RESISTANCE UNDER COMBINATORIAL TREATMENT IN ER+ AND ER- BREAST CANCER.

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

MTD Assessment protocol.

For standardized MTD assessments in drug combination studies

Protocol for standardized drug combination

A protocol for standardized drug combination screening and data analysis for both cell lines and expanded tumor material from PDX models.

Modeling and simulation methods

2 scientific papers describing the modeling and simulation methods and results where clinical trials are reproduced and resistance mechanism are investigated.

Molecular analysis of pts treatments with drug combinations

A report describing the molecular analyses of treating patients with neoadjuvant therapies.

Performance of the segmentation and IG approach on images.

Trained network and report on performance of the segmentation and IG approach on images.

Quality plan & risk registry

Quality plan & risk registry, used to monitor risks and assess quality/timing of results.

Bayesian models for drug synergies

A manuscript prepared for publication in a scientific journal describing the developed Bayesian modelling framework for predicting drug synergistic effects in drug combination experiments

Data Integration Report

Data integration report Describing the data integration process from existing datasets from CTs

Biological results inferred from cancer samples.

A report describing the approach to WSIs and an evaluation of its performance, as well as biological results inferred from cancer samples.

Blueprint of breast tumor microenvironment

Blueprint of breast tumor microenvironment based on scRNA-Seq, CITE-seq and TCR-Seq.

scRNA-Seq data

Second batch of raw seq. data. Raw sequencing (scRNA-Seq, CITE-Seq, scTCR-seq) data available on the second batch of patients (36-70).

Dissemination Plan

Dissemination Plan, describing the actions foreseen for dissemination and reporting on the dissemination framework established for the project.

In-silico simulation software

An open-source software for in silico simulations of drug response for the drug treatments used in the studied clinical trials.

Data management database

Data management database with front end ready.

Bayesian modelling framework for predicting drug synergies

An open-source software implementation of the developed Bayesian modelling framework for predicting drug synergistic effects in drug combination experiments

Data management plan

The DMP needs to be updated over the course of the project whenever significant changes arise, such as (but not limited to): - new data - changes in consortium policies (e.g. new innovation potential, decision to file for a patent) - changes in consortium composition and external factors (e.g. new consortium members joining or old members leaving).

Pubblicazioni

5P Circulating tumour DNA (ctDNA) dynamics using a standardized multi-gene panel in advanced breast cancer patients (pts) treated with CDK4/6 inhibitors (CDK4/6i)

Autori: O. Martínez-Sáez, T. Pascual, F. Brasó-Maristany, N. Chic, B. González-Farré, E. Sanfeliu, A. Rodríguez, D. Martínez, P. Galván, A. Rodriguez Hernandez, F. Schettini, B. Conte, M.J. Vidal, B. Adamo, M. Muñoz, R. Moreno, E.M. Ciruelos, I. Faull, J. Odegaard, A. Prat
Pubblicato in: Annals of Oncology, Numero 31, 2025, Pagina/e S17, ISSN 0923-7534
Editore: Oxford University Press
DOI: 10.1016/j.annonc.2020.03.141

Linking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer

Autori: L. Angelats, L. Paré, C. Rubio-Perez, E. Sanfeliu, A. González, E. Seguí, G. Villacampa, M. Marín-Aguilera, S. Pernas, B. Conte, V. Albarrán-Fernández, O. Martínez-Sáez, Á. Aguirre, P. Galván, A. Fernandez-Martinez, S. Cobo, M. Rey, A. Martínez-Romero, B. Walbaum, F. Schettini, M. Vidal, W. Buckingham, M. Muñoz, B. Adamo, Y. Agrawal, S. Guedan, T. Pascual, J. Agudo, M. Grzelak, N. Borc
Pubblicato in: ESMO Open, Numero 10, 2025, Pagina/e 104109, ISSN 2059-7029
Editore: Elsevier BV
DOI: 10.1016/j.esmoop.2024.104109

Correlative Biomarker Analysis of Intrinsic Subtypes and Efficacy Across the MONALEESA Phase III Studies

