RESISTANCE UNDER COMBINATORIAL TREATMENT IN ER+ AND ER- BREAST CANCER.

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

MTD Assessment protocol.

For standardized MTD assessments in drug combination studies

Protocol for standardized drug combination

A protocol for standardized drug combination screening and data analysis for both cell lines and expanded tumor material from PDX models.

Modeling and simulation methods

2 scientific papers describing the modeling and simulation methods and results where clinical trials are reproduced and resistance mechanism are investigated.

Molecular analysis of pts treatments with drug combinations

A report describing the molecular analyses of treating patients with neoadjuvant therapies.

Performance of the segmentation and IG approach on images.

Trained network and report on performance of the segmentation and IG approach on images.

Quality plan & risk registry

Quality plan & risk registry, used to monitor risks and assess quality/timing of results.

Bayesian models for drug synergies

A manuscript prepared for publication in a scientific journal describing the developed Bayesian modelling framework for predicting drug synergistic effects in drug combination experiments

Data Integration Report

Data integration report Describing the data integration process from existing datasets from CTs

Biological results inferred from cancer samples.

A report describing the approach to WSIs and an evaluation of its performance, as well as biological results inferred from cancer samples.

Blueprint of breast tumor microenvironment

Blueprint of breast tumor microenvironment based on scRNA-Seq, CITE-seq and TCR-Seq.

scRNA-Seq data

Second batch of raw seq. data. Raw sequencing (scRNA-Seq, CITE-Seq, scTCR-seq) data available on the second batch of patients (36-70).

Dissemination Plan

Dissemination Plan, describing the actions foreseen for dissemination and reporting on the dissemination framework established for the project.

In-silico simulation software

An open-source software for in silico simulations of drug response for the drug treatments used in the studied clinical trials.

Data management database

Data management database with front end ready.

Bayesian modelling framework for predicting drug synergies

An open-source software implementation of the developed Bayesian modelling framework for predicting drug synergistic effects in drug combination experiments

Data management plan

The DMP needs to be updated over the course of the project whenever significant changes arise, such as (but not limited to): - new data - changes in consortium policies (e.g. new innovation potential, decision to file for a patent) - changes in consortium composition and external factors (e.g. new consortium members joining or old members leaving).

Publikacje

5P Circulating tumour DNA (ctDNA) dynamics using a standardized multi-gene panel in advanced breast cancer patients (pts) treated with CDK4/6 inhibitors (CDK4/6i)

Autorzy: O. Martínez-Sáez, T. Pascual, F. Brasó-Maristany, N. Chic, B. González-Farré, E. Sanfeliu, A. Rodríguez, D. Martínez, P. Galván, A. Rodriguez Hernandez, F. Schettini, B. Conte, M.J. Vidal, B. Adamo, M. Muñoz, R. Moreno, E.M. Ciruelos, I. Faull, J. Odegaard, A. Prat
Opublikowane w: Annals of Oncology, Numer 31, 2025, Strona(/y) S17, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1016/j.annonc.2020.03.141

Linking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer

Autorzy: L. Angelats, L. Paré, C. Rubio-Perez, E. Sanfeliu, A. González, E. Seguí, G. Villacampa, M. Marín-Aguilera, S. Pernas, B. Conte, V. Albarrán-Fernández, O. Martínez-Sáez, Á. Aguirre, P. Galván, A. Fernandez-Martinez, S. Cobo, M. Rey, A. Martínez-Romero, B. Walbaum, F. Schettini, M. Vidal, W. Buckingham, M. Muñoz, B. Adamo, Y. Agrawal, S. Guedan, T. Pascual, J. Agudo, M. Grzelak, N. Borc
Opublikowane w: ESMO Open, Numer 10, 2025, Strona(/y) 104109, ISSN 2059-7029
Wydawca: Elsevier BV
DOI: 10.1016/j.esmoop.2024.104109

Correlative Biomarker Analysis of Intrinsic Subtypes and Efficacy Across the MONALEESA Phase III Studies

