FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA

Informazioni relative al progetto

FAIR

ID dell’accordo di sovvenzione: 847786

DOI 10.3030/847786

Data della firma CE 6 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 30 Giugno 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 10 162 903,75

Contributo UE € 10 162 903,75

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

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I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Branding

Logo, public website

Pubblicazioni

Peer reviewed articles (10)

HIF-1a stabilizattion in flagellin-stimulated human bronchial cells impairs barrier function

Autori: Ivan Ramirez-Moral, Bianca L. Ferreira, Joe M. Butler, Michel van Weeghel, Natasja A. Otto, Alex F. de Vos, Xiao Yu, Menno D. de Jong, Riekelt H. Houtkooper, and Tom van der Poll
Pubblicato in: Cells, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11030391

Association between age and the host response in critically ill patients with sepsis

Autori: Erik H. A. Michels, Joe M. Butler, Tom D. Y. Reijnders, Olaf L. Cremer, Brendon P. Scicluna, Fabrice Uhel, Hessel Peters-Sengers, Marcus J. Schultz, Julian C. Knight, Lonneke A. van Vught, Tom van der Poll
Pubblicato in: Critical Care, 2022, ISSN 1466-609X
Editore: BioMed Central
DOI: 10.1186/s13054-022-04266-9

The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia

Autori: Robin Michelet, Moreno Ursino, Sandrine Boulet, Sebastian Franck, Fiordiligie Casilag, Mara Baldry, Jens Rolff, Madelé van Dyk, Sebastian G. Wicha, Jean-Claude Sirard, Emmanuelle Comets, Sarah Zohar, Charlotte Kloft
Pubblicato in: Pharmaceutics, Numero 13/5, 2021, Pagina/e 601, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050601

Bayesian framework for multi-source data integration-Application to human extrapolation from preclinical studies

Autori: Sandrine Boulet, Moreno Ursino, Robin Michelet, Linda BS Aulin, Charlotte Kloft, Emmanuelle Comets, Sarah Zohar
Pubblicato in: Statistical Methods in Medical Research, Numero 33, 2024, Pagina/e 574-588, ISSN 0962-2802
Editore: SAGE Publications
DOI: 10.1177/09622802241231493

Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia

Autori: Erik H. A. Michels, Brent Appelman, Justin de Brabander, Rombout B. E. van Amstel, Christine C. A. van Linge, Osoul Chouchane, Tom D. Y. Reijnders, Alex R. Schuurman, Titia A. L. Sulzer, Augustijn M. Klarenbeek, Renée A. Douma, Lieuwe D. J. Bos, W. Joost Wiersinga, Hessel Peters-Sengers, Tom van der Poll, Michiel van Agtmael, Anne Geke Algera, Brent Appelman, Floor van Baarle, Martijn Beudel, Har
Pubblicato in: American Journal of Respiratory and Critical Care Medicine, Numero 209, 2024, Pagina/e 402-416, ISSN 1073-449X
Editore: American Thoracic Society
DOI: 10.1164/rccm.202305-0890oc

Triggering Toll-Like Receptor 5 Signaling During Pneumococcal Superinfection Prevents the Selection of Antibiotic Resistance

Autori: Charlotte Costa, Jean-Claude Sirard, Paddy S Gibson, Jan-Willem Veening, Erida Gjini, Mara Baldry
Pubblicato in: The Journal of Infectious Diseases, 2024, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiae239

Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of <i>Pseudomonas aeruginosa</i>

Autori: Ana Raquel Maia, Adeline Cezard, Delphine Fouquenet, Virginie Vasseur, Benoit Briard, Jean-Claude Sirard, Mustapha Si-Tahar, Virginie Hervé
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 68, 2024, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/aac.01361-23

Age-related changes in plasma biomarkers and their association with mortality in COVID-19

Autori: Erik H.A. Michels, Brent Appelman, Justin de Brabander, Rombout B.E. van Amstel, Osoul Chouchane, Christine C.A. van Linge, Alex R. Schuurman, Tom D.Y. Reijnders, Titia A.L. Sulzer, Augustijn M. Klarenbeek, Renée A. Douma, Lieuwe D.J. Bos, W. Joost Wiersinga, Hessel Peters-Sengers, Tom van der Poll, Michiel van Agtmael, Anne Geke Algera, Brent Appelman, Floor van Baarle, Martijn Beudel, Harm Jan
Pubblicato in: European Respiratory Journal, Numero 62, 2024, Pagina/e 2300011, ISSN 0903-1936
Editore: European Respiratory Society
DOI: 10.1183/13993003.00011-2023

Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells

Autori: Christine C. A. van Linge, Katina D. Hulme, Hessel Peters-Sengers, Jean-Claude Sirard, Wil H. F. Goessens, Menno D. de Jong, Colin A. Russell, Alex F. de Vos, Tom van der Poll
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2023, Pagina/e 309, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25010309

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

Autori: """ Liselot Dewachter, Julien Dénéréaz, Xue Liu, Vincent de Bakker, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Jan-Willem Veening"""
Pubblicato in: Elife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.75607