Genetics to understand cellular components of Alzheimer Disease pathogenesis

Informazioni relative al progetto

CELLPHASE_AD

ID dell’accordo di sovvenzione: 834682

DOI

10.3030/834682

Progetto chiuso

Data della firma CE 24 Ottobre 2019

Data di avvio 1 Novembre 2019

Data di completamento 31 Ottobre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 374 997,50

Contributo UE

€ 2 374 997,50

Coordinato da

VIB VZW
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (27)

Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s Disease

Autori: Sara Calafate, Gökhan Özturan, Nicky Thrupp, Jeroen Vanderlinden, Wei-Ting Chen, Mark Fiers, Ashley Lu, Eline Creemers, Katleen Craessaerts, Joris Vandenbempt, Luuk van Boekholdt, Suresh Poovathinga
Pubblicato in: nature neuroscience, 2021, ISSN 1546-1726
Editore: springer
DOI: 10.1101/2021.05.21.445007

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems

Autori: Amy F Lloyd, Anna Martinez-Muriana, Emma Davis, Michael JD Daniels, Pengfei Hou, Renzo Mancuso, Alejandro J Brenes, Ivana Geric, An Snellinx, Katleen Craessaerts, Tom Theys, Mark Fiers, Bart De Stroop
Pubblicato in: cell reports, 2025, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1101/2022.07.07.498804

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease

Autori: Kitty B. Murphy, Di Hu, Leen Wolfs, Susan K. Rohde, Gonzalo Leguía Fauró, Ivana Geric, Renzo Mancuso, Bart De Strooper, Sarah J. Marzi
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-60099-4

microRNA-132 regulates gene expression programs involved in microglial homeostasis

Autori: Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Emma Davis, Leen Wolfs, Annerieke Sierksma, Mayte Mars, Taofeng Bu, Nicola Thrupp, Lujia Zhou, Diederik Moechars, Renzo M
Pubblicato in: iScience, Numero 26, 2025, Pagina/e 106829, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/j.isci.2023.106829

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology

Autori: Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels,
Pubblicato in: Nature Neuroscience, Numero 27, 2024, Pagina/e 886-900, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-024-01600-y

Stem-cell-derived human microglia transplanted into mouse brain to study human disease

Autori: Nicola Fattorelli, Anna Martinez-Muriana, Leen Wolfs, Ivana Geric, Bart De Strooper, Renzo Mancuso
Pubblicato in: Nature Protocols, Numero 16/2, 2021, Pagina/e 1013-1033, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-020-00447-4

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

Autori: Hannah Walgrave, Lujia Zhou, Bart De Strooper, Evgenia Salta
Pubblicato in: Molecular Neurodegeneration, Numero Vol 16, no 1, 2021, Pagina/e p. 1-16, ISSN 1750-1326
Editore: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Human iPSC-derived Astrocytes Transplanted into the Mouse Brain Display three Morphological Responses to Amyloid-β Plaques

Autori: Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison Goate, Bart Destrooper, Amaia M Arranz
Pubblicato in: molecular neurodegeneration, 2021, ISSN 1750-1326
Editore: BioMed Central
DOI: 10.21203/rs.3.rs-112937/v1

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease

Autori: Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Willia
Pubblicato in: Brain, Numero 146, 2023, Pagina/e 690-699, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awac128

The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer’s Disease

Autori: Inmaculada Sanjuan Ruiz, Lutgarde Serneels, Katleen Craessaerts, Alison Goate, Wim Annaert, Lucia Chavez Gutierrez, Yonggang Shi, Nasim Sheikh-Bahaei, Joanna C. Jen, Eliana Marisa Ramos, Mihaela Campa
Pubblicato in: molecular neurodegneration advances, 2025, ISSN 3059-4944
Editore: sprnger
DOI: 10.21203/rs.3.rs-7222993/v1

New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of γ-secretases

Autori: Bart De Strooper, Eric Karran
Pubblicato in: The EMBO Journal, Numero 43, 2025, Pagina/e 887-903, ISSN 1460-2075
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00057-w

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease

Autori: Nóra Baligács, Giulia Albertini, Sarah C. Borrie, Lutgarde Serneels, Clare Pridans, Sriram Balusu, Bart De Strooper
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-54779-w

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Autori: Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price
Pubblicato in: Nature Communications, Numero 12, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24082-z

Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Autori: Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa-Marinha, Rafaela Morais-Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverría, Marcel
Pubblicato in: Nature Neuroscience, Numero 26, 2023, Pagina/e 1021-1031, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-023-01325-4

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques.

