Reshaping undesired Inflammation in challenged Tissue Homeostasis by Next-Generation regulatory T cell (Treg) Approaches – from Advanced Technology Developments to First-in-Human Trials | RESHAPE | Progetto | Risultati | H2020 | CORDIS

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Humanised vascularized skin Tx

Evaluation of 2 best-in-class Treg in the new humanised vascularised skin Tx model

Position paper CAR-Treg

Position /Viewpoint paper on CAR-Treg generation

RNAseq, TCRseq, Methylation report

All preseleted Treg products analysed

Position paper next generation Treg

Position paper on challenges and opportunities of nextgeneration Treg approaches

Final statement on IL-tgTreg

Final statement to the utility of IL-2tg Treg (WP1-3)

Final statement on off-the-shelf Treg

Final statement to the utility of off-the-shelf allogeneic Treg

Final statement on non-viral gene del.

Final statement to the utility of virusfree gene transfer methods for Treg

Cytometry report

All preseleted Treg products analysed

Final statement on epigenetic Treg

Final statement to the utility of epigenetically stabilised Treg

PoC rejection model on-chip

Evaluation of kidney rejection on-chip and the effects of Treg treatmentPoC

DigiWest/Luminex report

All preseleted Treg products analysed

Position paper Crispr/Cas in Tcells

Positon paper on challenges for using CRISPRCas9 modified T cells

Final statement on SPR Treg

Final statement to the utility of SPR Treg

GMP protocol for at least one tissue-specific Treg
Final statement on metabolic Treg

Final statement to the utility of mitochondrial reprogramming of Treg

Final statement on Cas9 TCR-Treg

Final statement to the utility of Cas9-specific TCR-Treg

Launching website

Pubblicazioni

Effector memory–type regulatory T cells display phenotypic and functional instability

Autori: Désirée Jacqueline Wendering, Leila Amini, Stephan Schlickeiser, Martí Farrera-Sal, Sarah Schulenberg, Lena Peter, Marco Mai, Tino Vollmer, Weijie Du, Maik Stein, Frederik Hamm, Alisier Malard, Carla Castro, Mingxing Yang, Ramon Ranka, Timo Rückert, Pawel Durek, Frederik Heinrich, Gilles Gasparoni, Abdulrahman Salhab, Jörn Walter, Dimitrios Laurin Wagner, Mir-Farzin Mashreghi, Sybille Landweh
Pubblicato in: Science Advances, Numero 10, 2024, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adn3470

Towards regulatory cellular therapies in solid organ transplantation

Autori: Matthew J.Bottomley,Matthew O.Brook,Sushma Shankar, Joanna Hester, Fadi Issa
Pubblicato in: Trends in Immunology, 2022, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2021.11.001

Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

Autori: Kristy Ou, Dania Hamo, Anne Schulze, Andy Roemhild, Daniel Kaiser, Gilles Gasparoni, Abdulrahman Salhab, Ghazaleh Zarrinrad, Leila Amini, Stephan Schlickeiser, Mathias Streitz, Jörn Walter, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Julia K Polansky
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 751590, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.751590

Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial

Autori: Andy Roemhild, Natalie Maureen Otto, Guido Moll, Mohamed Abou-El-Enein, Daniel Kaiser, Gantuja Bold, Thomas Schachtner, Mira Choi, Robert Oellinger, Sybille Landwehr-Kenzel, Karsten Juerchott, Birgit Sawitzki, Cordula Giesler, Anett Sefrin, Carola Beier, Dimitrios Laurin Wagner, Stephan Schlickeiser, Mathias Streitz, Michael Schmueck-Henneresse, Leila Amini, Ulrik Stervbo, Nina Babel, Hans-Dieter
Pubblicato in: British Medical Journal, Numero 371, 2020, ISSN 2057-0066
Editore: BMJ
DOI: 10.1136/bmj.m3734

Development of Beta-Amyloid-Specific CAR-Tregs for the Treatment of Alzheimer’s Disease

