Genetics to understand cellular components of Alzheimer Disease pathogenesis

Informacje na temat projektu

CELLPHASE_AD

Identyfikator umowy o grant: 834682

DOI

10.3030/834682

Projekt został zamknięty

Data podpisania przez KE 24 Października 2019

Data rozpoczęcia 1 Listopada 2019

Data zakończenia 31 Października 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 374 997,50

Wkład UE

€ 2 374 997,50

Koordynowany przez

VIB VZW
Belgium

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (27)

Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s Disease

Autorzy: Sara Calafate, Gökhan Özturan, Nicky Thrupp, Jeroen Vanderlinden, Wei-Ting Chen, Mark Fiers, Ashley Lu, Eline Creemers, Katleen Craessaerts, Joris Vandenbempt, Luuk van Boekholdt, Suresh Poovathinga
Opublikowane w: nature neuroscience, 2021, ISSN 1546-1726
Wydawca: springer
DOI: 10.1101/2021.05.21.445007

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems

Autorzy: Amy F Lloyd, Anna Martinez-Muriana, Emma Davis, Michael JD Daniels, Pengfei Hou, Renzo Mancuso, Alejandro J Brenes, Ivana Geric, An Snellinx, Katleen Craessaerts, Tom Theys, Mark Fiers, Bart De Stroop
Opublikowane w: cell reports, 2025, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1101/2022.07.07.498804

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease

Autorzy: Kitty B. Murphy, Di Hu, Leen Wolfs, Susan K. Rohde, Gonzalo Leguía Fauró, Ivana Geric, Renzo Mancuso, Bart De Strooper, Sarah J. Marzi
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-60099-4

microRNA-132 regulates gene expression programs involved in microglial homeostasis

Autorzy: Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Emma Davis, Leen Wolfs, Annerieke Sierksma, Mayte Mars, Taofeng Bu, Nicola Thrupp, Lujia Zhou, Diederik Moechars, Renzo M
Opublikowane w: iScience, Numer 26, 2025, Strona(/y) 106829, ISSN 2589-0042
Wydawca: Elsevier BV
DOI: 10.1016/j.isci.2023.106829

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology

Autorzy: Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels,
Opublikowane w: Nature Neuroscience, Numer 27, 2024, Strona(/y) 886-900, ISSN 1097-6256
Wydawca: Nature Publishing Group
DOI: 10.1038/s41593-024-01600-y

Stem-cell-derived human microglia transplanted into mouse brain to study human disease

Autorzy: Nicola Fattorelli, Anna Martinez-Muriana, Leen Wolfs, Ivana Geric, Bart De Strooper, Renzo Mancuso
Opublikowane w: Nature Protocols, Numer 16/2, 2021, Strona(/y) 1013-1033, ISSN 1754-2189
Wydawca: Nature Publishing Group
DOI: 10.1038/s41596-020-00447-4

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

Autorzy: Hannah Walgrave, Lujia Zhou, Bart De Strooper, Evgenia Salta
Opublikowane w: Molecular Neurodegeneration, Numer Vol 16, no 1, 2021, Strona(/y) p. 1-16, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Human iPSC-derived Astrocytes Transplanted into the Mouse Brain Display three Morphological Responses to Amyloid-β Plaques

Autorzy: Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison Goate, Bart Destrooper, Amaia M Arranz
Opublikowane w: molecular neurodegeneration, 2021, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.21203/rs.3.rs-112937/v1

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease

Autorzy: Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Willia
Opublikowane w: Brain, Numer 146, 2023, Strona(/y) 690-699, ISSN 0006-8950
Wydawca: Oxford University Press
DOI: 10.1093/brain/awac128

The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer’s Disease

Autorzy: Inmaculada Sanjuan Ruiz, Lutgarde Serneels, Katleen Craessaerts, Alison Goate, Wim Annaert, Lucia Chavez Gutierrez, Yonggang Shi, Nasim Sheikh-Bahaei, Joanna C. Jen, Eliana Marisa Ramos, Mihaela Campa
Opublikowane w: molecular neurodegneration advances, 2025, ISSN 3059-4944
Wydawca: sprnger
DOI: 10.21203/rs.3.rs-7222993/v1

New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of γ-secretases

Autorzy: Bart De Strooper, Eric Karran
Opublikowane w: The EMBO Journal, Numer 43, 2025, Strona(/y) 887-903, ISSN 1460-2075
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00057-w

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease

Autorzy: Nóra Baligács, Giulia Albertini, Sarah C. Borrie, Lutgarde Serneels, Clare Pridans, Sriram Balusu, Bart De Strooper
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-54779-w

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Autorzy: Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price
Opublikowane w: Nature Communications, Numer 12, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-24082-z

Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Autorzy: Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa-Marinha, Rafaela Morais-Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverría, Marcel
Opublikowane w: Nature Neuroscience, Numer 26, 2023, Strona(/y) 1021-1031, ISSN 1097-6256
Wydawca: Nature Publishing Group
DOI: 10.1038/s41593-023-01325-4

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques.

