Deciphering the cellular origin and evolution of malignant rhabdoid tumors

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Open Research Data Pilot

Publikacje

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

Autorzy: Jeff DeMartino, Michael Meister, Lindy Visser, Mariel Brok, Marian Groot Koerkamp, Laura Hiemcke-Jiwa, Terezinha de Souza, Hans Merks, Frank Holstege, Thanasis Margaritis, Jarno Drost.
Opublikowane w: BioRxiv, 2022, ISSN 2692-8205
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.07.15.497944

SMARCB1 loss creates patient-specific MYC topologies that drive malignant rhabdoid tumor growth

Autorzy: Ning Qing Liu, Irene Paassen, Lars Custers, Hans Teunissen, Dilara Ayyildiz, Jiayou He, Michael Meister, Eelco Hoving, Elzo de Wit, Jarno Drost.
Opublikowane w: BioRxiv, 2022, ISSN 2692-8205
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.11.21.516939

In vitro Modeling of Embryonal Tumors

Autorzy: Lars Custers, Irene Paassen, Jarno Drost
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer February 2021 | Volume 9 | Article 640633, 2021, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2021.640633

Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities

Autorzy: Camilla Calandrini, Jarno Drost
Opublikowane w: STAR Protocols, Numer Volume 3, Numer 1, 18 March 2022, 2022, ISSN 2666-1667
Wydawca: Cell Press
DOI: 10.1016/j.xpro.2021.101079

Generation of Human Kidney Tubuloids from Tissue and Urine

Autorzy: Camilla Calandrini, Jarno Drost
Opublikowane w: The Journal of Visualized Experiments, 2021, ISSN 1940-087X
Wydawca: MYJoVE Corporation
DOI: 10.3791/62404

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

Autorzy: Jeff DeMartino, Michael T. Meister, Lindy L. Visser, Mariël Brok, Marian J. A. Groot Koerkamp, Amber K. L. Wezenaar, Laura S. Hiemcke-Jiwa, Terezinha de Souza, Johannes H. M. Merks, Anne C. Rios, Frank C. P. Holstege, Thanasis Margaritis, Jarno Drost
Opublikowane w: Nature Communications, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-38886-8

Single cell derived mRNA signals across human kidney tumors

Autorzy: Matthew D. Young, Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H.
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23949-5

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Autorzy: Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-21675-6

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

Autorzy: Camilla Calandrini, Sander R. van Hooff, Irene Paassen, Dilara Ayyildiz, Sepide Derakhshan, M. Emmy M. Dolman, Karin P.S. Langenberg, Marieke van de Ven, Cecilia de Heus, Nalan Liv, Marcel Kool, Ronald R. de Krijger, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Jarno Drost
Opublikowane w: Cell Reports, Numer AUGUST 24, 2021, 2021, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.109568

Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution

Autorzy: Lennart Kester, Buys de Barbanson, Anna Lyubimova, Li-Ting Chen, Valérie van der Schrier, Anna Alemany, Dylan Mooijman, Josi Peterson-Maduro, Jarno Drost, Jeroen de Ridder, Alexander van Oudenaarden
Opublikowane w: Cell Genomics, 2022, ISSN 2666-979X
Wydawca: CellPress
DOI: 10.1016/j.xgen.2022.100096

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

Autorzy: Meister, M.T., Groot Koerkamp, M.J.A., de Souza, T., Breunis, W.B., Frazer-Mendelewska, E., Brok, M., DeMartino, J., Manders, F., Calandrini, C., Kerstens, H.H.D., Janse, A., Dolman, M.E.M., Eising, S., Langenberg, K.P.S., van Tuil, M., Knops, R.R.G., van Scheltinga, S.T., Hiemcke-Jiwa, L.S., Flucke, U., Merks, J.H.M., van Noesel, M.M., Tops, B.B.J., Hehir-Kwa, J.Y., Kemmeren, P., Molenaar, J.J.,
Opublikowane w: EMBO Molecular Medicine, 2022, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216001

SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors.

Autorzy: Ning Qing Liu, Irene Paassen, Lars Custers, Peter Zeller, Hans Teunissen, Dilara Ayyildiz, Jiayou He, Juliane Laura Buhl, Eelco Wieger Hoving, Alexander van Oudenaarden, Elzo de Wit, Jarno Drost.
Opublikowane w: Nature Communications, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-43498-3

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