Deciphering the cellular origin and evolution of malignant rhabdoid tumors

Informazioni relative al progetto

RhabdoEvo

ID dell’accordo di sovvenzione: 850571

DOI 10.3030/850571

Data della firma CE 26 Novembre 2019

Data di avvio 1 Dicembre 2019

Data di completamento 31 Maggio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 500 000,00

Contributo UE € 1 500 000,00

Coordinato da

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Open Research Data Pilot

Pubblicazioni

Other (2)

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

Autori: Jeff DeMartino, Michael Meister, Lindy Visser, Mariel Brok, Marian Groot Koerkamp, Laura Hiemcke-Jiwa, Terezinha de Souza, Hans Merks, Frank Holstege, Thanasis Margaritis, Jarno Drost.
Pubblicato in: BioRxiv, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.07.15.497944

SMARCB1 loss creates patient-specific MYC topologies that drive malignant rhabdoid tumor growth

Autori: Ning Qing Liu, Irene Paassen, Lars Custers, Hans Teunissen, Dilara Ayyildiz, Jiayou He, Michael Meister, Eelco Hoving, Elzo de Wit, Jarno Drost.
Pubblicato in: BioRxiv, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.11.21.516939

Peer reviewed articles (10)

In vitro Modeling of Embryonal Tumors

Autori: Lars Custers, Irene Paassen, Jarno Drost
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero February 2021 | Volume 9 | Article 640633, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.640633

Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities

Autori: Camilla Calandrini, Jarno Drost
Pubblicato in: STAR Protocols, Numero Volume 3, Numero 1, 18 March 2022, 2022, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2021.101079

Generation of Human Kidney Tubuloids from Tissue and Urine

Autori: Camilla Calandrini, Jarno Drost
Pubblicato in: The Journal of Visualized Experiments, 2021, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/62404

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

Autori: Jeff DeMartino, Michael T. Meister, Lindy L. Visser, Mariël Brok, Marian J. A. Groot Koerkamp, Amber K. L. Wezenaar, Laura S. Hiemcke-Jiwa, Terezinha de Souza, Johannes H. M. Merks, Anne C. Rios, Frank C. P. Holstege, Thanasis Margaritis, Jarno Drost
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38886-8

Single cell derived mRNA signals across human kidney tumors

Autori: Matthew D. Young, Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H.
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23949-5

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Autori: Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21675-6

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

Autori: Camilla Calandrini, Sander R. van Hooff, Irene Paassen, Dilara Ayyildiz, Sepide Derakhshan, M. Emmy M. Dolman, Karin P.S. Langenberg, Marieke van de Ven, Cecilia de Heus, Nalan Liv, Marcel Kool, Ronald R. de Krijger, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Jarno Drost
Pubblicato in: Cell Reports, Numero AUGUST 24, 2021, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109568

Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution

Autori: Lennart Kester, Buys de Barbanson, Anna Lyubimova, Li-Ting Chen, Valérie van der Schrier, Anna Alemany, Dylan Mooijman, Josi Peterson-Maduro, Jarno Drost, Jeroen de Ridder, Alexander van Oudenaarden
Pubblicato in: Cell Genomics, 2022, ISSN 2666-979X
Editore: CellPress
DOI: 10.1016/j.xgen.2022.100096

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

Autori: Meister, M.T., Groot Koerkamp, M.J.A., de Souza, T., Breunis, W.B., Frazer-Mendelewska, E., Brok, M., DeMartino, J., Manders, F., Calandrini, C., Kerstens, H.H.D., Janse, A., Dolman, M.E.M., Eising, S., Langenberg, K.P.S., van Tuil, M., Knops, R.R.G., van Scheltinga, S.T., Hiemcke-Jiwa, L.S., Flucke, U., Merks, J.H.M., van Noesel, M.M., Tops, B.B.J., Hehir-Kwa, J.Y., Kemmeren, P., Molenaar, J.J.,
Pubblicato in: EMBO Molecular Medicine, 2022, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216001

SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors.

Autori: Ning Qing Liu, Irene Paassen, Lars Custers, Peter Zeller, Hans Teunissen, Dilara Ayyildiz, Jiayou He, Juliane Laura Buhl, Eelco Wieger Hoving, Alexander van Oudenaarden, Elzo de Wit, Jarno Drost.
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-43498-3