Autorzy: Pranav Preman; Julia Tcw; Sara Calafate; An Snellinx; Maria Alfonso-Triguero; Nikky Corthout; Sebastian Munck; Dietmar Rudolf Thal; Alison Goate; Bart De Strooper; Bart De Strooper; Amaia M. Arranz
Opublikowane w: Molecular Neurodegeneration, Numer Vol 16, Iss 1, 2021, Strona(/y) Pp 1-18, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.1186/s13024-021-00487-8

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Autorzy: Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Nikky Corthout, Xiaoyan Qian, Jana Laláková, Malte Kühnemund, Iryna Voytyuk, Leen Wolfs, Renzo Mancuso, Evgenia Salta, Sriram Balusu, An Snellinx, Sebastian Munck, Aleksandra Jurek, Jose Fernandez Navarro, Takaomi C. Saido, Inge Huitinga, Joakim Lundeberg, Mark Fiers, Bart De Strooper
Opublikowane w: Cell, Numer 182/4, 2020, Strona(/y) 976-991.e19, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2020.06.038

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s Disease

Autorzy: Disha Shah, Willy Gsell, Jérôme Wahis, Emma S. Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wol
Opublikowane w: cell reports, 2023, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1101/2022.04.26.489446

APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia

Autorzy: Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Ma
Opublikowane w: EMBO Molecular Medicine, Numer 16, 2025, Strona(/y) 3113-3141, ISSN 1757-4684
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00162-7

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Autorzy: Emanuela Pasciuto, Oliver T. Burton, Carlos P. Roca, Vasiliki Lagou, Wenson D. Rajan, Tom Theys, Renzo Mancuso, Raul Y. Tito, Lubna Kouser, Zsuzsanna Callaerts-Vegh, Alerie G. de la Fuente, Teresa Prezzemolo, Loriana G. Mascali, Aleksandra Brajic, Carly E. Whyte, Lidia Yshii, Anna Martinez-Muriana, Michelle Naughton, Andrew Young, Alena Moudra, Pierre Lemaitre, Suresh Poovathingal, Jeroen Raes, Ba
Opublikowane w: Cell, Numer 182/3, 2020, Strona(/y) 625-640.e24, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2020.06.026

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Autorzy: Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V. Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper
Opublikowane w: Nature Neuroscience, Numer 22/12, 2019, Strona(/y) 2111-2116, ISSN 1097-6256
Wydawca: Nature Publishing Group
DOI: 10.1038/s41593-019-0525-x

Neurodegeneration cell per cell

Autorzy: Sriram Balusu, Roman Praschberger, Elsa Lauwers, Bart De Strooper, Patrik Verstreken
Opublikowane w: Neuron, Numer 111, 2025, Strona(/y) 767-786, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2023.01.016

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

Autorzy: Annerieke Sierksma, Valentina Escott-Price, Bart De Strooper
Opublikowane w: Science, Numer 370/6512, 2020, Strona(/y) 61-66, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.abb8575

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Autorzy: Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Opublikowane w: Molecular Neurodegeneration, Numer 15/1, 2020, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.1186/s13024-020-00399-z

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

Autorzy: Lutgarde Serneels, Annerieke Sierksma, Emanuela Pasciuto, Ivana Geric, Arya Nair, Anna Martinez-Muriana, An Snellinx, Bart De Strooper
Opublikowane w: Molecular Neurodegeneration, Numer 20, 2025, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.1186/s13024-025-00823-2

The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease

Autorzy: Sriram Balusu, Bart De Strooper
Opublikowane w: Acta Neuropathologica, Numer 147, 2024, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-024-02747-5

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease

Autorzy: Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx, Lutgarde Serneels, Dries T’Syen, Iordana Chrysidou, Amaia M. Arranz, Annerieke Sierksma, Joel Simrén, Thomas K. Karik
Opublikowane w: Science, Numer 381, 2024, Strona(/y) 1176-1182, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.abp9556

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

Autorzy: Nicola Thrupp, Carlo Sala Frigerio, Leen Wolfs, Nathan G. Skene, Nicola Fattorelli, Suresh Poovathingal, Yannick Fourne, Paul M. Matthews, Tom Theys, Renzo Mancuso, Bart de Strooper, Mark Fiers
Opublikowane w: Cell Reports, Numer 32/13, 2020, Strona(/y) 108189, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.108189