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Multivalent interactions driving RNP dynamics in development and disease


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TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Author(s): Brown AL, Wilkins OG, …, Secrier M, Lashley T, Ule J, Buratti E, Humphrey J, Ward ME, Fratta P
Published in: Nature, 2022, Page(s) Mar;603(7899):131-137, ISSN 1476-4687
Publisher: Springer
DOI: 10.1038/s41586-022-04436-3

MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration

Author(s): Simone R, Javad F, Emmett W, Wilkins OG, …, Warner TT, Plagnol V, Ule J, de Silva R.
Published in: Nature, 2021, ISSN 1476-4687
Publisher: Springer
DOI: 10.1038/s41586-021-03556-6

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

Author(s): Martina Hallegger; Martina Hallegger; Anob M. Chakrabarti; Flora C.Y. Lee; Flora C.Y. Lee; Bo Lim Lee; Aram G. Amalietti; Aram G. Amalietti; Hana M. Odeh; Katie E. Copley; Jack D. Rubien; Bede Portz; Klara Kuret; Ina Huppertz; Frédérique Rau; Frédérique Rau; Rickie Patani; Rickie Patani; Nicolas L. Fawzi; James Shorter; Nicholas M. Luscombe; Nicholas M. Luscombe; Jernej Ule; Jernej Ule
Published in: Cell, 2021, Page(s) vol. 184, no. 18, pp. 4680-4696,e1-e22, ISSN 1097-4172
Publisher: Cell
DOI: 10.1016/j.cell.2021.07.018