Induced pluripotent stem cell-based therapy for spinal regeneration

Spheroid-Like Cultures for Expanding Angiopoietin Receptor-1 (aka. Tie2) Positive Cells from the Human Intervertebral Disc

Auteurs: Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein
Publié dans: International Journal of Molecular Sciences, Numéro 21/24, 2020, Page(s) 9423, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249423

Roles and responsibilities in stem cell research: a focus group study with stem cell researchers and patients

Auteurs: Lars S Assen, Karin R Jongsma, Rosario Isasi, Marianna A Tryfonidou & Annelien L Bredenoord
Publié dans: Regenerative Medicine, 2022, ISSN 2613-5914
Éditeur: Future Medicine
DOI: 10.2217/rme-2022-0019

Harmonization and standardization of nucleus pulposus cell extraction and culture methods

Auteurs: Shaghayegh Basatvat, Frances C. Bach, Marcos N. Barcellona, Abbie L. Binch, Conor T. Buckley, Brian Bueno, Nadeen O. Chahine, Ana Chee, Laura B. Creemers, Stefan Dudli, Bailey Fearing, Stephen J. Ferguson, Jennifer Gansau, Benjamin Gantenbein, Rahul Gawri, Juliane D. Glaeser, Sibylle Grad, Julien Guerrero, Lisbet Haglund, Paula A. Hernandez, Judith A. Hoyland, Charles Huang, James C. Iatridis, Sve
Publié dans: JOR Spine, 2023, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1238

Detergent-Free Decellularization of Notochordal Cell-Derived Matrix Yields a Regenerative, Injectable, and Swellable Biomaterial

Auteurs: Tara C. Schmitz; Marina van Doeselaar; Marianna A. Tryfonidou; Keita Ito
Publié dans: Tissue Engineering and Regenerative Medicine, Numéro 10, 2022, ISSN 1932-7005
Éditeur: ACS Publications
DOI: 10.1021/acsbiomaterials.2c00790

Cell sources proposed for nucleus pulposus regeneration

Auteurs: Williams, Rebecca J.; Tryfonidou, Marianna A.; Snuggs, Joseph William; Le Maitre, Christine Lyn
Publié dans: JOR Spine, 2021, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1175

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration

Auteurs: Frances C Bach 1, Deepani W Poramba-Liyanage 1, Frank M Riemers 1, Jerome Guicheux 2 3 4, Anne Camus 2, James C Iatridis 5, Danny Chan 6, Keita Ito 7 8, Christine L Le Maitre 9, Marianna A Tryfonidou 1
Publié dans: Front Cell Dev Biol, 2021, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2021.780749

The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?

Auteurs: Guerrero, J.; Häckel, S.; Croft, A.S.; Hoppe, S.; Albers, C.E.; Gantenbein, B.
Publié dans: eCM (Eur Cell Mater / e Cells & Materials), Numéro 41, 2021, Page(s) 707-738, ISSN 1473-2262
Éditeur: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v041a46

EX VIVO INTERVERTEBRAL DISC CULTURES:DEGENERATION-INDUCTION METHODS AND THEIRIMPLICATIONS FOR CLINICAL TRANSLATION

Auteurs: E Salzer1 , T.C. Schmitz1 , V.H.M. Mouser1 , A. Vernengo2 , B. Gantenbein3,4, J.U. Jansen5 , C. Neidlinger-Wilke5 , H-J. Wilke5 , S. Grad2 , C.L. Le Maitre6 , M.A. Tryfonidou7 and K. Ito1 *
Publié dans: European Cells and Materials, 2023, ISSN 1473-2262
Éditeur: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v045a07

One-pot precipitation polymerisation strategy for tuneable injectable Laponite®-pNIPAM hydrogels: Polymerisation, processability and beyond

Auteurs: Victoria L.Boyes, RonakJanani, SimonPartridge, Lee A.Fielding, Christopher Breen, Jonathan Foulkes, Christine L.Le Maitre, Chris Sammon
Publié dans: Polymer, Numéro 233, 2021, ISSN 0032-3861
Éditeur: Elsevier BV
DOI: 10.1016/j.polymer.2021.124201

