At the epigenetics-cancer metabolism interface

Informazioni relative al progetto

EPICAMENTE

ID dell’accordo di sovvenzione: 852343

DOI

10.3030/852343

Progetto chiuso

Data della firma CE 11 Ottobre 2019

Data di avvio 1 Novembre 2019

Data di completamento 31 Ottobre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 996 904,00

Contributo UE

€ 1 996 904,00

Coordinato da

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan (DMP)

The DMP will explain a. the handling of research data during & after the end of the project b. what data will be collected, processed and/or generated c. which methodology & standards will be applied d. whether data will be shared/made open access and e. how data will be curated & preserved (including after the end of the project).

Pubblicazioni

Other (1)

Nuclear metabolism oscillation during the cell cycle reveals a link between the phosphatidylinositol pathway and histone methylation

Autori: Antoni Gañez-Zapater, Savvas Kourtis, Lorena Espinar, Laura García-López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, André C Müller, Sara Sdelci
Pubblicato in: 2026
Editore: openRxiv
DOI: 10.1101/2024.12.20.629614

Peer reviewed articles (10)

Hallmarks of nuclear metabolism: implications for genome integrity, nuclear signaling, and therapeutic targeting

Autori: Alisa Schmidt, Matilda Pfeiffer, Sara Sdelci
Pubblicato in: npj Metabolic Health and Disease, Numero 4, 2026, ISSN 2948-2828
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44324-025-00097-8

Nuclear localization of MTHFD2 is required for correct mitosis progression

Autori: Natalia Pardo-Lorente, Anestis Gkanogiannis, Luca Cozzuto, Antoni Gañez Zapater, Lorena Espinar, Ritobrata Ghose, Jacqueline Severino, Laura García-López, Rabia Gül Aydin, Laura Martin, Maria Victoria Neguembor, Evangelia Darai, Maria Pia Cosma, Laura Batlle-Morera, Julia Ponomarenko, Sara Sdelci
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-51847-z

Metabolic modulation of transcription: The role of one-carbon metabolism

Autori: Jung-Ming G. Lin Savvas Kourtis Ritobrata Ghose Natalia Pardo Lorente Stefan Kubicek Sara Sdelci
Pubblicato in: Cell Chemical Biology, 2022, ISSN 2451-9456
Editore: Cell Press
DOI: 10.1016/j.chembiol.2022.11.009

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

Autori: Amandine Moretton, Savvas Kourtis, Antoni Gañez Zapater, Chiara Calabrò, Maria Lorena Espinar Calvo, Frédéric Fontaine, Evangelia Darai, Etna Abad Cortel, Samuel Block, Laura Pascual‐Reguant, Natalia Pardo‐Lorente, Ritobrata Ghose, Matthew G Vander Heiden, Ana Janic, André C Müller, Joanna I Loizou, Sara Sdelci
Pubblicato in: Molecular Systems Biology, Numero 19, 2025, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.202211267

Detection of differential bait proteoforms through immunoprecipitation-mass spectrometry data analysis

Autori: Savvas Kourtis, Damiano Cianferoni, Luis Serrano, Sara Sdelci
Pubblicato in: Scientific Data, Numero 11, 2024, ISSN 2052-4463
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41597-024-03394-x

Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity

Autori: Lorena Espinar, Marta Garcia-Cao, Alisa Schmidt, Savvas Kourtis, Antoni Gañez Zapater, Carla Aranda-Vallejo, Ritobrata Ghose, Laura Garcia-Lopez, Ilir Sheraj, Natalia Pardo-Lorente, Marina Bantulà, Laura Pascual-Reguant, Evangelia Darai, Maria Guirola, Joan Montero, Sara Sdelci
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-53877-z

MTHFD2 in healthy and cancer cells: Canonical and non-canonical functions

Autori: Natalia Pardo-Lorente, Sara Sdelci
Pubblicato in: npj Metabolic Health and Disease, Numero 2, 2025, ISSN 2948-2828
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44324-024-00005-6

Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues

Autori: S. Kourtis, A. Gañez Zapater, CR Elbæk, A. Schmidt, R. Ghose, A. Coll Manzano, L. Espinar Calvo, M. Guirola, N. Pardo-Lorente, M. Garcia-Cao, M. Pfeiffer, S. Haynes, F. Fontaine, A. Müller, S. Sdelci
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-026-69217-2

Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer

Autori: Laura Pascual‐Reguant, Queralt Serra‐Camprubí, Debayan Datta, Damiano Cianferoni, Savvas Kourtis, Antoni Gañez‐Zapater, Chiara Cannatá, Lorena Espinar, Jessica Querol, Laura García‐López, Sara Musa‐Afaneh, Maria Guirola, Anestis Gkanogiannis, Andrea Miró Canturri, Marta Guzman, Olga Rodríguez, Andrea Herencia‐Ropero, Joaquin Arribas, Violeta Serra, Luis Serrano, Tian V Tian, San
Pubblicato in: EMBO Molecular Medicine, Numero 15, 2025, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318459

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects

Autori: Ritobrata Ghose, Fabio Pezzano, Rémi Badia, Savvas Kourtis, Ilir Sheraj, Shubhamay Das, Antoni Gañez Zapater, Upamanyu Ghose, Sara Musa-Afaneh, Lorena Espinar, Albert Coll-Manzano, Katja Parapatics, Saška Ivanova, Paula Sànchez-Fernàndez-de-Landa, Dragana Radivojevikj, Valeria Venturini, Stefan Wieser, Antonio Zorzano, André C. Müller, Verena Ruprecht, Sara Sdelci
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-61787-x

Non-peer reviewed articles (1)

The BRD4S-LOXL2-MED1 interaction at the forefront of cell cycle transcriptional control in triple-negative breast cancer

Autori: Laura Pascual-Reguant, Tian V. Tian, Debayan Datta, Damiano Cianferoni, Savvas Kourtis, Antoni Gañez-Zapater, Chiara Cannatá, Queralt Serra-Camprubi, Lorena Espinar, Maria Guirola, Jessica Querol, Andrea Miró Canturri, Joaquin Arribas, Luis Serrano, Sandra Peiró, Sara Sdelci
Pubblicato in: Biorxiv.org (submitted to Cancer Reaserch), 2022, ISSN 2692-8205
Editore: Biorxiv.org
DOI: 10.1101/2022.05.27.493725