Multivalent interactions driving RNP dynamics in development and disease

Project Information

RNPdynamics

Grant agreement ID: 835300

DOI

10.3030/835300

Project closed

EC signature date 2 December 2019

Start date 1 January 2020

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 396 261,25

EU contribution

€ 2 396 261,25

Coordinated by

KEMIJSKI INSTITUT
Slovenia

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Peer reviewed articles (14)

The FXR1 network acts as signaling scaffold for actomyosin remodeling

Author(s): Xiuzhen Chen, Mervin M. Fansler, Urška Janjoš, Jernej Ule, Christine Mayr
Published in: Cell, 2025, ISSN 1097-4172
Publisher: Cell press
DOI: 10.1101/2023.11.05.565677

Collective homeostasis of condensation-prone proteins via their mRNAs

Author(s): Rupert Faraway, Neve Costello Heaven, Holly Digby, Klara Kuret Hodnik, Jure Rebselj, Oscar G. Wilkins, Anob M. Chakrabarti, Ira A. Iosub, Neža Vadnjal, Rhys Dore, Lea Knez, Stefan L. Ameres, Clemens
Published in: Nature, Issue 647, 2025, Page(s) 798-808, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-09568-w

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Author(s): Brown AL, Wilkins OG, …, Secrier M, Lashley T, Ule J, Buratti E, Humphrey J, Ward ME, Fratta P
Published in: Nature, 2022, Page(s) Mar;603(7899):131-137, ISSN 1476-4687
Publisher: Springer
DOI: 10.1038/s41586-022-04436-3

An improved iCLIP protocol

Author(s): Flora C. Y. Lee, Anob M. Chakrabarti, Heike Hänel, Elisa Monzón-Casanova, Martina Hallegger, Cristina Militti, Federica Capraro, Christoph Sadée, Patrick Toolan-Kerr, Oscar Wilkins, Martin Turner,
Published in: bioRxiv, 2021, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.08.27.457890

CLIP and complementary methods

Author(s): Markus Hafner, Maria Katsantoni, Tino Köster, James Marks, Joyita Mukherjee, Dorothee Staiger, Jernej Ule, Mihaela Zavolan
Published in: Nature Reviews Methods Primers, Issue 1, 2024, ISSN 2662-8449
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43586-021-00018-1

MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration

Author(s): Simone R, Javad F, Emmett W, Wilkins OG, …, Warner TT, Plagnol V, Ule J, de Silva R.
Published in: Nature, 2021, ISSN 1476-4687
Publisher: Springer
DOI: 10.1038/s41586-021-03556-6

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

Author(s): Martina Hallegger; Martina Hallegger; Anob M. Chakrabarti; Flora C.Y. Lee; Flora C.Y. Lee; Bo Lim Lee; Aram G. Amalietti; Aram G. Amalietti; Hana M. Odeh; Katie E. Copley; Jack D. Rubien; Bede Portz; Klara Kuret; Ina Huppertz; Frédérique Rau; Frédérique Rau; Rickie Patani; Rickie Patani; Nicolas L. Fawzi; James Shorter; Nicholas M. Luscombe; Nicholas M. Luscombe; Jernej Ule; Jernej Ule
Published in: Cell, 2021, Page(s) vol. 184, no. 18, pp. 4680-4696,e1-e22, ISSN 1097-4172
Publisher: Cell
DOI: 10.1016/j.cell.2021.07.018

Interrogation of RNA-protein interaction dynamics in bacterial growth

Author(s): Mie Monti, Reyme Herman, Leonardo Mancini, Charlotte Capitanchik, Karen Davey, Charlotte S Dawson, Jernej Ule, Gavin H Thomas, Anne E Willis, Kathryn S Lilley, Eneko Villanueva
Published in: Molecular Systems Biology, Issue 20, 2024, Page(s) 573-589, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.1038/s44320-024-00031-y

Towards in silico CLIP-seq: predicting protein-RNA interaction via sequence-to-signal learning

Author(s): Marc Horlacher, Nils Wagner, Lambert Moyon, Klara Kuret, Nicolas Goedert, Marco Salvatore, Jernej Ule, Julien Gagneur, Ole Winther, Annalisa Marsico
Published in: Genome Biology, Issue 24, 2023, ISSN 1474-760X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s13059-023-03015-7

NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity

Author(s): Susan Kilgas, Aleem Syed, Patrick Toolan-Kerr, Michelle L. Swift, Shrabasti Roychoudhury, Aniruddha Sarkar, Sarah Wilkins, Mikayla Quigley, Anna R. Poetsch, Maria Victoria Botuyan, Gaofeng Cui, George
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52862-w

Positional motif analysis reveals the extent of specificity of protein-RNA interactions observed by CLIP

Author(s): Klara Kuret; Aram Gustav Amalietti; D. Marc Jones; Charlotte Capitanchik; Jernej Ule
Published in: Genome biology, Issue vol. 23, no. 1, 2022, Page(s) 1-34, ISSN 1474-7596
Publisher: BioMed Central
DOI: 10.1186/s13059-022-02755-2

CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1

Author(s): Milan Hluchý, Pavla Gajdušková, Igor Ruiz de los Mozos, Michal Rájecký, Michael Kluge, Benedict-Tilman Berger, Zuzana Slabá, David Potěšil, Elena Weiß, Jernej Ule, Zbyněk Zdráhal, Stefan Kn
Published in: Nature, Issue 609, 2024, Page(s) 829-834, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05204-z

Poised PABP-RNA hubs implement signal-dependent mRNA decay in development

Author(s): Miha Modic, Klara Kuret, Sebastian Steinhauser, Rupert Faraway, Emiel van Genderen, Flora Lee, Igor Ruiz de Los Mozos, Žiga Vičič, Jona Novljan, Derk ten Berge, Nicholas Luscombe, Jernej Ule
Published in: Nature Mol Str Biol, 2024, ISSN 1545-9985
Publisher: Springer
DOI: 10.21203/rs.3.rs-3227673/v1

Subcytoplasmic location of translation controls protein output

Author(s): Ellen L. Horste, Mervin M. Fansler, Ting Cai, Xiuzhen Chen, Sibylle Mitschka, Gang Zhen, Flora C. Y. Lee, Jernej Ule, Christine Mayr
Published in: Mol Cell, 2024, ISSN 1097-4164
Publisher: Cell press
DOI: 10.1101/2022.11.04.515216