Autori: Aleix Prat; Anwesha Chaudhury; Nadia Solovieff; Laia Paré; D. Martinez; Nuria Chic; Olga Martínez-Sáez; Fara Brasó-Maristany; Agnes Lteif; Tetiana Taran; Naveen Babbar; Fei Su
Pubblicato in: J Clin Oncol., Numero 1, 2021, ISSN 1527-7755
Editore: American Society of Clinical Oncology
DOI: 10.1200/jco.20.02977

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program

Autori: Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin B
Pubblicato in: npj Breast Cancer, Numero 10, 2024, ISSN 2374-4677
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41523-024-00637-3

Detecting significant expression patterns in single-cell and spatial transcriptomics with a flexible computational approach

Autori: Hadas Biran, Tamar Hashimshony, Tamar Lahav, Or Efrat, Yael Mandel-Gutfreund, Zohar Yakhini
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-75314-3

A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy.

Autori: Xiaoran Lai; Håkon A. Taskén; Torgeir Mo; Simon W. Funke; Arnoldo Frigessi; Arnoldo Frigessi; Marie E. Rognes; Alvaro Köhn-Luque
Pubblicato in: International Journal for Numerical Methods in Biomedical Engineering, Numero 16, 2021, Pagina/e e3542, ISSN 2040-7939
Editore: John Wiley & Sons Ltd.
DOI: 10.48550/arxiv.2105.00448

bayesynergy: flexible Bayesian modelling of synergistic interaction effects in in vitro drug combination experiments

Autori: Leiv Rønneberg, Andrea Cremaschi, Robert Hanes, Jorrit M Enserink, Manuela Zucknick
Pubblicato in: Briefings in Bioinformatics, 2021, ISSN 1467-5463
Editore: Oxford University Press
DOI: 10.1093/bib/bbab251

Nanofibrillar Cellulose Hydrogels with Anionic Surface Modifications for Modulating Macrophage Phenotype in 3D Culture

Autori: Maria Heilala, Rita Turpin, Nikolaos Pahimanolis, null Nonappa, Olli Ikkala, Juha Klefström, Pauliina M. Munne
Pubblicato in: ACS Applied Materials & Interfaces, Numero 17, 2025, Pagina/e 40082-40100, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.5c06549

Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling

Autori: Aino Peura, Rita Turpin, Ruixian Liu, Maria Heilala, Maria Salmela, July Aung, Piia Mikkonen, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Päivi Heikkilä, Päivi Palanne, Tiina Kantanen, Mikko Kilpeläinen, Outi Ukkonen, Maija Hollmén, Topi A. Tervonen, Juha Klefström, Pauliina M. Munne
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-60092-x

Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin

Autori: Topi A. Tervonen, Shishir M. Pant, Denis Belitškin, Johanna I. Englund, Katja Närhi, Caj Haglund, Panu E. Kovanen, Emmy W. Verschuren, Juha Klefström
Pubblicato in: Cancer Research, Numero 81, 2022, Pagina/e 1513-1527, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-1760

A Prognostic Model Based on PAM50 and Clinical Variables (PAM50MET) for Metastatic Hormone Receptor–positive HER2-negative Breast Cancer

Autori: Aleix Prat, Yi-Hsuan Tsai, Tomás Pascual, Laia Paré, Barbara Adamo, Maria Vidal, Fara Brasó-Maristany, Patricia Galván, Jan Christoph Brase, Vanessa Rodrik-Outmezguine, Stephen Johnston, Eva Ciruelos, Joel S. Parker
Pubblicato in: Clinical Cancer Research, Numero 26/23, 2020, Pagina/e 6141-6148, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-2793

Obesity-associated changes in molecular biology of primary breast cancer

Autori: Ha-Linh Nguyen; Tatjana Geukens; Marion Maetens; Samuel Aparicio; Ayse Bassez; Ake Borg; Jane Brock; Annegien Broeks; Carlos Caldas; Fatima Cardoso; Maxim De Schepper; Mauro Delorenzi; Caroline A. Drukker; Annuska M. Glas; Andrew R. Green; Edoardo Isnaldi; Jórunn Eyfjörð; Hazem Khout; Stian Knappskog; Savitri Krishnamurthy; Sunil R. Lakhani; Anita Langerod; John W. M. Martens; Amy E. McCart Ree
Pubblicato in: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023), Numero 19, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-2377863/v1

