Induced pluripotent stem cell-based therapy for spinal regeneration

Informacje na temat projektu

iPSpine

Identyfikator umowy o grant: 825925

DOI

10.3030/825925

Projekt został zamknięty

Data podpisania przez KE 7 Grudnia 2018

Data rozpoczęcia 1 Stycznia 2019

Data zakończenia 30 Czerwca 2024

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 15 396 031,25

Wkład UE

€ 14 959 781,25

Koordynowany przez

UNIVERSITEIT UTRECHT
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (4)

Updated Dissemination and Exploitation plan
Set up of Patient Advisory Board
Guidelines and requirements for pre-in vivo evaluation of IVD advanced therapeutics

Guidelines and requirements for prein vivo evaluation of IVD advanced therapeutics

Report to the PSC on Dissemination and Education activities

Open Research Data Pilot (1)

Data Management Plan

Other (1)

Optimized open-access knowledge platform available

Websites, patent fillings, videos etc. (2)

Project newsletter
Project website

Publikacje

Peer reviewed articles (38)

Spheroid-Like Cultures for Expanding Angiopoietin Receptor-1 (aka. Tie2) Positive Cells from the Human Intervertebral Disc

Autorzy: Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein
Opublikowane w: International Journal of Molecular Sciences, Numer 21/24, 2020, Strona(/y) 9423, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249423

Roles and responsibilities in stem cell research: a focus group study with stem cell researchers and patients

Autorzy: Lars S Assen, Karin R Jongsma, Rosario Isasi, Marianna A Tryfonidou & Annelien L Bredenoord
Opublikowane w: Regenerative Medicine, 2022, ISSN 2613-5914
Wydawca: Future Medicine
DOI: 10.2217/rme-2022-0019

Harmonization and standardization of nucleus pulposus cell extraction and culture methods

Autorzy: Shaghayegh Basatvat, Frances C. Bach, Marcos N. Barcellona, Abbie L. Binch, Conor T. Buckley, Brian Bueno, Nadeen O. Chahine, Ana Chee, Laura B. Creemers, Stefan Dudli, Bailey Fearing, Stephen J. Ferguson, Jennifer Gansau, Benjamin Gantenbein, Rahul Gawri, Juliane D. Glaeser, Sibylle Grad, Julien Guerrero, Lisbet Haglund, Paula A. Hernandez, Judith A. Hoyland, Charles Huang, James C. Iatridis, Sve
Opublikowane w: JOR Spine, 2023, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1238

Detergent-Free Decellularization of Notochordal Cell-Derived Matrix Yields a Regenerative, Injectable, and Swellable Biomaterial

Autorzy: Tara C. Schmitz; Marina van Doeselaar; Marianna A. Tryfonidou; Keita Ito
Opublikowane w: Tissue Engineering and Regenerative Medicine, Numer 10, 2022, ISSN 1932-7005
Wydawca: ACS Publications
DOI: 10.1021/acsbiomaterials.2c00790

Cell sources proposed for nucleus pulposus regeneration

Autorzy: Williams, Rebecca J.; Tryfonidou, Marianna A.; Snuggs, Joseph William; Le Maitre, Christine Lyn
Opublikowane w: JOR Spine, 2021, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1175

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration

Autorzy: Frances C Bach 1, Deepani W Poramba-Liyanage 1, Frank M Riemers 1, Jerome Guicheux 2 3 4, Anne Camus 2, James C Iatridis 5, Danny Chan 6, Keita Ito 7 8, Christine L Le Maitre 9, Marianna A Tryfonidou 1
Opublikowane w: Front Cell Dev Biol, 2021, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2021.780749

The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?

Autorzy: Guerrero, J.; Häckel, S.; Croft, A.S.; Hoppe, S.; Albers, C.E.; Gantenbein, B.
Opublikowane w: eCM (Eur Cell Mater / e Cells & Materials), Numer 41, 2021, Strona(/y) 707-738, ISSN 1473-2262
Wydawca: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v041a46

EX VIVO INTERVERTEBRAL DISC CULTURES:DEGENERATION-INDUCTION METHODS AND THEIRIMPLICATIONS FOR CLINICAL TRANSLATION

Autorzy: E Salzer1 , T.C. Schmitz1 , V.H.M. Mouser1 , A. Vernengo2 , B. Gantenbein3,4, J.U. Jansen5 , C. Neidlinger-Wilke5 , H-J. Wilke5 , S. Grad2 , C.L. Le Maitre6 , M.A. Tryfonidou7 and K. Ito1 *
Opublikowane w: European Cells and Materials, 2023, ISSN 1473-2262
Wydawca: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v045a07