An insight on the N-glycome of notochordal cell-rich porcine nucleus pulposus during maturation

Auteurs: Büşra Günay, Elizabeth Matthews, Jack Morgan, Marianna A. Tryfonidou, Radka Saldova, Abhay Pandit
Publié dans: FASEB BioAdvances, 2023, ISSN 2573-9832
Éditeur: FASEB
DOI: 10.1096/fba.2023-00011

Non-viral Gene Delivery Methods for Bone and Joints

Auteurs: Gantenbein, Benjamin; Tang, Shirley; Guerrero, Julien; Higuita-Castro, Natalia; Salazar-Puerta, Ana I.; Croft, Andreas S.; Gazdhar, Amiq; Purmessur, Devina
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 1, 2020, ISSN 2296-4185
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.598466

Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes

Auteurs: Martijn Beukers, Guy C. M. Grinwis, Johannes C. M. Vernooij, Lisanne van der Hoek, Anna R. Tellegen, Björn P. Meij, Stefanie Veraa, Dino Samartzis, Marianna A. Tryfonidou, Frances C. Bach
Publié dans: JOR Spine, 2023, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1273

The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency

Auteurs: Guerrero, Julien; Häckel, Sonja; Croft, Andreas S.; Albers, Christoph E.; Gantenbein, Benjamin
Publié dans: JOR Spine, Numéro 1, 2020, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1131

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Auteurs: Kieran Joyce, Georgina Targa Fabra, Yagmur Bozkurt & Abhay Pandit
Publié dans: Signal Transduction and Targeted Therapy, Numéro 6, 2021, ISSN 2059-3635
Éditeur: Springer Nature
DOI: 10.1038/s41392-021-00512-8

A comprehensive tool box for large animal studies of intervertebral disc degeneration

Auteurs: Lee, Naomi N.; Salzer, Elias; Bach, Frances C.; Bonilla, Andres F.; Cook, James L.; Gazit, Zulma; Grad, Sybille; Ito, Keita; Smith, Lachlan J.; Vernengo, Andrea; Wilke, Hans-Joachim; Engiles, Julie B.; Tryfonidou, Marianna A.
Publié dans: JOR Spine, 2021, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1162

Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration

Auteurs: Tilotta, Veronica; Vadala, Gianluca; Ambrosio, Luca; Russo, Fabrizio; Cicione, Claudia; Di Giacomo, Giuseppina; Papalia, Rocco; Denaro, Vincenzo
Publié dans: Applied Sciences, 2021, ISSN 2076-3417
Éditeur: MDPI
DOI: 10.3390/app112311222

New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials

Auteurs: Benjamin Gantenbein
Publié dans: Applied Sciences, 2021, ISSN 2076-3417
Éditeur: MDPI
DOI: 10.3390/app112411913

Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential

Auteurs: Andreas S. Croft, Julien Guerrero, Katharina A. C. Oswald, Sonja Häckel, Christoph E. Albers, Benjamin Gantenbein
Publié dans: JOR SPINE, 2021, ISSN 2572-1143
Éditeur: Wiley
DOI: 10.1002/jsp2.1140

A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series

Auteurs: Chitra Lekha Dahia; Chitra Lekha Dahia; Julie B. Engiles; Sarah E. Gullbrand; Sarah E. Gullbrand; James C. Iatridis; Alon Lai; Christine L. Le Maitre; Jeffrey C. Lotz; Koichi Masuda; Cheryle A. Séguin; Marianna A. Tryfonidou
Publié dans: JOR Spine, Numéro 1, 2021, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1165

Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization

Auteurs: Rebecca J. Williams, Lisanne T. Laagland, Frances C. Bach, Lizzy Ward, Wilson Chan, Vivian Tam, Adel Medzikovic, Shaghayegh Basatvat, Lily Paillat, Nicolas Vedrenne, Joseph W. Snuggs, Deepani W. Poramba-Liyanage, Judith A. Hoyland, Danny Chan, Anne Camus, Stephen M. Richardson, Marianna A. Tryfonidou, Christine L. Le Maitre
Publié dans: JOR Spine, 2023, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1272