Autorzy: Aleix Prat; Anwesha Chaudhury; Nadia Solovieff; Laia Paré; D. Martinez; Nuria Chic; Olga Martínez-Sáez; Fara Brasó-Maristany; Agnes Lteif; Tetiana Taran; Naveen Babbar; Fei Su
Opublikowane w: J Clin Oncol., Numer 1, 2021, ISSN 1527-7755
Wydawca: American Society of Clinical Oncology
DOI: 10.1200/jco.20.02977

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program

Autorzy: Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin B
Opublikowane w: npj Breast Cancer, Numer 10, 2024, ISSN 2374-4677
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41523-024-00637-3

Detecting significant expression patterns in single-cell and spatial transcriptomics with a flexible computational approach

Autorzy: Hadas Biran, Tamar Hashimshony, Tamar Lahav, Or Efrat, Yael Mandel-Gutfreund, Zohar Yakhini
Opublikowane w: Scientific Reports, Numer 14, 2024, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-024-75314-3

A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy.

Autorzy: Xiaoran Lai; Håkon A. Taskén; Torgeir Mo; Simon W. Funke; Arnoldo Frigessi; Arnoldo Frigessi; Marie E. Rognes; Alvaro Köhn-Luque
Opublikowane w: International Journal for Numerical Methods in Biomedical Engineering, Numer 16, 2021, Strona(/y) e3542, ISSN 2040-7939
Wydawca: John Wiley & Sons Ltd.
DOI: 10.48550/arxiv.2105.00448

bayesynergy: flexible Bayesian modelling of synergistic interaction effects in in vitro drug combination experiments

Autorzy: Leiv Rønneberg, Andrea Cremaschi, Robert Hanes, Jorrit M Enserink, Manuela Zucknick
Opublikowane w: Briefings in Bioinformatics, 2021, ISSN 1467-5463
Wydawca: Oxford University Press
DOI: 10.1093/bib/bbab251

Nanofibrillar Cellulose Hydrogels with Anionic Surface Modifications for Modulating Macrophage Phenotype in 3D Culture

Autorzy: Maria Heilala, Rita Turpin, Nikolaos Pahimanolis, null Nonappa, Olli Ikkala, Juha Klefström, Pauliina M. Munne
Opublikowane w: ACS Applied Materials & Interfaces, Numer 17, 2025, Strona(/y) 40082-40100, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.5c06549

Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling

Autorzy: Aino Peura, Rita Turpin, Ruixian Liu, Maria Heilala, Maria Salmela, July Aung, Piia Mikkonen, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Päivi Heikkilä, Päivi Palanne, Tiina Kantanen, Mikko Kilpeläinen, Outi Ukkonen, Maija Hollmén, Topi A. Tervonen, Juha Klefström, Pauliina M. Munne
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-60092-x

Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin

Autorzy: Topi A. Tervonen, Shishir M. Pant, Denis Belitškin, Johanna I. Englund, Katja Närhi, Caj Haglund, Panu E. Kovanen, Emmy W. Verschuren, Juha Klefström
Opublikowane w: Cancer Research, Numer 81, 2022, Strona(/y) 1513-1527, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-1760

A Prognostic Model Based on PAM50 and Clinical Variables (PAM50MET) for Metastatic Hormone Receptor–positive HER2-negative Breast Cancer

Autorzy: Aleix Prat, Yi-Hsuan Tsai, Tomás Pascual, Laia Paré, Barbara Adamo, Maria Vidal, Fara Brasó-Maristany, Patricia Galván, Jan Christoph Brase, Vanessa Rodrik-Outmezguine, Stephen Johnston, Eva Ciruelos, Joel S. Parker
Opublikowane w: Clinical Cancer Research, Numer 26/23, 2020, Strona(/y) 6141-6148, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-2793

Obesity-associated changes in molecular biology of primary breast cancer

Autorzy: Ha-Linh Nguyen; Tatjana Geukens; Marion Maetens; Samuel Aparicio; Ayse Bassez; Ake Borg; Jane Brock; Annegien Broeks; Carlos Caldas; Fatima Cardoso; Maxim De Schepper; Mauro Delorenzi; Caroline A. Drukker; Annuska M. Glas; Andrew R. Green; Edoardo Isnaldi; Jórunn Eyfjörð; Hazem Khout; Stian Knappskog; Savitri Krishnamurthy; Sunil R. Lakhani; Anita Langerod; John W. M. Martens; Amy E. McCart Ree
Opublikowane w: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023), Numer 19, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.21203/rs.3.rs-2377863/v1

