Connecting neural networks: Nervous-system-on-Chip Technology

Informations projet

CONNECT

N° de convention de subvention: 824070

DOI

10.3030/824070

Projet clôturé

Date de signature de la CE 23 Octobre 2018

Date de début 1 Janvier 2019

Date de fin 30 Juin 2024

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 6 807 867,50

Contribution de l’UE

€ 6 807 867,50

Coordonné par

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

Periodic Reporting for period 4 - CONNECT (Connecting neural networks: Nervous-system-on-Chip Technology)

Période du rapport: 2023-01-01 au 2024-06-30

Résumé du contexte et des objectifs généraux du projet

Many neurodegenerative diseases (NDDs) such as Parkinson's are still not curable. Medicines do not work as expected, the care of patients is complex, the affected and their relatives often suffer for many years. To better understand how NDD evolves and works, the University of Luxembourg, University of Sheffield, KU Leuven, Erasmus MC, Aalto University, FFUND and Eindhoven University of Technology have joined forces in an interdisciplinary science project (CONNECT).

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

Together, we want to model the functioning of our nervous systems in a chip-based in vitro model. The goal is to develop and test an artificial platform to support or discard researchers' hypotheses for disease causing molecules enter the brain by being backwards transported via the peripheral and enteric nervous system. These theses assume that diseases such as Parkinson's are triggered by defective protein compounds in the gut.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

The procedure using patient stem cells with our approach can help to improve predictions about the onset of NDD and thus develop effective drugs. The procedure is a way to reduce the development costs and time required to introduce new drugs. The current preclinical models are of limited use, and the transmission of results from animal experiments to the human system often fail. The novel CONNECT model of a human nervous system on a chip is the first step on a long road to finding more effective personalized treatment concepts for people with Parkinson's or any other NDD.

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