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individualizedPaediatricCure: Cloud-based virtual-patient models for precision paediatric oncology

Objective

Effective personalized medicine for paediatric cancers must address a multitude of challenges, including domain-specific challenges. To overcome these challenges, we propose a comprehensive computational effort to combine knowledge-base, machine-learning, and mechanistic models to predict optimal standard and experimental therapies for each child. Our approach is based on virtual patient models–in-silico avatars whose analysis can inform personalized diagnostics and recommend treatments. Our platform will also allow care givers to query models and infer benefits and drawbacks for specific treatment combinations for each child. To construct these models, we will combine state-of-the-art computational methods and data from molecular assays, and clinical and preclinical studies. We will test their predictions prospectively on data from clinical trials and test therapies in pre-clinical settings. We will focus on a select panel of paediatric tumours including both high-incidence and high-risk tumour types. To accomplish our goals, we have assembled an interdisciplinary team consisting of basic, translational, and clinical researchers—all amongst the leaders in their respective fields—and established strong relationships with European Centres of Excellence, patient organizations, and clinical trials focus on personalized medicine for our proposed case studies. We will produce, assemble, standardize, and harmonize accessible high-quality multi-disciplinary data and leverage the potential of Big Data and HPC for the personalized treatments of European citizens. We will make our models and data available through a cloud-based platform, whose exploitation will be maximised through a collaboration with the European Open Science Cloud initiative. In summary, iPC will address the critical need for personalized medicine for children with cancer, contribute to the digitalization of clinical workflows, and enable the Digital Single Market of the EU data infrastructure.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology
  • /natural sciences/computer and information sciences/data science/big data

Call for proposal

H2020-SC1-DTH-2018-1
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH
Address
Burgplatz 3A
9500 Villach
Austria
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 513 004,90

Participants (20)

IBM RESEARCH GMBH
Switzerland
EU contribution
€ 2 020 506,73
Address
Saeumerstrasse 4
8803 Rueschlikon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BAYLOR COLLEGE OF MEDICINE
United States
EU contribution
€ 1 104 991,11
Address
One Baylor Plaza T119
77030 Houston Tx
Activity type
Higher or Secondary Education Establishments
INSTITUT CURIE
France
EU contribution
€ 1 381 550,34
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
TECHNISCHE UNIVERSITAT DARMSTADT
Germany
EU contribution
€ 720 673,46
Address
Karolinenplatz 5
64289 Darmstadt
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 482 857,45
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgium
EU contribution
€ 668 974,33
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION
Spain
EU contribution
€ 980 414,89
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Research Organisations
XLAB RAZVOJ PROGRAMSKE OPREME IN SVETOVANJE DOO
Slovenia
EU contribution
€ 369 243,94
Address
Pot Za Brdom 100
1000 Ljubljana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
EU contribution
€ 629 109,94
Address
Heidelberglaan 25
3584CS Utrecht
Activity type
Other
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 769 881,06
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 437 262,55
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 452 750
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
EU contribution
€ 397 398,16
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
ALACRIS THERANOSTICS GMBH
Germany
EU contribution
€ 861 444,60
Address
Max Planck Strasse 3
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 1 451 213,36
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 531 691,33
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 414 838,83
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
THE CHILDREN'S HOSPITAL OF PHILADELPHIA NON PROFIT ORG
United States
EU contribution
€ 175 652,48
Address
Civic Center Blvd
19104 Philadelphia
Activity type
Other
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 384 940,54
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
CHILDREN'S MEDICAL RESEARCH INSTITUTE
Australia
EU contribution
€ 0
Address
214 Hawkesbury Road
2145 Westmead, New South Wales
Activity type
Research Organisations