Description du projet
Les technologies d’ARN dans la détection du cancer
Une prise en charge efficace du cancer nécessite un diagnostic précoce, une classification du pronostic et un bon suivi de la progression de la maladie après le traitement. Ces processus nécessitent des biomarqueurs spécifiques au cancer qui peuvent être détectés de manière non invasive et continue. Le projet RNADIAGON, financé par l’UE, cible de petites molécules d’ARN non codant (ARNnc) comme biomarqueurs alternatifs du cancer. Le principal avantage de ces molécules d’ARN est qu’elles peuvent circuler librement dans les fluides corporels comme le plasma sanguin ou sont encapsulées dans des microvésicules sécrétées à partir des cellules, ce qui les rend idéales pour un dépistage non invasif. L’identification de technologies d’ARNnc spécifiques au cancer devrait contribuer à la détection rapide et précise du cancer et améliorer l’observance du traitement par les patients, ce qui représente un problème avec les procédures invasives.
Objectif
Cancer occurs in more than 2 million individuals every year in Europe alone. It is widely recognized that early diagnosis and monitoring of the disease - during therapy and post-treatment follow-up- is a key step for successful patient management: it helps to offer on-time curative intervention and selecting the most appropriate therapy, improves the quality of life, while contributing to reduce the economic and social burden for both patients and society. There are screening programs available for early detection of some cancers such as colorectal cancer (CRC). Unfortunately, current CRC screening tests suffer with unsatisfactory sensitivity and specificity and low compliance of targeted population. On the other hand, there are cancers with poorly performing biomarkers as in the case of hepatocellular carcinoma (HCC), or no biomarkers at all (e.g. renal cell carcinoma (RCC), which limits not only the screening options but also the diagnosis or monitoring of the disease. Therefore, there is a need for new diagnostic biomarkers and accurate technologies to enable precise detection of asymptomatic tumors in a short time, low costs and, if possible, with minimal invasiveness and risks for the patients. From this perspective, cancer specific small non-coding RNAs (small ncRNAs) circulating in body fluids such as blood serum or plasma present promising diagnostic approach. Project RNADIAGON aims at development of personal skills and knowledge of early-stage and experienced researchers working in the field of small non-coding RNA diagnostics from five European research institutions through their long-term stays at one of the world-leading ncRNAs research centers in United States and traineeships at the education center and manufacturing facilities of industrial partner developing small ncRNAs-based certified diagnostics. This research and innovation staff exchange will increase the scientific excellence and quality of related research in the EU research institutions.
Champ scientifique
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Régime de financement
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinateur
601 77 Brno
Tchéquie