Autori: Valerie Saetzler, Tobias Riet, Andrea Schienke, Pierre Henschel, Kiara Freitag, Alexander Haake, Frank L. Heppner, Laura Elisa Buitrago-Molina, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski
Pubblicato in: Cells, Numero 12, 2025, Pagina/e 2115, ISSN 2073-4409
Editore: https://pubmed.ncbi.nlm.nih.gov/37626926/
DOI: 10.3390/cells12162115

Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective

Autori: Amini L, Kaeda J, Fritsche E, Roemhild A, Kaiser D, Reinke P
Pubblicato in: Front Cell Dev Biol, 2023, ISSN 2296-634X
Editore: Frontiers Media S.A
DOI: 10.3389/fcell.2022.1081644

Advanced Therapy Medicinal Products' Translation in Europe: A Developers' Perspective

Autori: Maja Pizevska, Jaspal Kaeda, Enrico Fritsche, Hisham Elazaly, Petra Reinke, Leila Amini
Pubblicato in: Frontiers in Medicine, Numero 757647, 2022, ISSN 2296-858X
Editore: Frontiers
DOI: 10.3389/fmed.2022.757647

Matching or genetic engineering of HLA Class I and II facilitates successful allogeneic ‘off-the-shelf’ regulatory T cell therapy

Autori: Oliver McCallion, Weijie Du, Viktor Glaser, Kate Milward, Clemens Franke, Jonas Kath, Mikhail Valkov, Mingxing Yang, Annette Künkele, Julia K. Polansky, Michael Schmueck-Henneresse, Hans-Dieter Volk, Petra Reinke, Dimitrios L. Wagner, Joanna Hester, Fadi Issa
Pubblicato in: -, 2023, ISSN 2692-8205
Editore: cold spring harbor Laboratory
DOI: 10.1101/2023.08.06.551956

Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis

Autori: Richard Taubert, Bastian Engel, Jana Diestelhorst, Katharina L. Hupa-Breier, Patrick Behrendt, Niklas T. Baerlecken, Kurt-Wolfram Sühs, Maciej K. Janik, Kalliopi Zachou, Marcial Sebode, Christoph Schramm, María-Carlota Londoño, Sarah Habes, the UK-AIH Consortium, Ye H. Oo, Claudine Lalanne, Simon Pape, Maren Schubert, Michael Hust, Stefan Dübel, Mario Thevis, Danny Jonigk, Julia Beimdiek, Falk
Pubblicato in: Hepatology, 2021, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.32134

Splenectomy induces biochemical remission and regeneration in experimental murine autoimmune hepatitis

Autori: Janine Dywicki, Laura Elisa Buitrago-Molina, Fatih Noyan, Jerome Schlue, Konstantinos Iordanidis, Michael P. Manns, Heiner Wedemeyer, Elmar Jaeckel, Matthias Hardtke-Wolenski
Pubblicato in: European Journal of Medical Research, 2022, ISSN 2047-783X
Editore: Springer Nature
DOI: 10.1186/s40001-022-00933-3

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells

Autori: Jonas Kath, Weijie Du, Alina Pruene, Tobias Braun, Bernice Thommandru, Rolf Turk, Morgan L Sturgeon, Gavin L Kurgan, Leila Amini, Maik Stein, Tatiana Zittel, Stefania Martini, Lennard Ostendorf, Andreas Wilhelm, Levent Akyüz, Armin Rehm, Uta E Höpken, Axel Pruß, Annette Künkele, Ashley M Jacobi, Hans-Dieter Volk, Michael Schmueck-Henneresse, Renata Stripecke, Petra Reinke, Dimitrios L Wagner
Pubblicato in: Mol Ther Methods Clin Dev, 2022, ISSN 2329-0501
Editore: Cell Press
DOI: 10.1016/j.omtm.2022.03.018

Severe Multiple Sclerosis patients exhibit functionally altered CD8+ regulatory T cells.

