Genetics to understand cellular components of Alzheimer Disease pathogenesis

Project Information

CELLPHASE_AD

Grant agreement ID: 834682

DOI

10.3030/834682

Project closed

EC signature date 24 October 2019

Start date 1 November 2019

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 374 997,50

EU contribution

€ 2 374 997,50

Coordinated by

VIB VZW
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (27)

Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s Disease

Author(s): Sara Calafate, Gökhan Özturan, Nicky Thrupp, Jeroen Vanderlinden, Wei-Ting Chen, Mark Fiers, Ashley Lu, Eline Creemers, Katleen Craessaerts, Joris Vandenbempt, Luuk van Boekholdt, Suresh Poovathinga
Published in: nature neuroscience, 2021, ISSN 1546-1726
Publisher: springer
DOI: 10.1101/2021.05.21.445007

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems

Author(s): Amy F Lloyd, Anna Martinez-Muriana, Emma Davis, Michael JD Daniels, Pengfei Hou, Renzo Mancuso, Alejandro J Brenes, Ivana Geric, An Snellinx, Katleen Craessaerts, Tom Theys, Mark Fiers, Bart De Stroop
Published in: cell reports, 2025, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1101/2022.07.07.498804

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease

Author(s): Kitty B. Murphy, Di Hu, Leen Wolfs, Susan K. Rohde, Gonzalo Leguía Fauró, Ivana Geric, Renzo Mancuso, Bart De Strooper, Sarah J. Marzi
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-60099-4

microRNA-132 regulates gene expression programs involved in microglial homeostasis

Author(s): Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Emma Davis, Leen Wolfs, Annerieke Sierksma, Mayte Mars, Taofeng Bu, Nicola Thrupp, Lujia Zhou, Diederik Moechars, Renzo M
Published in: iScience, Issue 26, 2025, Page(s) 106829, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2023.106829

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology

Author(s): Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels,
Published in: Nature Neuroscience, Issue 27, 2024, Page(s) 886-900, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01600-y

Stem-cell-derived human microglia transplanted into mouse brain to study human disease

Author(s): Nicola Fattorelli, Anna Martinez-Muriana, Leen Wolfs, Ivana Geric, Bart De Strooper, Renzo Mancuso
Published in: Nature Protocols, Issue 16/2, 2021, Page(s) 1013-1033, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-00447-4

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

Author(s): Hannah Walgrave, Lujia Zhou, Bart De Strooper, Evgenia Salta
Published in: Molecular Neurodegeneration, Issue Vol 16, no 1, 2021, Page(s) p. 1-16, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Human iPSC-derived Astrocytes Transplanted into the Mouse Brain Display three Morphological Responses to Amyloid-β Plaques

Author(s): Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison Goate, Bart Destrooper, Amaia M Arranz
Published in: molecular neurodegeneration, 2021, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.21203/rs.3.rs-112937/v1

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease

Author(s): Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Willia
Published in: Brain, Issue 146, 2023, Page(s) 690-699, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awac128

The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer’s Disease

Author(s): Inmaculada Sanjuan Ruiz, Lutgarde Serneels, Katleen Craessaerts, Alison Goate, Wim Annaert, Lucia Chavez Gutierrez, Yonggang Shi, Nasim Sheikh-Bahaei, Joanna C. Jen, Eliana Marisa Ramos, Mihaela Campa
Published in: molecular neurodegneration advances, 2025, ISSN 3059-4944
Publisher: sprnger
DOI: 10.21203/rs.3.rs-7222993/v1

New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of γ-secretases

Author(s): Bart De Strooper, Eric Karran
Published in: The EMBO Journal, Issue 43, 2025, Page(s) 887-903, ISSN 1460-2075
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00057-w

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease

Author(s): Nóra Baligács, Giulia Albertini, Sarah C. Borrie, Lutgarde Serneels, Clare Pridans, Sriram Balusu, Bart De Strooper
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-54779-w

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Author(s): Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price
Published in: Nature Communications, Issue 12, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24082-z

Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Author(s): Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa-Marinha, Rafaela Morais-Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverría, Marcel
Published in: Nature Neuroscience, Issue 26, 2023, Page(s) 1021-1031, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01325-4

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques.

