Descripción del proyecto
Avance del tratamiento de la epilepsia
El tratamiento de la epilepsia falla en cerca de un tercio de los pacientes, por lo que millones de personas sufren episodios epilépticos farmacorresistentes. La estimulación transcraneal no invasiva con corriente del encéfalo se está posicionando como una solución prometedora, pero la falta de conocimientos sobre sus efectos a corto y largo plazo limita su aplicación. El proyecto financiado con fondos europeos GALVANI está investigando el impacto que tienen los campos eléctricos débiles en la fisiología de las neuronas y las redes neuronales. El objetivo principal es comprender si estos pulsos eléctricos pueden mejorar la red epileptogénica específica de cada paciente. El proyecto generará información mecánica que se combinará con modelos computacionales para desarrollar protocolos personalizados de estimulación transcraneal con corriente y evitar crisis epilépticas.
Objetivo
Epilepsy is a neurological disorder affecting 65 million people worldwide. Pharmacological treatments or surgery are ineffective in one third of the cases – 19 million people. Recent findings indicate that non-invasive brain transcranial current stimulation (tCS) is safe and of therapeutic promise in epilepsy. However, it is not yet indicated as a standard treatment due to major scientific limitations: unknown mechanisms of action, insufficient account for patient-specific factors, poor understanding of short- and long-term effects.
Our ambition is to transform the care of a large fraction of patients living with drug-resistant epilepsies by solving a fundamental problem: to efficiently target and control large-scale epileptic brain networks with tCS-induced neuromodulatory weak electric fields.
To proceed, GALVANI’s synergetic research strategy addresses four interdisciplinary challenges: (1) Unravel the intricate relationship between weak electric fields and their neurophysiological effects at the level of neurons, neuronal assemblies and networks; (2) Maximize their therapeutic effects by altering the neurodynamics of patient-specific epileptogenic networks; (3) Develop optimal personalized neuromodulation protocols for novel multichannel tCS technologies; (4) Test optimized protocols in a cohort of patients and objectively define potential responders.
The required competences and resources are met in GALVANI, uniting the passion and background of three experts and their teams in biomathematics (computational neuroscience), biophysics (bioelectromagnetism) and medicine (epileptology).
The project vision is that critical features of pathological networks can be effectively captured in a new generation of hybrid computational models developed for tailored therapy. The inflection point is to prevent epileptic seizures from a bottom-up mechanistic understanding and control of tCS effects. This will entail a paradigm shift in epileptic disorders and beyond.
Ámbito científico
Palabras clave
Programa(s)
Tema(s)
Régimen de financiación
ERC-SyG - Synergy grantInstitución de acogida
75654 Paris
Francia