3D Living Tissues

Projektinformationen

3DLT

ID Finanzhilfevereinbarung: 855706

DOI

10.3030/855706

Projekt abgeschlossen

EK-Unterschriftsdatum 22 Januar 2019

Startdatum 1 Februar 2019

Enddatum 31 Juli 2019

Finanziert unter

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Gesamtkosten

€ 71 429,00

EU-Beitrag

€ 50 000,00

Koordiniert durch

PROMETHEUS S.R.L.
Italy

Periodic Reporting for period 1 - 3DLT (3D Living Tissues)

Berichtszeitraum: 2019-02-01 bis 2019-07-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Prometheus markets 3D tissues for regenerative medicine and drug testing. We are developing a 3D Lymph Node (3DLN) as preclinical predictive 3D model to test new immunotherapies against cancer. The proprietary 3D Bioprinter enables us to use human living cells as ink, creating a 3D tissue equal to the human one. The 3DLN is composed by immune and cancer cells and has the same cell composition and functionality of human tissue, covering gaps between preclinical results and human responses to drugs. Pharma companies spends €2,5B to develop a new anticancer drug, undertaking 3 experimental phases: on artificial tissues, on animals and on human. The 96% of drugs overcoming the first 2 steps, fails human trials and forced pharma companies to perform other expensive preclinical tests. The failure is due to the lack of translational models predicting in a reliable way the effect of drugs on human. Our predictive 3DLN will incentive the discovery of new anticancer drugs, reducing the needed investment and decreasing animal testing.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

Prometheus made an accurate estimation of market value (EU TAM €1.3B SAM €26M) and estimated its market share in 5 years (€3M). We defined a patent strategy, deciding to patent the extrusion system of our bioprinter and 3DLN formulation. We designed a commercial strategy and the first 5 EU countries of interest (IT, UK, Belgium, France, Germany). We defined a marketing plan (scientific papers, scientific events and online SEO). We understood the regulatory requirements for 3DLN manufacturing and the related investments. We will patent and mark the bioprinter as GMP class A ISO 5 and we will become ISO 9001 for manufacturing. We are negotiating with a skilled partner in automation and GMP facilities that will help us with the industrialization of the bioprinter. We made an accurate revenue forecast and cash flow analysis.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

We will go-to-market in 2022, reaching €600k in 2023 with 15 big customers and the BEP in 2024. We are optimizing the bioink formulation, we will industrialize the 3D bioprinter and we will perform testing of comparison between our 3DLN and products now in use. We are negotiating for the financing of the industrialization phase, giving royalties in exchange. After the go-to-market, the overall social impact will be huge, considering the related reduction of drug development cost thanks to a more reliable preclinical model, reducing the failure rate of new immune-therapies and encouraging the research against cancer.

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