Connecting neural networks: Nervous-system-on-Chip Technology

Informacje na temat projektu

CONNECT

Identyfikator umowy o grant: 824070

DOI

10.3030/824070

Projekt został zamknięty

Data podpisania przez KE 23 Października 2018

Data rozpoczęcia 1 Stycznia 2019

Data zakończenia 30 Czerwca 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 6 807 867,50

Wkład UE

€ 6 807 867,50

Koordynowany przez

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

Periodic Reporting for period 4 - CONNECT (Connecting neural networks: Nervous-system-on-Chip Technology)

Okres sprawozdawczy: 2023-01-01 do 2024-06-30

Podsumowanie kontekstu i ogólnych celów projektu

Many neurodegenerative diseases (NDDs) such as Parkinson's are still not curable. Medicines do not work as expected, the care of patients is complex, the affected and their relatives often suffer for many years. To better understand how NDD evolves and works, the University of Luxembourg, University of Sheffield, KU Leuven, Erasmus MC, Aalto University, FFUND and Eindhoven University of Technology have joined forces in an interdisciplinary science project (CONNECT).

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

Together, we want to model the functioning of our nervous systems in a chip-based in vitro model. The goal is to develop and test an artificial platform to support or discard researchers' hypotheses for disease causing molecules enter the brain by being backwards transported via the peripheral and enteric nervous system. These theses assume that diseases such as Parkinson's are triggered by defective protein compounds in the gut.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

The procedure using patient stem cells with our approach can help to improve predictions about the onset of NDD and thus develop effective drugs. The procedure is a way to reduce the development costs and time required to introduce new drugs. The current preclinical models are of limited use, and the transmission of results from animal experiments to the human system often fail. The novel CONNECT model of a human nervous system on a chip is the first step on a long road to finding more effective personalized treatment concepts for people with Parkinson's or any other NDD.

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