Connecting neural networks: Nervous-system-on-Chip Technology

Projektinformationen

CONNECT

ID Finanzhilfevereinbarung: 824070

DOI

10.3030/824070

Projekt abgeschlossen

EK-Unterschriftsdatum 23 Oktober 2018

Startdatum 1 Januar 2019

Enddatum 30 Juni 2024

Finanziert unter

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Gesamtkosten

€ 6 807 867,50

EU-Beitrag

€ 6 807 867,50

Koordiniert durch

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

Periodic Reporting for period 4 - CONNECT (Connecting neural networks: Nervous-system-on-Chip Technology)

Berichtszeitraum: 2023-01-01 bis 2024-06-30

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Many neurodegenerative diseases (NDDs) such as Parkinson's are still not curable. Medicines do not work as expected, the care of patients is complex, the affected and their relatives often suffer for many years. To better understand how NDD evolves and works, the University of Luxembourg, University of Sheffield, KU Leuven, Erasmus MC, Aalto University, FFUND and Eindhoven University of Technology have joined forces in an interdisciplinary science project (CONNECT).

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

Together, we want to model the functioning of our nervous systems in a chip-based in vitro model. The goal is to develop and test an artificial platform to support or discard researchers' hypotheses for disease causing molecules enter the brain by being backwards transported via the peripheral and enteric nervous system. These theses assume that diseases such as Parkinson's are triggered by defective protein compounds in the gut.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

The procedure using patient stem cells with our approach can help to improve predictions about the onset of NDD and thus develop effective drugs. The procedure is a way to reduce the development costs and time required to introduce new drugs. The current preclinical models are of limited use, and the transmission of results from animal experiments to the human system often fail. The novel CONNECT model of a human nervous system on a chip is the first step on a long road to finding more effective personalized treatment concepts for people with Parkinson's or any other NDD.

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