Autori: Nail Benallegue , Bryan Nicol , Juliette Lasselin , Severine Bézie , Lea Flippe , Hadrien Regue , Nadege Vimond , Severine Remy , Alexandra Garcia , Fabienne Le Frère , Ignacio Anegon , David Laplaud , Carole Guillonneau
Pubblicato in: Neurol Neuroimmunol Neuroinflamm, 2022, ISSN 2332-7812
Editore: American Academy of Neurology
DOI: 10.1212/nxi.0000000000200016

Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?

Autori: Matthias Hardtke-Wolenski, Sybille Landwehr-Kenzel
Pubblicato in: Molecular and Cellular Pediatrics, Numero 11, 2024, ISSN 2194-7791
Editore: springer
DOI: 10.1186/s40348-024-00176-8

Detection of SARS-CoV-2-specific memory B cells to delineate long-term COVID-19 immunity

Autori: Constantin J Thieme , Mohamed Abou-El-Enein, Enrico Fritsche, Moritz Anft, Krystallenia Paniskaki, Sarah Skrzypczyk, Adrian Doevelaar, Magdi Elsallab, Nicola Brindle, Arturo Blazquez-Navarro, Felix S Seibert, Toni L Meister, Stephanie Pfaender, Eike Steinmann, Oliver Witzke, Timm H Westhoff, Ulrik Stervbo, Guido Heine, Toralf Roch, Nina Babel
Pubblicato in: Allergy, 2021, ISSN 1398-9995
Editore: Wiley
DOI: 10.1111/all.14827

Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo

Autori: Daniel Kaiser, Natalie Maureen Otto, Oliver McCallion, Henrike Hoffmann, Ghazaleh Zarrinrad, Maik Stein, Carola Beier, Isabell Matz, Marleen Herschel, Joanna Hester, Guido Moll, Fadi Issa, Petra Reinke, Andy Roemhild
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 750286, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.750286

Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?

Autori: Helen L. Stark, Hayson C. Wang, Jasmina Kuburic, Alaa Alzhrani, Joanna Hester and Fadi Issa
Pubblicato in: Frontiers in Immunology, Numero 664244, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.664244

Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cell

Autori: Glaser V, Flugel C, Kath J, Du W, Drosdek V, Franke C, Stein M, Pruß A, Schmueck‐Henneresse M, Volk HD, Reinke P and Wagner DL
Pubblicato in: Genome Biology, 2023, ISSN 1474-760X
Editore: Springer BioMed Central
DOI: 10.1186/s13059-023-02928-7

Long-term in vitro maintenance of plasma cells in a hydrogel-enclosed human bone marrow microphysiological 3D model system

Autori: Stefania Martini, Norman Michael Drzeniek, Regina Stark, Matthias Reiner Kollert, Weijie Du, Simon Reinke, Melanie Ort, Sebastian Hardt, Iuliia Kotko, Jonas Kath, Stephan Schlickeiser, Sven Geißler, Dimitrios Laurin Wagner, Anna-Catharina Krebs, Hans-Dieter Volk
Pubblicato in: Biofabrication, Numero 16, 2024, Pagina/e 045005, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/ad5dfe

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD

Autori: Sybille Landwehr-Kenzel, Anne Zobel, Isabela Schmitt-Knosalla, Anne Forke, Henrike Hoffmann, Michael Schmueck-Henneresse, Robert Klopfleisch, Hans-Dieter Volk, Petra Reinke
Pubblicato in: Frontiers in Immunology, Numero 716629, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.716629

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer

Autori: Weijie Du, Fatih Noyan, Oliver McCallion, Vanessa Drosdek, Jonas Kath, Viktor Glaser, Carla Fuster-Garcia, Mingxing Yang, Maik Stein, Clemens Franke, Yaolin Pu, Olaf Weber, Julia K. Polansky, Toni Cathomen, Elmar Jaeckel, Joanna Hester, Fadi Issa, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Dimitrios L. Wagner
Pubblicato in: Molecular Therapy, 2025, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2025.01.045

Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application

Autori: Pierre Henschel, Sybille Landwehr-Kenzel , Niklas Engels, Andrea Schienke , Jakob Kremer, Tobias Riet , Nella Redel, Konstantinos Iordanidis , Valerie Saetzler , Katharina John, Miriam Heider, Matthias Hardtke-Wolenski , Heiner Wedemeyer, Elmar Jaeckel, Fatih Noya
Pubblicato in: J Autoimmun, 2023, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2023.103057

Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants

Autori: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa
Pubblicato in: Med, 2024, Pagina/e 100561, ISSN 2666-6340
Editore: Cell press
DOI: 10.1016/j.medj.2024.11.014

CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer

Autori: Darja Marolt Presen, Duško Lainšček, Jane Kinghorn, Zsolt Sebestyen, Jurgen Kuball, Leila Amini, Petra Reinke, Anke Fuchs, Roman Jerala, Mojca Benčina
Pubblicato in: Computational and Structural Biotechnology Journal, Numero 27, 2024, Pagina/e 10-16, ISSN 2001-0370
Editore: Elsevier
DOI: 10.1016/j.csbj.2024.11.051

Integration of ζ-deficient CARs into the CD3 ζ gene conveys potent cytotoxicity in T and NK cells

Autori: Jonas Kath, Clemens Franke, Vanessa Drosdek, Weijie Du, Viktor Glaser, Carla Fuster-Garcia, Maik Stein, Tatiana Zittel, Sarah Schulenberg, Caroline E. Porter, Lena Andersch, Annette Künkele, Joshua Alcaniz, Jens Hoffmann, Hinrich Abken, Mohamed Abou-el-Enein, Axel Pruß, Masataka Suzuki, Toni Cathomen, Renata Stripecke, Hans-Dieter Volk, Petra Reinke, Michael Schmueck-Henneresse, Dimitrios L. Wag
Pubblicato in: Blood, Numero 143, 2024, Pagina/e 2599-2611, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2023020973

Recent advances in our understanding of the allograft response

Autori: Conor Hennessy , Guido Lewik , Amy Cross , Joanna Hester , Fadi Issa
Pubblicato in: Faculty Opinions, Numero 10:21, 2021, ISSN 2634-0836
Editore: Faculty opinions
DOI: 10.12703/r/10-21

Toward an Optimized Process for Clinical Manufacturing of CAR-Treg Cell Therapy

Autori: Enrico Fritsche, Hans-Dieter Volk, Petra Reinke, Mohamed Abou-El-Enein
Pubblicato in: Trends in Biotechnology, 2020, Pagina/e 1-13, ISSN 0167-7799
Editore: Elsevier BV
DOI: 10.1016/j.tibtech.2019.12.009

Future prospects for CD8 + regulatory T cells in immune tolerance

Autori: Léa Flippe, Séverine Bézie, Ignacio Anegon, Carole Guillonneau
Pubblicato in: Immunological Reviews, Numero 292/1, 2019, Pagina/e 209-224, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.12812

Post-marketing safety and efficacy surveillance of cell and gene therapies in the EU: A critical review

Autori: Enrico Fritsche, Magdi Elsallab, Michaela Schaden, Spencer Phillips Hey, Mohamed Abou-El-Enein
Pubblicato in: Cell and Gene Therapy Insights, Numero 5/11, 2019, Pagina/e 1505-1521, ISSN 2059-7800
Editore: BIOINSIGHTS PUBLISHING
DOI: 10.18609/cgti.2019.156

In Vivo Analysis of Human Immune Responses in Immunodeficient Rats

Autori: Séverine Ménoret, Laure-Hélène Ouisse, Laurent Tesson, Séverine Remy, Claire Usal, Aude Guiffes, Vanessa Chenouard, Pierre-Joseph Royer, Gwenaelle Evanno, Bernard Vanhove, Eliane Piaggio, Ignacio Anegon
Pubblicato in: Transplantation, Numero 104/4, 2020, Pagina/e 715-723, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000003047

Humanization of Immunodeficient Animals for the Modeling of Transplantation, Graft Versus Host Disease and Regenerative Medicine

Autori: George Adigbli, Séverine Ménoret, Amy R. Cross, Joanna Hester, Fadi Issa, Ignacio Anegon
Pubblicato in: Transplantation, Numero Publish Ahead of Print, 2020, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000003177