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

Autorzy: Susana García-Recio; Aatish Thennavan; Michael P. East; Joel S. Parker; Juan Miguel Cejalvo; Joseph P. Garay; Daniel P. Hollern; Xiaping He; Kevin R. Mott; Patricia Galván; Cheng Fan; Sara R. Selitsky; Alisha R. Coffey; David Marron; Fara Brasó-Maristany; Octavio Burgues; Joan Albanell; Federico Rojo; Ana Lluch; Eduardo Martínez de Dueñas; Jeffery M. Rosen; Gary L. Johnson; Lisa A. Carey; Ale
Opublikowane w: instname:, Numer 12, 2020, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci130323

Intrinsic subtypes and therapeutic decision-making in hormone receptor-positive/HER2-negative metastatic breast cancer with visceral crisis: A case report

Autorzy: Francesco Schettini, Elia Seguí, Benedetta Conte, Esther Sanfeliu, Blanca Gonzalez-Farre , Pedro Jares , Sergi Vidal-Sicart , Sergi Ganau , Isaac Cebrecos, Fara Brasó-Maristany , Montserrat Muñoz, Aleix Prat, Maria Vidal
Opublikowane w: Frontiers Oncol., Numer 12, 2022, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.1009352

Inferring single-cell and spatial microRNA activity from transcriptomics data

Autorzy: Efrat Herbst, Yael Mandel-Gutfreund, Zohar Yakhini, Hadas Biran
Opublikowane w: Communications Biology, Numer 8, 2025, ISSN 2399-3642
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s42003-025-07454-9

Quantification of Tumor Hypoxia through Unsupervised Modelling of Consumption and Supply Hypoxia MR Imaging in Breast Cancer

Autorzy: Torgeir Mo; Siri Helene Bertelsen Brandal; Alvaro Köhn-Luque; Olav Engebraaten; Vessela N. Kristensen; Thomas Fleischer; Tord Hompland; Therese Seierstad
Opublikowane w: Cancers; Volume 14; Numer 5; Pages: 1326, Numer 3, 2022, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051326

Efficient gene expression signature for a breast cancer immuno-subtype

Autorzy: Ben Galili, Xavier Tekpli, Vessela N. Kristensen, Zohar Yakhini
Opublikowane w: PLOS ONE, Numer 16/1, 2021, Strona(/y) e0245215, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0245215

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses

Autorzy: Rita Turpin, Karita Peltonen, Jenna H. Rannikko, Ruixian Liu, Anita N. Kumari, Daniel Nicorici, Moon Hee Lee, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Petrus Järvinen, Kanerva Lahdensuo, Riikka Järvinen, Sara Tornberg, Tuomas Mirtti, Pia Boström, Ilkka Koskivuo, Anil Thotakura, Jeroen Pouwels, Maija Hollmén, Satu Mustjoki, Juha Klefström
Opublikowane w: OncoImmunology, Numer 14, 2025, ISSN 2162-402X
Wydawca: Informa UK Limited
DOI: 10.1080/2162402x.2025.2466305

Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent

Autorzy: Tuğba Akman, Lisa M. Arendt, Jürgen Geisler, Vessela N. Kristensen, Arnoldo Frigessi, Alvaro Köhn-Luque
Opublikowane w: Bulletin of Mathematical Biology, Numer 86, 2024, ISSN 0092-8240
Wydawca: Academic Press
DOI: 10.1007/s11538-023-01253-1

Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition

Autorzy: Leonard Schmiester, Fara Brasó-Maristany, Blanca González-Farré, Tomás Pascual, Joaquín Gavilá, Xavier Tekpli, Jürgen Geisler, Vessela N. Kristensen, Arnoldo Frigessi, Aleix Prat, Alvaro Köhn-Luque
Opublikowane w: Clinical Cancer Research, 2024, Strona(/y) OF1-OF9, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-24-0244

