Descripción del proyecto
Herramientas estadísticas para relacionar datos ómicos y rasgos
Los científicos recopilan conjuntos de datos ómicos para comprender mejor la evolución de los rasgos. La ómica es el término pseudocientífico para estos grupos. Por ejemplo, la genómica es el estudio de todo el genoma o todos los genes de un organismo, y la transcriptómica es el estudio del transcriptoma, el conjunto completo de transcritos de ARN producidos por el genoma. Los científicos analizan estos conjuntos de datos con rasgos de interés que se han ido midiendo en estudios a largo plazo. El proyecto ISULO, financiado con fondos europeos, desarrolla métodos estadísticos avanzados para analizar simultáneamente estos dos tipos de datos y explorar las interrelaciones entre conjuntos de datos ómicos a fin de generar conocimientos relevantes sobre la evolución.
Objetivo
In medicine and agronomy, there is a growing interest in identifying biological mechanisms involved in the evolution of traits along time. Nowadays, this challenging objective is achieved through the acquisition of high-dimensional –omic datasets from various biological levels, and with the collection of phenotype measures along time on the same individuals, so-called longitudinal data. A new research focus is emerging with the objective to analyze jointly these two types of data. In this project, we propose to develop innovative statistical methods to simultaneously analyze these types of data and to deal with their respective characteristics. Novel methodologies will be developed by combining statistical concepts from linear mixed model and variable selection in a Bayesian framework, and by incorporating or inferring biological relationships. The first aim will focus on the analysis of one or more longitudinal outcomes with one –omic data. Flexible modeling for approximating time-varying covariate effects combined with variable selection approaches will be proposed. Thus, a better understanding of the relationships along time between the outcomes and the relevant covariates will be reached. The second objective is to investigate the integration of multiple –omic datasets for explaining one univariate outcome, then one longitudinal response variable, and finally multivariate longitudinal outcomes. Bayesian hierarchical modeling with prior distributions allowing to capture relationships among –omic datasets will be investigated and new relationships among –omic datasets will be explored. The developments and findings of this project research will greatly contribute to the statistical and biological domains. New generic statistical methods will be developed and will be available for transversal applications in various fields. Finally, this project will highlight the added value brought by a collaborative and interdisciplinary work with experienced researchers.
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Régimen de financiación
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinador
75016 Paris
Francia