Author(s): Pranav Preman; Julia Tcw; Sara Calafate; An Snellinx; Maria Alfonso-Triguero; Nikky Corthout; Sebastian Munck; Dietmar Rudolf Thal; Alison Goate; Bart De Strooper; Bart De Strooper; Amaia M. Arranz
Published in: Molecular Neurodegeneration, Issue Vol 16, Iss 1, 2021, Page(s) Pp 1-18, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-021-00487-8

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Author(s): Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Nikky Corthout, Xiaoyan Qian, Jana Laláková, Malte Kühnemund, Iryna Voytyuk, Leen Wolfs, Renzo Mancuso, Evgenia Salta, Sriram Balusu, An Snellinx, Sebastian Munck, Aleksandra Jurek, Jose Fernandez Navarro, Takaomi C. Saido, Inge Huitinga, Joakim Lundeberg, Mark Fiers, Bart De Strooper
Published in: Cell, Issue 182/4, 2020, Page(s) 976-991.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.06.038

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s Disease

Author(s): Disha Shah, Willy Gsell, Jérôme Wahis, Emma S. Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wol
Published in: cell reports, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1101/2022.04.26.489446

APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia

Author(s): Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Ma
Published in: EMBO Molecular Medicine, Issue 16, 2025, Page(s) 3113-3141, ISSN 1757-4684
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00162-7

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Author(s): Emanuela Pasciuto, Oliver T. Burton, Carlos P. Roca, Vasiliki Lagou, Wenson D. Rajan, Tom Theys, Renzo Mancuso, Raul Y. Tito, Lubna Kouser, Zsuzsanna Callaerts-Vegh, Alerie G. de la Fuente, Teresa Prezzemolo, Loriana G. Mascali, Aleksandra Brajic, Carly E. Whyte, Lidia Yshii, Anna Martinez-Muriana, Michelle Naughton, Andrew Young, Alena Moudra, Pierre Lemaitre, Suresh Poovathingal, Jeroen Raes, Ba
Published in: Cell, Issue 182/3, 2020, Page(s) 625-640.e24, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.06.026

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Author(s): Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V. Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper
Published in: Nature Neuroscience, Issue 22/12, 2019, Page(s) 2111-2116, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-019-0525-x

Neurodegeneration cell per cell

Author(s): Sriram Balusu, Roman Praschberger, Elsa Lauwers, Bart De Strooper, Patrik Verstreken
Published in: Neuron, Issue 111, 2025, Page(s) 767-786, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.01.016

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

Author(s): Annerieke Sierksma, Valentina Escott-Price, Bart De Strooper
Published in: Science, Issue 370/6512, 2020, Page(s) 61-66, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abb8575

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Author(s): Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Published in: Molecular Neurodegeneration, Issue 15/1, 2020, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-020-00399-z

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

Author(s): Lutgarde Serneels, Annerieke Sierksma, Emanuela Pasciuto, Ivana Geric, Arya Nair, Anna Martinez-Muriana, An Snellinx, Bart De Strooper
Published in: Molecular Neurodegeneration, Issue 20, 2025, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-025-00823-2

The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease

Author(s): Sriram Balusu, Bart De Strooper
Published in: Acta Neuropathologica, Issue 147, 2024, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-024-02747-5

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease

Author(s): Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx, Lutgarde Serneels, Dries T’Syen, Iordana Chrysidou, Amaia M. Arranz, Annerieke Sierksma, Joel Simrén, Thomas K. Karik
Published in: Science, Issue 381, 2024, Page(s) 1176-1182, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abp9556

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

Author(s): Nicola Thrupp, Carlo Sala Frigerio, Leen Wolfs, Nathan G. Skene, Nicola Fattorelli, Suresh Poovathingal, Yannick Fourne, Paul M. Matthews, Tom Theys, Renzo Mancuso, Bart de Strooper, Mark Fiers
Published in: Cell Reports, Issue 32/13, 2020, Page(s) 108189, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108189