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

Autori: Susana García-Recio; Aatish Thennavan; Michael P. East; Joel S. Parker; Juan Miguel Cejalvo; Joseph P. Garay; Daniel P. Hollern; Xiaping He; Kevin R. Mott; Patricia Galván; Cheng Fan; Sara R. Selitsky; Alisha R. Coffey; David Marron; Fara Brasó-Maristany; Octavio Burgues; Joan Albanell; Federico Rojo; Ana Lluch; Eduardo Martínez de Dueñas; Jeffery M. Rosen; Gary L. Johnson; Lisa A. Carey; Ale
Pubblicato in: instname:, Numero 12, 2020, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci130323

Intrinsic subtypes and therapeutic decision-making in hormone receptor-positive/HER2-negative metastatic breast cancer with visceral crisis: A case report

Autori: Francesco Schettini, Elia Seguí, Benedetta Conte, Esther Sanfeliu, Blanca Gonzalez-Farre , Pedro Jares , Sergi Vidal-Sicart , Sergi Ganau , Isaac Cebrecos, Fara Brasó-Maristany , Montserrat Muñoz, Aleix Prat, Maria Vidal
Pubblicato in: Frontiers Oncol., Numero 12, 2022, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.1009352

Inferring single-cell and spatial microRNA activity from transcriptomics data

Autori: Efrat Herbst, Yael Mandel-Gutfreund, Zohar Yakhini, Hadas Biran
Pubblicato in: Communications Biology, Numero 8, 2025, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-025-07454-9

Quantification of Tumor Hypoxia through Unsupervised Modelling of Consumption and Supply Hypoxia MR Imaging in Breast Cancer

Autori: Torgeir Mo; Siri Helene Bertelsen Brandal; Alvaro Köhn-Luque; Olav Engebraaten; Vessela N. Kristensen; Thomas Fleischer; Tord Hompland; Therese Seierstad
Pubblicato in: Cancers; Volume 14; Numero 5; Pages: 1326, Numero 3, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051326

Efficient gene expression signature for a breast cancer immuno-subtype

Autori: Ben Galili, Xavier Tekpli, Vessela N. Kristensen, Zohar Yakhini
Pubblicato in: PLOS ONE, Numero 16/1, 2021, Pagina/e e0245215, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0245215

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses

Autori: Rita Turpin, Karita Peltonen, Jenna H. Rannikko, Ruixian Liu, Anita N. Kumari, Daniel Nicorici, Moon Hee Lee, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Petrus Järvinen, Kanerva Lahdensuo, Riikka Järvinen, Sara Tornberg, Tuomas Mirtti, Pia Boström, Ilkka Koskivuo, Anil Thotakura, Jeroen Pouwels, Maija Hollmén, Satu Mustjoki, Juha Klefström
Pubblicato in: OncoImmunology, Numero 14, 2025, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402x.2025.2466305

Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent

Autori: Tuğba Akman, Lisa M. Arendt, Jürgen Geisler, Vessela N. Kristensen, Arnoldo Frigessi, Alvaro Köhn-Luque
Pubblicato in: Bulletin of Mathematical Biology, Numero 86, 2024, ISSN 0092-8240
Editore: Academic Press
DOI: 10.1007/s11538-023-01253-1

Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition

Autori: Leonard Schmiester, Fara Brasó-Maristany, Blanca González-Farré, Tomás Pascual, Joaquín Gavilá, Xavier Tekpli, Jürgen Geisler, Vessela N. Kristensen, Arnoldo Frigessi, Aleix Prat, Alvaro Köhn-Luque
Pubblicato in: Clinical Cancer Research, 2024, Pagina/e OF1-OF9, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-24-0244

