RESISTANCE UNDER COMBINATORIAL TREATMENT IN ER+ AND ER- BREAST CANCER.

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

MTD Assessment protocol.

For standardized MTD assessments in drug combination studies

Protocol for standardized drug combination

A protocol for standardized drug combination screening and data analysis for both cell lines and expanded tumor material from PDX models.

Modeling and simulation methods

2 scientific papers describing the modeling and simulation methods and results where clinical trials are reproduced and resistance mechanism are investigated.

Molecular analysis of pts treatments with drug combinations

A report describing the molecular analyses of treating patients with neoadjuvant therapies.

Performance of the segmentation and IG approach on images.

Trained network and report on performance of the segmentation and IG approach on images.

Quality plan & risk registry

Quality plan & risk registry, used to monitor risks and assess quality/timing of results.

Bayesian models for drug synergies

A manuscript prepared for publication in a scientific journal describing the developed Bayesian modelling framework for predicting drug synergistic effects in drug combination experiments

Data Integration Report

Data integration report Describing the data integration process from existing datasets from CTs

Biological results inferred from cancer samples.

A report describing the approach to WSIs and an evaluation of its performance, as well as biological results inferred from cancer samples.

Blueprint of breast tumor microenvironment

Blueprint of breast tumor microenvironment based on scRNA-Seq, CITE-seq and TCR-Seq.

scRNA-Seq data

Second batch of raw seq. data. Raw sequencing (scRNA-Seq, CITE-Seq, scTCR-seq) data available on the second batch of patients (36-70).

Dissemination Plan

Dissemination Plan, describing the actions foreseen for dissemination and reporting on the dissemination framework established for the project.

In-silico simulation software

An open-source software for in silico simulations of drug response for the drug treatments used in the studied clinical trials.

Data management database

Data management database with front end ready.

Bayesian modelling framework for predicting drug synergies

An open-source software implementation of the developed Bayesian modelling framework for predicting drug synergistic effects in drug combination experiments

Data management plan

The DMP needs to be updated over the course of the project whenever significant changes arise, such as (but not limited to): - new data - changes in consortium policies (e.g. new innovation potential, decision to file for a patent) - changes in consortium composition and external factors (e.g. new consortium members joining or old members leaving).

Publicaciones

5P Circulating tumour DNA (ctDNA) dynamics using a standardized multi-gene panel in advanced breast cancer patients (pts) treated with CDK4/6 inhibitors (CDK4/6i)

Autores: O. Martínez-Sáez, T. Pascual, F. Brasó-Maristany, N. Chic, B. González-Farré, E. Sanfeliu, A. Rodríguez, D. Martínez, P. Galván, A. Rodriguez Hernandez, F. Schettini, B. Conte, M.J. Vidal, B. Adamo, M. Muñoz, R. Moreno, E.M. Ciruelos, I. Faull, J. Odegaard, A. Prat
Publicado en: Annals of Oncology, Edición 31, 2025, Página(s) S17, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1016/j.annonc.2020.03.141

Linking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer

Autores: L. Angelats, L. Paré, C. Rubio-Perez, E. Sanfeliu, A. González, E. Seguí, G. Villacampa, M. Marín-Aguilera, S. Pernas, B. Conte, V. Albarrán-Fernández, O. Martínez-Sáez, Á. Aguirre, P. Galván, A. Fernandez-Martinez, S. Cobo, M. Rey, A. Martínez-Romero, B. Walbaum, F. Schettini, M. Vidal, W. Buckingham, M. Muñoz, B. Adamo, Y. Agrawal, S. Guedan, T. Pascual, J. Agudo, M. Grzelak, N. Borc
Publicado en: ESMO Open, Edición 10, 2025, Página(s) 104109, ISSN 2059-7029
Editor: Elsevier BV
DOI: 10.1016/j.esmoop.2024.104109

Correlative Biomarker Analysis of Intrinsic Subtypes and Efficacy Across the MONALEESA Phase III Studies

Autores: Aleix Prat; Anwesha Chaudhury; Nadia Solovieff; Laia Paré; D. Martinez; Nuria Chic; Olga Martínez-Sáez; Fara Brasó-Maristany; Agnes Lteif; Tetiana Taran; Naveen Babbar; Fei Su
Publicado en: J Clin Oncol., Edición 1, 2021, ISSN 1527-7755
Editor: American Society of Clinical Oncology
DOI: 10.1200/jco.20.02977

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program

Autores: Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin B
Publicado en: npj Breast Cancer, Edición 10, 2024, ISSN 2374-4677
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41523-024-00637-3

Detecting significant expression patterns in single-cell and spatial transcriptomics with a flexible computational approach

Autores: Hadas Biran, Tamar Hashimshony, Tamar Lahav, Or Efrat, Yael Mandel-Gutfreund, Zohar Yakhini
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-75314-3

A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy.

Autores: Xiaoran Lai; Håkon A. Taskén; Torgeir Mo; Simon W. Funke; Arnoldo Frigessi; Arnoldo Frigessi; Marie E. Rognes; Alvaro Köhn-Luque
Publicado en: International Journal for Numerical Methods in Biomedical Engineering, Edición 16, 2021, Página(s) e3542, ISSN 2040-7939
Editor: John Wiley & Sons Ltd.
DOI: 10.48550/arxiv.2105.00448

bayesynergy: flexible Bayesian modelling of synergistic interaction effects in in vitro drug combination experiments

Autores: Leiv Rønneberg, Andrea Cremaschi, Robert Hanes, Jorrit M Enserink, Manuela Zucknick
Publicado en: Briefings in Bioinformatics, 2021, ISSN 1467-5463
Editor: Oxford University Press
DOI: 10.1093/bib/bbab251

Nanofibrillar Cellulose Hydrogels with Anionic Surface Modifications for Modulating Macrophage Phenotype in 3D Culture

Autores: Maria Heilala, Rita Turpin, Nikolaos Pahimanolis, null Nonappa, Olli Ikkala, Juha Klefström, Pauliina M. Munne
Publicado en: ACS Applied Materials & Interfaces, Edición 17, 2025, Página(s) 40082-40100, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.5c06549

Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling

Autores: Aino Peura, Rita Turpin, Ruixian Liu, Maria Heilala, Maria Salmela, July Aung, Piia Mikkonen, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Päivi Heikkilä, Päivi Palanne, Tiina Kantanen, Mikko Kilpeläinen, Outi Ukkonen, Maija Hollmén, Topi A. Tervonen, Juha Klefström, Pauliina M. Munne
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-60092-x

Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin

Autores: Topi A. Tervonen, Shishir M. Pant, Denis Belitškin, Johanna I. Englund, Katja Närhi, Caj Haglund, Panu E. Kovanen, Emmy W. Verschuren, Juha Klefström
Publicado en: Cancer Research, Edición 81, 2022, Página(s) 1513-1527, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-1760

A Prognostic Model Based on PAM50 and Clinical Variables (PAM50MET) for Metastatic Hormone Receptor–positive HER2-negative Breast Cancer

Autores: Aleix Prat, Yi-Hsuan Tsai, Tomás Pascual, Laia Paré, Barbara Adamo, Maria Vidal, Fara Brasó-Maristany, Patricia Galván, Jan Christoph Brase, Vanessa Rodrik-Outmezguine, Stephen Johnston, Eva Ciruelos, Joel S. Parker
Publicado en: Clinical Cancer Research, Edición 26/23, 2020, Página(s) 6141-6148, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-2793

Obesity-associated changes in molecular biology of primary breast cancer

Autores: Ha-Linh Nguyen; Tatjana Geukens; Marion Maetens; Samuel Aparicio; Ayse Bassez; Ake Borg; Jane Brock; Annegien Broeks; Carlos Caldas; Fatima Cardoso; Maxim De Schepper; Mauro Delorenzi; Caroline A. Drukker; Annuska M. Glas; Andrew R. Green; Edoardo Isnaldi; Jórunn Eyfjörð; Hazem Khout; Stian Knappskog; Savitri Krishnamurthy; Sunil R. Lakhani; Anita Langerod; John W. M. Martens; Amy E. McCart Ree
Publicado en: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023), Edición 19, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.21203/rs.3.rs-2377863/v1

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

Autores: Susana García-Recio; Aatish Thennavan; Michael P. East; Joel S. Parker; Juan Miguel Cejalvo; Joseph P. Garay; Daniel P. Hollern; Xiaping He; Kevin R. Mott; Patricia Galván; Cheng Fan; Sara R. Selitsky; Alisha R. Coffey; David Marron; Fara Brasó-Maristany; Octavio Burgues; Joan Albanell; Federico Rojo; Ana Lluch; Eduardo Martínez de Dueñas; Jeffery M. Rosen; Gary L. Johnson; Lisa A. Carey; Ale
Publicado en: instname:, Edición 12, 2020, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci130323

Intrinsic subtypes and therapeutic decision-making in hormone receptor-positive/HER2-negative metastatic breast cancer with visceral crisis: A case report

Autores: Francesco Schettini, Elia Seguí, Benedetta Conte, Esther Sanfeliu, Blanca Gonzalez-Farre , Pedro Jares , Sergi Vidal-Sicart , Sergi Ganau , Isaac Cebrecos, Fara Brasó-Maristany , Montserrat Muñoz, Aleix Prat, Maria Vidal
Publicado en: Frontiers Oncol., Edición 12, 2022, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.1009352

Inferring single-cell and spatial microRNA activity from transcriptomics data

Autores: Efrat Herbst, Yael Mandel-Gutfreund, Zohar Yakhini, Hadas Biran
Publicado en: Communications Biology, Edición 8, 2025, ISSN 2399-3642
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42003-025-07454-9

Quantification of Tumor Hypoxia through Unsupervised Modelling of Consumption and Supply Hypoxia MR Imaging in Breast Cancer

Autores: Torgeir Mo; Siri Helene Bertelsen Brandal; Alvaro Köhn-Luque; Olav Engebraaten; Vessela N. Kristensen; Thomas Fleischer; Tord Hompland; Therese Seierstad
Publicado en: Cancers; Volume 14; Edición 5; Pages: 1326, Edición 3, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14051326

Efficient gene expression signature for a breast cancer immuno-subtype

Autores: Ben Galili, Xavier Tekpli, Vessela N. Kristensen, Zohar Yakhini
Publicado en: PLOS ONE, Edición 16/1, 2021, Página(s) e0245215, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0245215

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses

Autores: Rita Turpin, Karita Peltonen, Jenna H. Rannikko, Ruixian Liu, Anita N. Kumari, Daniel Nicorici, Moon Hee Lee, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Petrus Järvinen, Kanerva Lahdensuo, Riikka Järvinen, Sara Tornberg, Tuomas Mirtti, Pia Boström, Ilkka Koskivuo, Anil Thotakura, Jeroen Pouwels, Maija Hollmén, Satu Mustjoki, Juha Klefström
Publicado en: OncoImmunology, Edición 14, 2025, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2025.2466305

Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent

Autores: Tuğba Akman, Lisa M. Arendt, Jürgen Geisler, Vessela N. Kristensen, Arnoldo Frigessi, Alvaro Köhn-Luque
Publicado en: Bulletin of Mathematical Biology, Edición 86, 2024, ISSN 0092-8240
Editor: Academic Press
DOI: 10.1007/s11538-023-01253-1

Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition

Autores: Leonard Schmiester, Fara Brasó-Maristany, Blanca González-Farré, Tomás Pascual, Joaquín Gavilá, Xavier Tekpli, Jürgen Geisler, Vessela N. Kristensen, Arnoldo Frigessi, Aleix Prat, Alvaro Köhn-Luque
Publicado en: Clinical Cancer Research, 2024, Página(s) OF1-OF9, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-24-0244

Author Correction: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Autores: Francesco Schettini, Nuria Chic, Fara Brasó-Maristany, Laia Paré, Tomás Pascual, Benedetta Conte, Olga Martínez-Sáez, Barbara Adamo, Maria Vidal, Esther Barnadas, Aranzazu Fernández-Martinez, Blanca González-Farre, Esther Sanfeliu, Juan Miguel Cejalvo, Giuseppe Perrone, Giovanna Sabarese, Francesca Zalfa, Vicente Peg, Roberta Fasani, Patricia Villagrasa, Joaquín Gavilá, Carlos H. Barrios,
Publicado en: npj Breast Cancer, Edición 9, 2023, ISSN 2374-4677
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41523-023-00538-x

EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets

Autores: Zhi Zhao, Manuela Zucknick, Tero Aittokallio
Publicado en: Bioinformatics Advances, Edición 2(1), 2022, Página(s) vbac073, ISSN 2635-0041
Editor: Oxford Academic
DOI: 10.1093/bioadv/vbac073

Multivariate Bayesian structured variable selection for pharmacogenomic studies

Autores: Zhi Zhao, Marco Banterle, Alex Lewin, Manuela Zucknick
Publicado en: Journal of the Royal Statistical Society Series C: Applied Statistics, Edición 73, 2024, Página(s) 420-443, ISSN 0035-9254
Editor: Blackwell Publishing Inc.
DOI: 10.1093/jrsssc/qlad102