New frontiers: cellular immunotherapy beyond cancer

Autori: Matthew Brook, Joanna Hester, Fadi Issa
Pubblicato in: Cell and Gene Therapy Insights, Numero 5/12, 2019, Pagina/e 1229-1236, ISSN 2059-7800
Editore: BIOINSIGHTS
DOI: 10.18609/cgti.2019.163

Non-viral TRAC-knocked-in CD19KICAR-T and gp350KICAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency

Autori: Tobias Braun, Alina Pruene, Milita Darguzyte, Alexander F. vom Stein, Phuong-Hien Nguyen, Dimitrios L. Wagner, Jonas Kath, Alicia Roig-Merino, Michael Heuser, Lucas L. Riehm, Andreas Schneider, Sabine Awerkiew, Steven R. Talbot, André Bleich, Constanca Figueiredo, Martin Bornhäuser, Renata Stripecke
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1086433

Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications

Autori: Leila Amini, Jenny Greig, Michael Schmueck-Henneresse, Hans-Dieter Volk, Séverine Bézie, Petra Reinke, Carole Guillonneau, Dimitrios L Wagner, Ignacio Anegon
Pubblicato in: Frontiers in Immunology, Numero 611638, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.611638

Review: Sustainable Clinical Development of CAR-T Cells - Switching From Viral Transduction Towards CRISPR-Cas Gene Editing

Autori: Dimitrios L Wagner, Ulrike Koehl, Markus Chmielewski, Christoph Scheid, Renata Stripecke
Pubblicato in: Front Immunol, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.865424

Cas9-directed immune tolerance in humans-a model to evaluate regulatory T cells in gene therapy?

Autori: Dimitrios Laurin Wagner, Lena Peter, Michael Schmueck-Henneresse
Pubblicato in: Gene Therapy, 2021, Pagina/e 549–559, ISSN 0969-7128
Editore: Nature Publishing Group
DOI: 10.1038/s41434-021-00232-2

Generation of Chimeric Antigen Receptors against Tetraspanin 7

Autori: Tom Pieper, Kristian Daniel Ralph Roth, Viktor Glaser, Tobias Riet, Laura Elisa Buitrago-Molina, Maike Hagedorn, Maren Lieber, Michael Hust, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski
Pubblicato in: Cells, 2023, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12111453

Adoptive transfer of ex vivo expanded regulatory T cells improves immune cell engraftment and therapy-refractory chronic GvHD

Autori: Sybille Landwehr-Kenzel, Leonie Müller-Jensen, Joern-Sven Kuehl, Mohamed Abou-el-Enein, Henrike Hoffmann, Sandra Muench, Daniel Kaiser, Andy Roemhild, Horst von Bernuth, Mirjam Voeller, Michael Schmueck-Henneresse, Bernd Gruhn, Ulrik Stervbo, Nina Babel, Hans-Dieter Volk, and Petra Reinke
Pubblicato in: Mol Ther, 2022, ISSN 2329-0501
Editore: Cell Press
DOI: 10.1016/j.ymthe.2022.02.025

Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Transplantation

Autori: Sabrina Wright, Conor Hennessy,Joanna Hester, Fadi Issa
Pubblicato in: Engineering, 2021, ISSN 2095-8099
Editore: Elsevier Ltd
DOI: 10.1016/j.eng.2021.10.018

CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for Advanced Adoptive Immunotherapy in Transplant Recipients

Autori: Amini L, Wagner DL, Rössler U, Zarrinrad G, Wagner LF, Vollmer T, Wendering DJ, Kornak U, Volk HD, Reinke P and Schmueck-Henneresse M
Pubblicato in: Mol Ther ., 2021, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.09.011

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors

Autori: Jakob Kremer, Pierre Henschel, Daniel Simon, Tobias Riet, Christine Falk, Matthias Hardtke-Wolenski, Heiner Wedemeyer, Fatih Noyan, Elmar Jaeckel
Pubblicato in: Front Immunol, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.1005582

Gene editing ofCD3 epsilongene to redirect regulatory T cells for adoptive T cell transfer