One-pot precipitation polymerisation strategy for tuneable injectable Laponite®-pNIPAM hydrogels: Polymerisation, processability and beyond

Autorzy: Victoria L.Boyes, RonakJanani, SimonPartridge, Lee A.Fielding, Christopher Breen, Jonathan Foulkes, Christine L.Le Maitre, Chris Sammon
Opublikowane w: Polymer, Numer 233, 2021, ISSN 0032-3861
Wydawca: Elsevier BV
DOI: 10.1016/j.polymer.2021.124201

An insight on the N-glycome of notochordal cell-rich porcine nucleus pulposus during maturation

Autorzy: Büşra Günay, Elizabeth Matthews, Jack Morgan, Marianna A. Tryfonidou, Radka Saldova, Abhay Pandit
Opublikowane w: FASEB BioAdvances, 2023, ISSN 2573-9832
Wydawca: FASEB
DOI: 10.1096/fba.2023-00011

Non-viral Gene Delivery Methods for Bone and Joints

Autorzy: Gantenbein, Benjamin; Tang, Shirley; Guerrero, Julien; Higuita-Castro, Natalia; Salazar-Puerta, Ana I.; Croft, Andreas S.; Gazdhar, Amiq; Purmessur, Devina
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 1, 2020, ISSN 2296-4185
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.598466

Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes

Autorzy: Martijn Beukers, Guy C. M. Grinwis, Johannes C. M. Vernooij, Lisanne van der Hoek, Anna R. Tellegen, Björn P. Meij, Stefanie Veraa, Dino Samartzis, Marianna A. Tryfonidou, Frances C. Bach
Opublikowane w: JOR Spine, 2023, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1273

The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency

Autorzy: Guerrero, Julien; Häckel, Sonja; Croft, Andreas S.; Albers, Christoph E.; Gantenbein, Benjamin
Opublikowane w: JOR Spine, Numer 1, 2020, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1131

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Autorzy: Kieran Joyce, Georgina Targa Fabra, Yagmur Bozkurt & Abhay Pandit
Opublikowane w: Signal Transduction and Targeted Therapy, Numer 6, 2021, ISSN 2059-3635
Wydawca: Springer Nature
DOI: 10.1038/s41392-021-00512-8

A comprehensive tool box for large animal studies of intervertebral disc degeneration

Autorzy: Lee, Naomi N.; Salzer, Elias; Bach, Frances C.; Bonilla, Andres F.; Cook, James L.; Gazit, Zulma; Grad, Sybille; Ito, Keita; Smith, Lachlan J.; Vernengo, Andrea; Wilke, Hans-Joachim; Engiles, Julie B.; Tryfonidou, Marianna A.
Opublikowane w: JOR Spine, 2021, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1162

Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration

Autorzy: Tilotta, Veronica; Vadala, Gianluca; Ambrosio, Luca; Russo, Fabrizio; Cicione, Claudia; Di Giacomo, Giuseppina; Papalia, Rocco; Denaro, Vincenzo
Opublikowane w: Applied Sciences, 2021, ISSN 2076-3417
Wydawca: MDPI
DOI: 10.3390/app112311222

New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials

Autorzy: Benjamin Gantenbein
Opublikowane w: Applied Sciences, 2021, ISSN 2076-3417
Wydawca: MDPI
DOI: 10.3390/app112411913

Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential

Autorzy: Andreas S. Croft, Julien Guerrero, Katharina A. C. Oswald, Sonja Häckel, Christoph E. Albers, Benjamin Gantenbein
Opublikowane w: JOR SPINE, 2021, ISSN 2572-1143
Wydawca: Wiley
DOI: 10.1002/jsp2.1140

Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization

Autorzy: Rebecca J. Williams, Lisanne T. Laagland, Frances C. Bach, Lizzy Ward, Wilson Chan, Vivian Tam, Adel Medzikovic, Shaghayegh Basatvat, Lily Paillat, Nicolas Vedrenne, Joseph W. Snuggs, Deepani W. Poramba-Liyanage, Judith A. Hoyland, Danny Chan, Anne Camus, Stephen M. Richardson, Marianna A. Tryfonidou, Christine L. Le Maitre
Opublikowane w: JOR Spine, 2023, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1272