Author Correction: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Autorzy: Francesco Schettini, Nuria Chic, Fara Brasó-Maristany, Laia Paré, Tomás Pascual, Benedetta Conte, Olga Martínez-Sáez, Barbara Adamo, Maria Vidal, Esther Barnadas, Aranzazu Fernández-Martinez, Blanca González-Farre, Esther Sanfeliu, Juan Miguel Cejalvo, Giuseppe Perrone, Giovanna Sabarese, Francesca Zalfa, Vicente Peg, Roberta Fasani, Patricia Villagrasa, Joaquín Gavilá, Carlos H. Barrios,
Opublikowane w: npj Breast Cancer, Numer 9, 2023, ISSN 2374-4677
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41523-023-00538-x

EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets

Autorzy: Zhi Zhao, Manuela Zucknick, Tero Aittokallio
Opublikowane w: Bioinformatics Advances, Numer 2(1), 2022, Strona(/y) vbac073, ISSN 2635-0041
Wydawca: Oxford Academic
DOI: 10.1093/bioadv/vbac073

Multivariate Bayesian structured variable selection for pharmacogenomic studies

Autorzy: Zhi Zhao, Marco Banterle, Alex Lewin, Manuela Zucknick
Opublikowane w: Journal of the Royal Statistical Society Series C: Applied Statistics, Numer 73, 2024, Strona(/y) 420-443, ISSN 0035-9254
Wydawca: Blackwell Publishing Inc.
DOI: 10.1093/jrsssc/qlad102

Cell-cycle inhibition and immune microenvironment in breast cancer treated with ribociclib and letrozole or chemotherapy

Autorzy: Tomás Pascual, Aranzazu Fernandez-Martinez, Yash Agrawal, Adam D. Pfefferle, Nuria Chic, Fara Brasó-Maristany, Blanca Gonzàlez-Farré, Laia Paré, Guillermo Villacampa, Cristina Saura, Cristina Hernando, Montserrat Muñoz, Patricia Galván, Xavier Gonzàlez-Farré, Mafalda Oliveira, Miguel Gil-Gil, Eva Ciruelos, Patricia Villagrasa, Joaquín Gavilá, Aleix Prat, Charles M. Perou
Opublikowane w: npj Breast Cancer, Numer 10, 2024, ISSN 2374-4677
Wydawca: NPJ
DOI: 10.1038/s41523-024-00625-7

Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7

Autorzy: Aleix Prat, Nadia Solovieff, Fabrice André, Joyce O'Shaughnessy, David A. Cameron, Wolfgang Janni, Gabe S. Sonke, Yoon-Sim Yap, Denise A. Yardley, Ann H. Partridge, Astrid Thuerigen, Juan Pablo Zarate, Agnes Lteif, Fei Su, Lisa A. Carey
Opublikowane w: Clinical Cancer Research, Numer 30, 2024, Strona(/y) 793-802, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-23-0561

Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer

Autorzy: Pauliina M, Munne; Lahja, Martikainen; Iiris, Räty; Kia, Bertula; , Nonappa; Janika, Ruuska; Hanna, Ala-Hongisto; Aino, Peura; Babette, Hollmann; Lilya, Euro; Kerim, Yavuz; Linda, Patrikainen; Maria, Salmela; Juho, Pokki; Mikko, Kivento; Juho, Väänänen; Tomi, Suomi; Liina, Nevalaita; Minna, Mutka; Panu, Kovanen; Marjut, Leidenius; Tuomo, Meretoja; Katja, Hukkinen; Outi, Monni; Jeroen, Pouwels;
Opublikowane w: Nature Communications, Numer 14, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-27220-9

Multiple kernel learning for integrative consensus clustering of omic datasets

Autorzy: Alessandra Cabassi, Paul D W Kirk
Opublikowane w: Bioinformatics, Numer 36/18, 2020, Strona(/y) 4789-4796, ISSN 1367-4803
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btaa593

