Deliverables
For standardized MTD assessments in drug combination studies
Performance of the segmentation and IG approach on images.Trained network and report on performance of the segmentation and IG approach on images.
Quality plan & risk registryQuality plan & risk registry, used to monitor risks and assess quality/timing of results.
Data Integration ReportData integration report Describing the data integration process from existing datasets from CTs
Dissemination Plan, describing the actions foreseen for dissemination and reporting on the dissemination framework established for the project.
Data management database with front end ready.
Bayesian modelling framework for predicting drug synergiesAn open-source software implementation of the developed Bayesian modelling framework for predicting drug synergistic effects in drug combination experiments
The DMP needs to be updated over the course of the project whenever significant changes arise, such as (but not limited to): - new data - changes in consortium policies (e.g. new innovation potential, decision to file for a patent) - changes in consortium composition and external factors (e.g. new consortium members joining or old members leaving).
Publications
Author(s):
Aleix Prat; Anwesha Chaudhury; Nadia Solovieff; Laia Paré; D. Martinez; Nuria Chic; Olga Martínez-Sáez; Fara Brasó-Maristany; Agnes Lteif; Tetiana Taran; Naveen Babbar; Fei Su
Published in:
J Clin Oncol., Issue 1, 2021, ISSN 1527-7755
Publisher:
American Society of Clinical Oncology
DOI:
10.1200/jco.20.02977
Author(s):
Xiaoran Lai; Håkon A. Taskén; Torgeir Mo; Simon W. Funke; Arnoldo Frigessi; Arnoldo Frigessi; Marie E. Rognes; Alvaro Köhn-Luque
Published in:
International Journal for Numerical Methods in Biomedical Engineering, Issue 16, 2021, Page(s) e3542, ISSN 2040-7939
Publisher:
John Wiley & Sons Ltd.
DOI:
10.48550/arxiv.2105.00448
Author(s):
Leiv Rønneberg, Andrea Cremaschi, Robert Hanes, Jorrit M Enserink, Manuela Zucknick
Published in:
Briefings in Bioinformatics, 2021, ISSN 1467-5463
Publisher:
Oxford University Press
DOI:
10.1093/bib/bbab251
Author(s):
Aleix Prat, Yi-Hsuan Tsai, Tomás Pascual, Laia Paré, Barbara Adamo, Maria Vidal, Fara Brasó-Maristany, Patricia Galván, Jan Christoph Brase, Vanessa Rodrik-Outmezguine, Stephen Johnston, Eva Ciruelos, Joel S. Parker
Published in:
Clinical Cancer Research, Issue 26/23, 2020, Page(s) 6141-6148, ISSN 1078-0432
Publisher:
American Association for Cancer Research
DOI:
10.1158/1078-0432.ccr-20-2793
Author(s):
Susana García-Recio; Aatish Thennavan; Michael P. East; Joel S. Parker; Juan Miguel Cejalvo; Joseph P. Garay; Daniel P. Hollern; Xiaping He; Kevin R. Mott; Patricia Galván; Cheng Fan; Sara R. Selitsky; Alisha R. Coffey; David Marron; Fara Brasó-Maristany; Octavio Burgues; Joan Albanell; Federico Rojo; Ana Lluch; Eduardo Martínez de Dueñas; Jeffery M. Rosen; Gary L. Johnson; Lisa A. Carey; Ale
Published in:
instname:, Issue 12, 2020, ISSN 0021-9738
Publisher:
American Society for Clinical Investigation
DOI:
10.1172/jci130323
Author(s):
Francesco Schettini, Elia Seguí, Benedetta Conte, Esther Sanfeliu, Blanca Gonzalez-Farre , Pedro Jares , Sergi Vidal-Sicart , Sergi Ganau , Isaac Cebrecos, Fara Brasó-Maristany , Montserrat Muñoz, Aleix Prat, Maria Vidal
Published in:
Frontiers Oncol., Issue 12, 2022, ISSN 2234-943X
Publisher:
Frontiers Media S. A.