Cell-cycle inhibition and immune microenvironment in breast cancer treated with ribociclib and letrozole or chemotherapy

Autores: Tomás Pascual, Aranzazu Fernandez-Martinez, Yash Agrawal, Adam D. Pfefferle, Nuria Chic, Fara Brasó-Maristany, Blanca Gonzàlez-Farré, Laia Paré, Guillermo Villacampa, Cristina Saura, Cristina Hernando, Montserrat Muñoz, Patricia Galván, Xavier Gonzàlez-Farré, Mafalda Oliveira, Miguel Gil-Gil, Eva Ciruelos, Patricia Villagrasa, Joaquín Gavilá, Aleix Prat, Charles M. Perou
Publicado en: npj Breast Cancer, Edición 10, 2024, ISSN 2374-4677
Editor: NPJ
DOI: 10.1038/s41523-024-00625-7

Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7

Autores: Aleix Prat, Nadia Solovieff, Fabrice André, Joyce O'Shaughnessy, David A. Cameron, Wolfgang Janni, Gabe S. Sonke, Yoon-Sim Yap, Denise A. Yardley, Ann H. Partridge, Astrid Thuerigen, Juan Pablo Zarate, Agnes Lteif, Fei Su, Lisa A. Carey
Publicado en: Clinical Cancer Research, Edición 30, 2024, Página(s) 793-802, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-23-0561

Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer

Autores: Pauliina M, Munne; Lahja, Martikainen; Iiris, Räty; Kia, Bertula; , Nonappa; Janika, Ruuska; Hanna, Ala-Hongisto; Aino, Peura; Babette, Hollmann; Lilya, Euro; Kerim, Yavuz; Linda, Patrikainen; Maria, Salmela; Juho, Pokki; Mikko, Kivento; Juho, Väänänen; Tomi, Suomi; Liina, Nevalaita; Minna, Mutka; Panu, Kovanen; Marjut, Leidenius; Tuomo, Meretoja; Katja, Hukkinen; Outi, Monni; Jeroen, Pouwels;
Publicado en: Nature Communications, Edición 14, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-27220-9

Multiple kernel learning for integrative consensus clustering of omic datasets

Autores: Alessandra Cabassi, Paul D W Kirk
Publicado en: Bioinformatics, Edición 36/18, 2020, Página(s) 4789-4796, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btaa593

Standardized assays to monitor drug sensitivity in hematologic cancers

Autores: Pilar Ayuda-Durán, Johanne U. Hermansen, Mariaserena Giliberto, Yanping Yin, Robert Hanes, Sandra Gordon, Heikki Kuusanmäki, Andrea M. Brodersen, Aram N. Andersen, Kjetil Taskén, Krister Wennerberg, Jorrit M. Enserink, Sigrid S. Skånland
Publicado en: Cell Death Discovery, Edición 9, 2024, ISSN 2058-7716
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41420-023-01722-5

Tissue-specific identification of multi-omics features for pan-cancer drug response prediction

Autores: Zhi Zhao, Shixiong Wang, Manuela Zucknick, Tero Aittokallio
Publicado en: iScience, Edición 25(8), 2022, Página(s) 104767, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2022.104767

HapA protease targets PAR-1/2 to modulate ERK signalling and reduce cancer cell viability

Autores: David Tena-Chaves, Inês Pontes-Gomes, José Ángel Palomeque, Eric Toh, Palwasha Baryalai, Gabor Kadler, Reto A. Schuepbach, Dorothea M. Heuberger, Antoni Hurtado, Sun Nyunt Wai
Publicado en: Cell Death Discovery, Edición 11, 2025, ISSN 2058-7716
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41420-025-02691-7

POIBM: batch correction of heterogeneous RNA-seq datasets through latent sample matching.

Autores: Susanna Holmström, Sampsa Hautaniemi, Antti Häkkinen
Publicado en: Bioinformatics, 2022, ISSN 1460-2059
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btac124

Identifying predictors of treatment response and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-negative breast cancer: the NEOENDO translational study

Autores: F. Schettini, F. Brasó-Maristany, T. Pascual, N. Lorman-Carbó, S. Nucera, M. Bergamino, P. Galván, B. Conte, E. Seguí, I. García Fructuoso, R. Gómez Bravo, A.B. Rodríguez, O. Martínez-Sáez, N. Chic, M. Vidal, B. Adamo, B. González-Farre, E. Sanfeliu, I. Cebrecos, E. Mensión, G. Oses, M. Locci, M. Mollà, S. Ganau, P. Jares, S. Vidal-Sicart, M. Muñoz, A. Prat
Publicado en: ESMO Open, Edición 9, 2026, Página(s) 103989, ISSN 2059-7029
Editor: Elsevier BV
DOI: 10.1016/j.esmoop.2024.103989

Obesity-associated changes in molecular biology of primary breast cancer

Autores: Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Ree
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-39996-z

The harmonized activities of HER2–HER3 heterodimer and deacetylated FOXA1 evade hormone response by regulating FOXA1 chromatin binding

Autores: Shixiong Wang, Gemma Santacana-Font, Darek Kedra, Siv Gilfillan, David Tena-Chaves, Helga Bergholtz, Olav Engebraaten, Ole Christian Lingjaerde, Javier Gutiérrez-Fernández, Jens Henrik Norum, Therese Sørlie, Sandra López-Aviles, Antoni Hurtado
Publicado en: Nucleic Acids Research, Edición 53, 2025, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaf1086

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy

Autores: Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong, Bram Boeckx, Sigrid Hatse, Thomas Van Brussel, Rogier Schepers, Cedric Van Aerde, Sarah Geurs, Vincent Vandecaveye, Esther Hauben, Vincent Vander Poorten, Sara Verbandt, Katy Vandereyken, Junbin Qian, Sabine Tejpar, Thierry Voet, Paul M. Clem
Publicado en: Immunity, Edición 57, 2024, Página(s) 541-558.e7, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2024.02.007

HER2DX and survival outcomes in early-stage HER2-positive breast cancer: an individual patient-level meta-analysis

Autores: Guillermo Villacampa, Tomás Pascual, Paolo Tarantino, Javier Cortés, José Perez-García, Antonio Llombart-Cussac, Pierfranco Conte, Mario Mancino, Valentina Guarneri, Maria Vittoria Dieci, Adrienne G Waks, Francesco Schettini, Fara Brasó-Maristany, Gaia Griguolo, Beatriz Alonso de Castro, Cristina Reboredo, Silvia Antolín, Coralia Bueno-Muiño, Isabel Echavarría, Sara López-Tarruella, Tatia
Publicado en: The Lancet Oncology, Edición 26, 2025, Página(s) 1100-1112, ISSN 1470-2045
Editor: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(25)00276-1

Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer

Autores: Aleix Prat, Fara Brasó-Maristany, Olga Martínez-Sáez, Esther Sanfeliu, Youli Xia, Meritxell Bellet, Patricia Galván, Débora Martínez, Tomás Pascual, Mercedes Marín-Aguilera, Anna Rodríguez, Nuria Chic, Barbara Adamo, Laia Paré, Maria Vidal, Mireia Margelí, Ester Ballana, Marina Gómez-Rey, Mafalda Oliveira, Eudald Felip, Judit Matito, Rodrigo Sánchez-Bayona, Anna Suñol, Cristina Saura
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36801-9

Jellyfish: integrative visualization of spatio-temporal tumor evolution and clonal dynamics

Autores: Kari Lavikka, Altti Ilari Maarala, Jaana Oikkonen, Sampsa Hautaniemi
Publicado en: Bioinformatics, Edición 41, 2025, ISSN 1367-4811
Editor: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btaf091

MRI Assessment of Changes in Tumor Vascularization during Neoadjuvant Anti-Angiogenic Treatment in Locally Advanced Breast Cancer Patients

Autores: Torgeir Mo, Siri Helene Bertelsen Brandal, Oliver Marcel Geier, Olav Engebråten, Line Brennhaug Nilsen, Vessela N. Kristensen, Knut Håkon Hole, Tord Hompland, Thomas Fleischer, Therese Seierstad
Publicado en: Cancers, Edición 15, 2025, Página(s) 4662, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15184662

Autores: Hussein Al‐Akhrass, Mika Pietilä, Johanna Lilja, Ella‐Maria Vesilahti, Johanna M. Anttila, Heidi M. Haikala, Pauliina M. Munne, Juha Klefström, Emilia Peuhu, Johanna Ivaska
Publicado en: Molecular Oncology, Edición 16, 2023, Página(s) 116-129, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.1002/1878-0261.13106

Patritumab deruxtecan in HER2-negative breast cancer: part B results of the window-of-opportunity SOLTI-1805 TOT-HER3 trial and biological determinants of early response

Autores: Fara Brasó-Maristany, Juan Manuel Ferrero-Cafiero, Claudette Falato, Olga Martínez-Sáez, Juan Miguel Cejalvo, Mireia Margelí, Pablo Tolosa, Francisco Javier Salvador-Bofill, Josefina Cruz, Blanca González-Farré, Esther Sanfeliu, Andreu Òdena, Violeta Serra, Francisco Pardo, Ana María Luna Barrera, Miriam Arumi, Juan Antonio Guerra, Guillermo Villacampa, Rodrigo Sánchez-Bayona, Eva Ciruelo
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-50056-y

Hepsin regulates TGFβ signaling via fibronectin proteolysis

Autores: Denis Belitškin, Shishir M Pant, Pauliina Munne, Ilida Suleymanova, Kati Belitškina, Hanna‐Ala Hongisto, Johanna Englund, Tiina Raatikainen, Olga Klezovitch, Valeri Vasioukhin, Shuo Li, Qingyu Wu, Outi Monni, Satu Kuure, Pirjo Laakkonen, Jeroen Pouwels, Topi A Tervonen, Juha Klefström
Publicado en: EMBO reports, Edición 22, 2025, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.202152532

HER2DX ERBB2 mRNA score in first-line advanced HER2-positive breast cancer treated with chemotherapy, trastuzumab, and pertuzumab

Autores: Rodrigo Sánchez-Bayona, Olga Martínez-Sáez, Denys Romero-Romero, Elia Seguí, Esther Carcelero, Pablo Tolosa, Jesús Soberino, Manuel Alva, Tomás Pascual, Laura Lema, Isabel Garcia-Fructuoso, Maria Angeles Cobos-Fernandez, Maria Rey, Luis Manso, Angela Aguirre, Ainhoa Madariaga, Valeria Sirenko, Cristina González-Deza, Paula Blasco, Astrid Mayhua, Oleguer Castillo, Patricia Galván, Esther Sa
Publicado en: npj Breast Cancer, Edición 11, 2025, ISSN 2374-4677
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41523-025-00753-8

Circulating tumor DNA dynamics in advanced breast cancer treated with CDK4/6 inhibition and endocrine therapy

Autores: Olga Martínez-Sáez, Tomás Pascual, Fara Brasó-Maristany, Nuria Chic, Blanca González-Farré, Esther Sanfeliu, Adela Rodríguez, Débora Martínez, Patricia Galván, Anna Belén Rodríguez, Francesco Schettini, Benedetta Conte, Maria Vidal, Barbara Adamo, Antoni Martínez, Montserrat Muñoz, Reinaldo Moreno, Patricia Villagrasa, Fernando Salvador, Eva M. Ciruelos, Iris Faull, Justin I. Odegaar
Publicado en: npj Breast Cancer, Edición 7, 2022, ISSN 2374-4677
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41523-021-00218-8

On the stability of log-rank test under labeling errors

Autores: Ben Galili, Anat Samohi, Zohar Yakhini
Publicado en: Bioinformatics, Edición 37, 2023, Página(s) 4451-4459, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btab495

HER2DX ERBB2 score in advanced HER2-positive gastric cancer treated with trastuzumab and chemotherapy

Autores: D. Pesántez, F. Brasó-Maristany, T. Pascual, L. Angelats, A. Indacochea, M. Cuatrecasas, S. López, E. Sanfeliu, G. Fernández-Esparrach, L. Notario, I. Méndez, D. Momblan, L. Candia, I. Macias, A. Prat, T. Sauri
Publicado en: ESMO Open, Edición 10, 2026, Página(s) 105563, ISSN 2059-7029
Editor: Elsevier BV
DOI: 10.1016/j.esmoop.2025.105563

Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Autores: Francesco Schettini, Nuria Chic, Fara Brasó-Maristany, Laia Paré, Tomás Pascual, Benedetta Conte, Olga Martínez-Sáez, Barbara Adamo, Maria Vidal, Esther Barnadas, Aranzazu Fernández-Martinez, Blanca González-Farre, Esther Sanfeliu, Juan Miguel Cejalvo, Giuseppe Perrone, Giovanna Sabarese, Francesca Zalfa, Vicente Peg, Roberta Fasani, Patricia Villagrasa, Joaquín Gavilá, Carlos H. Barrios,
Publicado en: npj Breast Cancer, Edición 7, 2023, ISSN 2374-4677
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41523-020-00208-2

Protocol for whole-slide image analysis of human multiplexed tumor tissues using QuPath and R