Standardized assays to monitor drug sensitivity in hematologic cancers

Autorzy: Pilar Ayuda-Durán, Johanne U. Hermansen, Mariaserena Giliberto, Yanping Yin, Robert Hanes, Sandra Gordon, Heikki Kuusanmäki, Andrea M. Brodersen, Aram N. Andersen, Kjetil Taskén, Krister Wennerberg, Jorrit M. Enserink, Sigrid S. Skånland
Opublikowane w: Cell Death Discovery, Numer 9, 2024, ISSN 2058-7716
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41420-023-01722-5

Tissue-specific identification of multi-omics features for pan-cancer drug response prediction

Autorzy: Zhi Zhao, Shixiong Wang, Manuela Zucknick, Tero Aittokallio
Opublikowane w: iScience, Numer 25(8), 2022, Strona(/y) 104767, ISSN 2589-0042
Wydawca: Cell Press
DOI: 10.1016/j.isci.2022.104767

HapA protease targets PAR-1/2 to modulate ERK signalling and reduce cancer cell viability

Autorzy: David Tena-Chaves, Inês Pontes-Gomes, José Ángel Palomeque, Eric Toh, Palwasha Baryalai, Gabor Kadler, Reto A. Schuepbach, Dorothea M. Heuberger, Antoni Hurtado, Sun Nyunt Wai
Opublikowane w: Cell Death Discovery, Numer 11, 2025, ISSN 2058-7716
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41420-025-02691-7

POIBM: batch correction of heterogeneous RNA-seq datasets through latent sample matching.

Autorzy: Susanna Holmström, Sampsa Hautaniemi, Antti Häkkinen
Opublikowane w: Bioinformatics, 2022, ISSN 1460-2059
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btac124

Identifying predictors of treatment response and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-negative breast cancer: the NEOENDO translational study

Autorzy: F. Schettini, F. Brasó-Maristany, T. Pascual, N. Lorman-Carbó, S. Nucera, M. Bergamino, P. Galván, B. Conte, E. Seguí, I. García Fructuoso, R. Gómez Bravo, A.B. Rodríguez, O. Martínez-Sáez, N. Chic, M. Vidal, B. Adamo, B. González-Farre, E. Sanfeliu, I. Cebrecos, E. Mensión, G. Oses, M. Locci, M. Mollà, S. Ganau, P. Jares, S. Vidal-Sicart, M. Muñoz, A. Prat
Opublikowane w: ESMO Open, Numer 9, 2026, Strona(/y) 103989, ISSN 2059-7029
Wydawca: Elsevier BV
DOI: 10.1016/j.esmoop.2024.103989

Obesity-associated changes in molecular biology of primary breast cancer

Autorzy: Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Ree
Opublikowane w: Nature Communications, Numer 14, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-39996-z

The harmonized activities of HER2–HER3 heterodimer and deacetylated FOXA1 evade hormone response by regulating FOXA1 chromatin binding

Autorzy: Shixiong Wang, Gemma Santacana-Font, Darek Kedra, Siv Gilfillan, David Tena-Chaves, Helga Bergholtz, Olav Engebraaten, Ole Christian Lingjaerde, Javier Gutiérrez-Fernández, Jens Henrik Norum, Therese Sørlie, Sandra López-Aviles, Antoni Hurtado
Opublikowane w: Nucleic Acids Research, Numer 53, 2025, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkaf1086

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy

Autorzy: Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong, Bram Boeckx, Sigrid Hatse, Thomas Van Brussel, Rogier Schepers, Cedric Van Aerde, Sarah Geurs, Vincent Vandecaveye, Esther Hauben, Vincent Vander Poorten, Sara Verbandt, Katy Vandereyken, Junbin Qian, Sabine Tejpar, Thierry Voet, Paul M. Clem
Opublikowane w: Immunity, Numer 57, 2024, Strona(/y) 541-558.e7, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2024.02.007

HER2DX and survival outcomes in early-stage HER2-positive breast cancer: an individual patient-level meta-analysis