Autori: Pranav Preman; Julia Tcw; Sara Calafate; An Snellinx; Maria Alfonso-Triguero; Nikky Corthout; Sebastian Munck; Dietmar Rudolf Thal; Alison Goate; Bart De Strooper; Bart De Strooper; Amaia M. Arranz
Pubblicato in: Molecular Neurodegeneration, Numero Vol 16, Iss 1, 2021, Pagina/e Pp 1-18, ISSN 1750-1326
Editore: BioMed Central
DOI: 10.1186/s13024-021-00487-8

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Autori: Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Nikky Corthout, Xiaoyan Qian, Jana Laláková, Malte Kühnemund, Iryna Voytyuk, Leen Wolfs, Renzo Mancuso, Evgenia Salta, Sriram Balusu, An Snellinx, Sebastian Munck, Aleksandra Jurek, Jose Fernandez Navarro, Takaomi C. Saido, Inge Huitinga, Joakim Lundeberg, Mark Fiers, Bart De Strooper
Pubblicato in: Cell, Numero 182/4, 2020, Pagina/e 976-991.e19, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2020.06.038

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s Disease

Autori: Disha Shah, Willy Gsell, Jérôme Wahis, Emma S. Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wol
Pubblicato in: cell reports, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1101/2022.04.26.489446

APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia

Autori: Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Ma
Pubblicato in: EMBO Molecular Medicine, Numero 16, 2025, Pagina/e 3113-3141, ISSN 1757-4684
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00162-7

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Autori: Emanuela Pasciuto, Oliver T. Burton, Carlos P. Roca, Vasiliki Lagou, Wenson D. Rajan, Tom Theys, Renzo Mancuso, Raul Y. Tito, Lubna Kouser, Zsuzsanna Callaerts-Vegh, Alerie G. de la Fuente, Teresa Prezzemolo, Loriana G. Mascali, Aleksandra Brajic, Carly E. Whyte, Lidia Yshii, Anna Martinez-Muriana, Michelle Naughton, Andrew Young, Alena Moudra, Pierre Lemaitre, Suresh Poovathingal, Jeroen Raes, Ba
Pubblicato in: Cell, Numero 182/3, 2020, Pagina/e 625-640.e24, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2020.06.026

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Autori: Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V. Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper
Pubblicato in: Nature Neuroscience, Numero 22/12, 2019, Pagina/e 2111-2116, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-019-0525-x

Neurodegeneration cell per cell

Autori: Sriram Balusu, Roman Praschberger, Elsa Lauwers, Bart De Strooper, Patrik Verstreken
Pubblicato in: Neuron, Numero 111, 2025, Pagina/e 767-786, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2023.01.016

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

Autori: Annerieke Sierksma, Valentina Escott-Price, Bart De Strooper
Pubblicato in: Science, Numero 370/6512, 2020, Pagina/e 61-66, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abb8575

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Autori: Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Pubblicato in: Molecular Neurodegeneration, Numero 15/1, 2020, ISSN 1750-1326
Editore: BioMed Central
DOI: 10.1186/s13024-020-00399-z

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

Autori: Lutgarde Serneels, Annerieke Sierksma, Emanuela Pasciuto, Ivana Geric, Arya Nair, Anna Martinez-Muriana, An Snellinx, Bart De Strooper
Pubblicato in: Molecular Neurodegeneration, Numero 20, 2025, ISSN 1750-1326
Editore: BioMed Central
DOI: 10.1186/s13024-025-00823-2

The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease

Autori: Sriram Balusu, Bart De Strooper
Pubblicato in: Acta Neuropathologica, Numero 147, 2024, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-024-02747-5

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease

Autori: Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx, Lutgarde Serneels, Dries T’Syen, Iordana Chrysidou, Amaia M. Arranz, Annerieke Sierksma, Joel Simrén, Thomas K. Karik
Pubblicato in: Science, Numero 381, 2024, Pagina/e 1176-1182, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abp9556

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

Autori: Nicola Thrupp, Carlo Sala Frigerio, Leen Wolfs, Nathan G. Skene, Nicola Fattorelli, Suresh Poovathingal, Yannick Fourne, Paul M. Matthews, Tom Theys, Renzo Mancuso, Bart de Strooper, Mark Fiers
Pubblicato in: Cell Reports, Numero 32/13, 2020, Pagina/e 108189, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108189