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

Autorzy: Laagland, Lisanne T; Bach, Frances C; Creemers, Laura B; Le Maitre, Christine L; Poramba-Liyanage, Deepani W; Tryfonidou, Marianna A; Chirurgie; CS_Locomotion
Opublikowane w: JOR Spine, Numer 10, 2022, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1219

Issues with Tissues: Trends in Tissue-Engineered Products in Clinical Trials in the European Union

Autorzy: Kieran Joyce, Zaklina Buljovcic, Goran Rosic, Marietta Kaszkin-Bettag, and Abhay Pandit
Opublikowane w: Tissue Engineering Part B, 2023, ISSN 2152-4955
Wydawca: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.teb.2022.0094

Modeling policy development: examining national governance of stem cell-based embryo models

Autorzy: Morris Fabbri, Margaret Ginoza, Lars Assen, Karin Jongsma & Rosario Isasi
Opublikowane w: Regnerative Medicine, 2023, ISSN 2613-5914
Wydawca: Future Medicine
DOI: 10.2217/rme-2022-0136

Using responsibility as a strategy

Autorzy: Assen, LS; Jongsma, KR; Isasi, R; Utomo, L; Tryfonidou, MA; Bredenoord, AL; Chirurgie; CS_Locomotion
Opublikowane w: Regenerative Medicine, 18(3). Future Medicine Ltd., Numer 7, 2023, ISSN 2613-5914
Wydawca: Future Medicine
DOI: 10.2217/rme-2022-0187

Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods

Autorzy: Daniela A. Frauchiger, Adel Tekari, Rahel D. May, Emina Džafo, Samantha C.W. Chan, Jivko Stoyanov, Alessandro Bertolo, Xingshuo Zhang, Julien Guerrero, Daisuke Sakai, Jordy Schol, Sibylle Grad, Marianna Tryfonidou, Lorin M. Benneker, Benjamin Gantenbein
Opublikowane w: Tissue Engineering Part C: Methods, Numer 25/10, 2019, Strona(/y) 571-580, ISSN 1937-3384
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2018.0375

Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification

Autorzy: Frances C. Bach, Kim M. Rooij, Frank M. Riemers, Joseph W. Snuggs, Willem A. M. Jong, Ying Zhang, Laura B. Creemers, Danny Chan, Christine Le Maitre, Marianna A. Tryfonidou
Opublikowane w: JOR SPINE, Numer 2/4, 2019, ISSN 2572-1143
Wydawca: Wiley
DOI: 10.1002/jsp2.1071

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues

Autorzy: Abbie Binch, Joseph Snuggs, Christine L. Le Maitre
Opublikowane w: JOR SPINE, 2020, ISSN 2572-1143
Wydawca: Wiley
DOI: 10.1002/jsp2.1098

NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate

Autorzy: Pauline Colombier, Boris Halgand, Claire Chédeville, Caroline Chariau, Valentin François-Campion, Stéphanie Kilens, Nicolas Vedrenne, Johann Clouet, Laurent David, Jérôme Guicheux, Anne Camus
Opublikowane w: Cells, Numer 9/2, 2020, Strona(/y) 509, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells9020509

Moral imagination as an instrument for ethics education for biomedical researchers

Autorzy: Elianne M. Gerrits, Lars S. Assen, Liesbeth Noordegraaf-Eelens, Annelien L. Bredenoord & Marc H. W. van Mil
Opublikowane w: International Journal of Ethics Education, 2023, ISSN 2364-0006
Wydawca: Springer
DOI: 10.1007/s40889-023-00171-z 

A Combined Western and Bead-Based Multiplex Platform to Characterize Extracellular Vesicles

Autorzy: Josette C. van Maanen, Frances C. Bach, Theresa S. Braun, Alberta Giovanazzi, Bas W.M. van Balkom, Markus Templin, Marca H.M. Wauben, and Marianna A. Tryfonidou
Opublikowane w: Tissue Engineer Part C, 2023, ISSN 2152-4955
Wydawca: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.tec.2023.0056

A bovine nucleus pulposus explant culture model

Autorzy: Salzer, Elias; Mouser, Vivian H.M.; Tryfonidou, Marianna A.; Ito, Keita
Opublikowane w: Journal of Orthopaedic Research, 2021, ISSN 1554-527X
Wydawca: Wiley-Blackwell
DOI: 10.1002/jor.25226