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

Auteurs: Laagland, Lisanne T; Bach, Frances C; Creemers, Laura B; Le Maitre, Christine L; Poramba-Liyanage, Deepani W; Tryfonidou, Marianna A; Chirurgie; CS_Locomotion
Publié dans: JOR Spine, Numéro 10, 2022, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1219

Issues with Tissues: Trends in Tissue-Engineered Products in Clinical Trials in the European Union

Auteurs: Kieran Joyce, Zaklina Buljovcic, Goran Rosic, Marietta Kaszkin-Bettag, and Abhay Pandit
Publié dans: Tissue Engineering Part B, 2023, ISSN 2152-4955
Éditeur: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.teb.2022.0094

DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

Auteurs: Vivian Tam Peikai Chen Danny Chan
Publié dans: eLife, 2020, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.64940

Using responsibility as a strategy

Auteurs: Assen, LS; Jongsma, KR; Isasi, R; Utomo, L; Tryfonidou, MA; Bredenoord, AL; Chirurgie; CS_Locomotion
Publié dans: Regenerative Medicine, 18(3). Future Medicine Ltd., Numéro 7, 2023, ISSN 2613-5914
Éditeur: Future Medicine
DOI: 10.2217/rme-2022-0187

Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods

Auteurs: Daniela A. Frauchiger, Adel Tekari, Rahel D. May, Emina Džafo, Samantha C.W. Chan, Jivko Stoyanov, Alessandro Bertolo, Xingshuo Zhang, Julien Guerrero, Daisuke Sakai, Jordy Schol, Sibylle Grad, Marianna Tryfonidou, Lorin M. Benneker, Benjamin Gantenbein
Publié dans: Tissue Engineering Part C: Methods, Numéro 25/10, 2019, Page(s) 571-580, ISSN 1937-3384
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2018.0375

Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification

Auteurs: Frances C. Bach, Kim M. Rooij, Frank M. Riemers, Joseph W. Snuggs, Willem A. M. Jong, Ying Zhang, Laura B. Creemers, Danny Chan, Christine Le Maitre, Marianna A. Tryfonidou
Publié dans: JOR SPINE, Numéro 2/4, 2019, ISSN 2572-1143
Éditeur: Wiley
DOI: 10.1002/jsp2.1071

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues

Auteurs: Abbie Binch, Joseph Snuggs, Christine L. Le Maitre
Publié dans: JOR SPINE, 2020, ISSN 2572-1143
Éditeur: Wiley
DOI: 10.1002/jsp2.1098

NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate

Auteurs: Pauline Colombier, Boris Halgand, Claire Chédeville, Caroline Chariau, Valentin François-Campion, Stéphanie Kilens, Nicolas Vedrenne, Johann Clouet, Laurent David, Jérôme Guicheux, Anne Camus
Publié dans: Cells, Numéro 9/2, 2020, Page(s) 509, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells9020509

Moral imagination as an instrument for ethics education for biomedical researchers

Auteurs: Elianne M. Gerrits, Lars S. Assen, Liesbeth Noordegraaf-Eelens, Annelien L. Bredenoord & Marc H. W. van Mil
Publié dans: International Journal of Ethics Education, 2023, ISSN 2364-0006
Éditeur: Springer
DOI: 10.1007/s40889-023-00171-z

A Combined Western and Bead-Based Multiplex Platform to Characterize Extracellular Vesicles

Auteurs: Josette C. van Maanen, Frances C. Bach, Theresa S. Braun, Alberta Giovanazzi, Bas W.M. van Balkom, Markus Templin, Marca H.M. Wauben, and Marianna A. Tryfonidou
Publié dans: Tissue Engineer Part C, 2023, ISSN 2152-4955
Éditeur: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.tec.2023.0056

A bovine nucleus pulposus explant culture model

Auteurs: Salzer, Elias; Mouser, Vivian H.M.; Tryfonidou, Marianna A.; Ito, Keita
Publié dans: Journal of Orthopaedic Research, 2021, ISSN 1554-527X
Éditeur: Wiley-Blackwell
DOI: 10.1002/jor.25226