Author Correction: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Autori: Francesco Schettini, Nuria Chic, Fara Brasó-Maristany, Laia Paré, Tomás Pascual, Benedetta Conte, Olga Martínez-Sáez, Barbara Adamo, Maria Vidal, Esther Barnadas, Aranzazu Fernández-Martinez, Blanca González-Farre, Esther Sanfeliu, Juan Miguel Cejalvo, Giuseppe Perrone, Giovanna Sabarese, Francesca Zalfa, Vicente Peg, Roberta Fasani, Patricia Villagrasa, Joaquín Gavilá, Carlos H. Barrios,
Pubblicato in: npj Breast Cancer, Numero 9, 2023, ISSN 2374-4677
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41523-023-00538-x

EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets

Autori: Zhi Zhao, Manuela Zucknick, Tero Aittokallio
Pubblicato in: Bioinformatics Advances, Numero 2(1), 2022, Pagina/e vbac073, ISSN 2635-0041
Editore: Oxford Academic
DOI: 10.1093/bioadv/vbac073

Multivariate Bayesian structured variable selection for pharmacogenomic studies

Autori: Zhi Zhao, Marco Banterle, Alex Lewin, Manuela Zucknick
Pubblicato in: Journal of the Royal Statistical Society Series C: Applied Statistics, Numero 73, 2024, Pagina/e 420-443, ISSN 0035-9254
Editore: Blackwell Publishing Inc.
DOI: 10.1093/jrsssc/qlad102

Cell-cycle inhibition and immune microenvironment in breast cancer treated with ribociclib and letrozole or chemotherapy

Autori: Tomás Pascual, Aranzazu Fernandez-Martinez, Yash Agrawal, Adam D. Pfefferle, Nuria Chic, Fara Brasó-Maristany, Blanca Gonzàlez-Farré, Laia Paré, Guillermo Villacampa, Cristina Saura, Cristina Hernando, Montserrat Muñoz, Patricia Galván, Xavier Gonzàlez-Farré, Mafalda Oliveira, Miguel Gil-Gil, Eva Ciruelos, Patricia Villagrasa, Joaquín Gavilá, Aleix Prat, Charles M. Perou
Pubblicato in: npj Breast Cancer, Numero 10, 2024, ISSN 2374-4677
Editore: NPJ
DOI: 10.1038/s41523-024-00625-7

Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7

Autori: Aleix Prat, Nadia Solovieff, Fabrice André, Joyce O'Shaughnessy, David A. Cameron, Wolfgang Janni, Gabe S. Sonke, Yoon-Sim Yap, Denise A. Yardley, Ann H. Partridge, Astrid Thuerigen, Juan Pablo Zarate, Agnes Lteif, Fei Su, Lisa A. Carey
Pubblicato in: Clinical Cancer Research, Numero 30, 2024, Pagina/e 793-802, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-23-0561

Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer

Autori: Pauliina M, Munne; Lahja, Martikainen; Iiris, Räty; Kia, Bertula; , Nonappa; Janika, Ruuska; Hanna, Ala-Hongisto; Aino, Peura; Babette, Hollmann; Lilya, Euro; Kerim, Yavuz; Linda, Patrikainen; Maria, Salmela; Juho, Pokki; Mikko, Kivento; Juho, Väänänen; Tomi, Suomi; Liina, Nevalaita; Minna, Mutka; Panu, Kovanen; Marjut, Leidenius; Tuomo, Meretoja; Katja, Hukkinen; Outi, Monni; Jeroen, Pouwels;
Pubblicato in: Nature Communications, Numero 14, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27220-9

Multiple kernel learning for integrative consensus clustering of omic datasets

Autori: Alessandra Cabassi, Paul D W Kirk
Pubblicato in: Bioinformatics, Numero 36/18, 2020, Pagina/e 4789-4796, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btaa593

Standardized assays to monitor drug sensitivity in hematologic cancers

Autori: Pilar Ayuda-Durán, Johanne U. Hermansen, Mariaserena Giliberto, Yanping Yin, Robert Hanes, Sandra Gordon, Heikki Kuusanmäki, Andrea M. Brodersen, Aram N. Andersen, Kjetil Taskén, Krister Wennerberg, Jorrit M. Enserink, Sigrid S. Skånland
Pubblicato in: Cell Death Discovery, Numero 9, 2024, ISSN 2058-7716
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41420-023-01722-5