Autores: Amelie Franken, Michel Bila, Diether Lambrechts
Publicado en: STAR Protocols, Edición 5, 2025, Página(s) 103270, ISSN 2666-1667
Editor: Elsevier BV
DOI: 10.1016/j.xpro.2024.103270

screenwerk: a modular tool for the design and analysis of drug combination screens

Autores: Robert Hanes, Pilar Ayuda-Durán, Leiv Rønneberg, Sigve Nakken, Eivind Hovig, Manuela Zucknick, Jorrit M Enserink
Publicado en: Bioinformatics, Edición btac840, 2022, Página(s) 1-3, ISSN 1477-4054
Editor: Oxford Academic
DOI: 10.1093/bioinformatics/btac840

CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition

Autores: Irene Andreu-Saumell, Alba Rodriguez-Garcia, Vanessa Mühlgrabner, Marta Gimenez-Alejandre, Berta Marzal, Joan Castellsagué, Fara Brasó-Maristany, Hugo Calderon, Laura Angelats, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes B. Huppa, Sonia Guedan
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-47799-z

Spatial transcriptomics inferred from pathology whole-slide images links tumor heterogeneity to survival in breast and lung cancer

Autores: Alona Levy-Jurgenson, Xavier Tekpli, Vessela N. Kristensen, Zohar Yakhini
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-75708-z

Deciphering cancer genomes with GenomeSpy: a grammar-based visualization toolkit

Autores: Kari Lavikka, Jaana Oikkonen, Yilin Li, Taru Muranen, Giulia Micoli, Giovanni Marchi, Alexandra Lahtinen, Kaisa Huhtinen, Rainer Lehtonen, Sakari Hietanen, Johanna Hynninen, Anni Virtanen, Sampsa Hautaniemi
Publicado en: GigaScience, Edición 13, 2024, ISSN 2047-217X
Editor: Oxford University Press (OUP)
DOI: 10.1093/gigascience/giae040

Tutorial on survival modeling with applications to omics data

Autores: Zhi Zhao, John Zobolas, Manuela Zucknick, Tero Aittokallio
Publicado en: Bioinformatics, Edición 40, 2024, ISSN 1367-4811
Editor: Bioinformatics
DOI: 10.1093/bioinformatics/btae132

Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models

Autores: Verona Buocikova, Eleonora Marta Longhin, Eleftherios Pilalis, Chara Mastrokalou, Svetlana Miklikova, Marina Cihova, et al.
Publicado en: Biomedicine & Pharmacotherapy, Edición Volume 147, March 2022, 112662, 2022, ISSN 1950-6007
Editor: Elsevier
DOI: 10.1016/j.biopha.2022.112662

Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer

Autores: Christina Metoikidou, Vadim Karnaukhov, Bram Boeckx, Eleonora Timperi, Pierre-Emmanuel Bonté, Ling Wang, Marion Espenel, Benoit Albaud, Delphine Loirat, Xiaoxiao Wang, Christos Sotiriou, Philippe Aftimos, Kevin Punie, Hans Wildiers, Viktorija Labroska, Ming-Wei Wang, Joshua J. Waterfall, Martine Piccart-Gebhart, Thierry Mora, Aleksandra Walczak, Olivier Lantz, Laurence Buisseret, Diether Lambrech
Publicado en: Cell Reports Medicine, Edición 6, 2025, Página(s) 101973, ISSN 2666-3791
Editor: Elsevier BV
DOI: 10.1016/j.xcrm.2025.101973

miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer

Autores: Shay Ben-Elazar, Miriam Ragle Aure, Kristin Jonsdottir, Suvi-Katri Leivonen, Vessela N. Kristensen, Emiel A. M. Janssen, Kristine Kleivi Sahlberg, Ole Christian Lingjærde, Zohar Yakhini
Publicado en: PLOS Computational Biology, Edición 17, 2024, Página(s) e1008608, ISSN 1553-7358
Editor: PLOS Comput Biol
DOI: 10.1371/journal.pcbi.1008608

Improved detection of lipidated Atg8a by immunoblotting in <i>Drosophila melanogaster</i> cells and tissues enables precise investigation of Atg8a flux and its termination

Autores: Siri Andresen, Amani Al Outa, Miriam Formica, Jorrit Enserink, Helene Knævelsrud
Publicado en: Autophagy, Edición 21, 2025, Página(s) 2497-2517, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2025.2508551

Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment

Autores: Rita Turpin, Ruixian Liu, Pauliina M Munne, Aino Peura, Jenna H Rannikko, Gino Philips, Bram Boeckx, Natasha Salmelin, Elina Hurskainen, Ilida Suleymanova, July Aung, Elisa M Vuorinen, Laura Lehtinen, Minna Mutka, Panu E Kovanen, Laura Niinikoski, Tuomo J Meretoja, Johanna Mattson, Satu Mustjoki, Päivi Saavalainen, Andrei Goga, Diether Lambrechts, Jeroen Pouwels, Maija Hollmén, Juha Klefström
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 12, 2024, Página(s) e008053, ISSN 2051-1426
Editor: Journal for Immunotherapy Cancer
DOI: 10.1136/jitc-2023-008053

Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis

Autores: Begüm Utz, Rita Turpin, Johanna Lampe, Jeroen Pouwels, Juha Klefström
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-75411-z

CELLULAR, A Cell Autophagy Imaging Dataset

Autores: Amani Al Outa, Steven Hicks, Vajira Thambawita, Siri Andresen, Jorrit M. Enserink, Pål Halvorsen, Michael A. Riegler, Helene Knævelsrud
Publicado en: Scientific Data, Edición 10, 2023, ISSN 2052-4463
Editor: Nature
DOI: 10.1038/s41597-023-02687-x

Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation

Autores: Katalin Erdélyi, Tamás Ditrói, Henrik J. Johansson, Ágnes Czikora, Noémi Balog, Laxmi Silwal-Pandit, Tomoaki Ida, Judit Olasz, Dorottya Hajdú, Zoltán Mátrai, Orsolya Csuka, Koji Uchida, József Tóvári, Olav Engebraten, Takaaki Akaike, Anne-Lise Børresen Dale, Miklós Kásler, Janne Lehtiö, Péter Nagy
Publicado en: Proceedings of the National Academy of Sciences, Edición 118, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2100050118

BayesSUR: An R Package for High-Dimensional Multivariate Bayesian Variable and Covariance Selection in Linear Regression

Autores: Zhi Zhao; Marco Banterle; Leonardo Bottolo; Sylvia Richardson; Alex Lewin; Manuela Zucknick
Publicado en: Journal of Statistical Software; Vol. 100 (2021); 1 - 32, Edición 4, 2021, ISSN 1548-7660
Editor: University of California at Los Angeles
DOI: 10.48550/arxiv.2104.14008

