Quantifying minute forces: How mechanoregulation determines the behavior of pathogenic bacteria

Project Information

BacForce

Grant agreement ID: 852585

DOI

10.3030/852585

EC signature date 27 January 2020

Start date 1 August 2020

End date 31 July 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 864,00

EU contribution

€ 1 498 864,00

Coordinated by

TECHNISCHE UNIVERSITAT DORTMUND
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Type-IV pili tune an adhesion-migration trade-off during surface colonization of Pseudomonas aeruginosa

Author(s): A.N. Simsek, M.D. Koch, J.E. Sanfilippo, Z. Gitai, G. Gompper, B. Sabass
Published in: bioRxiv Preprint, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/2023.05.09.538458

Sparse inference and active learning of stochastic differential equations from data

Author(s): Y. Huang, Y. Mabrouk, Gompper, Sabass
Published in: Sci Rep, Issue 12, 21691, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-25638-9

Sensory adaptation in a continuum model of bacterial chemotaxis—working range, cost-accuracy relation, and coupled systems

Author(s): Vansh Kharbanda, Benedikt Sabass
Published in: New Journal of Physics, Issue 26, 2024, Page(s) 023045, ISSN 1367-2630
Publisher: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ad26ba

Bacteria Tune a Trade-off between Adhesion and Migration to Colonize Surfaces under Flow

Author(s): Ahmet Nihat Simsek, Matthias D. Koch, Joseph E. Sanfilippo, Zemer Gitai, Gerhard Gompper, Benedikt Sabass
Published in: PRX Life, Issue 2, 2024, ISSN 2835-8279
Publisher: American Physical Society (APS)
DOI: 10.1103/prxlife.2.023003

Multi-Modal Analysis of Satellite Cells Reveals Early Impairments at Pre-Contractile Stages of Myogenesis in Duchenne Muscular Dystrophy

Author(s): Sophie Franzmeier, Shounak Chakraborty, Armina Mortazavi, Jan B. Stöckl, Jianfei Jiang, Nicole Pfarr, Benedikt Sabass, Thomas Fröhlich, Clara Kaufhold, Michael Stirm, Eckhard Wolf, Jürgen Schlegel, Kaspar Matiasek
Published in: Cells, Issue 14, 2025, Page(s) 892, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells14120892

Shear force enhances adhesion of Pseudomonas aeruginosa by counteracting pilus-driven surface departure

Author(s): J.-J. S Palalay, A.N. Simsek, B. Sabass, J.E. Sanfilippo
Published in: Proc. Nat. Acad. Sci., 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1101/2023.05.08.539440

Non-equilibrium dynamics of bacterial colonies -- growth, active fluctuations, segregation, adhesion, and invasion

Author(s): Kai Zhou, Marc Hennes, Berenike Maier, Gerhard Gompper, Benedikt Sabass
Published in: Communications Physics, Issue volume 5, Article number: 251, 2022, ISSN 2399-3650
Publisher: Springer Nature
DOI: 10.1038/s42005-022-01018-7

Clutch model for focal adhesions predicts reduced self-stabilization under oblique pulling

Author(s): Andrea Braeutigam, Anton F Burnet, Gerhard Gompper, Benedikt Sabass
Published in: Journal of Physics: Condensed Matter, Issue 36, 2024, Page(s) 295101, ISSN 0953-8984
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-648x/ad3ac1

Shear force enhances adhesion of <i>Pseudomonas aeruginosa</i> by counteracting pilus-driven surface departure

Author(s): Jessica-Jae S. Palalay, Ahmet N. Simsek, Jessie L. Reed, Matthias D. Koch, Benedikt Sabass, Joseph E. Sanfilippo
Published in: Proceedings of the National Academy of Sciences, Issue 120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2307718120

EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

Author(s): Jasmin I.Maier, Manuel Rogg, Martin Helmstädter, Alena Sammarco, Oliver Schilling, Benedikt Sabass, Jeffrey H. Miner, Jörn Dengjel, Gerd Walz, Martin Werner, Tobias B.Huber, Christoph Schell
Published in: Cell Reports, Issue Volume 34, Issue 12, 23 March 2021, 2021, Page(s) 108883, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108883

A generic self-stabilization mechanism for biomolecular adhesions under load

Author(s): Braeutigam, Andrea; Simsek, Ahmet Nihat; Gompper, Gerhard; Sabass, Benedikt
Published in: Nature Communications, Issue volume 13, Article number: 2197, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29823-2

Book chapters (2)

Quantitative Analysis of Myofibroblast Contraction by Traction Force Microscopy

Author(s): Shuying Yang, Fernando R. Valencia, Benedikt Sabass, Sergey V. Plotnikov
Published in: Methods in Molecular Biology book series (MIMB,volume 2299), 2021
Publisher: Springer Nature
DOI: 10.1007/978-1-0716-1382-5_14

Computational Physics of Active Matter

Author(s): Sabass, Benedikt and Winkler, Roland G and Auth, Thorsten and Elgeti, Jens and Fedosov, Dmitry A and Ripoll, Marisol and Vliegenthart, Gerard A and Gompper, Gerhard
Published in: Out-of-equilibrium Soft Matter, 2023, Page(s) 354--390
Publisher: The Royal Society of Chemistry

Thesis and dissertations (3)

Micromechanics of bacterial surface-migration

Author(s): Ahmet Simsek
Published in: 2021
Publisher: Kölner Publikationsserver

Advanced data analysis for traction force microscopy and data-driven discovery of physical equations

Author(s): Yunfei Huang
Published in: 2021
Publisher: Kölner Publikationsserver

Response of stochastic adhesion clusters to pulling and shearing forces.

Author(s): Andrea Bräutigam
Published in: 2021
Publisher: Kölner Publikationsserver

Other (4)

Hijacked Immune Cells Traverse Microenvironmental Barriers by Positioning and Pushing their Intracellular Parasite Cargo

Author(s): Mauricio J.A. Ruiz-Fernandez, Jianfei Jiang, Armina Mortazavi, Bingzhi Wang, Artur Kuznetcov, Jack Merrin, Markus Meissner, Javier Periz, Benedikt Sabass, Jörg Renkawitz
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.05.03.592378

Not just a number: what cells feel depends on how they grab it

Author(s): B. Sabass
Published in: Biophys. J., Issue Volume 121, ISSUE 9, 2022, Page(s) 1581-1582
Publisher: Cell Press
DOI: 10.1016/j.bpj.2022.04.004

A reliable<i>in vitro</i>rumen culture system and workflow for screening anti-methanogenic compounds

Author(s): Philip P. Laric, Armina Mortazavi, Ewa Węgrzyn, Kathrin Simon, Pauline S. Rittel, Florian M. Trefz, Benedikt Sabass
Published in: 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.03.03.641173

Traction Force Microscopy with DNA FluoroCubes

Author(s): Armina Mortazavi, Jianfei Jiang, Philip Laric, Dominic A. Helmerich, Rick Seifert, Markus Sauer, Benedikt Sabass
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.04.12.589182