Autorzy: Guillermo Villacampa, Tomás Pascual, Paolo Tarantino, Javier Cortés, José Perez-García, Antonio Llombart-Cussac, Pierfranco Conte, Mario Mancino, Valentina Guarneri, Maria Vittoria Dieci, Adrienne G Waks, Francesco Schettini, Fara Brasó-Maristany, Gaia Griguolo, Beatriz Alonso de Castro, Cristina Reboredo, Silvia Antolín, Coralia Bueno-Muiño, Isabel Echavarría, Sara López-Tarruella, Tatia
Opublikowane w: The Lancet Oncology, Numer 26, 2025, Strona(/y) 1100-1112, ISSN 1470-2045
Wydawca: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(25)00276-1

Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer

Autorzy: Aleix Prat, Fara Brasó-Maristany, Olga Martínez-Sáez, Esther Sanfeliu, Youli Xia, Meritxell Bellet, Patricia Galván, Débora Martínez, Tomás Pascual, Mercedes Marín-Aguilera, Anna Rodríguez, Nuria Chic, Barbara Adamo, Laia Paré, Maria Vidal, Mireia Margelí, Ester Ballana, Marina Gómez-Rey, Mafalda Oliveira, Eudald Felip, Judit Matito, Rodrigo Sánchez-Bayona, Anna Suñol, Cristina Saura
Opublikowane w: Nature Communications, Numer 14, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-36801-9

Jellyfish: integrative visualization of spatio-temporal tumor evolution and clonal dynamics

Autorzy: Kari Lavikka, Altti Ilari Maarala, Jaana Oikkonen, Sampsa Hautaniemi
Opublikowane w: Bioinformatics, Numer 41, 2025, ISSN 1367-4811
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btaf091

MRI Assessment of Changes in Tumor Vascularization during Neoadjuvant Anti-Angiogenic Treatment in Locally Advanced Breast Cancer Patients

Autorzy: Torgeir Mo, Siri Helene Bertelsen Brandal, Oliver Marcel Geier, Olav Engebråten, Line Brennhaug Nilsen, Vessela N. Kristensen, Knut Håkon Hole, Tord Hompland, Thomas Fleischer, Therese Seierstad
Opublikowane w: Cancers, Numer 15, 2025, Strona(/y) 4662, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15184662

Autorzy: Hussein Al‐Akhrass, Mika Pietilä, Johanna Lilja, Ella‐Maria Vesilahti, Johanna M. Anttila, Heidi M. Haikala, Pauliina M. Munne, Juha Klefström, Emilia Peuhu, Johanna Ivaska
Opublikowane w: Molecular Oncology, Numer 16, 2023, Strona(/y) 116-129, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.1002/1878-0261.13106

Patritumab deruxtecan in HER2-negative breast cancer: part B results of the window-of-opportunity SOLTI-1805 TOT-HER3 trial and biological determinants of early response

Autorzy: Fara Brasó-Maristany, Juan Manuel Ferrero-Cafiero, Claudette Falato, Olga Martínez-Sáez, Juan Miguel Cejalvo, Mireia Margelí, Pablo Tolosa, Francisco Javier Salvador-Bofill, Josefina Cruz, Blanca González-Farré, Esther Sanfeliu, Andreu Òdena, Violeta Serra, Francisco Pardo, Ana María Luna Barrera, Miriam Arumi, Juan Antonio Guerra, Guillermo Villacampa, Rodrigo Sánchez-Bayona, Eva Ciruelo
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
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Hepsin regulates TGFβ signaling via fibronectin proteolysis

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Hepsin promotes breast tumor growth signaling via the <scp>TGFβ‐EGFR</scp> axis

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Opublikowane w: Molecular Oncology, Numer 18, 2024, Strona(/y) 547-561, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.1002/1878-0261.13545

Unexpected Durable Complete Response With Anti–PD-L1 Blockade in Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report With Host and Tumor Biomarker Analysis

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Wydawca: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/po.23.00051

Efficacy of anti-PD1 therapy in PD1-high mRNA tumors across multiple cancer types: results from cohort 1 and cohort 2 of the phase II SOLTI-1904 ACROPOLI trial