Autori: Weijie Du, Fatih Noyan, Oliver McCallion, Vanessa Drosdek, Jonas Kath, Viktor Glaser, Carla Fuster-Garcia, Mingxing Yang, Maik Stein, Olaf Weber, Julia K. Polansky, Toni Cathomen, Elmar Jaeckel, Joanna Hester, Fadi Issa, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Dimitrios L. Wagner
Pubblicato in: Biorxiv, 2024, ISSN 2692-8205
Editore: cold spring harbor Laboratory
DOI: 10.1101/2024.03.18.584896

Genetic engineering of human and mouse CD4+ and CD8+ Tregs using lentiviral vectors encoding chimeric antigen receptors

Autori: Nadège Vimond, Juliette Lasselin, Ignacio Anegon, Carole Guillonneau, Séverine Bézie
Pubblicato in: Molecular Therapy - Methods & Clinical Development, Numero 20, 2020, Pagina/e 69-85, ISSN 2329-0501
Editore: Elsevier
DOI: 10.1016/j.omtm.2020.11.008

Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis

Autori: Laura Elisa Buitrago-Molina, Julia Pietrek, Fatih Noyan, Jerome Schlue, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel
Pubblicato in: Journal of Autoimmunity, Numero 117, 2021, Pagina/e 102591, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2020.102591

Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype

Autori: Christopher Kressler, Gilles Gasparoni, Karl Nordström, Dania Hamo, Abdulrahman Salhab, Christoforos Dimitropoulos, Sascha Tierling, Petra Reinke, Hans-Dieter Volk, Jörn Walter, Alf Hamann and Julia K. Polansky
Pubblicato in: Frontiers in Immunology, Numero 609891, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.609891

Low-Dose Interleukin-2 Therapy: Fine-tuning Treg in Solid Organ Transplantation?

Autori: Leila Amini, Jaspal Kaeda, Olaf Weber, Petra Reinke
Pubblicato in: Transplantation, 2024, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004866

Identification, selection, and expansion of non-gene modified alloantigen-reactive Tregs for clinical therapeutic use

Autori: Alaa Alzhrani , Matthew Bottomley , Kathryn Wood , Joanna Hester , Fadi Issa
Pubblicato in: Cellular Immunology, Numero 357:104214, 2020, ISSN 1090-2163
Editore: Elsevier
DOI: 10.1016/j.cellimm.2020.104214

TCAIM controls effector T cell generation by preventing Mitochondria-Endoplasmic Reticulum Contact Site-initiated Cholesterol Biosynthesis

Autori: Christina Iwert, Julia Stein, Christine Appelt, Katrin Vogt, Roman Josef Rainer, Katja Tummler, Kerstin Mühle, Katarina Stanko, Julia Schumann, Doreen Uebe, Karsten Jürchott, Jan Lisec, Katharina Janek, Christoph Gille, Kathrin Textoris-Taube, Somesh Sai, Ansgar Petersen, Anja A. Kühl, Edda Klipp, Christian Meisel, Birgit Sawitzki
Pubblicato in: bioRxiv, 2021, ISSN 2692-8205
Editore: Cold Sping Harbor Laboratory
DOI: 10.1101/2021.04.20.440500

Fast, efficient and virus-free generation of TRAC-replaced CAR T cells

Autori: Jonas Kath, Weijie Du, Bernice Thommandru, Rolf Turk, Leila Amini, Maik Stein, Tatiana Zittel, Stefania Martini, Lennard Ostendorf, Andreas Wilhelm, Levent Akyüz, Armin Rehm, Uta E. Höpken, Axel Pruß, Annette Künkele, Ashley M. Jacobi, Hans-Dieter Volk, Michael SchmueckHenneresse, Petra Reinke, Dimitrios L. Wagner
Pubblicato in: bioRxiv, 2021, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.02.14.431017

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Reshaping undesired Inflammation in challenged Tissue Homeostasis by Next-Generation regulatory T cell (Treg) Approaches – from Advanced Technology Developments to First-in-Human Trials

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