Genetics to understand cellular components of Alzheimer Disease pathogenesis

Project Information

CELLPHASE_AD

Grant agreement ID: 834682

DOI

10.3030/834682

EC signature date 24 October 2019

Start date 1 November 2019

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 374 997,50

EU contribution

€ 2 374 997,50

Coordinated by

VIB VZW
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Stem-cell-derived human microglia transplanted into mouse brain to study human disease

Author(s): Nicola Fattorelli, Anna Martinez-Muriana, Leen Wolfs, Ivana Geric, Bart De Strooper, Renzo Mancuso
Published in: Nature Protocols, Issue 16/2, 2021, Page(s) 1013-1033, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-00447-4

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

Author(s): Hannah Walgrave, Lujia Zhou, Bart De Strooper, Evgenia Salta
Published in: Molecular Neurodegeneration, Issue Vol 16, no 1, 2021, Page(s) p. 1-16, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques.

Author(s): Pranav Preman; Julia Tcw; Sara Calafate; An Snellinx; Maria Alfonso-Triguero; Nikky Corthout; Sebastian Munck; Dietmar Rudolf Thal; Alison Goate; Bart De Strooper; Bart De Strooper; Amaia M. Arranz
Published in: Molecular Neurodegeneration, Issue Vol 16, Iss 1, 2021, Page(s) Pp 1-18, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-021-00487-8

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Author(s): Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Nikky Corthout, Xiaoyan Qian, Jana Laláková, Malte Kühnemund, Iryna Voytyuk, Leen Wolfs, Renzo Mancuso, Evgenia Salta, Sriram Balusu, An Snellinx, Sebastian Munck, Aleksandra Jurek, Jose Fernandez Navarro, Takaomi C. Saido, Inge Huitinga, Joakim Lundeberg, Mark Fiers, Bart De Strooper
Published in: Cell, Issue 182/4, 2020, Page(s) 976-991.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.06.038

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Author(s): Emanuela Pasciuto, Oliver T. Burton, Carlos P. Roca, Vasiliki Lagou, Wenson D. Rajan, Tom Theys, Renzo Mancuso, Raul Y. Tito, Lubna Kouser, Zsuzsanna Callaerts-Vegh, Alerie G. de la Fuente, Teresa Prezzemolo, Loriana G. Mascali, Aleksandra Brajic, Carly E. Whyte, Lidia Yshii, Anna Martinez-Muriana, Michelle Naughton, Andrew Young, Alena Moudra, Pierre Lemaitre, Suresh Poovathingal, Jeroen Raes, Ba
Published in: Cell, Issue 182/3, 2020, Page(s) 625-640.e24, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.06.026

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Author(s): Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V. Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper
Published in: Nature Neuroscience, Issue 22/12, 2019, Page(s) 2111-2116, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-019-0525-x

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

Author(s): Annerieke Sierksma, Valentina Escott-Price, Bart De Strooper
Published in: Science, Issue 370/6512, 2020, Page(s) 61-66, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abb8575

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Author(s): Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Published in: Molecular Neurodegeneration, Issue 15/1, 2020, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-020-00399-z

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

Author(s): Nicola Thrupp, Carlo Sala Frigerio, Leen Wolfs, Nathan G. Skene, Nicola Fattorelli, Suresh Poovathingal, Yannick Fourne, Paul M. Matthews, Tom Theys, Renzo Mancuso, Bart de Strooper, Mark Fiers
Published in: Cell Reports, Issue 32/13, 2020, Page(s) 108189, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108189