Tissue-specific identification of multi-omics features for pan-cancer drug response prediction

Autori: Zhi Zhao, Shixiong Wang, Manuela Zucknick, Tero Aittokallio
Pubblicato in: iScience, Numero 25(8), 2022, Pagina/e 104767, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2022.104767

HapA protease targets PAR-1/2 to modulate ERK signalling and reduce cancer cell viability

Autori: David Tena-Chaves, Inês Pontes-Gomes, José Ángel Palomeque, Eric Toh, Palwasha Baryalai, Gabor Kadler, Reto A. Schuepbach, Dorothea M. Heuberger, Antoni Hurtado, Sun Nyunt Wai
Pubblicato in: Cell Death Discovery, Numero 11, 2025, ISSN 2058-7716
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41420-025-02691-7

POIBM: batch correction of heterogeneous RNA-seq datasets through latent sample matching.

Autori: Susanna Holmström, Sampsa Hautaniemi, Antti Häkkinen
Pubblicato in: Bioinformatics, 2022, ISSN 1460-2059
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btac124

Identifying predictors of treatment response and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-negative breast cancer: the NEOENDO translational study

Autori: F. Schettini, F. Brasó-Maristany, T. Pascual, N. Lorman-Carbó, S. Nucera, M. Bergamino, P. Galván, B. Conte, E. Seguí, I. García Fructuoso, R. Gómez Bravo, A.B. Rodríguez, O. Martínez-Sáez, N. Chic, M. Vidal, B. Adamo, B. González-Farre, E. Sanfeliu, I. Cebrecos, E. Mensión, G. Oses, M. Locci, M. Mollà, S. Ganau, P. Jares, S. Vidal-Sicart, M. Muñoz, A. Prat
Pubblicato in: ESMO Open, Numero 9, 2026, Pagina/e 103989, ISSN 2059-7029
Editore: Elsevier BV
DOI: 10.1016/j.esmoop.2024.103989

Obesity-associated changes in molecular biology of primary breast cancer

Autori: Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Ree
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-39996-z

The harmonized activities of HER2–HER3 heterodimer and deacetylated FOXA1 evade hormone response by regulating FOXA1 chromatin binding

Autori: Shixiong Wang, Gemma Santacana-Font, Darek Kedra, Siv Gilfillan, David Tena-Chaves, Helga Bergholtz, Olav Engebraaten, Ole Christian Lingjaerde, Javier Gutiérrez-Fernández, Jens Henrik Norum, Therese Sørlie, Sandra López-Aviles, Antoni Hurtado
Pubblicato in: Nucleic Acids Research, Numero 53, 2025, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaf1086

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy

Autori: Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong, Bram Boeckx, Sigrid Hatse, Thomas Van Brussel, Rogier Schepers, Cedric Van Aerde, Sarah Geurs, Vincent Vandecaveye, Esther Hauben, Vincent Vander Poorten, Sara Verbandt, Katy Vandereyken, Junbin Qian, Sabine Tejpar, Thierry Voet, Paul M. Clem
Pubblicato in: Immunity, Numero 57, 2024, Pagina/e 541-558.e7, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2024.02.007

HER2DX and survival outcomes in early-stage HER2-positive breast cancer: an individual patient-level meta-analysis

Autori: Guillermo Villacampa, Tomás Pascual, Paolo Tarantino, Javier Cortés, José Perez-García, Antonio Llombart-Cussac, Pierfranco Conte, Mario Mancino, Valentina Guarneri, Maria Vittoria Dieci, Adrienne G Waks, Francesco Schettini, Fara Brasó-Maristany, Gaia Griguolo, Beatriz Alonso de Castro, Cristina Reboredo, Silvia Antolín, Coralia Bueno-Muiño, Isabel Echavarría, Sara López-Tarruella, Tatia
Pubblicato in: The Lancet Oncology, Numero 26, 2025, Pagina/e 1100-1112, ISSN 1470-2045
Editore: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(25)00276-1

Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer

Autori: Aleix Prat, Fara Brasó-Maristany, Olga Martínez-Sáez, Esther Sanfeliu, Youli Xia, Meritxell Bellet, Patricia Galván, Débora Martínez, Tomás Pascual, Mercedes Marín-Aguilera, Anna Rodríguez, Nuria Chic, Barbara Adamo, Laia Paré, Maria Vidal, Mireia Margelí, Ester Ballana, Marina Gómez-Rey, Mafalda Oliveira, Eudald Felip, Judit Matito, Rodrigo Sánchez-Bayona, Anna Suñol, Cristina Saura
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36801-9

Jellyfish: integrative visualization of spatio-temporal tumor evolution and clonal dynamics

Autori: Kari Lavikka, Altti Ilari Maarala, Jaana Oikkonen, Sampsa Hautaniemi
Pubblicato in: Bioinformatics, Numero 41, 2025, ISSN 1367-4811
Editore: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btaf091

MRI Assessment of Changes in Tumor Vascularization during Neoadjuvant Anti-Angiogenic Treatment in Locally Advanced Breast Cancer Patients

Autori: Torgeir Mo, Siri Helene Bertelsen Brandal, Oliver Marcel Geier, Olav Engebråten, Line Brennhaug Nilsen, Vessela N. Kristensen, Knut Håkon Hole, Tord Hompland, Thomas Fleischer, Therese Seierstad
Pubblicato in: Cancers, Numero 15, 2025, Pagina/e 4662, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15184662

Autori: Hussein Al‐Akhrass, Mika Pietilä, Johanna Lilja, Ella‐Maria Vesilahti, Johanna M. Anttila, Heidi M. Haikala, Pauliina M. Munne, Juha Klefström, Emilia Peuhu, Johanna Ivaska
Pubblicato in: Molecular Oncology, Numero 16, 2023, Pagina/e 116-129, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.13106

Patritumab deruxtecan in HER2-negative breast cancer: part B results of the window-of-opportunity SOLTI-1805 TOT-HER3 trial and biological determinants of early response

Autori: Fara Brasó-Maristany, Juan Manuel Ferrero-Cafiero, Claudette Falato, Olga Martínez-Sáez, Juan Miguel Cejalvo, Mireia Margelí, Pablo Tolosa, Francisco Javier Salvador-Bofill, Josefina Cruz, Blanca González-Farré, Esther Sanfeliu, Andreu Òdena, Violeta Serra, Francisco Pardo, Ana María Luna Barrera, Miriam Arumi, Juan Antonio Guerra, Guillermo Villacampa, Rodrigo Sánchez-Bayona, Eva Ciruelo
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-50056-y

Hepsin regulates TGFβ signaling via fibronectin proteolysis

Autori: Denis Belitškin, Shishir M Pant, Pauliina Munne, Ilida Suleymanova, Kati Belitškina, Hanna‐Ala Hongisto, Johanna Englund, Tiina Raatikainen, Olga Klezovitch, Valeri Vasioukhin, Shuo Li, Qingyu Wu, Outi Monni, Satu Kuure, Pirjo Laakkonen, Jeroen Pouwels, Topi A Tervonen, Juha Klefström
Pubblicato in: EMBO reports, Numero 22, 2025, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.202152532

HER2DX ERBB2 mRNA score in first-line advanced HER2-positive breast cancer treated with chemotherapy, trastuzumab, and pertuzumab

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A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

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Unexpected Durable Complete Response With Anti–PD-L1 Blockade in Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report With Host and Tumor Biomarker Analysis

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Editore: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/po.23.00051

Efficacy of anti-PD1 therapy in PD1-high mRNA tumors across multiple cancer types: results from cohort 1 and cohort 2 of the phase II SOLTI-1904 ACROPOLI trial