Context-aware modeling for knowledge-intensive medicinal product development processes

Autorzy: Zeynep Ozturk Yurt, Rik Eshuis, Anna Wilbik & Irene Vanderfeesten
Opublikowane w: Software and Systems Modeling, 2023, ISSN 1619-1374
Wydawca: Springer Link
DOI: 10.1007/s10270-022-01070-5

Simple, fast and efficient iTOP-mediated delivery of CRISPR/Cas9 RNP in difficult-to-transduce human cells including primary T cells

Autorzy: Waleed M Kholosy, Marieke Visscher, Kim Ogink, Helen Buttstedt, Kelli Griffin, Axel Beier, Jan Patrick Gerlach, Jan J Molenaar, Niels Geijsen, Marco de Boer, Anna Chatsisvili
Opublikowane w: Journal of Biotechnology, Numer 338, 2021, Strona(/y) 71-80, ISSN 0168-1656
Wydawca: Elsevier BV
DOI: 10.1016/j.jbiotec.2021.07.006

Characterization of biomaterials intended for use in the nucleus pulposus of degenerated intervertebral discs

Autorzy: Tara C. Schmitz, Elias Salzer, João F. Crispim, Georgina Targa Fabra, Catherine LeVisage, Abhay Pandit, Marianna Tryfonidou, Christine Le Maitre, Keita Ito
Opublikowane w: Acta Biomaterialia, Numer 114, 2020, Strona(/y) 1-15, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2020.08.001

Influence of Angiopoietin Treatment with Hypoxia and Normoxia on Human Intervertebral Disc Progenitor Cell's Proliferation, Metabolic Activity, and Phenotype

Autorzy: Bischof, Muriel C.; Häckel, Sonja; Oberli, Andrea; Croft, Andreas S.; Oswald, Katharina A.C.; Albers, Christoph E.; Gantenbein, Benjamin; Guerrero, Julien
Opublikowane w: Applied Sciences, 2021, ISSN 2076-3417
Wydawca: MDPI
DOI: 10.3390/app11157144

Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative

Autorzy: Le Maitre, Christine C.; Dahia, Chitra L.; Giers, Morgan; Illien-Junger, Svenja; Cicione, Claudia; Samartzis, Dino; Vadala, Gianluca; Fields, Aaron; Lotz, Jeffrey
Opublikowane w: JOR Spine, 2021, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1167

Recognizing the ethical implications of stem cell research: A call for broadening the scope

Autorzy: Assen, L.S.; Jongsma, K.R.; Isasi, R.; Tryfonidou, M.A.; Bredenoord, A.L.
Opublikowane w: Stem Cell Reports, Numer 16, 2021, Strona(/y) 1656-1661, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2021.05.021

Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue

Autorzy: Elias Salzer; Vivian H. M. Mouser; Jurgen A. Bulsink; Marianna A. Tryfonidou; Keita Ito
Opublikowane w: JOR Spine, Numer 5, 2023, ISSN 2572-1143
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1240

Towards Tissue-Specific Stem Cell Therapy for the Intervertebral Disc: PPARδ Agonist Increases the Yield of Human Nucleus Pulposus Progenitor Cells in Expansion

Autorzy: Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Katharina A.C. Oswald, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein
Opublikowane w: Surgeries, Numer 2/1, 2021, Strona(/y) 92-104, ISSN 2673-4095
Wydawca: MDPI
DOI: 10.3390/surgeries2010008

Monographic books (1)

Intervertebral Disc Regeneration II

Autorzy: Benjamin Gantenbein
Opublikowane w: 2023
Wydawca: MDPI
DOI: 10.3390/books978-3-0365-8199-6

Non-peer reviewed articles (1)

Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects

Autorzy: Bram Zoetebier; Tara C Schmitz; Keita Ito; Marcel Karperien; Marianna A Tryfonidou; Julieta Paez
Opublikowane w: Tissue Engineering, Numer 16, 2022, ISSN 2152-4955
Wydawca: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.tea.2021.0226

Conference proceedings (1)

BPM Support for Regulatory Compliance in ATMP Development Processes

Autorzy: Ozturk Yurt, Zeynep
Opublikowane w: CEUR Workshop Proceedings, Numer 2973, 2021
Wydawca: CEUR-WS