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The role of ASCL1 and MYCN in human brain development

Project description

Unravelling the mechanisms of cortical expansion in humans

Humans have exceptional skills and abilities relative to other mammals, even other primates, and larger neocortices. The neural progenitor cells (NPCs) that give rise to many, if not all, of the glial and neuronal cell types in the central nervous system have longer proliferative phases in humans than in other mammals, particularly mice. With the support of the Marie Skłodowska-Curie Actions programme, the mAMBo project is investigating the mechanisms behind this, focusing on the potential role of two proteins broadly expressed in humans and known to promote proliferation of NPCs in mice. Insight could shed light on the differences in brain sizes among species and point to potential mechanisms underlying neurodevelopmental diseases.


Net EU contribution
€ 212 933,76
1 Midland Road
NW1 1AT London
United Kingdom

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London Inner London — West Camden and City of London
Activity type
Research Organisations
Non-EU contribution
€ 0,00