DOI:
10.3389/fonc.2022.1009352
Author(s):
Torgeir Mo; Siri Helene Bertelsen Brandal; Alvaro Köhn-Luque; Olav Engebraaten; Vessela N. Kristensen; Thomas Fleischer; Tord Hompland; Therese Seierstad
Published in:
Cancers; Volume 14; Issue 5; Pages: 1326, Issue 3, 2022, ISSN 2072-6694
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers14051326
Author(s):
Ben Galili, Xavier Tekpli, Vessela N. Kristensen, Zohar Yakhini
Published in:
PLOS ONE, Issue 16/1, 2021, Page(s) e0245215, ISSN 1932-6203
Publisher:
Public Library of Science
DOI:
10.1371/journal.pone.0245215
Author(s):
Zhi Zhao, Manuela Zucknick, Tero Aittokallio
Published in:
Bioinformatics Advances, Issue 2(1), 2022, Page(s) vbac073, ISSN 2635-0041
Publisher:
Oxford Academic
DOI:
10.1093/bioadv/vbac073
Author(s):
Pauliina M, Munne; Lahja, Martikainen; Iiris, Räty; Kia, Bertula; , Nonappa; Janika, Ruuska; Hanna, Ala-Hongisto; Aino, Peura; Babette, Hollmann; Lilya, Euro; Kerim, Yavuz; Linda, Patrikainen; Maria, Salmela; Juho, Pokki; Mikko, Kivento; Juho, Väänänen; Tomi, Suomi; Liina, Nevalaita; Minna, Mutka; Panu, Kovanen; Marjut, Leidenius; Tuomo, Meretoja; Katja, Hukkinen; Outi, Monni; Jeroen, Pouwels;
Published in:
Nature Communications, Issue 14, 2022, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-021-27220-9
Author(s):
Alessandra Cabassi, Paul D W Kirk
Published in:
Bioinformatics, Issue 36/18, 2020, Page(s) 4789-4796, ISSN 1367-4803
Publisher:
Oxford University Press
DOI:
10.1093/bioinformatics/btaa593
Author(s):
Zhi Zhao, Shixiong Wang, Manuela Zucknick, Tero Aittokallio
Published in:
iScience, Issue 25(8), 2022, Page(s) 104767, ISSN 2589-0042
Publisher:
Cell Press
DOI:
10.1016/j.isci.2022.104767
Author(s):
Susanna Holmström, Sampsa Hautaniemi, Antti Häkkinen
Published in:
Bioinformatics, 2022, ISSN 1460-2059
Publisher:
Oxford University Press
DOI:
10.1093/bioinformatics/btac124
Author(s):
Robert Hanes, Pilar Ayuda-Durán, Leiv Rønneberg, Sigve Nakken, Eivind Hovig, Manuela Zucknick, Jorrit M Enserink
Published in:
Bioinformatics, Issue btac840, 2022, Page(s) 1-3, ISSN 1477-4054
Publisher:
Oxford Academic
DOI:
10.1093/bioinformatics/btac840
Author(s):
Alona Levy-Jurgenson, Xavier Tekpli, Vessela N. Kristensen, Zohar Yakhini
Published in:
Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-020-75708-z
Author(s):
Verona Buocikova, Eleonora Marta Longhin, Eleftherios Pilalis, Chara Mastrokalou, Svetlana Miklikova, Marina Cihova, et al.
Published in:
Biomedicine & Pharmacotherapy, Issue Volume 147, March 2022, 112662, 2022, ISSN 1950-6007
Publisher:
Elsevier
DOI:
10.1016/j.biopha.2022.112662
Author(s):
Begüm Utz, Rita Turpin, Johanna Lampe, Jeroen Pouwels, Juha Klefström
Published in:
Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-020-75411-z
Author(s):
Zhi Zhao; Marco Banterle; Leonardo Bottolo; Sylvia Richardson; Alex Lewin; Manuela Zucknick
Published in:
Journal of Statistical Software; Vol. 100 (2021); 1 - 32, Issue 4, 2021, ISSN 1548-7660
Publisher:
University of California at Los Angeles
DOI:
10.48550/arxiv.2104.14008
Author(s):
Thomas Thorne, Paul D W Kirk, Heather A Harrington
Published in:
Bioinformatics, Issue btac118, 2020, Page(s) 2529–2535, ISSN 1367-4803
Publisher:
Oxford University Press
DOI:
10.1093/bioinformatics/btac118
Author(s):
Nuria Chic; Blanca Gonzalez-Farre; Laia Paré; T. Pascual; Cristina Saura; C. Hernando Melia; Montse Muñoz; Pascual Fernández; Dianny Martínez; Esther Sanfeliu; Fara Brasó-Maristany; X. González-Farré; Mafalda Oliveira; Miguel Gil-Gil; Pamela Céliz; E.M. Ciruelos; Patricia Villagrasa; J. Gavila Gregori; Andreu Prat
Published in:
Annals of Oncology, Issue 13, 2020, ISSN 0923-7534
Publisher:
Oxford University Press
DOI:
10.1016/j.annonc.2020.03.148
Author(s):
Claudette Falato; Francesco Schettini; Tomás Pascual; Fara Brasó-Maristany; Aleix Prat
Published in:
cancer treatment reviews, Issue 9, 2022, ISSN 0305-7372
Publisher:
W. B. Saunders Co., Ltd.
DOI:
10.1016/j.ctrv.2022.102496
Author(s):
Gaia Griguolo; Fara Brasó-Maristany; Blanca Gonzalez-Farre; Tomás Pascual; Nuria Chic; Tamara Saurí; Ronald E. Kates; Oleg Gluz; D. Martinez; Laia Paré; Vassilena Tsvetkova; David Pesantez; Maria Vidal; Barbara Adamo; Montserrat Muñoz; Patricia Galván; Laura Barberá; Miriam Cuatrecasas; Mathias Christgen; Hans Kreipe; Inés Monge-Escartín; Patricia Villagrasa; Dolors Soy; Tommaso Giarratan
Published in:
Cancers (Basel), Issue 11, 2020, ISSN 2072-6694
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers12071902
Author(s):
Ayse Bassez, Hanne Vos, Laurien Van Dyck, Giuseppe Floris, Ingrid Arijs, Christine Desmedt, Bram Boeckx, Marlies Vanden Bempt, Ines Nevelsteen, Kathleen Lambein, Kevin Punie, Patrick Neven, Abhishek D. Garg, Hans Wildiers, Junbin Qian, Ann Smeets, Diether Lambrechts
Published in:
Nature Medicine, Issue 27/5, 2021, Page(s) 820-832, ISSN 1078-8956
Publisher:
Nature Publishing Group
DOI:
10.1038/s41591-021-01323-8
Author(s):
Francesco Schettini, Fara Brasó-Maristany, Nicole M. Kuderer & Aleix Prat
Published in:
npj breast cancer, Issue 8:85, 2022, ISSN 2374-4677
Publisher:
Springer Nature
DOI:
10.1038/s41523-022-00451-9
Author(s):
Solon Karapanagiotis, Umberto Benedetto, Sach Mukherjee, Paul D W Kirk, Paul J Newcombe
Published in:
Biostatistics, 2021, ISSN 1465-4644
Publisher:
Oxford University Press
DOI:
10.1093/biostatistics/kxab023
Author(s):
Henri Pesonen, Umberto Simola, Alvaro Köhn-Luque, Henri Vuollekoski, Xiaoran Lai, Arnoldo Frigessi, Samuel Kaski, David T. Frazier, Worapree Maneesoonthorn, Gael M. Martin, Jukka Corander
Published in:
International Statistical Review, Issue n/a, 2022, Page(s) n/a, ISSN 1751-5823
Publisher:
Wiley
DOI:
10.1111/insr.12522
Author(s):
Fara Brasó-Maristany; Laia Paré; Nuria Chic; Olga Martínez-Sáez; Tomás Pascual; Meritxell Mallafre-Larrosa; Francesco Schettini; Blanca Gonzalez-Farre; Esther Sanfeliu; D. Martinez; Patricia Galván; Esther Barnadas; Belinda Salinas; P. Tolosa; Eva Ciruelos; Esther Carcelero; Cecilia Guillen; Barbara Adamo; Reinaldo Moreno; Maria Vidal; Montserrat Muñoz; Aleix Prat
Published in:
Molecular Oncology, Issue 8, 2021, ISSN 1574-7891
Publisher:
Elsevier BV
DOI:
10.1002/1878-0261.13021
Author(s):
Leiv Rønneberg, Paul D.W. Kirk, Manuela Zucknick
Published in:
ResearchSquare, Issue rs-1465185, 2022, Page(s) 2529–2535, ISSN 2693-5015
Publisher:
Research Square Platform LLC
DOI:
10.21203/rs.3.rs-1465185/v2
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