Topological approximate Bayesian computation for parameter inference of an angiogenesis model

Autores: Thomas Thorne, Paul D W Kirk, Heather A Harrington
Publicado en: Bioinformatics, Edición btac118, 2020, Página(s) 2529–2535, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btac118

Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells

Autores: Maria Heilala, Arttu Lehtonen, Ossi Arasalo, Aino Peura, Juho Pokki, Olli Ikkala, null Nonappa, Juha Klefström, Pauliina M. Munne
Publicado en: Advanced Healthcare Materials, Edición 12, 2025, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301137

12P Gene expression profiling in early breast cancer treated with neoadjuvant ribociclib plus letrozole (R+L) versus chemotherapy (CT): A correlative analysis of the SOLTI-1402/CORALLEEN phase II trial

Autores: Nuria Chic; Blanca Gonzalez-Farre; Laia Paré; T. Pascual; Cristina Saura; C. Hernando Melia; Montse Muñoz; Pascual Fernández; Dianny Martínez; Esther Sanfeliu; Fara Brasó-Maristany; X. González-Farré; Mafalda Oliveira; Miguel Gil-Gil; Pamela Céliz; E.M. Ciruelos; Patricia Villagrasa; J. Gavila Gregori; Andreu Prat
Publicado en: Annals of Oncology, Edición 13, 2020, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1016/j.annonc.2020.03.148

Latent representation of H&E images retains biological information in a breast cancer cohort

Autores: Chloé Benmussa, Esther Sanfeliu, Anabel Martínez-Romero, Blanca González-Farré, Tomás Pascual, Joaquín Gavilá, Alona Levy-Jurgenson, Ariel Shamir, Fara Brasó-Maristany, Aleix Prat, Zohar Yakhini
Publicado en: PLOS One, Edición 20, 2025, Página(s) e0329221, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0329221

The FLARE Score and Circulating Neutrophils in Patients with Cancer and COVID-19 Disease

Autores: Elia Seguí, Juan Manuel Torres, Edouard Auclin, David Casadevall, Sara Peiro Carmona, Juan Aguilar-Company, Marta García de Herreros, Teresa Gorría, Juan Carlos Laguna, Marta Rodríguez, Azucena González, Nicolas Epaillard, Javier Gavira, Victor Bolaño, Jose C. Tapia, Marco Tagliamento, Cristina Teixidó, Hugo Arasanz, Sara Pilotto, Rafael Lopez-Castro, Xabier Mielgo-Rubio, Cristina Urbano, G
Publicado en: Cancers, Edición 16, 2025, Página(s) 2974, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16172974

Comparative biological activity of palbociclib and ribociclib in hormone receptor-positive breast cancer

Autores: Natàlia Lorman-Carbó, Olga Martínez-Sáez, Aranzazu Fernandez-Martinez, Patricia Galván, Nuria Chic, Isabel Garcia-Fructuoso, Adela Rodríguez, Raquel Gómez-Bravo, Francesco Schettini, Paula Blasco, Oleguer Castillo, Blanca González-Farré, Barbara Adamo, Maria Vidal, Montserrat Muñoz, Charles M. Perou, Marcos Malumbres, Joaquín Gavilá, Tomás Pascual, Aleix Prat, Fara Brasó-Maristany
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-67126-2

The SRC-family serves as a therapeutic target in triple negative breast cancer with acquired resistance to chemotherapy

Autores: Eivind Valen Egeland, Kotryna Seip, Eleni Skourti, Geir Frode Øy, Solveig J. Pettersen, Abhilash D. Pandya, Maria A. Dahle, Mads H. Haugen, Alexander Kristian, Sigve Nakken, Olav Engebraaten, Gunhild M. Mælandsmo, Lina Prasmickaite
Publicado en: British Journal of Cancer, Edición 131, 2024, Página(s) 1656-1667, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-024-02875-5

Clinical implications of the intrinsic molecular subtypes in hormone receptor-positive and HER2-negative metastatic breast cancer

Autores: Claudette Falato; Francesco Schettini; Tomás Pascual; Fara Brasó-Maristany; Aleix Prat
Publicado en: cancer treatment reviews, Edición 9, 2022, ISSN 0305-7372
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2022.102496

Robust scoring of selective drug responses for patient-tailored therapy selection

Autores: Yingjia Chen, Liye He, Aleksandr Ianevski, Pilar Ayuda-Durán, Swapnil Potdar, Jani Saarela, Juho J. Miettinen, Sari Kytölä, Susanna Miettinen, Mikko Manninen, Caroline A. Heckman, Jorrit M. Enserink, Krister Wennerberg, Tero Aittokallio
Publicado en: Nature Protocols, Edición 19, 2024, Página(s) 60-82, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-023-00903-x

Development of mesothelioma-specific oncolytic immunotherapy enabled by immunopeptidomics of murine and human mesothelioma tumors

Autores: Jacopo Chiaro, Gabriella Antignani, Sara Feola, Michaela Feodoroff, Beatriz Martins, Hanne Cojoc, Salvatore Russo, Manlio Fusciello, Firas Hamdan, Valentina Ferrari, Daniele Ciampi, Ilkka Ilonen, Jari Räsänen, Mikko Mäyränpää, Jukka Partanen, Satu Koskela, Jarno Honkanen, Jussi Halonen, Lukasz Kuryk, Maria Rescigno, Mikaela Grönholm, Rui M. Branca, Janne Lehtiö, Vincenzo Cerullo
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-42668-7

Chemoresistant tumor cell secretome potentiates immune suppression in triple negative breast cancer

Autores: Eleni Skourti, Kotryna Seip, Nadia Mensali, Shakila Jabeen, Siri Juell, Inger Øynebråten, Solveig Pettersen, Olav Engebraaten, Alexandre Corthay, Else Marit Inderberg, Helmut Dolznig, Gunhild Mari Mælandsmo, Eivind Valen Egeland, Lina Prasmickaite
Publicado en: Breast Cancer Research, Edición 27, 2025, ISSN 1465-542X
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13058-025-02082-x

Preoperative Radiation Therapy-Induced Molecular and Immune Modulation in Early-Stage Breast Cancer: Results From the YOUNGSTER trial

Autores: Carles Gomà, Meritxell Mollà, Gabriela Oses, Esther Sanfeliu, Adela Rodríguez-Hernández, Blanca González-Farré, Patricia Galván, Valeria Sirenko, Oleguer Castillo, Paula Blasco, Alba Llop-Guevara, Violeta Serra, Sergi Ganau, Belén Úbeda, Xavier Bargalló, Carla Cases, Artur Latorre-Musoll, Olga Martínez-Sáez, Isabel Garcia-Fructuoso, Raquel Gómez-Bravo, Francesco Schettini, Barbara Ada
Publicado en: International Journal of Radiation Oncology*Biology*Physics, Edición 124, 2026, Página(s) 122-132, ISSN 0360-3016
Editor: Elsevier BV
DOI: 10.1016/j.ijrobp.2025.07.1443

ERBB2 mRNA Expression and Response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-Positive Breast Cancer.

