Description du projet
Faire avancer le traitement de l’épilepsie
Le traitement de l’épilepsie s’avère inefficace chez près d’un tiers des patients, laissant ainsi des millions d’entre eux souffrir de crises d’épilepsie résistantes aux médicaments. La stimulation transcrânienne à courant (tCS) non invasive constitue depuis peu une solution prometteuse, mais une mauvaise compréhension de ses effets à court et long terme limite son application. Le projet GALVANI, financé par l’UE, étudie l’impact des champs électriques faibles sur la physiologie des neurones et les circuits neuronaux. Le principal objectif consiste à comprendre si ces impulsions électriques peuvent améliorer le réseau épileptogène spécifique au patient. Le projet génèrera des informations mécanistes qui seront combinées à des modèles informatiques afin de développer des protocoles personnalisés de tCS et de prévenir les crises d’épilepsie.
Objectif
Epilepsy is a neurological disorder affecting 65 million people worldwide. Pharmacological treatments or surgery are ineffective in one third of the cases – 19 million people. Recent findings indicate that non-invasive brain transcranial current stimulation (tCS) is safe and of therapeutic promise in epilepsy. However, it is not yet indicated as a standard treatment due to major scientific limitations: unknown mechanisms of action, insufficient account for patient-specific factors, poor understanding of short- and long-term effects.
Our ambition is to transform the care of a large fraction of patients living with drug-resistant epilepsies by solving a fundamental problem: to efficiently target and control large-scale epileptic brain networks with tCS-induced neuromodulatory weak electric fields.
To proceed, GALVANI’s synergetic research strategy addresses four interdisciplinary challenges: (1) Unravel the intricate relationship between weak electric fields and their neurophysiological effects at the level of neurons, neuronal assemblies and networks; (2) Maximize their therapeutic effects by altering the neurodynamics of patient-specific epileptogenic networks; (3) Develop optimal personalized neuromodulation protocols for novel multichannel tCS technologies; (4) Test optimized protocols in a cohort of patients and objectively define potential responders.
The required competences and resources are met in GALVANI, uniting the passion and background of three experts and their teams in biomathematics (computational neuroscience), biophysics (bioelectromagnetism) and medicine (epileptology).
The project vision is that critical features of pathological networks can be effectively captured in a new generation of hybrid computational models developed for tailored therapy. The inflection point is to prevent epileptic seizures from a bottom-up mechanistic understanding and control of tCS effects. This will entail a paradigm shift in epileptic disorders and beyond.
Champ scientifique
Mots‑clés
Programme(s)
Thème(s)
Régime de financement
ERC-SyG - Synergy grantInstitution d’accueil
75654 Paris
France