Descripción del proyecto
Tecnologías de ARN en la detección del cáncer
La gestión efectiva del cáncer requiere un diagnóstico temprano, la determinación del pronóstico y un control eficiente de la progresión de la enfermedad tras el tratamiento. Para ello, se necesitan biomarcadores específicos del cáncer que puedan detectarse de una forma no invasiva y continua. El proyecto RNADIAGON, financiado con fondos europeos, se centra en pequeñas moléculas de ARN no codificante (ARNnc) como biomarcadores alternativos del cáncer. La principal ventaja de estas moléculas de ARN es que circulan libremente por los fluidos corporales como el plasma sanguíneo o están empaquetadas en microvesículas secretadas por las células, lo que las hace ideales para la detección no invasiva. Se espera que la identificación de tecnologías de ARNnc específicos del cáncer ayude a una detección rápida y precisa del cáncer y mejore el cumplimiento del paciente, que es un problema con los procedimientos invasivos.
Objetivo
Cancer occurs in more than 2 million individuals every year in Europe alone. It is widely recognized that early diagnosis and monitoring of the disease - during therapy and post-treatment follow-up- is a key step for successful patient management: it helps to offer on-time curative intervention and selecting the most appropriate therapy, improves the quality of life, while contributing to reduce the economic and social burden for both patients and society. There are screening programs available for early detection of some cancers such as colorectal cancer (CRC). Unfortunately, current CRC screening tests suffer with unsatisfactory sensitivity and specificity and low compliance of targeted population. On the other hand, there are cancers with poorly performing biomarkers as in the case of hepatocellular carcinoma (HCC), or no biomarkers at all (e.g. renal cell carcinoma (RCC), which limits not only the screening options but also the diagnosis or monitoring of the disease. Therefore, there is a need for new diagnostic biomarkers and accurate technologies to enable precise detection of asymptomatic tumors in a short time, low costs and, if possible, with minimal invasiveness and risks for the patients. From this perspective, cancer specific small non-coding RNAs (small ncRNAs) circulating in body fluids such as blood serum or plasma present promising diagnostic approach. Project RNADIAGON aims at development of personal skills and knowledge of early-stage and experienced researchers working in the field of small non-coding RNA diagnostics from five European research institutions through their long-term stays at one of the world-leading ncRNAs research centers in United States and traineeships at the education center and manufacturing facilities of industrial partner developing small ncRNAs-based certified diagnostics. This research and innovation staff exchange will increase the scientific excellence and quality of related research in the EU research institutions.
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MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinador
601 77 Brno
Chequia