Autores: Gaia Griguolo; Fara Brasó-Maristany; Blanca Gonzalez-Farre; Tomás Pascual; Nuria Chic; Tamara Saurí; Ronald E. Kates; Oleg Gluz; D. Martinez; Laia Paré; Vassilena Tsvetkova; David Pesantez; Maria Vidal; Barbara Adamo; Montserrat Muñoz; Patricia Galván; Laura Barberá; Miriam Cuatrecasas; Mathias Christgen; Hans Kreipe; Inés Monge-Escartín; Patricia Villagrasa; Dolors Soy; Tommaso Giarratan
Publicado en: Cancers (Basel), Edición 11, 2020, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12071902

Associations of the HER2DX Genomic Test with Biological and Pathologic Features in HER2-Positive Breast Cancer

Autores: Esther Sanfeliu, Anabel Martínez-Romero, Mercedes Marín-Aguilera, Sandra Cobo, Blanca González-Farré, Eva Hernandez-Illan, Pedro Jares, Joan Antón Puig-Butillé, Montserrat Muñoz, Raquel Gómez-Bravo, Marta Tapia, Cristina Tebar, Cristina Saura, Santiago Escrivà-de-Romaní, Jesús Soberino, Javier Cortés, Serafin Morales, Kepa Amillano, Laia Paré, Patricia Villagrasa, Wesley Buckingham, F
Publicado en: Clinical Cancer Research, Edición 32, 2026, Página(s) 570-580, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-25-3123

A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer

Autores: Ayse Bassez, Hanne Vos, Laurien Van Dyck, Giuseppe Floris, Ingrid Arijs, Christine Desmedt, Bram Boeckx, Marlies Vanden Bempt, Ines Nevelsteen, Kathleen Lambein, Kevin Punie, Patrick Neven, Abhishek D. Garg, Hans Wildiers, Junbin Qian, Ann Smeets, Diether Lambrechts
Publicado en: Nature Medicine, Edición 27/5, 2021, Página(s) 820-832, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-021-01323-8

A perspective on the development and lack of interchangeability of the breast cancer intrinsic subtypes

Autores: Francesco Schettini, Fara Brasó-Maristany, Nicole M. Kuderer & Aleix Prat
Publicado en: npj breast cancer, Edición 8:85, 2022, ISSN 2374-4677
Editor: Springer Nature
DOI: 10.1038/s41523-022-00451-9

Frequency and spectrum of PIK3CA somatic mutations in breast cancer

Autores: Olga Martínez-Sáez, Nuria Chic, Tomás Pascual, Barbara Adamo, Maria Vidal, Blanca González-Farré, Esther Sanfeliu, Francesco Schettini, Benedetta Conte, Fara Brasó-Maristany, Adela Rodríguez, Débora Martínez, Patricia Galván, Ana Belén Rodríguez, Antonio Martinez, Montserrat Muñoz, Aleix Prat
Publicado en: Breast Cancer Research, Edición 22, 2022, ISSN 1465-542X
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13058-020-01284-9

Tailored Bayes: a risk modeling framework under unequal misclassification costs

Autores: Solon Karapanagiotis, Umberto Benedetto, Sach Mukherjee, Paul D W Kirk, Paul J Newcombe
Publicado en: Biostatistics, 2021, ISSN 1465-4644
Editor: Oxford University Press
DOI: 10.1093/biostatistics/kxab023

TNBC-DX genomic test in early-stage triple-negative breast cancer treated with neoadjuvant taxane-based therapy

Autores: M. Martín, S.R. Stecklein, O. Gluz, G. Villacampa, M. Monte-Millán, U. Nitz, S. Cobo, M. Christgen, F. Brasó-Maristany, E.L. Álvarez, I. Echavarría, B. Conte, S. Kuemmel, C. Bueno-Muiño, Y. Jerez, R. Kates, M. Cebollero, C. Kolberg-Liedtke, O. Bueno, J.Á. García-Saenz, F. Moreno, E.-M. Grischke, H. Forstbauer, M. Braun, M. Warm, J. Hackmann, C. Uleer, B. Aktas, C. Schumacher, R. Wuerstlein
Publicado en: Annals of Oncology, Edición 36, 2025, Página(s) 158-171, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1016/j.annonc.2024.10.012

ABC of the future

Autores: Henri Pesonen, Umberto Simola, Alvaro Köhn-Luque, Henri Vuollekoski, Xiaoran Lai, Arnoldo Frigessi, Samuel Kaski, David T. Frazier, Worapree Maneesoonthorn, Gael M. Martin, Jukka Corander
Publicado en: International Statistical Review, Edición n/a, 2022, Página(s) n/a, ISSN 1751-5823
Editor: Wiley
DOI: 10.1111/insr.12522

A 14-gene B-cell immune signature in early-stage triple-negative breast cancer (TNBC): a pooled analysis of seven studies

Autores: Benedetta Conte, Fara Brasó-Maristany, Adela Rodríguez Hernández, Tomás Pascual, Guillermo Villacampa, Francesco Schettini, Maria J. Vidal Losada, Elia Seguí, Laura Angelats, Isabel Garcia-Fructuoso, Raquel Gómez-Bravo, Natàlia Lorman-Carbó, Laia Paré, Mercedes Marín-Aguilera, Olga Martínez-Sáez, Barbara Adamo, Esther Sanfeliu, Beatrice Fratini, Claudette Falato, Núria Chic, Ana Vivan
Publicado en: eBioMedicine, Edición 102, 2024, Página(s) 105043, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105043

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

Autores: Salim Ghannoum, Damiano Fantini, Muhammad Zahoor, Veronika Reiterer, Santosh Phuyal, Waldir Leoncio Netto, Øystein Sørensen, Arvind Iyer, Debarka Sengupta, Lina Prasmickaite, Gunhild Mari Mælandsmo, Alvaro Köhn-Luque, Hesso Farhan
Publicado en: PLOS Computational Biology, Edición 19, 2023, Página(s) e1010995, ISSN 1553-7358
Editor: PLOS Computational Biology
DOI: 10.1371/journal.pcbi.1010995

