Genetics to understand cellular components of Alzheimer Disease pathogenesis

Información del proyecto

CELLPHASE_AD

Identificador del acuerdo de subvención: 834682

DOI

10.3030/834682

Proyecto cerrado

Fecha de la firma de la CE 24 Octubre 2019

Fecha de inicio 1 Noviembre 2019

Fecha de finalización 31 Octubre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 374 997,50

Aportación de la UE

€ 2 374 997,50

Coordinado por

VIB VZW
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (27)

Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s Disease

Autores: Sara Calafate, Gökhan Özturan, Nicky Thrupp, Jeroen Vanderlinden, Wei-Ting Chen, Mark Fiers, Ashley Lu, Eline Creemers, Katleen Craessaerts, Joris Vandenbempt, Luuk van Boekholdt, Suresh Poovathinga
Publicado en: nature neuroscience, 2021, ISSN 1546-1726
Editor: springer
DOI: 10.1101/2021.05.21.445007

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems

Autores: Amy F Lloyd, Anna Martinez-Muriana, Emma Davis, Michael JD Daniels, Pengfei Hou, Renzo Mancuso, Alejandro J Brenes, Ivana Geric, An Snellinx, Katleen Craessaerts, Tom Theys, Mark Fiers, Bart De Stroop
Publicado en: cell reports, 2025, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1101/2022.07.07.498804

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease

Autores: Kitty B. Murphy, Di Hu, Leen Wolfs, Susan K. Rohde, Gonzalo Leguía Fauró, Ivana Geric, Renzo Mancuso, Bart De Strooper, Sarah J. Marzi
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-60099-4

microRNA-132 regulates gene expression programs involved in microglial homeostasis

Autores: Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Emma Davis, Leen Wolfs, Annerieke Sierksma, Mayte Mars, Taofeng Bu, Nicola Thrupp, Lujia Zhou, Diederik Moechars, Renzo M
Publicado en: iScience, Edición 26, 2025, Página(s) 106829, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/j.isci.2023.106829

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology

Autores: Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels,
Publicado en: Nature Neuroscience, Edición 27, 2024, Página(s) 886-900, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-024-01600-y

Stem-cell-derived human microglia transplanted into mouse brain to study human disease

Autores: Nicola Fattorelli, Anna Martinez-Muriana, Leen Wolfs, Ivana Geric, Bart De Strooper, Renzo Mancuso
Publicado en: Nature Protocols, Edición 16/2, 2021, Página(s) 1013-1033, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-020-00447-4

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

Autores: Hannah Walgrave, Lujia Zhou, Bart De Strooper, Evgenia Salta
Publicado en: Molecular Neurodegeneration, Edición Vol 16, no 1, 2021, Página(s) p. 1-16, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Human iPSC-derived Astrocytes Transplanted into the Mouse Brain Display three Morphological Responses to Amyloid-β Plaques

Autores: Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison Goate, Bart Destrooper, Amaia M Arranz
Publicado en: molecular neurodegeneration, 2021, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.21203/rs.3.rs-112937/v1

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease

Autores: Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Willia
Publicado en: Brain, Edición 146, 2023, Página(s) 690-699, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awac128

The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer’s Disease

Autores: Inmaculada Sanjuan Ruiz, Lutgarde Serneels, Katleen Craessaerts, Alison Goate, Wim Annaert, Lucia Chavez Gutierrez, Yonggang Shi, Nasim Sheikh-Bahaei, Joanna C. Jen, Eliana Marisa Ramos, Mihaela Campa
Publicado en: molecular neurodegneration advances, 2025, ISSN 3059-4944
Editor: sprnger
DOI: 10.21203/rs.3.rs-7222993/v1

New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of γ-secretases

Autores: Bart De Strooper, Eric Karran
Publicado en: The EMBO Journal, Edición 43, 2025, Página(s) 887-903, ISSN 1460-2075
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00057-w

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease

Autores: Nóra Baligács, Giulia Albertini, Sarah C. Borrie, Lutgarde Serneels, Clare Pridans, Sriram Balusu, Bart De Strooper
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-54779-w

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Autores: Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price
Publicado en: Nature Communications, Edición 12, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24082-z

Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Autores: Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa-Marinha, Rafaela Morais-Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverría, Marcel
Publicado en: Nature Neuroscience, Edición 26, 2023, Página(s) 1021-1031, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-023-01325-4

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques.