Context-aware modeling for knowledge-intensive medicinal product development processes

Auteurs: Zeynep Ozturk Yurt, Rik Eshuis, Anna Wilbik & Irene Vanderfeesten
Publié dans: Software and Systems Modeling, 2023, ISSN 1619-1374
Éditeur: Springer Link
DOI: 10.1007/s10270-022-01070-5

Simple, fast and efficient iTOP-mediated delivery of CRISPR/Cas9 RNP in difficult-to-transduce human cells including primary T cells

Auteurs: Waleed M Kholosy, Marieke Visscher, Kim Ogink, Helen Buttstedt, Kelli Griffin, Axel Beier, Jan Patrick Gerlach, Jan J Molenaar, Niels Geijsen, Marco de Boer, Anna Chatsisvili
Publié dans: Journal of Biotechnology, Numéro 338, 2021, Page(s) 71-80, ISSN 0168-1656
Éditeur: Elsevier BV
DOI: 10.1016/j.jbiotec.2021.07.006

Characterization of biomaterials intended for use in the nucleus pulposus of degenerated intervertebral discs

Auteurs: Tara C. Schmitz, Elias Salzer, João F. Crispim, Georgina Targa Fabra, Catherine LeVisage, Abhay Pandit, Marianna Tryfonidou, Christine Le Maitre, Keita Ito
Publié dans: Acta Biomaterialia, Numéro 114, 2020, Page(s) 1-15, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2020.08.001

Influence of Angiopoietin Treatment with Hypoxia and Normoxia on Human Intervertebral Disc Progenitor Cell's Proliferation, Metabolic Activity, and Phenotype

Auteurs: Bischof, Muriel C.; Häckel, Sonja; Oberli, Andrea; Croft, Andreas S.; Oswald, Katharina A.C.; Albers, Christoph E.; Gantenbein, Benjamin; Guerrero, Julien
Publié dans: Applied Sciences, 2021, ISSN 2076-3417
Éditeur: MDPI
DOI: 10.3390/app11157144

Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative

Auteurs: Le Maitre, Christine C.; Dahia, Chitra L.; Giers, Morgan; Illien-Junger, Svenja; Cicione, Claudia; Samartzis, Dino; Vadala, Gianluca; Fields, Aaron; Lotz, Jeffrey
Publié dans: JOR Spine, 2021, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1167

Recognizing the ethical implications of stem cell research: A call for broadening the scope

Auteurs: Assen, L.S.; Jongsma, K.R.; Isasi, R.; Tryfonidou, M.A.; Bredenoord, A.L.
Publié dans: Stem Cell Reports, Numéro 16, 2021, Page(s) 1656-1661, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2021.05.021

Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue

Auteurs: Elias Salzer; Vivian H. M. Mouser; Jurgen A. Bulsink; Marianna A. Tryfonidou; Keita Ito
Publié dans: JOR Spine, Numéro 5, 2023, ISSN 2572-1143
Éditeur: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1240

Towards Tissue-Specific Stem Cell Therapy for the Intervertebral Disc: PPARδ Agonist Increases the Yield of Human Nucleus Pulposus Progenitor Cells in Expansion

Auteurs: Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Katharina A.C. Oswald, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein
Publié dans: Surgeries, Numéro 2/1, 2021, Page(s) 92-104, ISSN 2673-4095
Éditeur: MDPI
DOI: 10.3390/surgeries2010008

Intervertebral Disc Regeneration II

Auteurs: Benjamin Gantenbein
Publié dans: 2023
Éditeur: MDPI
DOI: 10.3390/books978-3-0365-8199-6

Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects

Auteurs: Bram Zoetebier; Tara C Schmitz; Keita Ito; Marcel Karperien; Marianna A Tryfonidou; Julieta Paez
Publié dans: Tissue Engineering, Numéro 16, 2022, ISSN 2152-4955
Éditeur: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.tea.2021.0226

BPM Support for Regulatory Compliance in ATMP Development Processes

Auteurs: Ozturk Yurt, Zeynep
Publié dans: CEUR Workshop Proceedings, Numéro 2973, 2021
Éditeur: CEUR-WS

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