Gene expression profiles of breast cancer metastasis according to organ site

Autores: Fara Brasó-Maristany; Laia Paré; Nuria Chic; Olga Martínez-Sáez; Tomás Pascual; Meritxell Mallafre-Larrosa; Francesco Schettini; Blanca Gonzalez-Farre; Esther Sanfeliu; D. Martinez; Patricia Galván; Esther Barnadas; Belinda Salinas; P. Tolosa; Eva Ciruelos; Esther Carcelero; Cecilia Guillen; Barbara Adamo; Reinaldo Moreno; Maria Vidal; Montserrat Muñoz; Aleix Prat
Publicado en: Molecular Oncology, Edición 8, 2021, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.1002/1878-0261.13021

Assessing heterogeneity in spatial data using the HTA index with applications to spatial transcriptomics and imaging

Autores: Alona Levy-Jurgenson, Xavier Tekpli, Zohar Yakhini
Publicado en: Bioinformatics, Edición 37, 2023, Página(s) 3796-3804, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btab569

Breast cancer patient-derived explant cultures recapitulate in vivo drug responses

Autores: Solveig Pettersen, Geir Frode Øy, Eivind Valen Egeland, Siri Juell, Olav Engebråten, Gunhild Mari Mælandsmo, Lina Prasmickaite
Publicado en: Frontiers in Oncology, Edición 13, 2023, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2023.1040665

Hepsin promotes breast tumor growth signaling via the <scp>TGFβ‐EGFR</scp> axis

Autores: Denis Belitškin, Pauliina Munne, Shishir M. Pant, Johanna M. Anttila, Ilida Suleymanova, Kati Belitškina, Daniel Kirchhofer, James Janetka, Taivo Käsper, Sami Jalil, Jeroen Pouwels, Topi A. Tervonen, Juha Klefström
Publicado en: Molecular Oncology, Edición 18, 2024, Página(s) 547-561, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.1002/1878-0261.13545

Unexpected Durable Complete Response With Anti–PD-L1 Blockade in Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report With Host and Tumor Biomarker Analysis

Autores: David Pesántez, Alberto Indacochea, Laura Angelats, Marianna Sirico, Iván Victoria, Esther Sanfeliu, Cristina Teixido, Azucena E. González-Navarro, Patricia Galván, Fara Brasó-Maristany, Pedro Jares, Manel Juan, Aleix Prat, Francesco Schettini, Javier García-Corbacho
Publicado en: JCO Precision Oncology, 2024, ISSN 2473-4284
Editor: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/po.23.00051

Efficacy of anti-PD1 therapy in PD1-high mRNA tumors across multiple cancer types: results from cohort 1 and cohort 2 of the phase II SOLTI-1904 ACROPOLI trial

Autores: E. Seguí, F. Brasó-Maristany, T. Pascual, E. Sanfeliu, I. Victoria, C. Saura, C. Hierro, A. López-González, Y. Izarzugaza, E. Ciruelos, J. Gavilá, F. Racca, J.M. Cejalvo, K. Amillano, L. Paz-Ares, M. Juan, E. Felip, E. Garralda, B. González, A. Arance, J. Martín-Liberal, B. Conte, B. Walbaum, A. Indacochea, O. Castillo, P. Blasco, F. Pardo, Á. Aguirre, V. Sirenko, X. González, P. Galván,
Publicado en: ESMO Open, Edición 10, 2026, Página(s) 105838, ISSN 2059-7029
Editor: Elsevier BV
DOI: 10.1016/j.esmoop.2025.105838

Unraveling the clinicopathological and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-low and HER2-0 breast cancer

Autores: F. Schettini, S. Nucera, F. Brasó-Maristany, I. De Santo, T. Pascual, M. Bergamino, P. Galván, B. Conte, E. Seguí, I. García Fructuoso, R. Gómez Bravo, P. Rivera, A.B. Rodríguez, O. Martínez-Sáez, S. Ganau, E. Sanfeliu, B. González-Farre, M.J. Vidal Losada, B. Adamo, I. Cebrecos, E. Mension, G. Oses, P. Jares, S. Vidal-Sicart, M. Mollà, M. Muñoz, A. Prat
Publicado en: ESMO Open, Edición 9, 2024, Página(s) 103619, ISSN 2059-7029
Editor: ESMO OPen
DOI: 10.1016/j.esmoop.2024.103619

Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients

Autores: Pierre Van Moll, Elena Donders, Diether Lambrechts, Els Wauters
Publicado en: International Review of Cell and Molecular Biology, Immune Checkpoint Biology in Health and Disease, 2025, Página(s) 181-206
Editor: Elsevier
DOI: 10.1016/bs.ircmb.2023.04.003

Permutation invariant multi-output Gaussian Processes for drug combination prediction in cancer

Autores: Leiv Rønneberg; Vidhi Lalchand; Paul D. W. Kirk
Publicado en: CoRR, Edición 8, 2024
Editor: Arxiv
DOI: 10.48550/arxiv.2407.00175

Gene expression before and after neoadjuvant chemotherapy or endocrine therapy and survival outcomes in hormone receptor-positive, HER2-negative breast cancer: the NEOENDO study

Autores: Francesco Schettini, Fara Brasó-Maristany, Tomás Pascual, Natàlia Lorman-Carbó, Sabrina Nucera, Milana Bergamino, Pablo Rivera, Patricia Galván, Benedetta Conte, Elia Seguí, Isabel García Fructuoso, Raquel Gómez Bravo, Ana Belén Rodríguez, Olga Martínez-Sáez, Nuria Chic, Maria Vidal, Barbara Adamo, Blanca González-Farre, Esther Sanfeliu, Isaac Cebrecos, Eduard Mensión, Gabriela Oses,
Publicado en: 2024
Editor: Preprint in Research Square
DOI: 10.21203/rs.3.rs-3937385/v1

Annealed variational mixtures for disease subtyping and biomarker discovery

Autores: Prevot, Emma; Toogood, Rory; Pagani, Filippo; Kirk, Paul D. W.
Publicado en: Edición 20, 2024
Editor: Arxiv
DOI: 10.48550/arxiv.2411.19262

CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition

Autores: Sonia Guedan, Irene Andreu-Saumell, Alba Rodriguez-Garcia, Marta Gimenez-Alejandre, Joan Castellsagué, Vanessa Mühlgrabner, Fara Brasó-Maristany, Hugo Calderon, Berta Marzal, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes Huppa
Publicado en: 2024
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-3415822/v1

Dose-response prediction for in-vitro drug combination datasets: a probabilistic approach

Autores: Leiv Rønneberg, Paul D.W. Kirk, Manuela Zucknick
Publicado en: ResearchSquare, Edición rs-1465185, 2022, Página(s) 2529–2535, ISSN 2693-5015
Editor: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-1465185/v2

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