Autorzy: E. Seguí, F. Brasó-Maristany, T. Pascual, E. Sanfeliu, I. Victoria, C. Saura, C. Hierro, A. López-González, Y. Izarzugaza, E. Ciruelos, J. Gavilá, F. Racca, J.M. Cejalvo, K. Amillano, L. Paz-Ares, M. Juan, E. Felip, E. Garralda, B. González, A. Arance, J. Martín-Liberal, B. Conte, B. Walbaum, A. Indacochea, O. Castillo, P. Blasco, F. Pardo, Á. Aguirre, V. Sirenko, X. González, P. Galván,
Opublikowane w: ESMO Open, Numer 10, 2026, Strona(/y) 105838, ISSN 2059-7029
Wydawca: Elsevier BV
DOI: 10.1016/j.esmoop.2025.105838

Unraveling the clinicopathological and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-low and HER2-0 breast cancer

Autorzy: F. Schettini, S. Nucera, F. Brasó-Maristany, I. De Santo, T. Pascual, M. Bergamino, P. Galván, B. Conte, E. Seguí, I. García Fructuoso, R. Gómez Bravo, P. Rivera, A.B. Rodríguez, O. Martínez-Sáez, S. Ganau, E. Sanfeliu, B. González-Farre, M.J. Vidal Losada, B. Adamo, I. Cebrecos, E. Mension, G. Oses, P. Jares, S. Vidal-Sicart, M. Mollà, M. Muñoz, A. Prat
Opublikowane w: ESMO Open, Numer 9, 2024, Strona(/y) 103619, ISSN 2059-7029
Wydawca: ESMO OPen
DOI: 10.1016/j.esmoop.2024.103619

Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients

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Opublikowane w: International Review of Cell and Molecular Biology, Immune Checkpoint Biology in Health and Disease, 2025, Strona(/y) 181-206
Wydawca: Elsevier
DOI: 10.1016/bs.ircmb.2023.04.003

Permutation invariant multi-output Gaussian Processes for drug combination prediction in cancer

Autorzy: Leiv Rønneberg; Vidhi Lalchand; Paul D. W. Kirk
Opublikowane w: CoRR, Numer 8, 2024
Wydawca: Arxiv
DOI: 10.48550/arxiv.2407.00175

Gene expression before and after neoadjuvant chemotherapy or endocrine therapy and survival outcomes in hormone receptor-positive, HER2-negative breast cancer: the NEOENDO study

Autorzy: Francesco Schettini, Fara Brasó-Maristany, Tomás Pascual, Natàlia Lorman-Carbó, Sabrina Nucera, Milana Bergamino, Pablo Rivera, Patricia Galván, Benedetta Conte, Elia Seguí, Isabel García Fructuoso, Raquel Gómez Bravo, Ana Belén Rodríguez, Olga Martínez-Sáez, Nuria Chic, Maria Vidal, Barbara Adamo, Blanca González-Farre, Esther Sanfeliu, Isaac Cebrecos, Eduard Mensión, Gabriela Oses,
Opublikowane w: 2024
Wydawca: Preprint in Research Square
DOI: 10.21203/rs.3.rs-3937385/v1

Annealed variational mixtures for disease subtyping and biomarker discovery

Autorzy: Prevot, Emma; Toogood, Rory; Pagani, Filippo; Kirk, Paul D. W.
Opublikowane w: Numer 20, 2024
Wydawca: Arxiv
DOI: 10.48550/arxiv.2411.19262

CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition

Autorzy: Sonia Guedan, Irene Andreu-Saumell, Alba Rodriguez-Garcia, Marta Gimenez-Alejandre, Joan Castellsagué, Vanessa Mühlgrabner, Fara Brasó-Maristany, Hugo Calderon, Berta Marzal, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes Huppa
Opublikowane w: 2024
Wydawca: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-3415822/v1

Dose-response prediction for in-vitro drug combination datasets: a probabilistic approach

Autorzy: Leiv Rønneberg, Paul D.W. Kirk, Manuela Zucknick
Opublikowane w: ResearchSquare, Numer rs-1465185, 2022, Strona(/y) 2529–2535, ISSN 2693-5015
Wydawca: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-1465185/v2

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