Connecting neural networks: Nervous-system-on-Chip Technology

Información del proyecto

CONNECT

Identificador del acuerdo de subvención: 824070

DOI

10.3030/824070

Proyecto cerrado

Fecha de la firma de la CE 23 Octubre 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 6 807 867,50

Aportación de la UE

€ 6 807 867,50

Coordinado por

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

Periodic Reporting for period 4 - CONNECT (Connecting neural networks: Nervous-system-on-Chip Technology)

Período documentado: 2023-01-01 hasta 2024-06-30

Resumen del contexto y de los objetivos generales del proyecto

Many neurodegenerative diseases (NDDs) such as Parkinson's are still not curable. Medicines do not work as expected, the care of patients is complex, the affected and their relatives often suffer for many years. To better understand how NDD evolves and works, the University of Luxembourg, University of Sheffield, KU Leuven, Erasmus MC, Aalto University, FFUND and Eindhoven University of Technology have joined forces in an interdisciplinary science project (CONNECT).

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Together, we want to model the functioning of our nervous systems in a chip-based in vitro model. The goal is to develop and test an artificial platform to support or discard researchers' hypotheses for disease causing molecules enter the brain by being backwards transported via the peripheral and enteric nervous system. These theses assume that diseases such as Parkinson's are triggered by defective protein compounds in the gut.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

The procedure using patient stem cells with our approach can help to improve predictions about the onset of NDD and thus develop effective drugs. The procedure is a way to reduce the development costs and time required to introduce new drugs. The current preclinical models are of limited use, and the transmission of results from animal experiments to the human system often fail. The novel CONNECT model of a human nervous system on a chip is the first step on a long road to finding more effective personalized treatment concepts for people with Parkinson's or any other NDD.

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