Autori: E. Seguí, F. Brasó-Maristany, T. Pascual, E. Sanfeliu, I. Victoria, C. Saura, C. Hierro, A. López-González, Y. Izarzugaza, E. Ciruelos, J. Gavilá, F. Racca, J.M. Cejalvo, K. Amillano, L. Paz-Ares, M. Juan, E. Felip, E. Garralda, B. González, A. Arance, J. Martín-Liberal, B. Conte, B. Walbaum, A. Indacochea, O. Castillo, P. Blasco, F. Pardo, Á. Aguirre, V. Sirenko, X. González, P. Galván,
Pubblicato in: ESMO Open, Numero 10, 2026, Pagina/e 105838, ISSN 2059-7029
Editore: Elsevier BV
DOI: 10.1016/j.esmoop.2025.105838

Unraveling the clinicopathological and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-low and HER2-0 breast cancer

Autori: F. Schettini, S. Nucera, F. Brasó-Maristany, I. De Santo, T. Pascual, M. Bergamino, P. Galván, B. Conte, E. Seguí, I. García Fructuoso, R. Gómez Bravo, P. Rivera, A.B. Rodríguez, O. Martínez-Sáez, S. Ganau, E. Sanfeliu, B. González-Farre, M.J. Vidal Losada, B. Adamo, I. Cebrecos, E. Mension, G. Oses, P. Jares, S. Vidal-Sicart, M. Mollà, M. Muñoz, A. Prat
Pubblicato in: ESMO Open, Numero 9, 2024, Pagina/e 103619, ISSN 2059-7029
Editore: ESMO OPen
DOI: 10.1016/j.esmoop.2024.103619

Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients

Autori: Pierre Van Moll, Elena Donders, Diether Lambrechts, Els Wauters
Pubblicato in: International Review of Cell and Molecular Biology, Immune Checkpoint Biology in Health and Disease, 2025, Pagina/e 181-206
Editore: Elsevier
DOI: 10.1016/bs.ircmb.2023.04.003

Permutation invariant multi-output Gaussian Processes for drug combination prediction in cancer

Autori: Leiv Rønneberg; Vidhi Lalchand; Paul D. W. Kirk
Pubblicato in: CoRR, Numero 8, 2024
Editore: Arxiv
DOI: 10.48550/arxiv.2407.00175

Gene expression before and after neoadjuvant chemotherapy or endocrine therapy and survival outcomes in hormone receptor-positive, HER2-negative breast cancer: the NEOENDO study

Autori: Francesco Schettini, Fara Brasó-Maristany, Tomás Pascual, Natàlia Lorman-Carbó, Sabrina Nucera, Milana Bergamino, Pablo Rivera, Patricia Galván, Benedetta Conte, Elia Seguí, Isabel García Fructuoso, Raquel Gómez Bravo, Ana Belén Rodríguez, Olga Martínez-Sáez, Nuria Chic, Maria Vidal, Barbara Adamo, Blanca González-Farre, Esther Sanfeliu, Isaac Cebrecos, Eduard Mensión, Gabriela Oses,
Pubblicato in: 2024
Editore: Preprint in Research Square
DOI: 10.21203/rs.3.rs-3937385/v1

Annealed variational mixtures for disease subtyping and biomarker discovery

Autori: Prevot, Emma; Toogood, Rory; Pagani, Filippo; Kirk, Paul D. W.
Pubblicato in: Numero 20, 2024
Editore: Arxiv
DOI: 10.48550/arxiv.2411.19262

CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition

Autori: Sonia Guedan, Irene Andreu-Saumell, Alba Rodriguez-Garcia, Marta Gimenez-Alejandre, Joan Castellsagué, Vanessa Mühlgrabner, Fara Brasó-Maristany, Hugo Calderon, Berta Marzal, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes Huppa
Pubblicato in: 2024
Editore: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-3415822/v1

Dose-response prediction for in-vitro drug combination datasets: a probabilistic approach

Autori: Leiv Rønneberg, Paul D.W. Kirk, Manuela Zucknick
Pubblicato in: ResearchSquare, Numero rs-1465185, 2022, Pagina/e 2529–2535, ISSN 2693-5015
Editore: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-1465185/v2

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