Autores: Pranav Preman; Julia Tcw; Sara Calafate; An Snellinx; Maria Alfonso-Triguero; Nikky Corthout; Sebastian Munck; Dietmar Rudolf Thal; Alison Goate; Bart De Strooper; Bart De Strooper; Amaia M. Arranz
Publicado en: Molecular Neurodegeneration, Edición Vol 16, Iss 1, 2021, Página(s) Pp 1-18, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-021-00487-8

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Autores: Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Nikky Corthout, Xiaoyan Qian, Jana Laláková, Malte Kühnemund, Iryna Voytyuk, Leen Wolfs, Renzo Mancuso, Evgenia Salta, Sriram Balusu, An Snellinx, Sebastian Munck, Aleksandra Jurek, Jose Fernandez Navarro, Takaomi C. Saido, Inge Huitinga, Joakim Lundeberg, Mark Fiers, Bart De Strooper
Publicado en: Cell, Edición 182/4, 2020, Página(s) 976-991.e19, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.06.038

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s Disease

Autores: Disha Shah, Willy Gsell, Jérôme Wahis, Emma S. Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wol
Publicado en: cell reports, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1101/2022.04.26.489446

APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia

Autores: Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Ma
Publicado en: EMBO Molecular Medicine, Edición 16, 2025, Página(s) 3113-3141, ISSN 1757-4684
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00162-7

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Autores: Emanuela Pasciuto, Oliver T. Burton, Carlos P. Roca, Vasiliki Lagou, Wenson D. Rajan, Tom Theys, Renzo Mancuso, Raul Y. Tito, Lubna Kouser, Zsuzsanna Callaerts-Vegh, Alerie G. de la Fuente, Teresa Prezzemolo, Loriana G. Mascali, Aleksandra Brajic, Carly E. Whyte, Lidia Yshii, Anna Martinez-Muriana, Michelle Naughton, Andrew Young, Alena Moudra, Pierre Lemaitre, Suresh Poovathingal, Jeroen Raes, Ba
Publicado en: Cell, Edición 182/3, 2020, Página(s) 625-640.e24, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.06.026

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Autores: Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V. Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper
Publicado en: Nature Neuroscience, Edición 22/12, 2019, Página(s) 2111-2116, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-019-0525-x

Neurodegeneration cell per cell

Autores: Sriram Balusu, Roman Praschberger, Elsa Lauwers, Bart De Strooper, Patrik Verstreken
Publicado en: Neuron, Edición 111, 2025, Página(s) 767-786, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.01.016

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

Autores: Annerieke Sierksma, Valentina Escott-Price, Bart De Strooper
Publicado en: Science, Edición 370/6512, 2020, Página(s) 61-66, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abb8575

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Autores: Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Publicado en: Molecular Neurodegeneration, Edición 15/1, 2020, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-020-00399-z

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

Autores: Lutgarde Serneels, Annerieke Sierksma, Emanuela Pasciuto, Ivana Geric, Arya Nair, Anna Martinez-Muriana, An Snellinx, Bart De Strooper
Publicado en: Molecular Neurodegeneration, Edición 20, 2025, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-025-00823-2

The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease

Autores: Sriram Balusu, Bart De Strooper
Publicado en: Acta Neuropathologica, Edición 147, 2024, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-024-02747-5

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease

Autores: Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx, Lutgarde Serneels, Dries T’Syen, Iordana Chrysidou, Amaia M. Arranz, Annerieke Sierksma, Joel Simrén, Thomas K. Karik
Publicado en: Science, Edición 381, 2024, Página(s) 1176-1182, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abp9556

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

Autores: Nicola Thrupp, Carlo Sala Frigerio, Leen Wolfs, Nathan G. Skene, Nicola Fattorelli, Suresh Poovathingal, Yannick Fourne, Paul M. Matthews, Tom Theys, Renzo Mancuso, Bart de Strooper, Mark Fiers
Publicado en: Cell Reports, Edición 32/13, 2020, Página(s) 108189, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108189