pressing global problem of antimicrobial resistance not only in TB, but in a wide spectrum of diseases.

Invito a presentare proposte

H2020-MSCA-RISE-2018
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Coordinatore

ASTON UNIVERSITY
Indirizzo
Aston Triangle
B4 7ET Birmingham
United Kingdom
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 138 000

Partecipanti (5)

INSTITUT BIOHIMII IM.O.V. PALLADINA NACIONALNOY AKADEMII NAUK UKRAINI
Ucraina
Contributo UE
€ 423 200
Indirizzo
Leontovicha Street 9
01601 Kyiv
Tipo di attività
Research Organisations
TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV
Ucraina
Contributo UE
€ 87 400
Indirizzo
Volodymyrska St 60
01033 Kyiv
Tipo di attività
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spagna
Contributo UE
€ 9 200
Indirizzo
Calle Serrano 117
28006 Madrid
Tipo di attività
Research Organisations
UNIVERSITY OF SURREY
United Kingdom
Contributo UE
€ 27 600
Indirizzo
Stag Hill
GU2 7XH Guildford
Tipo di attività
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI MESSINA
Italia
Contributo UE
€ 46 000
Indirizzo
Piazza Pugliatti 1
98122 Messina
Tipo di attività
Higher or Secondary Education Establishments

Partner (5)

FEDERAL STATE INSTITUTION SAINT PETERSBURG RESEARCH INSTITUTE OF PHTHISIOPULMONOLOGY OF THE FEDERAL AGENCY FOR HIGH TECHNOLOGY MEDICAL AID
Russia
Indirizzo
Ligovsky Prospekt 2-4
193063 Saint Petersburg
Tipo di attività
Research Organisations
SAINT PETERSBURG STATE UNIVERSITY
Russia
Indirizzo
Universitetskaya Nab 7/9
199034 Saint Petersburg
Tipo di attività
Higher or Secondary Education Establishments
KURSK STATE UNIVERSITY
Russia
Indirizzo
Radishcheva St 33
305000 Kursk
Tipo di attività
Higher or Secondary Education Establishments
RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH
Giappone
Indirizzo
Hirosawa 2-1
351 0198 Wako Shi Saitama
Tipo di attività
Research Organisations
ESCUELA POLITECNICA NACIONAL
Ecuador
Indirizzo
Ladron De Guevara
17012759 Quito
Tipo di attività
Higher or Secondary Education Establishments